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Aliases for FOSL1 Gene

Aliases for FOSL1 Gene

  • FOS Like 1, AP-1 Transcription Factor Subunit 2 3 5
  • FRA1 3 4
  • FOS Like 1, AP-1 Trancription Factor Subunit 3
  • Fos-Related Antigen 1 3
  • FOS-Like Antigen-1 3
  • FOS Like Antigen 1 2
  • Fra-1 3
  • FRA-1 4
  • FRA 3

External Ids for FOSL1 Gene

Previous GeneCards Identifiers for FOSL1 Gene

  • GC11M068193
  • GC11M067341
  • GC11M065435
  • GC11M065416
  • GC11M065659
  • GC11M061986

Summaries for FOSL1 Gene

Entrez Gene Summary for FOSL1 Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for FOSL1 Gene

FOSL1 (FOS Like 1, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSL1 include T-Cell Leukemia and Pfeiffer Syndrome. Among its related pathways are ERK Signaling and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL2.

Gene Wiki entry for FOSL1 Gene

Additional gene information for FOSL1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOSL1 Gene

Genomics for FOSL1 Gene

GeneHancer (GH) Regulatory Elements for FOSL1 Gene

Promoters and enhancers for FOSL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 659.7 +5.1 5115 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP DRAP1 RBM14 ENSG00000258297 KAT5 MUS81 SART1 SF3B2 RBM4
GH11J065910 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.8 -15.2 -15154 11.4 CLOCK MLX ZFP64 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 DRAP1 C11orf68 RBM14 LOC105369352 ZFPL1 ENSG00000254461 MUS81 ENSG00000258297 EIF1AD PCNX3
GH11J065927 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.9 -27.7 -27672 2.4 HDGF SMAD1 RB1 NFRKB ZBTB40 IRF4 TCF12 ZNF766 ZNF143 ETV6 EIF1AD CST6 FIBP CCDC85B CTSW SART1 FOSL1 CFL1 MUS81 BANF1
GH11J065940 Enhancer 1.1 Ensembl ENCODE 12.1 -40.8 -40795 2 PKNOX1 ATF1 ARNT TCF12 GATA2 FOS ATF7 ZNF263 NCOA1 ATF4 SART1 MUS81 EIF1AD ENSG00000258297 RBM14 SF3B2 RBM4 PCNX3 RCE1 KAT5
GH11J065945 Enhancer 0.8 Ensembl ENCODE 12.5 -45.2 -45223 1.2 GATAD2A RFX1 FOXA3 CEBPG RARA SKI SP1 POLR2A SCRT2 FOXP1 LOC105369350 TSGA10IP C11orf68 DRAP1 FOSL1 BANF1 EIF1AD CST6 CTSW EFEMP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FOSL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOSL1 gene promoter:
  • TBP
  • STAT1
  • p53
  • p300
  • ATF-2
  • C/EBPalpha

Genomic Locations for FOSL1 Gene

Genomic Locations for FOSL1 Gene
chr11:65,892,049-65,900,573
(GRCh38/hg38)
Size:
8,525 bases
Orientation:
Minus strand
chr11:65,659,520-65,668,044
(GRCh37/hg19)
Size:
8,525 bases
Orientation:
Minus strand

Genomic View for FOSL1 Gene

Genes around FOSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOSL1 Gene

Proteins for FOSL1 Gene

  • Protein details for FOSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15407-FOSL1_HUMAN
    Recommended name:
    Fos-related antigen 1
    Protein Accession:
    P15407
    Secondary Accessions:
    • B4DR11
    • Q6FG51

    Protein attributes for FOSL1 Gene

    Size:
    271 amino acids
    Molecular mass:
    29413 Da
    Quaternary structure:
    • Heterodimer.

    Alternative splice isoforms for FOSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOSL1 Gene

Post-translational modifications for FOSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOSL1 Gene

Domains & Families for FOSL1 Gene

Gene Families for FOSL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOSL1 Gene

Graphical View of Domain Structure for InterPro Entry

P15407

UniProtKB/Swiss-Prot:

FOSL1_HUMAN :
  • Belongs to the bZIP family. Fos subfamily.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOSL1: view

Function for FOSL1 Gene

Molecular function for FOSL1 Gene

GENATLAS Biochemistry:
fos antigen-like 1,target molecule for retinoid action in pancreatic carcinoma cell line Dan-G

Phenotypes From GWAS Catalog for FOSL1 Gene

Gene Ontology (GO) - Molecular Function for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 21673316
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with FOSL1: view
genes like me logo Genes that share phenotypes with FOSL1: view

Animal Models for FOSL1 Gene

MGI Knock Outs for FOSL1:

Animal Model Products

miRNA for FOSL1 Gene

miRTarBase miRNAs that target FOSL1

Transcription Factor Targets for FOSL1 Gene

Selected GeneGlobe predicted Target genes for FOSL1
Targeted motifs for FOSL1 Gene
HOMER Transcription Factor Regulatory Elements motif FOSL1
  • Consensus sequence: NNATGASTCATH Submotif: canonical Cell Type: BT549 GEO ID: GSE46166

Clone Products

  • Addgene plasmids for FOSL1

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for FOSL1 Gene

Localization for FOSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOSL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOSL1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 3
extracellular 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA 10918580
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IEA --
GO:0042734 presynaptic membrane IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with FOSL1: view

Pathways & Interactions for FOSL1 Gene

genes like me logo Genes that share pathways with FOSL1: view

Gene Ontology (GO) - Biological Process for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS,IEA 10918580
GO:0006366 transcription by RNA polymerase II TAS 2107490
GO:0006935 chemotaxis TAS 10918580
genes like me logo Genes that share ontologies with FOSL1: view

No data available for SIGNOR curated interactions for FOSL1 Gene

Drugs & Compounds for FOSL1 Gene

(11) Drugs for FOSL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for FOSL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOSL1: view

Transcripts for FOSL1 Gene

Unigene Clusters for FOSL1 Gene

FOS-like antigen 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for FOSL1

Alternative Splicing Database (ASD) splice patterns (SP) for FOSL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2:
SP3: - -
SP4: -
SP5: -
SP6: - -

Relevant External Links for FOSL1 Gene

GeneLoc Exon Structure for
FOSL1
ECgene alternative splicing isoforms for
FOSL1

Expression for FOSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOSL1 Gene

mRNA differential expression in normal tissues according to GTEx for FOSL1 Gene

This gene is overexpressed in Minor Salivary Gland (x5.4), Esophagus - Mucosa (x4.5), and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for FOSL1 Gene

This gene is overexpressed in Cardia (35.6) and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOSL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FOSL1 Gene:

FOSL1

SOURCE GeneReport for Unigene cluster for FOSL1 Gene:

Hs.283565

Evidence on tissue expression from TISSUES for FOSL1 Gene

  • Skin(4.7)
  • Blood(4.3)
  • Heart(4.3)
  • Liver(3.7)
  • Nervous system(2.3)
  • Pancreas(2.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with FOSL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOSL1 Gene

Orthologs for FOSL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOSL1 34 33
  • 99.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FOSL1 34 33
  • 88.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FOSL1 34 33
  • 88.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fosl1 16 34 33
  • 83.27 (n)
rat
(Rattus norvegicus)
Mammalia Fosl1 33
  • 81.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FOSL1 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOSL1 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fosl1 33
  • 60.36 (n)
zebrafish
(Danio rerio)
Actinopterygii fosl1a 34 33
  • 60.43 (n)
OneToMany
fosl1b 34 34
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta kay 34
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToMany
Species where no ortholog for FOSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOSL1 Gene

ENSEMBL:
Gene Tree for FOSL1 (if available)
TreeFam:
Gene Tree for FOSL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOSL1: view image

Paralogs for FOSL1 Gene

Paralogs for FOSL1 Gene

(3) SIMAP similar genes for FOSL1 Gene using alignment to 5 proteins:

  • FOSL1_HUMAN
  • B4DR11_HUMAN
  • E9PKL5_HUMAN
  • E9PPX2_HUMAN
  • E9PQT6_HUMAN

Pseudogenes.org Pseudogenes for FOSL1 Gene

genes like me logo Genes that share paralogs with FOSL1: view

Variants for FOSL1 Gene

Sequence variations from dbSNP and Humsavar for FOSL1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000088891 -- 65,893,986(-) A/T intron_variant
rs1000469488 -- 65,899,188(-) C/T intron_variant
rs1000784638 -- 65,893,516(-) G/A intron_variant
rs1001062319 -- 65,893,831(-) C/T intron_variant
rs1001235039 -- 65,899,526(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FOSL1 Gene

Variant ID Type Subtype PubMed ID
nsv951019 CNV deletion 24416366
nsv832191 CNV loss 17160897
nsv555215 CNV loss 21841781
nsv39194 CNV deletion 16902084
nsv1159905 CNV duplication 26073780
esv2759834 CNV gain 17122850

Variation tolerance for FOSL1 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOSL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOSL1 Gene

Disorders for FOSL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FOSL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
pfeiffer syndrome
  • acrocephalosyndactyly, type v; acs5
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search FOSL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOSL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FOSL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOSL1 Gene

Publications for FOSL1 Gene

  1. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PMID: 2107490) Matsui M … Ishizaki R (Oncogene 1990) 2 3 4 22 58
  2. AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis. (PMID: 20353950) Singh NK … Rao GN (The Journal of biological chemistry 2010) 3 22 58
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58
  4. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 44 58
  5. Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene. (PMID: 17572495) Song Y … Guo N (Molecular immunology 2008) 3 22 58

Products for FOSL1 Gene

  • Addgene plasmids for FOSL1

Sources for FOSL1 Gene

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