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Aliases for FOPNL Gene

Aliases for FOPNL Gene

  • FGFR1OP N-Terminal Like 2 3 5
  • FOP-Related Protein Of 20 KDa 2 3 4
  • Pluripotent Embryonic Stem Cell-Related Protein 2 3
  • C16orf63 3 4
  • PHSECRG2 3 4
  • FOR20 3 4
  • LisH Domain-Containing Protein C16orf63 3
  • LisH Domain-Containing Protein FOPNL 3
  • Chromosome 16 Open Reading Frame 63 2
  • FGFR1OP N-Terminal-Like Protein 4

External Ids for FOPNL Gene

Previous HGNC Symbols for FOPNL Gene

  • C16orf63

Previous GeneCards Identifiers for FOPNL Gene

  • GC16M015959

Summaries for FOPNL Gene

GeneCards Summary for FOPNL Gene

FOPNL (FGFR1OP N-Terminal Like) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FOPNL Gene

  • Involved in the biogenesis of cilia (PubMed:20551181). Required for the recruitement of PLK1 to centrosomes and S phase progression (PubMed:24018379).

Additional gene information for FOPNL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOPNL Gene

Genomics for FOPNL Gene

GeneHancer (GH) Regulatory Elements for FOPNL Gene

Promoters and enhancers for FOPNL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J015884 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 656.2 +1.6 1553 4.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 FOPNL MYH11 NDE1 ENSG00000262171
GH16J015897 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 655 -11.0 -10960 4.5 HDGF PKNOX1 FOXA2 MLX SIN3A IRF4 SLC30A9 FOS DEK ZNF263 FOPNL ABCC1 ENSG00000262171 RNU6-213P MYH11 LOC100505915 ENSG00000263065 GC16M015891 RPL15P20
GH16J015857 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11.2 +30.5 30467 1.8 SUZ12 SIN3A ZNF2 ZNF48 ZNF335 ZNF366 PATZ1 ZNF143 ATF7 ZNF444 MYH11 ABCC1 FOPNL RNU6-213P
GH16J016018 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -132.7 -132711 5.4 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 SLC30A9 POLR2B E2F8 FOPNL RNU6-213P MYH11 ABCC1 GC16P016010 RPL17P40
GH16J015992 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -108.3 -108265 8.6 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 FOS SP5 ZHX2 ABCC1 RNU6-213P FOPNL NDE1 GC16P016010
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FOPNL on UCSC Golden Path with GeneCards custom track

Genomic Locations for FOPNL Gene

Genomic Locations for FOPNL Gene
22,931 bases
Minus strand

Genomic View for FOPNL Gene

Genes around FOPNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOPNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOPNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOPNL Gene

Proteins for FOPNL Gene

  • Protein details for FOPNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LisH domain-containing protein FOPNL
    Protein Accession:
    Secondary Accessions:
    • B3KPU9

    Protein attributes for FOPNL Gene

    174 amino acids
    Molecular mass:
    19778 Da
    Quaternary structure:
    • Homooligomer; probably required for localization to centrosomes (PubMed:20551181). Forms a complex with KIAA0753/OFIP and OFD1; within this complex may stabilize the interaction between OFD1 and KIAA0753/OFIP (PubMed:26643951). Interacts with PCM1; this interaction may be mediated by KIAA0753/OFIP (PubMed:26643951). Interacts with PLK1 in later G1, S, G2 and M phases of the cell cycle; this interaction recruits PLK1 to centrosomes (PubMed:24018379).

    Alternative splice isoforms for FOPNL Gene


neXtProt entry for FOPNL Gene

Post-translational modifications for FOPNL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOPNL Gene

Domains & Families for FOPNL Gene

Gene Families for FOPNL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FOPNL Gene

Suggested Antigen Peptide Sequences for FOPNL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FGFR1OP family.
  • Belongs to the FGFR1OP family.
genes like me logo Genes that share domains with FOPNL: view

Function for FOPNL Gene

Molecular function for FOPNL Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of cilia (PubMed:20551181). Required for the recruitement of PLK1 to centrosomes and S phase progression (PubMed:24018379).

Phenotypes From GWAS Catalog for FOPNL Gene

genes like me logo Genes that share phenotypes with FOPNL: view

Animal Model Products

miRNA for FOPNL Gene

miRTarBase miRNAs that target FOPNL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOPNL Gene

Localization for FOPNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOPNL Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the centrosome throughout cell cycle progression (PubMed:24018379). Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP (PubMed:26643951). {ECO:0000269 PubMed:24018379, ECO:0000269 PubMed:26643951}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOPNL gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOPNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with FOPNL: view

Pathways & Interactions for FOPNL Gene

SuperPathways for FOPNL Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOPNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0034453 microtubule anchoring IEA --
GO:0060271 cilium assembly IMP 15616553
genes like me logo Genes that share ontologies with FOPNL: view

No data available for Pathways by source and SIGNOR curated interactions for FOPNL Gene

Drugs & Compounds for FOPNL Gene

No Compound Related Data Available

Transcripts for FOPNL Gene

Unigene Clusters for FOPNL Gene

FGFR1OP N-terminal like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOPNL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for FOPNL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOPNL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOPNL Gene

Protein differential expression in normal tissues from HIPED for FOPNL Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOPNL Gene

Protein tissue co-expression partners for FOPNL Gene

NURSA nuclear receptor signaling pathways regulating expression of FOPNL Gene:


SOURCE GeneReport for Unigene cluster for FOPNL Gene:


mRNA Expression by UniProt/SwissProt for FOPNL Gene:

Tissue specificity: Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine.

Evidence on tissue expression from TISSUES for FOPNL Gene

  • Lung(4.2)
  • Nervous system(4)
  • Heart(2)
genes like me logo Genes that share expression patterns with FOPNL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOPNL Gene

Orthologs for FOPNL Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOPNL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOPNL 34
  • 100 (a)
(Canis familiaris)
Mammalia FOPNL 34 33
  • 87.55 (n)
(Bos Taurus)
Mammalia FOPNL 34 33
  • 85.63 (n)
(Rattus norvegicus)
Mammalia Fopnl 33
  • 82.47 (n)
(Mus musculus)
Mammalia Fopnl 16 34 33
  • 81.7 (n)
(Monodelphis domestica)
Mammalia FOPNL 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia FOPNL 34
  • 77 (a)
(Gallus gallus)
Aves FOPNL 34 33
  • 65.9 (n)
(Anolis carolinensis)
Reptilia FOPNL 34
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fopnl 33
  • 64.46 (n)
Str.3182 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7611 33
(Danio rerio)
Actinopterygii fopnl 34 33
  • 59.95 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14123 33
Species where no ortholog for FOPNL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOPNL Gene

Gene Tree for FOPNL (if available)
Gene Tree for FOPNL (if available)
Evolutionary constrained regions (ECRs) for FOPNL: view image

Paralogs for FOPNL Gene

(26) SIMAP similar genes for FOPNL Gene using alignment to 9 proteins:

  • I3L0K3_HUMAN
  • I3L0U4_HUMAN
  • I3L269_HUMAN
  • I3L2N4_HUMAN
  • I3L3N6_HUMAN
  • I3L4V2_HUMAN
  • I3NI25_HUMAN
genes like me logo Genes that share paralogs with FOPNL: view

No data available for Paralogs for FOPNL Gene

Variants for FOPNL Gene

Sequence variations from dbSNP and Humsavar for FOPNL Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000100124 -- 15,879,574(-) A/T intron_variant
rs1000156667 -- 15,887,005(-) C/T intron_variant
rs1000275775 -- 15,884,765(-) A/T intron_variant
rs1000282587 -- 15,874,165(-) C/G intron_variant
rs1000341967 -- 15,873,411(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FOPNL Gene

Variant ID Type Subtype PubMed ID
dgv2773n100 CNV gain 25217958
dgv2774n100 CNV gain 25217958
dgv345n27 CNV gain 19166990
dgv4924n54 CNV gain 21841781
dgv4926n54 CNV gain 21841781
esv23840 CNV gain+loss 19812545
esv2421345 CNV duplication 20811451
esv2714015 CNV deletion 23290073
esv2760415 CNV gain 21179565
esv3570387 CNV gain 25503493
esv3638041 CNV gain 21293372
esv3638042 CNV gain 21293372
nsv1045194 CNV gain 25217958
nsv1047898 CNV loss 25217958
nsv1048188 CNV gain 25217958
nsv1049647 CNV gain+loss 25217958
nsv1125134 CNV deletion 24896259
nsv435664 CNV deletion 17901297
nsv442391 CNV gain 18776908
nsv457428 CNV gain 19166990
nsv457432 CNV gain 19166990
nsv457436 CNV gain 19166990
nsv471085 CNV gain 18288195
nsv514795 CNV gain 21397061
nsv571543 CNV gain 21841781
nsv833149 CNV loss 17160897

Variation tolerance for FOPNL Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.45; 88.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOPNL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOPNL Gene

Disorders for FOPNL Gene

Additional Disease Information for FOPNL

No disorders were found for FOPNL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOPNL Gene

Publications for FOPNL Gene

  1. Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. (PMID: 20551181) Sedjaï F … Rosnet O (Journal of cell science 2010) 2 3 4 58
  2. Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes. (PMID: 24018379) Shen M … Zhou T (Cell research 2013) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for FOPNL Gene

Sources for FOPNL Gene

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