Aliases for FNIP2 Gene
External Ids for FNIP2 Gene
Previous GeneCards Identifiers for FNIP2 Gene
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
GeneCards Summary for FNIP2 Gene
FNIP2 (Folliculin Interacting Protein 2) is a Protein Coding gene. Diseases associated with FNIP2 include Familial Renal Oncocytoma and Birt-Hogg-Dube Syndrome. Among its related pathways are PI3K / Akt Signaling and mTOR signaling pathway (KEGG). An important paralog of this gene is FNIP1.
UniProtKB/Swiss-Prot Summary for FNIP2 Gene
Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1 (PubMed:27353360). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:18403135). May regulate phosphorylation of RPS6KB1 (PubMed:18663353).