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The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
FOSB (FosB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSB include Osteoblastoma and Histiocytoid Hemangioma. Among its related pathways are Neuroscience and Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOS.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
GO:0003677 | DNA binding | TAS | 1900040 |
GO:0003690 | double-stranded DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA,IDA | 22387553 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
|
|
2 | IL-17 Family Signaling Pathways |
Mucin expression in CF via IL-6, IL-17 signaling pathways
.48
|
|
3 | Amphetamine addiction | ||
4 | Immune response IL-2 activation and signaling pathway |
Immune response IL-2 activation and signaling pathway
.41
|
Immune response IL-3 activation and signaling pathway
.41
|
5 | DNA Damage |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | 1900040 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0006366 | transcription by RNA polymerase II | IEA | -- |
GO:0007565 | female pregnancy | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||
SP2: | - | ||||||||||||||||
SP3: | - | - | - | - | |||||||||||||
SP4: | - | - | |||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | FOSB 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FOSB 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fosb 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fosb 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FOSB 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FOSB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100490871 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fosb 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | kay 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
757700 | Likely Benign: not provided | 45,471,283(+) | G/C | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
762409 | Likely Benign: not provided | 45,472,655(+) | G/A | SYNONYMOUS_VARIANT | |
785628 | Benign: not provided | 45,468,683(+) | G/A | MISSENSE_VARIANT | |
rs28381241 | - | p.Gly33Ser |
Disorder | Aliases | PubMed IDs |
---|---|---|
osteoblastoma |
|
|
histiocytoid hemangioma |
|
|
proliferative fasciitis |
|
|
malignant epithelioid hemangioendothelioma |
|
|
hemangioendothelioma |
|
|