The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FO... See more...

Aliases for FOS Gene

Aliases for FOS Gene

  • Fos Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • FBJ Murine Osteosarcoma Viral Oncogene Homolog 2 3
  • G0/G1 Switch Regulatory Protein 7 3 4
  • Proto-Oncogene C-Fos 3 4
  • AP-1 2 3
  • FBJ Murine Osteosarcoma Viral (V-Fos) Oncogene Homolog (Oncogene FOS) 3
  • V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog 2
  • Fos Proto-Oncogene, AP-1 Trancription Factor Subunit 3
  • Cellular Oncogene C-Fos 3
  • Cellular Oncogene Fos 4
  • Activator Protein 1 3
  • C-FOS 3
  • C-Fos 2
  • G0S7 4
  • P55 3
  • FOS 5

External Ids for FOS Gene

Previous GeneCards Identifiers for FOS Gene

  • GC14P073251
  • GC14P069562
  • GC14P073735
  • GC14P074815
  • GC14P075745
  • GC14P055913

Summaries for FOS Gene

Entrez Gene Summary for FOS Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

CIViC Summary for FOS Gene

GeneCards Summary for FOS Gene

FOS (Fos Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOS include Berardinelli-Seip Congenital Lipodystrophy and Pertussis. Among its related pathways are Integrin Pathway and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOSL2.

UniProtKB/Swiss-Prot Summary for FOS Gene

  • Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Gene Wiki entry for FOS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOS Gene

Genomics for FOS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FOS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOS

Top Transcription factor binding sites by QIAGEN in the FOS gene promoter:
  • MyoD
  • SRF
  • SRF (504 AA)
  • STAT1

Genomic Locations for FOS Gene

Genomic Locations for FOS Gene
chr14:75,278,826-75,282,230
(GRCh38/hg38)
Size:
3,405 bases
Orientation:
Plus strand
chr14:75,745,477-75,748,937
(GRCh37/hg19)
Size:
3,461 bases
Orientation:
Plus strand

Genomic View for FOS Gene

Genes around FOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOS Gene

Proteins for FOS Gene

  • Protein details for FOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01100-FOS_HUMAN
    Recommended name:
    Proto-oncogene c-Fos
    Protein Accession:
    P01100
    Secondary Accessions:
    • A8K4E2
    • B4DQ65
    • P18849

    Protein attributes for FOS Gene

    Size:
    380 amino acids
    Molecular mass:
    40695 Da
    Quaternary structure:
    • Heterodimer; with JUN (By similarity). Interacts with MAFB (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1 promoter site. Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with MAFB. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with CDS1 and PI4K2A (By similarity).

    Three dimensional structures from OCA and Proteopedia for FOS Gene

    Alternative splice isoforms for FOS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOS Gene

Post-translational modifications for FOS Gene

  • Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity).
  • Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.
  • In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the association with endoplasmic reticulum membranes and activation of phospholipid synthesis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for FOS

No data available for DME Specific Peptides for FOS Gene

Domains & Families for FOS Gene

Gene Families for FOS Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOS Gene

InterPro:
Blocks:
  • Fos transforming protein signature
  • bZIP transcription factor, bZIP_1
ProtoNet:

Suggested Antigen Peptide Sequences for FOS Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77786 (A8K4E2_HUMAN)
  • cDNA FLJ55132, highly similar to Proto-oncogene protein c-fos (B4DQ65_HUMAN)
  • G0/G1 switch regulatory protein 7 (FOS_HUMAN)
  • cDNA FLJ76842, highly similar to Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS), mRNA (Q6FG41_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01100

UniProtKB/Swiss-Prot:

FOS_HUMAN :
  • Belongs to the bZIP family. Fos subfamily.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOS: view

Function for FOS Gene

Molecular function for FOS Gene

UniProtKB/Swiss-Prot Function:
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
GENATLAS Biochemistry:
murine FBJ osteosarcoma viral (v-fos) oncogene homolog,ligand induced,immediate (primary) early response gene

Phenotypes From GWAS Catalog for FOS Gene

Gene Ontology (GO) - Molecular Function for FOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 9732876
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IMP 10704222
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001102 RNA polymerase II activating transcription factor binding IPI 10508860
genes like me logo Genes that share ontologies with FOS: view
genes like me logo Genes that share phenotypes with FOS: view

Human Phenotype Ontology for FOS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FOS Gene

MGI Knock Outs for FOS:
  • Fos Fos<tm1Pa>
  • Fos Fos<tm2(Fosl1)Wag>
  • Fos Fos<tm1Wag>

Animal Model Products

CRISPR Products

miRNA for FOS Gene

miRTarBase miRNAs that target FOS

Transcription Factor Targets for FOS Gene

Selected GeneGlobe predicted Target genes for FOS
Targeted motifs for FOS Gene
HOMER Transcription Factor Regulatory Elements motif FOS
  • Consensus sequence: ATGACTCATC Submotif: canonical Cell Type: ThioMac GEO ID: GSE21512

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOS

No data available for Enzyme Numbers (IUBMB) for FOS Gene

Localization for FOS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOS Gene

Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOS gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 3
mitochondrion 3
peroxisome 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus TAS,IDA 22387553
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FOS: view

Pathways & Interactions for FOS Gene

PathCards logo

SuperPathways for FOS Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 IL-2 Pathway
.59
.51
.49
.48
.47
.44
.43
.37
.36
.35
3 Toll-Like receptor Signaling Pathways
.42
.41
4 Development Angiotensin activation of ERK
.73
.73
.68
.65
.54
.48
5 Toll-like Receptor Signaling Pathway
genes like me logo Genes that share pathways with FOS: view

Pathways by source for FOS Gene

43 GeneGo (Thomson Reuters) pathways for FOS Gene
  • Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
  • Cell cycle ESR1 regulation of G1/S transition
  • Cell cycle Regulation of G1/S transition (part 2)
  • Development ACM2 and ACM4 activation of ERK
  • Development Activation of ERK by Alpha-1 adrenergic receptors
1 Tocris pathway for FOS Gene
82 Qiagen pathways for FOS Gene
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • Androgen Signaling
  • Antioxidant Action of Vitamin-C
  • APRIL Pathway
2 Cell Signaling Technology pathways for FOS Gene

SIGNOR curated interactions for FOS Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001661 conditioned taste aversion IEA --
GO:0006306 DNA methylation TAS 9888853
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0006366 transcription by RNA polymerase II TAS,IEA --
genes like me logo Genes that share ontologies with FOS: view

Drugs & Compounds for FOS Gene

(78) Drugs for FOS Gene - From: DrugBank, ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nadroparin Approved, Investigational Pharma Target, inhibitor 40
Pseudoephedrine Approved Pharma Target, inhibitor 426
Inulin Approved, Investigational Nutra 182
Bifidobacterium Pharma 400
Proton Pump Inhibitors Pharma 1315

(67) Additional Compounds for FOS Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 11302
160162-42-5

(1) Tocris Compounds for FOS Gene

Compound Action Cas Number
SR 11302 AP-1 inhibitor; antitumor agent 160162-42-5

(1) ApexBio Compounds for FOS Gene

Compound Action Cas Number
T-5224 C-Fos/AP-1 inhibitor 530141-72-1
genes like me logo Genes that share compounds with FOS: view

Drug Products

Transcripts for FOS Gene

mRNA/cDNA for FOS Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOS

Alternative Splicing Database (ASD) splice patterns (SP) for FOS Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for FOS Gene

GeneLoc Exon Structure for
FOS

Expression for FOS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOS Gene

This gene is overexpressed in Fallopian Tube (x7.2).

Protein differential expression in normal tissues from HIPED for FOS Gene

This gene is overexpressed in Monocytes (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOS Gene



Protein tissue co-expression partners for FOS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOS

SOURCE GeneReport for Unigene cluster for FOS Gene:

Hs.25647

Evidence on tissue expression from TISSUES for FOS Gene

  • Nervous system(5)
  • Blood(5)
  • Intestine(5)
  • Pancreas(4.9)
  • Lung(4.3)
  • Kidney(4.3)
  • Heart(4.3)
  • Thyroid gland(4.2)
  • Muscle(4.1)
  • Adrenal gland(4)
  • Eye(4)
  • Bone marrow(3.9)
  • Liver(3.8)
  • Spleen(3.8)
  • Stomach(3.7)
  • Lymph node(3.6)
  • Skin(3.6)
  • Bone(3.4)
  • Gall bladder(3.4)
  • Urine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FOS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • face
  • forehead
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • pituitary gland
  • salivary gland
  • skull
  • tooth
Thorax:
  • breast
  • chest wall
  • clavicle
  • diaphragm
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • duodenum
  • intestine
  • kidney
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
Pelvis:
  • fallopian tube
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with FOS: view

No data available for mRNA Expression by UniProt/SwissProt for FOS Gene

Orthologs for FOS Gene

This gene was present in the common ancestor of animals.

Orthologs for FOS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C-FOS 31
  • 100 (a)
OneToOne
FOS 30
  • 99.65 (n)
Dog
(Canis familiaris)
Mammalia FOS 30 31
  • 92.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FOS 30 31
  • 92.11 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FOS 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fos 30
  • 88.51 (n)
Mouse
(Mus musculus)
Mammalia Fos 30 17 31
  • 88.33 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FOS 31
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FOS 30 31
  • 76.7 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FOS 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fos 30
  • 66.02 (n)
Str.20514 30
Zebrafish
(Danio rerio)
Actinopterygii fos 30 31
  • 61.82 (n)
OneToMany
FOS (2 of 3) 31
  • 45 (a)
OneToMany
FOS (3 of 3) 31
  • 35 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta kay 31
  • 14 (a)
OneToMany
Species where no ortholog for FOS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FOS Gene

ENSEMBL:
Gene Tree for FOS (if available)
TreeFam:
Gene Tree for FOS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOS: view image

Paralogs for FOS Gene

Paralogs for FOS Gene

(6) SIMAP similar genes for FOS Gene using alignment to 10 proteins:

  • FOS_HUMAN
  • A8K4E2_HUMAN
  • B4DQ65_HUMAN
  • G3V289_HUMAN
  • G3V2V7_HUMAN
  • G3V5J9_HUMAN
  • G3V5N7_HUMAN
  • G3V5N9_HUMAN
  • H0YJM3_HUMAN
  • Q6FG41_HUMAN
genes like me logo Genes that share paralogs with FOS: view

Variants for FOS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOS Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
710469 Benign: not provided 75,280,809(+) G/C MISSENSE_VARIANT
714336 Likely Benign: not provided 75,280,978(+) C/G MISSENSE_VARIANT
720688 Benign: not provided 75,279,924(+) G/A SYNONYMOUS_VARIANT
722208 Benign: not provided 75,281,262(+) G/A SYNONYMOUS_VARIANT
724642 Likely Benign: not provided 75,280,562(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for FOS Gene

Structural Variations from Database of Genomic Variants (DGV) for FOS Gene

Variant ID Type Subtype PubMed ID
nsv832833 CNV gain 17160897

Variation tolerance for FOS Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOS Gene

Human Gene Mutation Database (HGMD)
FOS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOS Gene

Disorders for FOS Gene

MalaCards: The human disease database

(99) MalaCards diseases for FOS Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
berardinelli-seip congenital lipodystrophy
  • lipoatrophic diabetes
pertussis
  • bordetella infection
osteoblastoma
fibrodysplasia ossificans progressiva
  • fop
osteoid osteoma
- elite association - COSMIC cancer census association via MalaCards
Search FOS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FOS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOS Gene

Publications for FOS Gene

  1. Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. (PMID: 16055710) Bossis G … Piechaczyk M (Molecular and cellular biology 2005) 2 3 4 23
  2. Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. (PMID: 16123044) Monje P … Gutkind JS (The Journal of biological chemistry 2005) 2 3 23
  3. The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity. (PMID: 22105363) Ferrero GO … Caputto BL (Oncogene 2012) 3 4
  4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 41
  5. Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics. (PMID: 20493519) Nakakuki T … Kholodenko BN (Cell 2010) 3 23

Products for FOS Gene