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This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activiti... See more...
Aliases for FNIP1 Gene
Aliases for FNIP1 Gene
External Ids for FNIP1 Gene
- HGNC: 29418
- Entrez Gene: 96459
- Ensembl: ENSG00000217128
- OMIM: 610594
- UniProtKB: Q8TF40
Previous GeneCards Identifiers for FNIP1 Gene
- GC00U921652
- GC03M008999
- GC05M130792
- GC05M131006
- GC05M130977
- GC05M126169
- GC05M130761
Summaries for FNIP1 Gene
-
This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
GeneCards Summary for FNIP1 Gene
FNIP1 (Folliculin Interacting Protein 1) is a Protein Coding gene. Diseases associated with FNIP1 include Interdigitating Dendritic Cell Sarcoma and Pneumothorax, Primary Spontaneous. Among its related pathways are mTOR signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is FNIP2.
UniProtKB/Swiss-Prot Summary for FNIP1 Gene
-
Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:17028174). May regulate phosphorylation of RPS6KB1 (PubMed:18663353).
Additional gene information for FNIP1 Gene
- Monarch Initiative
- Search for FNIP1 at DataMed
- Search for FNIP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FNIP1 Gene
Genomics for FNIP1 Gene
GeneHancer (GH) Regulatory Elements for FNIP1 Gene
Promoters and enhancers for FNIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FNIP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FNIP1 gene promoter:
-
- aMEF-2
- AML1a
- HTF
- ISGF-3
- MEF-2A
- Meis-1
- Meis-1a
- Meis-1b
- RORalpha2
- Spz1
Genomic Locations for FNIP1 Gene
Genomic Locations for FNIP1 Gene
- chr5:131,641,714-131,797,063
- (GRCh38/hg38)
- Size:
- 155,350 bases
- Orientation:
- Minus strand
- chr5:130,977,407-131,132,756
- (GRCh37/hg19)
- Size:
- 155,350 bases
- Orientation:
- Minus strand
Genomic View for FNIP1 Gene
Genes around FNIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by HGNC
- 5q31.1 by Entrez Gene
- 5q31.1 by Ensembl
FNIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FNIP1 Gene
Proteins for FNIP1 Gene
-
Protein details for FNIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TF40-FNIP1_HUMAN
- Recommended name:
- Folliculin-interacting protein 1
- Protein Accession:
- Q8TF40
- D6RJH5
- Q86T47
- Q9BUT0
Protein attributes for FNIP1 Gene
- Size:
- 1166 amino acids
- Molecular mass:
- 130555 Da
- Quaternary structure:
-
- Homodimer and homomultimer. Heterodimer and heteromultimer with FNIP2 (PubMed:27353360, PubMed:18403135). Interacts with FLCN (via C-terminus) (PubMed:17028174, PubMed:27353360). Interacts with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK are preferentially bound (PubMed:17028174). Interacts with HSP70, STIP1, PTGES3, CDC37, BRAF, GCR and CDK4. Interacts with HSP90AA1; the interaction inhibits HSP90AA1 ATPase activity (PubMed:27353360).
- Miscellaneous:
-
- Elevated expression levels in histologic variants of renal tumors.
Protein Expression for FNIP1 Gene
Post-translational modifications for FNIP1 Gene
- Phosphorylated by AMPK.
-
Ubiquitination at Lys161
- NX_Q8TF40 (NX_Q8TF40-1)
- Modification sites at PhosphoSitePlus
Other Protein References for FNIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-FNIP1 Antibody (HPA068099) and Anti-FNIP1 Antibody (HPA071213)
- Creative Diagnostics Anti-FNIP1 (N-terminal) polyclonal antibody, Anti-FNIP1 monoclonal antibody, and Anti-FNIP1 polyclonal antibody
- Novus Biologicals Antibodies for FNIP1
-
Abcam antibodies for FNIP1
- Invitrogen Antibodies for FNIP1 (AFLGC-FNIP1)
-
Biorbyt antibodies for FNIP1
Protein Products
-
OriGene Purified Proteins for FNIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for FNIP1
- Origene Custom Protein Services for FNIP1
No data available for DME Specific Peptides for FNIP1 Gene
Domains & Families for FNIP1 Gene
Gene Families for FNIP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FNIP1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FNIP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Folliculin-interacting protein 1 (FNIP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TF40- Family:
-
- Belongs to the FNIP family.
Function for FNIP1 Gene
Molecular function for FNIP1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:17028174). May regulate phosphorylation of RPS6KB1 (PubMed:18663353).
Phenotypes From GWAS Catalog for FNIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | IDA | 22977732 |
| GO:0005515 | protein binding | IPI | 17028174 |
| GO:0042030 | ATPase inhibitor activity | IDA | 27353360 |
| GO:0051087 | chaperone binding | IDA | 27353360 |
Phenotypes for FNIP1 Gene
- MGI mutant phenotypes for FNIP1:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for FNIP1:
Animal Models for FNIP1 Gene
- MGI Knock Outs for FNIP1:
-
- Fnip1 Fnip1<tm1.2Baba>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for FNIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FNIP1
- genomics-online: gRNA clones - Search for available FNIP1 gRNA products
- Overview of 76 available FNIP1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for FNIP1 - Select products 50% OFF >
- * FNIP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FNIP1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for FNIP1
miRNA for FNIP1 Gene
- miRTarBase miRNAs that target FNIP1
-
- hsa-mir-186-5p (MIRT021199)
- hsa-mir-18a-3p (MIRT040939)
- hsa-mir-30d-5p (MIRT047802)
- hsa-mir-92a-3p (MIRT049426)
- hsa-let-7a-5p (MIRT052578)
- hsa-mir-136-5p (MIRT440623)
- hsa-mir-379-3p (MIRT440624)
- hsa-mir-493-5p (MIRT440625)
- hsa-mir-382-5p (MIRT440626)
- hsa-mir-218-5p (MIRT440627)
- hsa-mir-223-5p (MIRT548196)
- hsa-mir-4719 (MIRT548197)
- hsa-mir-511-3p (MIRT548198)
- hsa-mir-489-3p (MIRT548199)
- hsa-mir-137 (MIRT548200)
- hsa-mir-363-3p (MIRT548201)
- hsa-mir-92b-3p (MIRT548202)
- hsa-mir-367-3p (MIRT548203)
- hsa-mir-32-5p (MIRT548204)
- hsa-mir-25-3p (MIRT548205)
- hsa-mir-5096 (MIRT668311)
- hsa-mir-5687 (MIRT668312)
- hsa-mir-627-3p (MIRT668313)
- hsa-mir-548o-3p (MIRT668314)
- hsa-mir-1323 (MIRT668315)
- hsa-mir-4773 (MIRT668316)
- hsa-mir-23b-3p (MIRT668317)
- hsa-mir-23a-3p (MIRT668318)
- hsa-mir-130a-5p (MIRT668319)
- hsa-mir-23c (MIRT668320)
- hsa-mir-6516-5p (MIRT688184)
- hsa-mir-6780a-5p (MIRT688185)
- hsa-mir-6779-5p (MIRT688186)
- hsa-mir-3689c (MIRT688187)
- hsa-mir-3689b-3p (MIRT688188)
- hsa-mir-3689a-3p (MIRT688189)
- hsa-mir-30b-3p (MIRT688190)
- hsa-mir-1273h-5p (MIRT688191)
- hsa-mir-455-3p (MIRT688192)
- hsa-mir-203b-3p (MIRT688193)
- hsa-mir-7106-5p (MIRT688194)
- hsa-mir-25-5p (MIRT688195)
- hsa-mir-658 (MIRT688196)
- hsa-mir-6499-3p (MIRT688197)
- hsa-mir-767-5p (MIRT688198)
- hsa-mir-6086 (MIRT688199)
- hsa-mir-377-5p (MIRT688200)
- hsa-mir-6087 (MIRT688201)
- hsa-mir-4487 (MIRT688202)
- hsa-mir-558 (MIRT688203)
- hsa-mir-3160-3p (MIRT688204)
- hsa-mir-4459 (MIRT688205)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FNIP1
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNIP1
- genomics-online: shRNA clones - Search for available FNIP1 shRNA products
- Overview of 76 available FNIP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FNIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FNIP1
- genomics-online: cdna clones - Search for available FNIP1 CDNA products
- Overview of 76 available FNIP1 gene related products
- orf clones - Search for available FNIP1 ORF products
- Overview of 76 available FNIP1 gene related products
- Applied Biological Materials (abm): Clones for FNIP1 - Select products 50% OFF >
- * FNIP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FNIP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for FNIP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNIP1 Gene
Localization for FNIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FNIP1 Gene
- Cytoplasm. Note=Colocalizes with FLCN in the cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA,IEA | 17028174 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FNIP1 Gene
Pathways & Interactions for FNIP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mTOR signaling pathway (KEGG) | ||
Pathways by source for FNIP1 Gene
1 KEGG pathway for FNIP1 Gene
Interacting Proteins for FNIP1 Gene
Selected Interacting proteins:
Q8TF40-FNIP1_HUMAN
ENSP00000421985
for FNIP1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FNIP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 21209915 |
| GO:0001932 | regulation of protein phosphorylation | IDA | 18663353 |
| GO:0001934 | positive regulation of protein phosphorylation | IMP | 17028174 |
| GO:0002327 | immature B cell differentiation | ISS | -- |
| GO:0002904 | positive regulation of B cell apoptotic process | ISS | -- |
No data available for SIGNOR curated interactions for FNIP1 Gene
Transcripts for FNIP1 Gene
mRNA/cDNA for FNIP1 Gene
- (4) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000307968 6388 bps (ENST00000307968.11)
- ENST00000307954 6366 bps (ENST00000307954.12)
- ENST00000510461 6568 bps (ENST00000510461.5)
- ENST00000511848 1720 bps (ENST00000511848.1)
- ENST00000623690 1373 bps (ENST00000623690.1)
CRISPR Products
-
OriGene CRISPR knockouts for FNIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FNIP1
- genomics-online: gRNA clones - Search for available FNIP1 gRNA products
- Overview of 76 available FNIP1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for FNIP1 - Select products 50% OFF >
- * FNIP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FNIP1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for FNIP1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FNIP1
- Browse OriGene Inhibitory RNA Products For FNIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNIP1
- genomics-online: shRNA clones - Search for available FNIP1 shRNA products
- Overview of 76 available FNIP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FNIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FNIP1
- genomics-online: cdna clones - Search for available FNIP1 CDNA products
- Overview of 76 available FNIP1 gene related products
- orf clones - Search for available FNIP1 ORF products
- Overview of 76 available FNIP1 gene related products
- Applied Biological Materials (abm): Clones for FNIP1 - Select products 50% OFF >
- * FNIP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FNIP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for FNIP1 Gene
This gene is overexpressed in Testis (38.8) and Spleen (20.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FNIP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FNIP1 Gene:
FNIP1SOURCE GeneReport for Unigene cluster for FNIP1 Gene:
Hs.591273mRNA Expression by UniProt/SwissProt for FNIP1 Gene:
Q8TF40-FNIP1_HUMAN
Tissue specificity:
Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.
Evidence on tissue expression from TISSUES for FNIP1 Gene
- Liver(4.4)
- Muscle(4.4)
- Nervous system(4.4)
- Lung(4.3)
- Eye(2.3)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs for FNIP1
- genomics-online: primer clones - Search for available FNIP1 Primer products
- Overview of 76 available FNIP1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNIP1 Gene
Orthologs for FNIP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FNIP1 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FNIP1 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FNIP1 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fnip1 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fnip1 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FNIP1 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FNIP1 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FNIP1 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FNIP1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fnip1 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | FNIP1 33 |
|
OneToOne | |
| fnip1 32 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG3764 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | T04C4.1 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for FNIP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for FNIP1 Gene
- ENSEMBL:
- Gene Tree for FNIP1 (if available)
- TreeFam:
- Gene Tree for FNIP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FNIP1: view image
Paralogs for FNIP1 Gene
(2) SIMAP similar genes for FNIP1 Gene using alignment to 2 proteins:
- FNIP1_HUMAN
- J3KNG8_HUMAN
Variants for FNIP1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1554092867 | uncertain-significance, Wolff-Parkinson-White pattern | 131,671,688(-) | TCTTT/T | coding_sequence_variant, frameshift, genic_downstream_transcript_variant | |
| rs1554096246 | uncertain-significance, Wolff-Parkinson-White pattern | 131,719,316(-) | C/T | splice_donor_variant | |
| rs1000029077 | -- | 131,765,953(-) | G/A | intron_variant | |
| rs1000033261 | -- | 131,741,094(-) | A/G | intron_variant | |
| rs1000044854 | -- | 131,654,866(-) | T/C | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1136463 | CNV | deletion | 17803354 |
| esv1591239 | CNV | deletion | 17803354 |
| esv2730780 | CNV | deletion | 23290073 |
| esv2730781 | CNV | deletion | 23290073 |
| esv2730782 | CNV | deletion | 23290073 |
| esv3570416 | CNV | loss | 25503493 |
| esv3575881 | CNV | gain | 25503493 |
| esv990609 | CNV | deletion | 20482838 |
| nsv1032888 | CNV | loss | 25217958 |
| nsv1074871 | CNV | deletion | 25765185 |
| nsv1117579 | CNV | deletion | 24896259 |
| nsv968984 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.14;
61.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FNIP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNIP1 Gene
Disorders for FNIP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| interdigitating dendritic cell sarcoma |
|
|
| pneumothorax, primary spontaneous |
|
|
| birt-hogg-dube syndrome |
|
|
| kidney angiomyolipoma |
|
|
| pleural disease |
|
|
Search FNIP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FNIP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FNIP1 Gene
Publications for FNIP1 Gene
- Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PMID: 17028174) Baba M … Zbar B (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 4 56
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 56
- The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford MR … Mollapour M (Nature communications 2016) 3 4 56
- Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. (PMID: 18804346) Edwards TL … Chen X (Schizophrenia research 2008) 3 43 56
- Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. (PMID: 18663353) Takagi Y … Hino O (Oncogene 2008) 3 4 56
ExternalLinks
Products for FNIP1 Gene
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- Browse Recombinant Antibodies
- Invitrogen Antibodies for FNIP1 (AFLGC-FNIP1)
- antibodies-online: Show 21 available FNIP1 Antibodies ranked by validation data
- Compare Top FNIP1 Antibodies
- antibodies-online: Search results for available FNIP1 related products ranked by validation data
- antibodies-online: Search results for available FNIP1 related products ranked by validation data
- Horizon Cell Lines for FNIP1
- genomics-online: cdna clones - Search for available FNIP1 CDNA products
- Overview of 76 available FNIP1 gene related products
- orf clones - Search for available FNIP1 ORF products
- Overview of 76 available FNIP1 gene related products
- genomics-online: gRNA clones - Search for available FNIP1 gRNA products
- Overview of 76 available FNIP1 gene related products
- genomics-online: primer clones - Search for available FNIP1 Primer products
- Overview of 76 available FNIP1 gene related products
- genomics-online: shRNA clones - Search for available FNIP1 shRNA products
- Overview of 76 available FNIP1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FNIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FNIP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FNIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNIP1
- Biorbyt antibodies for FNIP1
Sources for FNIP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource