Aliases for FOSB Gene
External Ids for FOSB Gene
Previous GeneCards Identifiers for FOSB Gene
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOSB Gene
FOSB (FosB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSB include Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly and Cerebral Arterial Disease. Among its related pathways are IL-1 Family Signaling Pathways and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOS.
UniProtKB/Swiss-Prot Summary for FOSB Gene
FosB interacts with Jun proteins enhancing their DNA binding activity.