Aliases for FOSL1 Gene
External Ids for FOSL1 Gene
Previous GeneCards Identifiers for FOSL1 Gene
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for FOSL1 Gene
FOSL1 (FOS Like 1, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSL1 include Trichorhinophalangeal Syndrome, Type I and Breast Cancer. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL2.