Aliases for FOLH1 Gene
- Folate Hydrolase 1 2 3 4 5
- Glutamate Carboxypeptidase 2 2 3 4
- N-Acetylated-Alpha-Linked Acidic Dipeptidase I 3 4
- Pteroylpoly-Gamma-Glutamate Carboxypeptidase 3 4
- Folylpoly-Gamma-Glutamate Carboxypeptidase 3 4
- Cell Growth-Inhibiting Gene 27 Protein 3 4
- Membrane Glutamate Carboxypeptidase 3 4
- Glutamate Carboxypeptidase II 3 4
- Glutamate Carboxylase II 2 3
- EC 22.214.171.124 4 52
- NAALADase I 3 4
- NAALAD1 3 4
External Ids for FOLH1 Gene
Previous HGNC Symbols for FOLH1 Gene
Previous GeneCards Identifiers for FOLH1 Gene
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
GeneCards Summary for FOLH1 Gene
FOLH1 (Folate Hydrolase 1) is a Protein Coding gene. Diseases associated with FOLH1 include Prostate Cancer and Canavan Disease. Among its related pathways are One carbon pool by folate and Metabolism. Gene Ontology (GO) annotations related to this gene include peptidase activity and carboxypeptidase activity. An important paralog of this gene is NAALAD2.
UniProtKB/Swiss-Prot Summary for FOLH1 Gene
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups; serine-type carboxypeptidases, metallocarboxypeptidases, and cysteine-type carboxypeptidases.