The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding d... See more...

Aliases for FOSL1 Gene

Aliases for FOSL1 Gene

  • FOS Like 1, AP-1 Transcription Factor Subunit 2 3 5
  • Fos-Related Antigen 1 3 4
  • Fra-1 2 3
  • FRA1 3 4
  • FOS Like 1, AP-1 Trancription Factor Subunit 3
  • FOS Like Antigen 1 2
  • FOS-Like Antigen-1 3
  • FOSL1 5
  • FRA-1 4
  • FRA 3

External Ids for FOSL1 Gene

Previous GeneCards Identifiers for FOSL1 Gene

  • GC11M068193
  • GC11M067341
  • GC11M065909
  • GC11M065435
  • GC11M065416
  • GC11M065659
  • GC11M061986
  • GC11M066208

Summaries for FOSL1 Gene

Entrez Gene Summary for FOSL1 Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for FOSL1 Gene

FOSL1 (FOS Like 1, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSL1 include Trichorhinophalangeal Syndrome, Type I and Human T-Cell Leukemia Virus Type 1. Among its related pathways are Toll-Like receptor Signaling Pathways and IL-17 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL2.

Gene Wiki entry for FOSL1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOSL1 Gene

Genomics for FOSL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FOSL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065884 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 259.8 +6.1 6133 20.5 BCLAF1 SP1 ZNF207 NCOR1 MYC ZNF654 ZNF600 IKZF1 SIX5 SSRP1 FOSL1 FIBP DRAP1 HSALNG0084963 RBM14 KAT5 SNX32 RBM4 MUS81 ENSG00000254461
GH11J065910 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.8 -15.2 -15154 11.4 BCLAF1 SP1 ZNF654 MYC ZNF207 ZNF600 IKZF1 SSRP1 JUND ZNF592 DRAP1 C11orf68 MN309271 RBM14 KAT5 ENSG00000254461 SF3B2 RNASEH2C ZFPL1 RBM4
GH11J065945 Promoter/Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 12.5 -45.1 -45102 1.5 CEBPA POLR2A SMAD4 RARA FOXP1 TAF1 RFX1 CEBPG SP1 GATAD2A HSALNG0084970 HSALNG0084971 LOC105369350 TSGA10IP EIF1AD C11orf68 DRAP1 FOSL1 BANF1 CST6
GH11J065927 Enhancer 1.1 FANTOM5 ENCODE 12 -27.7 -27672 2.4 SP1 NCOR1 ZNF592 TRIM22 IRF2 SAP130 IRF4 EBF1 CBFB RELA EIF1AD CST6 CCDC85B FIBP CTSW SART1 FOSL1 CFL1 MUS81 BANF1
GH11J065932 Enhancer 0.9 Ensembl ENCODE 11.9 -32.0 -32027 3.2 NCOR1 NFIC REST TAL1 USF2 STAT5A CTCF FOXM1 RAD51 FOXA1 PACS1 CCDC85B FIBP CTSW FOSL1 SART1 CFL1 MUS81 SNX32 EIF1AD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOSL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOSL1

Top Transcription factor binding sites by QIAGEN in the FOSL1 gene promoter:
  • ATF-2
  • C/EBPalpha
  • p300
  • p53
  • STAT1
  • TBP

Genomic Locations for FOSL1 Gene

Latest Assembly
chr11:65,892,049-65,900,573
(GRCh38/hg38)
Size:
8,525 bases
Orientation:
Minus strand

Previous Assembly
chr11:65,659,520-65,668,016
(GRCh37/hg19 by Entrez Gene)
Size:
8,497 bases
Orientation:
Minus strand

chr11:65,659,520-65,668,044
(GRCh37/hg19 by Ensembl)
Size:
8,525 bases
Orientation:
Minus strand

Genomic View for FOSL1 Gene

Genes around FOSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOSL1 Gene

Proteins for FOSL1 Gene

  • Protein details for FOSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15407-FOSL1_HUMAN
    Recommended name:
    Fos-related antigen 1
    Protein Accession:
    P15407
    Secondary Accessions:
    • B4DR11
    • Q6FG51

    Protein attributes for FOSL1 Gene

    Size:
    271 amino acids
    Molecular mass:
    29413 Da
    Quaternary structure:
    • Heterodimer.

    Alternative splice isoforms for FOSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOSL1 Gene

Post-translational modifications for FOSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOSL1 Gene

Domains & Families for FOSL1 Gene

Gene Families for FOSL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOSL1 Gene

InterPro:
Blocks:
  • Fos transforming protein signature
  • bZIP transcription factor, bZIP_1

Suggested Antigen Peptide Sequences for FOSL1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51532, highly similar to Fos-related antigen 1 (B4DDQ7_HUMAN)
  • cDNA FLJ51531, highly similar to Fos-related antigen 1 (B4DR11_HUMAN)
  • Fos-related antigen 1 (FOSL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15407

UniProtKB/Swiss-Prot:

FOSL1_HUMAN :
  • Belongs to the bZIP family. Fos subfamily.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOSL1: view

Function for FOSL1 Gene

Molecular function for FOSL1 Gene

GENATLAS Biochemistry:
fos antigen-like 1,target molecule for retinoid action in pancreatic carcinoma cell line Dan-G

Phenotypes From GWAS Catalog for FOSL1 Gene

Gene Ontology (GO) - Molecular Function for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 21673316
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with FOSL1: view
genes like me logo Genes that share phenotypes with FOSL1: view

Animal Models for FOSL1 Gene

MGI Knock Outs for FOSL1:

miRNA for FOSL1 Gene

miRTarBase miRNAs that target FOSL1

Transcription Factor Targets for FOSL1 Gene

Selected GeneGlobe predicted Target genes for FOSL1
Targeted motifs for FOSL1 Gene
HOMER Transcription Factor Regulatory Elements motif FOSL1
  • Consensus sequence: NNATGASTCATH Submotif: canonical Cell Type: BT549 GEO ID: GSE46166

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOSL1

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for FOSL1 Gene

Localization for FOSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOSL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOSL1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IEA --
GO:0042734 presynaptic membrane IEA --
genes like me logo Genes that share ontologies with FOSL1: view

Pathways & Interactions for FOSL1 Gene

PathCards logo

SuperPathways for FOSL1 Gene

genes like me logo Genes that share pathways with FOSL1: view

Pathways by source for FOSL1 Gene

1 PharmGKB pathway for FOSL1 Gene
8 GeneGo (Thomson Reuters) pathways for FOSL1 Gene
  • Immune response CD16 signaling in NK cells
  • Immune response IL-1 signaling pathway
  • Immune response IL-2 activation and signaling pathway
  • Immune response IL-3 activation and signaling pathway
  • Immune response Oncostatin M signaling via MAPK in human cells
9 Qiagen pathways for FOSL1 Gene
  • Ceramide Pathway
  • Epithelial Tight Junctions
  • ERK5 Signaling
  • ILK Signaling
  • iNOS Signaling
1 Cell Signaling Technology pathway for FOSL1 Gene

SIGNOR curated interactions for FOSL1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0006935 chemotaxis TAS 10918580
GO:0006968 cellular defense response TAS 10918580
genes like me logo Genes that share ontologies with FOSL1: view

Drugs & Compounds for FOSL1 Gene

(11) Drugs for FOSL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for FOSL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOSL1: view

Transcripts for FOSL1 Gene

mRNA/cDNA for FOSL1 Gene

5 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOSL1

Alternative Splicing Database (ASD) splice patterns (SP) for FOSL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2:
SP3: - -
SP4: -
SP5: -
SP6: - -

Relevant External Links for FOSL1 Gene

GeneLoc Exon Structure for
FOSL1

Expression for FOSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOSL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for FOSL1 Gene

This gene is overexpressed in Minor Salivary Gland (x5.4), Esophagus - Mucosa (x4.5), and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for FOSL1 Gene

This gene is overexpressed in Cardia (35.6) and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOSL1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOSL1

SOURCE GeneReport for Unigene cluster for FOSL1 Gene:

Hs.283565

Evidence on tissue expression from TISSUES for FOSL1 Gene

  • Skin(4.8)
  • Blood(4.5)
  • Heart(4.4)
  • Liver(4)
  • Pancreas(3)
  • Nervous system(2.7)
  • Intestine(2.5)
  • Bone marrow(2.2)
  • Lung(2.1)
  • Muscle(2.1)
  • Stomach(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with FOSL1: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOSL1 Gene

Orthologs for FOSL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOSL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FOSL1 29 30
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FOSL1 29 30
  • 88.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FOSL1 29 30
  • 88.18 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fosl1 29 16 30
  • 83.27 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fosl1 29
  • 81.3 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FOSL1 30
  • 67 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FOSL1 30
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fosl1 29
  • 60.36 (n)
Zebrafish
(Danio rerio)
Actinopterygii fosl1a 29 30
  • 60.43 (n)
OneToMany
fosl1b 30 30
  • 58 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta kay 30
  • 11 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 20 (a)
OneToMany
Species where no ortholog for FOSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FOSL1 Gene

ENSEMBL:
Gene Tree for FOSL1 (if available)
TreeFam:
Gene Tree for FOSL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOSL1: view image
Alliance of Genome Resources:
Additional Orthologs for FOSL1

Paralogs for FOSL1 Gene

Paralogs for FOSL1 Gene

(3) SIMAP similar genes for FOSL1 Gene using alignment to 5 proteins:

  • FOSL1_HUMAN
  • B4DR11_HUMAN
  • E9PKL5_HUMAN
  • E9PPX2_HUMAN
  • E9PQT6_HUMAN

Pseudogenes.org Pseudogenes for FOSL1 Gene

genes like me logo Genes that share paralogs with FOSL1: view

Variants for FOSL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOSL1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs114787843 Benign: not provided 65,893,177(-) C/T
NM_005438.5(FOSL1):c.525G>A (p.Pro175=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR
rs142119979 Benign: not provided 65,892,907(-) A/G
NM_005438.5(FOSL1):c.795T>C (p.Ser265=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR
rs144760068 Benign: not provided 65,893,129(-) G/T
NM_005438.5(FOSL1):c.573C>A (p.Ser191Arg)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FOSL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FOSL1 Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv39194 CNV deletion 16902084
nsv555215 CNV loss 21841781
nsv832191 CNV loss 17160897
nsv951019 CNV deletion 24416366

Variation tolerance for FOSL1 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOSL1
Leiden Open Variation Database (LOVD)
FOSL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOSL1 Gene

Disorders for FOSL1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for FOSL1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
trichorhinophalangeal syndrome, type i
  • trps1
human t-cell leukemia virus type 1
  • htlv-1
krabbe disease
  • globoid cell leukodystrophy; gld; gcl
breast cancer
  • breast cancer, familial
t-cell lymphoblastic leukemia/lymphoma
  • t-cell leukemia
- elite association - COSMIC cancer census association via MalaCards
Search FOSL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOSL1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FOSL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOSL1 Gene

Publications for FOSL1 Gene

  1. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PMID: 2107490) Matsui M … Ishizaki R (Oncogene 1990) 2 3 4 22
  2. Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. (PMID: 8230424) Tsuchiya H … Seiki M (Journal of virology 1993) 3 4 22
  3. AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis. (PMID: 20353950) Singh NK … Rao GN (The Journal of biological chemistry 2010) 3 22
  4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 40
  5. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 40

Products for FOSL1 Gene

Sources for FOSL1 Gene