FNIP2 Gene (Protein Coding)

Folliculin Interacting Protein 2

GC04P158769
GIFtS:
38
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has ... See more...

Aliases for FNIP2 Gene

Aliases for FNIP2 Gene

  • Folliculin Interacting Protein 2 2 3 5
  • FNIPL 2 3 4
  • MAPO1 2 3 4
  • O6-Methylguanine-Induced Apoptosis 1 Protein 3 4
  • Folliculin-Interacting Protein 2 3 4
  • FNIP1-Like Protein 3 4
  • KIAA1450 2 4
  • O6-Methylguanine-Induced Apoptosis 1 2
  • FNIP2 5

External Ids for FNIP2 Gene

Previous GeneCards Identifiers for FNIP2 Gene

  • GC04P159911
  • GC04P159690
  • GC04P155440

Summaries for FNIP2 Gene

Entrez Gene Summary for FNIP2 Gene

  • This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

GeneCards Summary for FNIP2 Gene

FNIP2 (Folliculin Interacting Protein 2) is a Protein Coding gene. Diseases associated with FNIP2 include Familial Renal Oncocytoma and Birt-Hogg-Dube Syndrome. Among its related pathways are mTOR signaling pathway (KEGG) and PI3K / Akt Signaling. An important paralog of this gene is FNIP1.

UniProtKB/Swiss-Prot Summary for FNIP2 Gene

  • Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:18663353, PubMed:31672913). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:18403135). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:18403135). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:18403135). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity).

Additional gene information for FNIP2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FNIP2 Gene

Genomics for FNIP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FNIP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FNIP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FNIP2

Top Transcription factor binding sites by QIAGEN in the FNIP2 gene promoter:
  • HFH-1
  • HNF-3beta
  • LCR-F1
  • NF-E2
  • NF-E2 p45
  • PPAR-gamma1
  • PPAR-gamma2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for FNIP2 Gene

Latest Assembly
chr4:158,769,026-158,908,050
(GRCh38/hg38)
Size:
139,025 bases
Orientation:
Plus strand

Previous Assembly
chr4:159,690,178-159,829,202
(GRCh37/hg19 by Entrez Gene)
Size:
139,025 bases
Orientation:
Plus strand

chr4:159,690,290-159,829,201
(GRCh37/hg19 by Ensembl)
Size:
138,912 bases
Orientation:
Plus strand

Genomic View for FNIP2 Gene

Genes around FNIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNIP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FNIP2 Gene

Proteins for FNIP2 Gene

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  • Protein details for FNIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P278-FNIP2_HUMAN
    Recommended name:
    Folliculin-interacting protein 2
    Protein Accession:
    Q9P278
    Secondary Accessions:
    • Q05DC3
    • Q96I31
    • Q9H994

    Protein attributes for FNIP2 Gene

    Size:
    1114 amino acids
    Molecular mass:
    122115 Da
    Quaternary structure:
    • Homodimer and homomultimer (PubMed:18403135, PubMed:27353360). Heterodimer and heteromultimer with FNIP1 (PubMed:18403135, PubMed:27353360). Interacts (via C-terminus) with FLCN (via C-terminus) (PubMed:18403135, PubMed:18663353, PubMed:27353360). Phosphorylated FLCN is preferentially bound (PubMed:18663353). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator (PubMed:31704029, PubMed:31672913). Interacts with PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (PubMed:18403135, PubMed:27353360). Interacts with HSP70, HSP90AA1, STIP1, PTGES3, CDC37, BRAF, GCR and CDK4 (PubMed:27353360).
    SequenceCaution:
    • Sequence=AAH07861.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH16638.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA95974.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14338.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FNIP2 Gene

    Alternative splice isoforms for FNIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNIP2 Gene

Protein Expression for FNIP2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FNIP2 Gene

Other Protein References for FNIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNIP2 Gene

Domains & Families for FNIP2 Gene

Gene Families for FNIP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FNIP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNIP2 Gene

GenScript: Design optimal peptide antigens:
  • O6-methylguanine-induced apoptosis 1 protein (FNIP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P278

UniProtKB/Swiss-Prot:

FNIP2_HUMAN :
  • Belongs to the FNIP family.
Family:
  • Belongs to the FNIP family.
genes like me logo Genes that share domains with FNIP2: view

Function for FNIP2 Gene

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Molecular function for FNIP2 Gene

UniProtKB/Swiss-Prot Function:
Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:18663353, PubMed:31672913). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:18403135). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:18403135). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:18403135). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity).

Phenotypes From GWAS Catalog for FNIP2 Gene

Gene Ontology (GO) - Molecular Function for FNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18403135
GO:0042030 ATPase inhibitor activity IBA,IDA 27353360
GO:0051087 chaperone binding IBA,IDA 27353360
genes like me logo Genes that share ontologies with FNIP2: view
genes like me logo Genes that share phenotypes with FNIP2: view

Animal Models for FNIP2 Gene

MGI Knock Outs for FNIP2:
  • Fnip2 Fnip2<tm1.2Lss>
  • Fnip2 Fnip2<tm1a(KOMP)Wtsi>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNIP2 Gene

Localization for FNIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNIP2 Gene

Lysosome membrane. Cytoplasm. Note=Colocalizes with FLCN in the cytoplasm. {ECO:0000269 PubMed:18403135, ECO:0000269 PubMed:18663353}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNIP2 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
lysosome 4
nucleus 3
plasma membrane 2
mitochondrion 2
extracellular 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 18403135
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FNIP2: view

Pathways & Interactions for FNIP2 Gene

PathCards logo

SuperPathways for FNIP2 Gene

genes like me logo Genes that share pathways with FNIP2: view

Pathways by source for FNIP2 Gene

1 KEGG pathway for FNIP2 Gene
1 Cell Signaling Technology pathway for FNIP2 Gene

SIGNOR curated interactions for FNIP2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for FNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 21209915
GO:0001932 regulation of protein phosphorylation IDA 18663353
GO:0006468 protein phosphorylation IDA 18663353
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage ISS --
genes like me logo Genes that share ontologies with FNIP2: view

Drugs & Compounds for FNIP2 Gene

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No Compound Related Data Available

Transcripts for FNIP2 Gene

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mRNA/cDNA for FNIP2 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNIP2

Alternative Splicing Database (ASD) splice patterns (SP) for FNIP2 Gene

No ASD Table

Relevant External Links for FNIP2 Gene

GeneLoc Exon Structure for
FNIP2

Expression for FNIP2 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FNIP2 Gene

mRNA expression in normal human tissues for FNIP2 Gene
mRNA expression by GTEx for FNIP2 GenemRNA expression by BioGPS for FNIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FNIP2 Gene

This gene is overexpressed in Oral epithelium (27.6) and Monocytes (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FNIP2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FNIP2

SOURCE GeneReport for Unigene cluster for FNIP2 Gene:

Hs.652441

mRNA Expression by UniProt/SwissProt for FNIP2 Gene:

Q9P278-FNIP2_HUMAN
Tissue specificity: Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas (PubMed:18403135, PubMed:18663353, PubMed:27353360). Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue (PubMed:18403135). Higher levels detected in oncocytoma tumors than in normal kidney. Higher levels detected in renal cell carcinoma tumors than in normal kidney tissue (PubMed:27353360).

Evidence on tissue expression from TISSUES for FNIP2 Gene

  • Nervous system(4.8)
  • Kidney(2.8)
  • Lung(2.4)
  • Heart(2.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with FNIP2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNIP2 Gene

Orthologs for FNIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FNIP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia FNIP2 30 31
  • 99.25 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia FNIP2 30 31
  • 85.75 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Fnip2 30
  • 81.32 (n)
Mouse
(Mus musculus)
 Mammalia Fnip2 30 17 31
  • 80.65 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia FNIP2 30 31
  • 76.51 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia FNIP2 31
  • 71 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia FNIP2 31
  • 64 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves FNIP2 30 31
  • 68.22 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia FNIP2 31
  • 61 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia fnip2 30
  • 63.95 (n)
Zebrafish
(Danio rerio)
 Actinopterygii si:ch211-42i9.8 30
  • 64.15 (n)
FNIP2 31
  • 44 (a)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG3764 31
  • 6 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea T04C4.1 31
  • 12 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 44 (a)
 OneToMany
Species where no ortholog for FNIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FNIP2 Gene

ENSEMBL:
Gene Tree for FNIP2 (if available)
TreeFam:
Gene Tree for FNIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FNIP2: view image

Paralogs for FNIP2 Gene

Paralogs for FNIP2 Gene

(2) SIMAP similar genes for FNIP2 Gene using alignment to 3 proteins:

  • FNIP2_HUMAN
  • D6RFH5_HUMAN
  • H0Y8F3_HUMAN
genes like me logo Genes that share paralogs with FNIP2: view

Variants for FNIP2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FNIP2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs147318337 Benign: not provided 158,868,251(+) G/C
NM_020840.3(FNIP2):c.1615G>C (p.Gly539Arg) 		MISSENSE
rs368062140 Likely Benign: not provided 158,868,529(+) A/G
NM_020840.3(FNIP2):c.1893A>G (p.Ala631=) 		SYNONYMOUS
rs62001913 Likely Benign: not provided 158,868,858(+) G/A
NM_020840.3(FNIP2):c.2222G>A (p.Arg741Gln) 		MISSENSE
rs75305192 Benign: not provided 158,868,112(+) C/T
NM_020840.3(FNIP2):c.1476C>T (p.Tyr492=) 		SYNONYMOUS
rs2276938 - p.Thr298Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FNIP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FNIP2 Gene

Variant ID Type Subtype PubMed ID
dgv9332n54 CNV gain 21841781
esv22076 CNV loss 19812545
esv23058 CNV loss 19812545
esv2607605 CNV deletion 19546169
esv2675186 CNV deletion 23128226
esv2728614 CNV deletion 23290073
esv2728615 CNV deletion 23290073
esv3564857 CNV deletion 23714750
esv3602840 CNV loss 21293372
nsv1126701 CNV deletion 24896259
nsv4570 CNV deletion 18451855
nsv830125 CNV gain 17160897
nsv830127 CNV loss 17160897
nsv830128 CNV gain 17160897

Variation tolerance for FNIP2 Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.37; 70.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FNIP2 Gene

Human Gene Mutation Database (HGMD)
FNIP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNIP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNIP2 Gene

Disorders for FNIP2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for FNIP2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
familial renal oncocytoma
birt-hogg-dube syndrome
  • bhd
multilocular clear cell renal cell carcinoma
  • cystadenocarcinoma of kidney
familial renal papillary carcinoma
  • hereditary papillary renal carcinoma
oncocytoma
  • oxyphilic adenoma
- elite association - COSMIC cancer census association via MalaCards
Search FNIP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FNIP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FNIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNIP2 Gene

Publications for FNIP2 Gene

  1. Identification and characterization of a novel folliculin-interacting protein FNIP2. (PMID: 18403135) Hasumi H … Schmidt LS (Gene 2008) 2 3 4
  2. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford MR … Mollapour M (Nature communications 2016) 3 4
  3. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. (PMID: 25126726) Dunlop EA … Tee AR (Autophagy 2014) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA. (PMID: 19137017) Komori K … Hidaka M (Oncogene 2009) 3 4

ExternalLinks

View latest publications for FNIP2 gene in Mastermind

Products for FNIP2 Gene

  • Addgene plasmids for FNIP2

Sources for FNIP2 Gene