Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative... See more...

Aliases for FNTA Gene

Aliases for FNTA Gene

  • Farnesyltransferase, CAAX Box, Alpha 2 3 5
  • Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha 2 3 4
  • Protein Prenyltransferase Alpha Subunit Repeat Containing 2 2 3
  • Ras Proteins Prenyltransferase Subunit Alpha 3 4
  • GGTase-I-Alpha 3 4
  • FTase-Alpha 3 4
  • PGGT1A 2 3
  • PTAR2 2 3
  • FPTA 2 3
  • Type I Protein Geranyl-Geranyltransferase Alpha Subunit 3
  • Type I Protein Geranyl-Geranyltransferase Subunit Alpha 4
  • Farnesyl-Protein Transferase Alpha-Subunit 3
  • CAAX Farnesyltransferase Subunit Alpha 4
  • EC 2.5.1.58 4
  • EC 2.5.1.59 4
  • FNTA 5

External Ids for FNTA Gene

Previous GeneCards Identifiers for FNTA Gene

  • GC08P042647
  • GC08P042981
  • GC08P042928
  • GC08P043030
  • GC08P041434

Summaries for FNTA Gene

Entrez Gene Summary for FNTA Gene

  • Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

GeneCards Summary for FNTA Gene

FNTA (Farnesyltransferase, CAAX Box, Alpha) is a Protein Coding gene. Diseases associated with FNTA include Dystonia 6, Torsion and Non-Functioning Pancreatic Endocrine Tumor. Among its related pathways are Signaling by GPCR and G-protein signaling_Rap2B regulation pathway. Gene Ontology (GO) annotations related to this gene include microtubule binding and alpha-tubulin binding. An important paralog of this gene is RABGGTA.

UniProtKB/Swiss-Prot Summary for FNTA Gene

  • Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Tocris Summary for FNTA Gene

Gene Wiki entry for FNTA Gene

Additional gene information for FNTA Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FNTA Gene

Genomics for FNTA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FNTA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FNTA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FNTA

Top Transcription factor binding sites by QIAGEN in the FNTA gene promoter:
  • AML1a
  • ATF-2
  • CRE-BP1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for FNTA Gene

Genomic Locations for FNTA Gene
chr8:43,034,194-43,085,788
(GRCh38/hg38)
Size:
51,595 bases
Orientation:
Plus strand
chr8:42,889,337-42,940,931
(GRCh37/hg19)
Size:
51,595 bases
Orientation:
Plus strand

Genomic View for FNTA Gene

Genes around FNTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNTA Gene

Proteins for FNTA Gene

  • Protein details for FNTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49354-FNTA_HUMAN
    Recommended name:
    Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    Protein Accession:
    P49354
    Secondary Accessions:
    • A6NJW0
    • Q53XJ9
    • Q9UDC1

    Protein attributes for FNTA Gene

    Size:
    379 amino acids
    Molecular mass:
    44409 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase).

    Three dimensional structures from OCA and Proteopedia for FNTA Gene

    Alternative splice isoforms for FNTA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNTA Gene

Post-translational modifications for FNTA Gene

  • Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FNTA Gene

Domains & Families for FNTA Gene

Gene Families for FNTA Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for FNTA Gene

InterPro:
Blocks:
  • Protein prenyltransferase, alpha subunit
ProtoNet:

Suggested Antigen Peptide Sequences for FNTA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ16794 fis, clone TBAES2007504, highly similar to Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (EC 2.5.1.58) (B3KVN2_HUMAN)
  • Farnesyltransferase, CAAX box, alpha, isoform CRA_a (D3DSY9_HUMAN)
  • Type I protein geranyl-geranyltransferase subunit alpha (FNTA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49354

UniProtKB/Swiss-Prot:

FNTA_HUMAN :
  • Belongs to the protein prenyltransferase subunit alpha family.
Family:
  • Belongs to the protein prenyltransferase subunit alpha family.
genes like me logo Genes that share domains with FNTA: view

Function for FNTA Gene

Molecular function for FNTA Gene

UniProtKB/Swiss-Prot Function:
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:13345, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11535, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:86019, ChEBI:CHEBI:175763; EC=2.5.1.58; Evidence={ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533, ChEBI:CHEBI:86021; EC=2.5.1.59; Evidence={ECO:0000269|PubMed:16893176};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by the AGRIN-induced phosphorylation which is mediated by MUSK.
GENATLAS Biochemistry:
CAAX farnesyltransferase,alpha subunit promoting the prenylation of Ras,first step of a series of post translational modification of RAS,required for its association with the inner surface of the plasma membrane,also involved in maturation of other proteins including Ras family members,the gamma subunit of G proteins and nuclear lamins

Enzyme Numbers (IUBMB) for FNTA Gene

Phenotypes From GWAS Catalog for FNTA Gene

Gene Ontology (GO) - Molecular Function for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004659 prenyltransferase activity IEA --
GO:0004660 contributes_to protein farnesyltransferase activity TAS,IDA 19228685
GO:0004661 protein geranylgeranyltransferase activity TAS,IDA 16893176
GO:0004662 contributes_to CAAX-protein geranylgeranyltransferase activity IEA,IBA 21873635
GO:0004663 Rab geranylgeranyltransferase activity IEA --
genes like me logo Genes that share ontologies with FNTA: view
genes like me logo Genes that share phenotypes with FNTA: view

Animal Models for FNTA Gene

MGI Knock Outs for FNTA:
  • Fnta Fnta<tm1b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for FNTA

CRISPR Products

miRNA for FNTA Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNTA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNTA Gene

Localization for FNTA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNTA gene
Compartment Confidence
cytoskeleton 4
cytosol 4
plasma membrane 3
extracellular 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS,IBA 21873635
GO:0005829 cytosol TAS --
GO:0005875 microtubule associated complex IDA 19228685
GO:0005886 plasma membrane IEA --
GO:0005953 CAAX-protein geranylgeranyltransferase complex IBA,IDA 16893176
genes like me logo Genes that share ontologies with FNTA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FNTA Gene

Pathways & Interactions for FNTA Gene

genes like me logo Genes that share pathways with FNTA: view

Pathways by source for FNTA Gene

10 GeneGo (Thomson Reuters) pathways for FNTA Gene
  • Cytoskeleton remodeling_RalA regulation pathway
  • G-protein signaling_H-RAS regulation pathway
  • G-protein signaling_K-RAS regulation pathway
  • G-protein signaling_Rac2 regulation pathway
  • G-protein signaling_Rap1A regulation pathway

SIGNOR curated interactions for FNTA Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 8599089
GO:0007528 neuromuscular junction development IEA --
GO:0018342 protein prenylation IEA --
GO:0018343 protein farnesylation TAS,IDA 16893176
GO:0018344 protein geranylgeranylation TAS,IDA 16893176
genes like me logo Genes that share ontologies with FNTA: view

Drugs & Compounds for FNTA Gene

(19) Drugs for FNTA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
farnesyl diphosphate Experimental Pharma Antagonist, Agonist, Target 0
(11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE Experimental Pharma Target 0
(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE Experimental Pharma Target 0
(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE Experimental Pharma Target 0
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Experimental Pharma Target 0

(4) Additional Compounds for FNTA Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Geranylgeranyl-PP
  • all-trans-Geranylgeranyl diphosphate
  • all-trans-Geranylgeranyl pyrophosphate
  • Geranylgeranyl diphosphate
  • Geranylgeranyl pyrophosphate
  • GGDP
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
FTI 277
1217447-06-7
GGTI 298
1217457-86-7

(3) Tocris Compounds for FNTA Gene

Compound Action Cas Number
FTI 277 Prodrug form of FTI 276 (Cat. No. 2406) 1217447-06-7
GGTI 298 Geranylgeranyltransferase I (GGTase I) inhibitor 1217457-86-7
LB 42708 Selective farnesyltransferase (FTase) inhibitor 226929-39-1

(4) ApexBio Compounds for FNTA Gene

Compound Action Cas Number
FTI 277 HCl FTase inhibitor 180977-34-8
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
Tipifarnib (Zarnestra) Farnesyltransferase inhibitor,potent and specific 192185-72-1
genes like me logo Genes that share compounds with FNTA: view

Drug Products

Transcripts for FNTA Gene

mRNA/cDNA for FNTA Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNTA

Alternative Splicing Database (ASD) splice patterns (SP) for FNTA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: -
SP7: -
SP8:
SP9: - - - -

Relevant External Links for FNTA Gene

GeneLoc Exon Structure for
FNTA

Expression for FNTA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FNTA Gene

Protein differential expression in normal tissues from HIPED for FNTA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FNTA Gene



Protein tissue co-expression partners for FNTA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FNTA

SOURCE GeneReport for Unigene cluster for FNTA Gene:

Hs.370312

Evidence on tissue expression from TISSUES for FNTA Gene

  • Lung(4.5)
  • Intestine(4.4)
  • Eye(4.2)
  • Nervous system(3.9)
  • Skin(2.8)
  • Heart(2.4)
  • Kidney(2.3)
  • Liver(2.2)
  • Muscle(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with FNTA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNTA Gene

Orthologs for FNTA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FNTA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FNTA 30
  • 99.56 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 94 (a)
OneToMany
FNTA 30
  • 92.7 (n)
Cow
(Bos Taurus)
Mammalia FNTA 30 31
  • 89.78 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Fnta 30
  • 88.42 (n)
Mouse
(Mus musculus)
Mammalia Fnta 30 17 31
  • 87.98 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 81 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 79 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 82 (a)
OneToMany
FNTA 30
  • 78.72 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 79 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fnta 30
  • 74.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12400 30
Zebrafish
(Danio rerio)
Actinopterygii fnta 30 31
  • 66.77 (n)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5468 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011767 30
  • 54.9 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG2976 30 31 32
  • 54.86 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea fnta-1 30 31
  • 50 (n)
OneToMany
R02D3.5 32
  • 40 (a)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17975g 30
  • 47.45 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAM2 30 31 33
  • 46.64 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR094C 30
  • 46.17 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons FTA 30
  • 50.7 (n)
Rice
(Oryza sativa)
Liliopsida Os09g0514400 30
  • 51.85 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2143 31
  • 58 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cwp1 30
  • 50.37 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU03632 30
  • 45.29 (n)
Species where no ortholog for FNTA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FNTA Gene

ENSEMBL:
Gene Tree for FNTA (if available)
TreeFam:
Gene Tree for FNTA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FNTA: view image

Paralogs for FNTA Gene

Paralogs for FNTA Gene

Pseudogenes.org Pseudogenes for FNTA Gene

genes like me logo Genes that share paralogs with FNTA: view

Variants for FNTA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FNTA Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
768238 Benign: not provided 43,084,791(+) C/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
783524 Benign: not provided 43,056,536(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for FNTA Gene

Structural Variations from Database of Genomic Variants (DGV) for FNTA Gene

Variant ID Type Subtype PubMed ID
dgv7187n100 CNV gain 25217958
esv2235385 CNV deletion 18987734
esv2547171 CNV deletion 19546169
esv2668009 CNV deletion 23128226
esv3617025 CNV loss 21293372
esv3891387 CNV gain 25118596
nsv1032781 CNV gain 25217958
nsv470208 CNV gain 18288195
nsv831302 CNV loss 17160897
nsv967584 CNV duplication 23825009

Variation tolerance for FNTA Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FNTA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNTA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNTA Gene

Disorders for FNTA Gene

MalaCards: The human disease database

(2) MalaCards diseases for FNTA Gene - From: DISEASES

Disorder Aliases PubMed IDs
dystonia 6, torsion
  • dyt6
non-functioning pancreatic endocrine tumor
  • non functioning pancreatic endocrine tumor
- elite association - COSMIC cancer census association via MalaCards
Search FNTA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FNTA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FNTA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNTA Gene

Publications for FNTA Gene

  1. cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. (PMID: 8276393) Andres DA … Francke U (Genomics 1993) 2 3 4
  2. Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PMID: 19841875) Fontaine-Bisson B … Morange PE (Journal of molecular medicine (Berlin, Germany) 2010) 3 41
  3. Conversion of protein farnesyltransferase to a geranylgeranyltransferase. (PMID: 16893176) Terry KL … Beese LS (Biochemistry 2006) 3 4
  4. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. (PMID: 15451670) Reid TS … Beese LS (Journal of molecular biology 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for FNTA Gene

  • Signalway Proteins for FNTA

Sources for FNTA Gene