FOSB Gene (Protein Coding)

FosB Proto-Oncogene, AP-1 Transcription Factor Subunit

GC19P045467
GIFtS:
43
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript varia... See more...

Aliases for FOSB Gene

Aliases for FOSB Gene

  • FosB Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • G0S3 2 3 4
  • FBJ Murine Osteosarcoma Viral Oncogene Homolog B 2 3
  • G0/G1 Switch Regulatory Protein 3 3 4
  • Activator Protein 1 2 3
  • Protein FosB 3 4
  • AP-1 2 3
  • GOS3 2 3
  • GOSB 2 3
  • FosB Proto-Oncogene, AP-1 Trancription Factor Subunit 3
  • Oncogene FOS-B 2
  • DKFZp686C0818 2
  • MGC42291 2
  • FOSB 5

External Ids for FOSB Gene

Previous GeneCards Identifiers for FOSB Gene

  • GC19P046615
  • GC19P046362
  • GC19P050647
  • GC19P050663
  • GC19P045971
  • GC19P042400

Summaries for FOSB Gene

Entrez Gene Summary for FOSB Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOSB Gene

FOSB (FosB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSB include Osteoblastoma and Histiocytoid Hemangioma. Among its related pathways are Toll-Like receptor Signaling Pathways and IL-17 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOS.

UniProtKB/Swiss-Prot Summary for FOSB Gene

  • FosB interacts with Jun proteins enhancing their DNA binding activity.

Gene Wiki entry for FOSB Gene

Additional gene information for FOSB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOSB Gene

Genomics for FOSB Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FOSB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOSB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOSB

Top Transcription factor binding sites by QIAGEN in the FOSB gene promoter:
  • c-Myc
  • CREB
  • deltaCREB
  • Max

Genomic Locations for FOSB Gene

Latest Assembly
chr19:45,467,995-45,475,179
(GRCh38/hg38)
Size:
7,185 bases
Orientation:
Plus strand

Previous Assembly
chr19:45,971,254-45,978,437
(GRCh37/hg19 by Entrez Gene)
Size:
7,184 bases
Orientation:
Plus strand

chr19:45,971,253-45,978,437
(GRCh37/hg19 by Ensembl)
Size:
7,185 bases
Orientation:
Plus strand

Genomic View for FOSB Gene

Genes around FOSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOSB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FOSB Gene

Proteins for FOSB Gene

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  2. Protein products for research
  3. Assay products for research

neXtProt entry for FOSB Gene

Protein Expression for FOSB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FOSB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOSB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for FOSB

No data available for DME Specific Peptides for FOSB Gene

Domains & Families for FOSB Gene

Gene Families for FOSB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOSB Gene

InterPro:
Blocks:
  • Fos transforming protein signature

Suggested Antigen Peptide Sequences for FOSB Gene

GenScript: Design optimal peptide antigens:
  • FOSB protein (A1L186_HUMAN)
  • FBJ murine osteosarcoma viral oncogene-like B variant 1 (A8VJE1_HUMAN)
  • FBJ murine osteosarcoma viral oncogene-like B variant 2 (A8VJE6_HUMAN)
  • FBJ murine osteosarcoma viral oncogene-like B variant 3 (A8VJF0_HUMAN)
  • FBJ murine osteosarcoma viral oncogene-like B variant 4 (A8VJF3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53539

UniProtKB/Swiss-Prot:

FOSB_HUMAN :
  • Belongs to the bZIP family. Fos subfamily.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOSB: view

Function for FOSB Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for FOSB Gene

UniProtKB/Swiss-Prot Function:
FosB interacts with Jun proteins enhancing their DNA binding activity.
GENATLAS Biochemistry:
murine FBJ osteosarcoma viral (v-fos) oncogen homolog B,ligand induced,immediate (primary) early response gene

Phenotypes From GWAS Catalog for FOSB Gene

Gene Ontology (GO) - Molecular Function for FOSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding TAS 1900040
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with FOSB: view
genes like me logo Genes that share phenotypes with FOSB: view

Animal Models for FOSB Gene

MGI Knock Outs for FOSB:
  • Fosb Fosb<tm1Brv>
  • Fosb Fosb<tm1Meg>
  • Fosb Fosb<tm1b(KOMP)Wtsi>
  • Fosb Fosb<tm2.1Yun>

Animal Models for research

miRNA for FOSB Gene

miRTarBase miRNAs that target FOSB

Transcription Factor Targets for FOSB Gene

Selected GeneGlobe predicted Target genes for FOSB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOSB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for FOSB Gene

Localization for FOSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOSB Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOSB gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IBA,IDA 22387553
GO:0005654 nucleoplasm TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FOSB: view

Pathways & Interactions for FOSB Gene

PathCards logo

SuperPathways for FOSB Gene

SuperPathway Contained pathways
1 Toll-Like receptor Signaling Pathways
NOD-like Receptor Signaling Pathways
.59
Toll-Like receptor Signaling Pathways
.59
Inflammasome Activation Pathways
.51
IL-1 Family Signaling Pathways
.43
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
2 IL-17 Family Signaling Pathways
IL-17 Family Signaling Pathways
.51
Mucin expression in CF via IL-6, IL-17 signaling pathways
.48
IL-17 signaling pathway
.33
3 Amphetamine addiction
Amphetamine addiction
.42
Cocaine addiction
.42
4 Immune response IL-2 activation and signaling pathway
Immune response IL-2 activation and signaling pathway
.41
Immune response IL-3 activation and signaling pathway
.41
5 DNA Damage
DNA Damage
-
genes like me logo Genes that share pathways with FOSB: view

Pathways by source for FOSB Gene

1 PharmGKB pathway for FOSB Gene
7 GeneGo (Thomson Reuters) pathways for FOSB Gene
  • Immune response CD16 signaling in NK cells
  • Immune response IL-1 signaling pathway
  • Immune response IL-2 activation and signaling pathway
  • Immune response IL-3 activation and signaling pathway
  • Immune response Oncostatin M signaling via MAPK in human cells
7 Qiagen pathways for FOSB Gene
  • CDK5 Pathway
  • Ceramide Pathway
  • Epithelial Tight Junctions
  • ILK Signaling
  • iNOS Signaling
3 Cell Signaling Technology pathways for FOSB Gene

SIGNOR curated interactions for FOSB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FOSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 1900040
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006366 transcription by RNA polymerase II IEA --
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with FOSB: view

Drugs & Compounds for FOSB Gene

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  1. Drug products for research

(8) Drugs for FOSB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for FOSB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOSB: view

Transcripts for FOSB Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for FOSB Gene

2 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOSB

Alternative Splicing Database (ASD) splice patterns (SP) for FOSB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for FOSB Gene

GeneLoc Exon Structure for
FOSB

Expression for FOSB Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOSB Gene

mRNA expression in normal human tissues for FOSB Gene
mRNA expression by BioGPS for FOSB GenemRNA expression by GTEx for FOSB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOSB Gene

This gene is overexpressed in Fallopian Tube (x12.9) and Adipose - Visceral (Omentum) (x8.9).

Protein differential expression in normal tissues from HIPED for FOSB Gene

This gene is overexpressed in Adrenal (57.9) and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOSB Gene



Protein tissue co-expression partners for FOSB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOSB

SOURCE GeneReport for Unigene cluster for FOSB Gene:

Hs.590958

Evidence on tissue expression from TISSUES for FOSB Gene

  • Nervous system(4.8)
  • Blood(4.6)
  • Thyroid gland(4.6)
  • Lung(3.4)
  • Intestine(3)
  • Bone marrow(3)
  • Adrenal gland(2.9)
  • Liver(2.8)
  • Kidney(2.7)
  • Heart(2.6)
  • Lymph node(2.6)
  • Muscle(2.6)
  • Spleen(2.5)
  • Gall bladder(2.3)
  • Skin(2.3)
  • Pancreas(2.3)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with FOSB: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOSB Gene

Orthologs for FOSB Gene

This gene was present in the common ancestor of animals.

Orthologs for FOSB Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
 Mammalia FOSB 29 30
  • 95.76 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia FOSB 29 30
  • 94.58 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Fosb 29 16 30
  • 90.73 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Fosb 29
  • 90.34 (n)
Oppossum
(Monodelphis domestica)
 Mammalia FOSB 30
  • 84 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia FOSB 30
  • 64 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100490871 29
  • 57.53 (n)
Zebrafish
(Danio rerio)
 Actinopterygii fosb 29 30
  • 70.51 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta kay 30
  • 12 (a)
 OneToMany
Species where no ortholog for FOSB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FOSB Gene

ENSEMBL:
Gene Tree for FOSB (if available)
TreeFam:
Gene Tree for FOSB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOSB: view image
Alliance of Genome Resources:
Additional Orthologs for FOSB

Paralogs for FOSB Gene

Paralogs for FOSB Gene

(6) SIMAP similar genes for FOSB Gene using alignment to 18 proteins:

  • FOSB_HUMAN
  • A1L186_HUMAN
  • A8VJE6_HUMAN
  • A8VJF0_HUMAN
  • A8VJF3_HUMAN
  • A8VJF7_HUMAN
  • A8VJG1_HUMAN
  • A8VJG5_HUMAN
  • A8VJG9_HUMAN
  • E7EPR6_HUMAN
  • K7EJ89_HUMAN
  • K7EKA0_HUMAN
  • K7EKC1_HUMAN
  • K7EMJ6_HUMAN
  • K7EPR3_HUMAN
  • K7ERZ8_HUMAN
  • Q49AD7_HUMAN
  • Q6FGK6_HUMAN
genes like me logo Genes that share paralogs with FOSB: view

Variants for FOSB Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOSB Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs201050620 Likely Benign: not provided 45,472,655(+) G/A
NM_006732.3(FOSB):c.660G>A (p.Pro220=) 		SYNONYMOUS
rs28381241 Benign: not provided 45,468,683(+) G/Ap.Gly33Ser
NM_006732.3(FOSB):c.97G>A (p.Gly33Ser) 		MISSENSE
rs373321658 Likely Benign: not provided 45,471,283(+) G/C
NM_006732.3(FOSB):c.537G>C (p.Leu179=) 		SYNONYMOUS_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FOSB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FOSB Gene

Variant ID Type Subtype PubMed ID
nsv428365 CNV gain+loss 18775914
nsv833846 CNV loss 17160897
nsv833848 CNV loss 17160897

Variation tolerance for FOSB Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOSB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOSB
Leiden Open Variation Database (LOVD)
FOSB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOSB Gene

Disorders for FOSB Gene

MalaCards: The human disease database

(10) MalaCards diseases for FOSB Gene - From: COP and GCD

Disorder Aliases PubMed IDs
osteoblastoma
histiocytoid hemangioma
  • angiolymphoid hyperplasia with eosinophilia
malignant epithelioid hemangioendothelioma
  • epithelioid hemangioendothelioma, malignant
hemangioendothelioma
proliferative fasciitis
- elite association - COSMIC cancer census association via MalaCards
Search FOSB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOSB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FOSB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOSB Gene

Publications for FOSB Gene

  1. Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3). (PMID: 8985116) Heximer SP … Forsdyke DR (DNA and cell biology 1996) 3 4 22
  2. Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3. (PMID: 1301997) Martin-Gallardo A … Liu LI (Nature genetics 1992) 2 3 4
  3. Regulation of megakaryocytic differentiation of K562 cells by FosB, a member of the Fos family of AP-1 transcription factors. (PMID: 19381435) Limb JK … Kim J (Cellular and molecular life sciences : CMLS 2009) 3 22
  4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 40
  5. Identification of immunohistochemical prognostic markers for survival after resection of pulmonary metastases from colorectal carcinoma. (PMID: 19795327) Pfannschmidt J … Herpel E (The Thoracic and cardiovascular surgeon 2009) 3 22

ExternalLinks

View latest publications for FOSB gene in Mastermind

Products for FOSB Gene

Sources for FOSB Gene