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FOLH1B (Folate Hydrolase 1B) is a Protein Coding gene. Among its related pathways are One carbon pool by folate and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and dipeptidase activity.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J089634 | Enhancer | 0.2 | dbSUPER | 613 | -0.1 | -90 | 5.3 | FOLH1B TUBAP2 NOX4 RF00004-026 | ||
GH11J089606 | Enhancer | 0.7 | Ensembl ENCODE | 10.1 | -30.2 | -30179 | 4.4 | TFE3 GABPA FOXA1 FOXA2 CREB1 GABPB1 JUN LCORL ATF1 ELF3 | NOX4 FOLH1B ENSG00000255429 RF00004-026 | |
GH11J089660 | Enhancer | 0.6 | Ensembl dbSUPER | 11.2 | +22.8 | 22821 | 0.4 | CTCF SP1 RAD21 HNF4A RXRA | FOLH1B lnc-TRIM77-11 TRIM77 | |
GH11J089556 | Enhancer | 0.7 | Ensembl ENCODE | 10.1 | -80.0 | -79975 | 1.6 | FOXA1 RFX1 CTBP1 GATA3 DPF2 JUND PRDM6 SMARCE1 | ENSG00000279056 FOLH1B ENSG00000280201 NOX4 ENSG00000255429 TYR | |
GH11J089616 | Enhancer | 0.6 | Ensembl dbSUPER | 9.8 | -21.0 | -20979 | 1.2 | CTCF RAD21 ESRRA SMC3 ZNF654 | FOLH1B RF00004-026 NOX4 ENSG00000255429 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004180 | carboxypeptidase activity | IBA | 21873635 |
GO:0004181 | metallocarboxypeptidase activity | IDA | 17241121 |
GO:0016805 | dipeptidase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | IBA, TAS | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Amino acid synthesis and interconversion (transamination) | ||
2 | Metabolism |
.40
|
|
3 | Viral mRNA Translation | ||
4 | One carbon pool by folate |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0008652 | cellular amino acid biosynthetic process | TAS | -- |
GO:0035609 | C-terminal protein deglutamylation | IDA | 17241121 |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10830339 | - | p.Asn151Lys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2762931 | CNV | gain | 21179565 |
esv32702 | CNV | gain+loss | 17666407 |
esv3579993 | CNV | gain | 25503493 |
esv3627174 | CNV | loss | 21293372 |
esv3627175 | CNV | loss | 21293372 |
esv3627176 | CNV | gain | 21293372 |
esv3892057 | CNV | gain | 25118596 |
nsv1043643 | CNV | gain | 25217958 |
nsv1052092 | CNV | gain | 25217958 |
nsv468785 | CNV | gain | 19166990 |
nsv527380 | CNV | loss | 19592680 |
nsv555770 | CNV | gain | 21841781 |
nsv975964 | CNV | duplication | 23825009 |
No disorders were found for FOLH1B Gene.