Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activiti... See more...
Aliases for FNIP1 Gene
Aliases for FNIP1 Gene
External Ids for FNIP1 Gene
- HGNC: 29418
- Entrez Gene: 96459
- Ensembl: ENSG00000217128
- OMIM: 610594
- UniProtKB: Q8TF40
Previous GeneCards Identifiers for FNIP1 Gene
- GC00U921652
- GC03M008999
- GC05M130792
- GC05M131006
- GC05M130977
- GC05M126169
- GC05M130761
Summaries for FNIP1 Gene
-
This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
GeneCards Summary for FNIP1 Gene
FNIP1 (Folliculin Interacting Protein 1) is a Protein Coding gene. Diseases associated with FNIP1 include Interdigitating Dendritic Cell Sarcoma and Multilocular Clear Cell Renal Cell Carcinoma. Among its related pathways are mTOR signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is FNIP2.
UniProtKB/Swiss-Prot Summary for FNIP1 Gene
-
Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases (PubMed:24081491). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Required for B-cell development (By similarity).
Additional gene information for FNIP1 Gene
- HGNC(29418)
- Entrez Gene(96459)
- Ensembl(ENSG00000217128)
- OMIM(610594)
- UniProtKB(Q8TF40)
- Open Targets Platform(ENSG00000217128)
- Monarch Initiative
- Search for FNIP1 at DataMed
- Search for FNIP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FNIP1 Gene
Genomics for FNIP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FNIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FNIP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FNIP1
- Top Transcription factor binding sites by QIAGEN in the FNIP1 gene promoter:
-
- aMEF-2
- AML1a
- HTF
- ISGF-3
- MEF-2A
- Meis-1
- Meis-1a
- Meis-1b
- RORalpha2
- Spz1
Genomic Locations for FNIP1 Gene
Genomic Locations for FNIP1 Gene
- chr5:131,641,714-131,797,063
- (GRCh38/hg38)
- Size:
- 155,350 bases
- Orientation:
- Minus strand
- chr5:130,977,407-131,132,756
- (GRCh37/hg19)
- Size:
- 155,350 bases
- Orientation:
- Minus strand
Genomic View for FNIP1 Gene
Genes around FNIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by HGNC
- 5q31.1 by Entrez Gene
- 5q31.1 by Ensembl
FNIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FNIP1 Gene
Proteins for FNIP1 Gene
-
Protein details for FNIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TF40-FNIP1_HUMAN
- Recommended name:
- Folliculin-interacting protein 1
- Protein Accession:
- Q8TF40
- D6RJH5
- Q86T47
- Q9BUT0
Protein attributes for FNIP1 Gene
- Size:
- 1166 amino acids
- Molecular mass:
- 130555 Da
- Quaternary structure:
-
- Homodimer and homomultimer (PubMed:18403135, PubMed:27353360). Heterodimer and heteromultimer with FNIP2 (PubMed:18403135, PubMed:27353360). Interacts with FLCN (via C-terminus) (PubMed:17028174, PubMed:27353360). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator (By similarity). Interacts with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK) (PubMed:17028174). Phosphorylated FLCN and AMPK are preferentially bound (PubMed:17028174). Interacts with HSP70, STIP1, PTGES3, CDC37, BRAF, GCR and CDK4 (PubMed:27353360). Interacts with HSP90AA1; the interaction inhibits HSP90AA1 ATPase activity (PubMed:27353360, PubMed:30699359).
Protein Expression for FNIP1 Gene
Post-translational modifications for FNIP1 Gene
- Sequential phosphorylation by CK2 promotes its gradual interaction with HSP90AA1/Hsp90 (PubMed:30699359). Priming phosphorylation at Ser-938 is followed by relay phosphorylation at Ser-939, Ser-941, Ser-946 and Ser-948, promoting its gradual interaction with HSP90AA1/Hsp90 (PubMed:30699359). This leads to incremental inhibition of HSP90AA1/Hsp90 ATPase activity and gradual activation of both kinase and non-kinase clients (PubMed:30699359). Dephosphorylated by protein phosphatase 5 (PP5), promoting glycosylation by OGT (PubMed:30699359). Phosphorylated by AMPK (PubMed:17028174).
- GlcNAcylation at Ser-938 by OGT following dephosphorylation by protein phosphatase 5 (PP5) promotes ubiquitination and degradation by the proteasome.
- Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties at Lys-1119 following glycosylation by OGT, leading to its degradation by the proteasome.
-
Ubiquitination at Lys161
- NX_Q8TF40 (NX_Q8TF40-1)
- Modification sites at PhosphoSitePlus
Other Protein References for FNIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-FNIP1 (N-terminal) polyclonal antibody
- Novus Biologicals Antibodies for FNIP1
-
Abcam antibodies for FNIP1
- Invitrogen Antibodies for FNIP1 (AFLGC-FNIP1)
-
Biorbyt antibodies for FNIP1
Protein Products
-
OriGene Purified Proteins for FNIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for FNIP1
- Origene Custom Protein Services for FNIP1
No data available for DME Specific Peptides for FNIP1 Gene
Domains & Families for FNIP1 Gene
Gene Families for FNIP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FNIP1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FNIP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Folliculin-interacting protein 1 (FNIP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TF40- Family:
-
- Belongs to the FNIP family.
Function for FNIP1 Gene
Molecular function for FNIP1 Gene
- UniProtKB/Swiss-Prot Function:
- Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases (PubMed:24081491). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Required for B-cell development (By similarity).
Phenotypes From GWAS Catalog for FNIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | IDA | 22977732 |
| GO:0005515 | protein binding | IPI | 17028174 |
| GO:0019899 | enzyme binding | IPI | 30699359 |
| GO:0042030 | ATPase inhibitor activity | IDA | 27353360 |
| GO:0051087 | chaperone binding | IDA | 27353360 |
Phenotypes for FNIP1 Gene
- MGI mutant phenotypes for FNIP1:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for FNIP1:
Animal Models for FNIP1 Gene
- MGI Knock Outs for FNIP1:
-
- Fnip1 Fnip1<tm1.2Baba>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FNIP1 - Select products 50% OFF >
- * FNIP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FNIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FNIP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FNIP1
miRNA for FNIP1 Gene
- miRTarBase miRNAs that target FNIP1
-
- mmu-miR-26a-5p (MIRT011371)
- mmu-let-7b-5p (MIRT012217)
- mmu-miR-30e-5p (MIRT013345)
- mmu-miR-9-5p (MIRT015470)
- hsa-miR-186-5p (MIRT021199)
- hsa-miR-18a-3p (MIRT040939)
- hsa-miR-30d-5p (MIRT047802)
- hsa-miR-92a-3p (MIRT049426)
- hsa-let-7a-5p (MIRT052578)
- hsa-miR-136-5p (MIRT440623)
- hsa-miR-379-3p (MIRT440624)
- hsa-miR-493-5p (MIRT440625)
- hsa-miR-382-5p (MIRT440626)
- hsa-miR-218-5p (MIRT440627)
- hsa-miR-223-5p (MIRT548196)
- hsa-miR-4719 (MIRT548197)
- hsa-miR-511-3p (MIRT548198)
- hsa-miR-489-3p (MIRT548199)
- hsa-miR-137 (MIRT548200)
- hsa-miR-363-3p (MIRT548201)
- hsa-miR-92b-3p (MIRT548202)
- hsa-miR-367-3p (MIRT548203)
- hsa-miR-32-5p (MIRT548204)
- hsa-miR-25-3p (MIRT548205)
- mmu-miR-692 (MIRT594664)
- mmu-miR-129-5p (MIRT594665)
- hsa-miR-5096 (MIRT668311)
- hsa-miR-5687 (MIRT668312)
- hsa-miR-627-3p (MIRT668313)
- hsa-miR-548o-3p (MIRT668314)
- hsa-miR-1323 (MIRT668315)
- hsa-miR-4773 (MIRT668316)
- hsa-miR-23b-3p (MIRT668317)
- hsa-miR-23a-3p (MIRT668318)
- hsa-miR-130a-5p (MIRT668319)
- hsa-miR-23c (MIRT668320)
- hsa-miR-6516-5p (MIRT688184)
- hsa-miR-6780a-5p (MIRT688185)
- hsa-miR-6779-5p (MIRT688186)
- hsa-miR-3689c (MIRT688187)
- hsa-miR-3689b-3p (MIRT688188)
- hsa-miR-3689a-3p (MIRT688189)
- hsa-miR-30b-3p (MIRT688190)
- hsa-miR-1273h-5p (MIRT688191)
- hsa-miR-455-3p (MIRT688192)
- hsa-miR-203b-3p (MIRT688193)
- hsa-miR-7106-5p (MIRT688194)
- hsa-miR-25-5p (MIRT688195)
- hsa-miR-658 (MIRT688196)
- hsa-miR-6499-3p (MIRT688197)
- hsa-miR-767-5p (MIRT688198)
- hsa-miR-6086 (MIRT688199)
- hsa-miR-377-5p (MIRT688200)
- hsa-miR-6087 (MIRT688201)
- hsa-miR-4487 (MIRT688202)
- hsa-miR-558 (MIRT688203)
- hsa-miR-3160-3p (MIRT688204)
- hsa-miR-4459 (MIRT688205)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FNIP1
- Browse OriGene Inhibitory RNA Products For FNIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNIP1
Clone Products
- Applied Biological Materials (abm): Clones for FNIP1 - Select products 50% OFF >
- * FNIP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FNIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FNIP1
Cell Line Products
-
Horizon Cell Lines for FNIP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNIP1 Gene
Localization for FNIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FNIP1 Gene
- Lysosome membrane. Cytoplasm, cytosol. Note=Localizes to lysosome membrane in amino acid-depleted conditions and relocalizes to the cytosol upon refeeding (PubMed:29848618). Colocalizes with FLCN in the cytoplasm (PubMed:18663353). {ECO:0000269 PubMed:18663353, ECO:0000269 PubMed:29848618}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| lysosome | 5 |
| nucleus | 3 |
| mitochondrion | 2 |
| endosome | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 17028174 |
| GO:0005765 | lysosomal membrane | IDA | 24081491 |
| GO:0005829 | cytosol | IDA | 24081491 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FNIP1 Gene
Pathways & Interactions for FNIP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mTOR signaling pathway (KEGG) | ||
Pathways by source for FNIP1 Gene
1 KEGG pathway for FNIP1 Gene
Interacting Proteins for FNIP1 Gene
Selected Interacting proteins:
Q8TF40-FNIP1_HUMAN
ENSP00000421985
for FNIP1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FNIP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 21209915 |
| GO:0001932 | regulation of protein phosphorylation | IDA | 18663353 |
| GO:0001934 | positive regulation of protein phosphorylation | IMP | 17028174 |
| GO:0002327 | immature B cell differentiation | ISS | -- |
| GO:0002904 | positive regulation of B cell apoptotic process | ISS | -- |
No data available for SIGNOR curated interactions for FNIP1 Gene
Transcripts for FNIP1 Gene
mRNA/cDNA for FNIP1 Gene
- 4 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000307954 6366 nts (view in UCSC)
- ENST00000307968 6388 nts (view in UCSC)
- ENST00000510461 6568 nts (view in UCSC)
- ENST00000511848 1720 nts (view in UCSC)
- ENST00000615660 6589 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FNIP1 - Select products 50% OFF >
- * FNIP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FNIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FNIP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FNIP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FNIP1
- Browse OriGene Inhibitory RNA Products For FNIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNIP1
Clone Products
- Applied Biological Materials (abm): Clones for FNIP1 - Select products 50% OFF >
- * FNIP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FNIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FNIP1
Relevant External Links for FNIP1 Gene
- GeneLoc Exon Structure for
- FNIP1
Expression for FNIP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
This gene is overexpressed in Testis (38.8) and Spleen (20.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FNIP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FNIP1
SOURCE GeneReport for Unigene cluster for FNIP1 Gene:
Hs.591273mRNA Expression by UniProt/SwissProt for FNIP1 Gene:
Q8TF40-FNIP1_HUMAN
Tissue specificity:
Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.
Evidence on tissue expression from TISSUES for FNIP1 Gene
- Liver(4.5)
- Muscle(4.5)
- Nervous system(4.5)
- Lung(4.4)
- Kidney(2.7)
- Blood(2.4)
- Lymph node(2.3)
- Eye(2.3)
- Thyroid gland(2.2)
- Heart(2.1)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for FNIP1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNIP1 Gene
Orthologs for FNIP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FNIP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FNIP1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FNIP1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fnip1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fnip1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FNIP1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FNIP1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FNIP1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FNIP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fnip1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | FNIP1 31 |
|
OneToOne | |
| fnip1 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG3764 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | T04C4.1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for FNIP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for FNIP1 Gene
- ENSEMBL:
- Gene Tree for FNIP1 (if available)
- TreeFam:
- Gene Tree for FNIP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FNIP1: view image
Paralogs for FNIP1 Gene
(2) SIMAP similar genes for FNIP1 Gene using alignment to 2 proteins:
- FNIP1_HUMAN
- J3KNG8_HUMAN
Variants for FNIP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FNIP1 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1554092867 | Uncertain Significance: Wolff-Parkinson-White pattern | 131,671,687(-) | CTCTT/C | FRAMESHIFT_VARIANT | |
| rs1554096246 | Uncertain Significance: Wolff-Parkinson-White pattern | 131,719,316(-) | C/T | SPLICE_DONOR_VARIANT | |
| rs12109782 | - | p.Val738Leu | |||
| rs13177318 | - | p.Ser354Leu | |||
| rs26008 | - | p.Gln648Arg |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1136463 | CNV | deletion | 17803354 |
| esv1591239 | CNV | deletion | 17803354 |
| esv2730780 | CNV | deletion | 23290073 |
| esv2730781 | CNV | deletion | 23290073 |
| esv2730782 | CNV | deletion | 23290073 |
| esv3570416 | CNV | loss | 25503493 |
| esv3575881 | CNV | gain | 25503493 |
| esv990609 | CNV | deletion | 20482838 |
| nsv1032888 | CNV | loss | 25217958 |
| nsv1074871 | CNV | deletion | 25765185 |
| nsv1117579 | CNV | deletion | 24896259 |
| nsv968984 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.14;
61.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FNIP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNIP1 Gene
Disorders for FNIP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| interdigitating dendritic cell sarcoma |
|
|
| multilocular clear cell renal cell carcinoma |
|
|
| birt-hogg-dube syndrome |
|
|
| familial renal oncocytoma |
|
|
| pneumothorax, primary spontaneous |
|
|
Search FNIP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FNIP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FNIP1 Gene
Publications for FNIP1 Gene
- Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PMID: 17028174) Baba M … Zbar B (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 4
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4
- Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90. (PMID: 30699359) Sager RA … Mollapour M (Cell reports 2019) 3 4
- GATOR1-dependent recruitment of FLCN-FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids. (PMID: 29848618) Meng J … Ferguson SM (The Journal of cell biology 2018) 3 4
- The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford MR … Mollapour M (Nature communications 2016) 3 4
ExternalLinks
Products for FNIP1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FNIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for FNIP1
- Origene Custom Protein Services for FNIP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FNIP1
- Browse OriGene Inhibitory RNA Products For FNIP1
- OriGene qPCR primer pairs for FNIP1
- OriGene CRISPR knockouts for FNIP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FNIP1
- Sino Biological Human cDNA Clone for FNIP1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FNIP1
- Novus Biologicals proteins and lysates for FNIP1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for FNIP1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for FNIP1 (AFLGC-FNIP1)
- VectorBuilder Custom and pre-made DNA vectors for FNIP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FNIP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FNIP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FNIP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FNIP1
- antibodies-online: Show 21 available FNIP1 Antibodies ranked by validation data
- Compare Top FNIP1 Antibodies
- antibodies-online: Search results for available FNIP1 related products ranked by validation data
- antibodies-online: Search results for available FNIP1 related products ranked by validation data
- Horizon Cell Lines for FNIP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FNIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FNIP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FNIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNIP1
- Biorbyt antibodies for FNIP1
Sources for FNIP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB