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Aliases for FOLR3 Gene

Aliases for FOLR3 Gene

  • Folate Receptor Gamma 2 3 4
  • Folate Receptor 3 2 4 5
  • Folate Receptor 3 (Gamma) 2 3
  • FR-Gamma 3 4
  • Gamma-HFR 3
  • FRgamma 3
  • FR-G 3

External Ids for FOLR3 Gene

Previous GeneCards Identifiers for FOLR3 Gene

  • GC11P074178
  • GC11P073386
  • GC11P072048
  • GC11P071573
  • GC11P071524
  • GC11P071846
  • GC11P068140
  • GC11P071825

Summaries for FOLR3 Gene

Entrez Gene Summary for FOLR3 Gene

  • This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for FOLR3 Gene

FOLR3 (Folate Receptor Gamma) is a Protein Coding gene. Diseases associated with FOLR3 include Primary Peritoneal Carcinoma and Myelomeningocele. Among its related pathways are Innate Immune System and Selenium Micronutrient Network. Gene Ontology (GO) annotations related to this gene include folic acid binding. An important paralog of this gene is FOLR2.

UniProtKB/Swiss-Prot for FOLR3 Gene

  • Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.

Additional gene information for FOLR3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOLR3 Gene

Genomics for FOLR3 Gene

GeneHancer (GH) Regulatory Elements for FOLR3 Gene

Promoters and enhancers for FOLR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J072110 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 600.7 -1.8 -1844 4.6 ZNF652 SP1 ZFX CC2D1A ELF3 MNT NKRF POLR2A MLLT1 GTF2F1 ANAPC15 FOLR3 LAMTOR1 NUMA1 FAM86C1 LRTOMT OR7E128P ENSG00000284922
GH11J072115 Enhancer 0.8 ENCODE dbSUPER 600.7 +1.0 1041 0.8 GTF2F1 BACH1 ZNF740 NFE2 MAFG CUX1 ZNF592 ZFP3 TAF7 EMSY FOLR3 GC11P072115 LRTOMT NUMA1 FAM86C1 RPEP6
GH11J072135 Promoter 0.6 EPDnew 600.3 +20.8 20837 0.1 CTCF FOLR3 LRTOMT RPEP6 GC11P072156
GH11J072143 Enhancer 1 ENCODE dbSUPER 52.4 +29.8 29839 2.8 CTCF RAD21 FOSL2 ZNF143 REST TRIM22 PATZ1 CEBPB SCRT2 JUN FOLR3 NUMA1 LOC100128494 IL18BP ZNF705E ENSG00000254469 ANAPC15 LAMTOR1 LRTOMT PHOX2A
GH11J072189 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 18.8 +76.2 76191 3.8 ZNF148 EGR1 IKZF1 HDAC1 CEBPB CHD2 POLR2A CTBP1 MAX MAZ FOLR1 GC11P072192 GC11P072195 GC11P072194 GC11P072193 FOLR3 PHOX2A NUMA1 ENSG00000256403 LRTOMT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOLR3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOLR3 gene promoter:
  • FOXD3
  • FOXI1
  • HFH-3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • PPAR-alpha
  • YY1

Genomic Locations for FOLR3 Gene

Genomic Locations for FOLR3 Gene
chr11:72,114,869-72,139,892
(GRCh38/hg38)
Size:
25,024 bases
Orientation:
Plus strand
chr11:71,825,915-71,850,936
(GRCh37/hg19)
Size:
25,022 bases
Orientation:
Plus strand

Genomic View for FOLR3 Gene

Genes around FOLR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOLR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOLR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOLR3 Gene

Proteins for FOLR3 Gene

  • Protein details for FOLR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41439-FOLR3_HUMAN
    Recommended name:
    Folate receptor gamma
    Protein Accession:
    P41439
    Secondary Accessions:
    • A0A087WXH3
    • J3KQ90
    • Q05C14

    Protein attributes for FOLR3 Gene

    Size:
    245 amino acids
    Molecular mass:
    27885 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA18381.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA18382.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA83553.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA83566.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FOLR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOLR3 Gene

Post-translational modifications for FOLR3 Gene

  • Glycosylation at isoforms=3159, posLast=199199, and isoforms=3119
  • Modification sites at PhosphoSitePlus

Other Protein References for FOLR3 Gene

No data available for DME Specific Peptides for FOLR3 Gene

Domains & Families for FOLR3 Gene

Gene Families for FOLR3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for FOLR3 Gene

Suggested Antigen Peptide Sequences for FOLR3 Gene

GenScript: Design optimal peptide antigens:
  • Folate receptor 3 (FOLR3_HUMAN)
  • FOLR3 protein (Q05C14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41439

UniProtKB/Swiss-Prot:

FOLR3_HUMAN :
  • Belongs to the folate receptor family.
Family:
  • Belongs to the folate receptor family.
genes like me logo Genes that share domains with FOLR3: view

Function for FOLR3 Gene

Molecular function for FOLR3 Gene

UniProtKB/Swiss-Prot Function:
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.

Phenotypes From GWAS Catalog for FOLR3 Gene

Gene Ontology (GO) - Molecular Function for FOLR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005542 folic acid binding IEA --
GO:0038023 signaling receptor activity IBA 21873635
genes like me logo Genes that share ontologies with FOLR3: view
genes like me logo Genes that share phenotypes with FOLR3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOLR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOLR3 Gene

Localization for FOLR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOLR3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOLR3 gene
Compartment Confidence
extracellular 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for FOLR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0016020 membrane TAS 8110752
GO:0019898 extrinsic component of membrane TAS 8110752
GO:0031362 anchored component of external side of plasma membrane IBA 21873635
GO:0035580 specific granule lumen TAS --
genes like me logo Genes that share ontologies with FOLR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOLR3 Gene

Pathways & Interactions for FOLR3 Gene

genes like me logo Genes that share pathways with FOLR3: view

Pathways by source for FOLR3 Gene

1 BioSystems pathway for FOLR3 Gene
3 Reactome pathways for FOLR3 Gene
2 KEGG pathways for FOLR3 Gene

Interacting Proteins for FOLR3 Gene

Gene Ontology (GO) - Biological Process for FOLR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization IBA 21873635
GO:0015884 folic acid transport TAS 8110752
GO:0035036 sperm-egg recognition IBA 21873635
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with FOLR3: view

No data available for SIGNOR curated interactions for FOLR3 Gene

Drugs & Compounds for FOLR3 Gene

(3) Drugs for FOLR3 Gene - From: DrugBank, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Folic Acid Approved, Vet_approved Nutra Target, binder 4566
Pemetrexed Approved, Investigational Pharma TS, DHFR,GARFT and AICARFT inhibitor, DHFR and Thymidylate synthase inhibitor, Anti-Folates 757
Vintafolide Investigational Pharma Target Folate-targeted tubulin inhibitor 0
genes like me logo Genes that share compounds with FOLR3: view

Transcripts for FOLR3 Gene

mRNA/cDNA for FOLR3 Gene

Unigene Clusters for FOLR3 Gene

Folate receptor 3 (gamma):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOLR3

Alternative Splicing Database (ASD) splice patterns (SP) for FOLR3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for FOLR3 Gene

GeneLoc Exon Structure for
FOLR3
ECgene alternative splicing isoforms for
FOLR3

Expression for FOLR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOLR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOLR3 Gene

This gene is overexpressed in Whole Blood (x48.5).

Protein differential expression in normal tissues from HIPED for FOLR3 Gene

This gene is overexpressed in Neutrophil (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOLR3 Gene



Protein tissue co-expression partners for FOLR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FOLR3 Gene:

FOLR3

SOURCE GeneReport for Unigene cluster for FOLR3 Gene:

Hs.352

mRNA Expression by UniProt/SwissProt for FOLR3 Gene:

P41439-FOLR3_HUMAN
Tissue specificity: Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma.

Evidence on tissue expression from TISSUES for FOLR3 Gene

  • Blood(4.3)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with FOLR3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FOLR3 Gene

Orthologs for FOLR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOLR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOLR3 35 34
  • 99.32 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FOLR1 35
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 23 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOLR1 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
Species where no ortholog for FOLR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOLR3 Gene

ENSEMBL:
Gene Tree for FOLR3 (if available)
TreeFam:
Gene Tree for FOLR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOLR3: view image

Paralogs for FOLR3 Gene

Paralogs for FOLR3 Gene

(3) SIMAP similar genes for FOLR3 Gene using alignment to 6 proteins:

  • FOLR3_HUMAN
  • E9PGT2_HUMAN
  • F5H2G8_HUMAN
  • J3KQ90_HUMAN
  • J3KQY0_HUMAN
  • Q05C14_HUMAN

Pseudogenes.org Pseudogenes for FOLR3 Gene

genes like me logo Genes that share paralogs with FOLR3: view

Variants for FOLR3 Gene

Sequence variations from dbSNP and Humsavar for FOLR3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000335892 -- 72,139,656(+) TTT/TT coding_sequence_variant, frameshift
rs1001095575 -- 72,135,385(+) C/A upstream_transcript_variant
rs1001210108 -- 72,134,248(+) C/T upstream_transcript_variant
rs1001277731 -- 72,135,532(+) T/A/C upstream_transcript_variant
rs1001369035 -- 72,139,565(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FOLR3 Gene

Variant ID Type Subtype PubMed ID
esv2671723 CNV deletion 23128226
esv2744761 CNV deletion 23290073
nsv1054858 CNV gain 25217958

Variation tolerance for FOLR3 Gene

Gene Damage Index Score: 6.27; 76.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOLR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOLR3
Human Gene Mutation Database (HGMD)
FOLR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOLR3 Gene

Disorders for FOLR3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FOLR3 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
primary peritoneal carcinoma
  • serous surface papillary carcinoma
myelomeningocele
  • meningomyelocele
- elite association - COSMIC cancer census association via MalaCards
Search FOLR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOLR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FOLR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOLR3 Gene

Publications for FOLR3 Gene

  1. Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. (PMID: 8110752) Shen F … Ratnam M (Biochemistry 1994) 2 3 4 26 58
  2. Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. (PMID: 7727426) Shen F … Ratnam M (Biochemistry 1995) 3 4 26 58
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 45 58
  4. Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele. (PMID: 20683905) O'Byrne MR … Northrup H (Birth defects research. Part A, Clinical and molecular teratology 2010) 3 45 58
  5. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. (PMID: 19048631) Boyles AL … Lie RT (Genetic epidemiology 2009) 3 45 58

Products for FOLR3 Gene

Sources for FOLR3 Gene

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