Aliases for FOLR2 Gene
External Ids for FOLR2 Gene
Previous GeneCards Identifiers for FOLR2 Gene
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOLR2 Gene
FOLR2 (Folate Receptor Beta) is a Protein Coding gene. Diseases associated with FOLR2 include Neural Tube Defects and Myelomeningocele. Among its related pathways are Metabolism of proteins and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include folic acid binding and folic acid transmembrane transporter activity. An important paralog of this gene is FOLR3.
UniProtKB/Swiss-Prot Summary for FOLR2 Gene
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.