Aliases for FNDC9 Gene

Aliases for FNDC9 Gene

  • Fibronectin Type III Domain Containing 9 2 3 5
  • Fibronectin Type III Domain-Containing Protein 9 3 4
  • C5orf40 3 4
  • Fibronectin Type-III Domain-Containing Protein C5orf40 3
  • Chromosome 5 Open Reading Frame 40 2

External Ids for FNDC9 Gene

Previous HGNC Symbols for FNDC9 Gene

  • C5orf40

Previous GeneCards Identifiers for FNDC9 Gene

  • GC05M156768

Summaries for FNDC9 Gene

GeneCards Summary for FNDC9 Gene

FNDC9 (Fibronectin Type III Domain Containing 9) is a Protein Coding gene. An important paralog of this gene is ENSG00000285868.

Additional gene information for FNDC9 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FNDC9 Gene

Genomics for FNDC9 Gene

GeneHancer (GH) Regulatory Elements for FNDC9 Gene

Promoters and enhancers for FNDC9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FNDC9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FNDC9

Genomic Locations for FNDC9 Gene

Genomic Locations for FNDC9 Gene
chr5:157,341,598-157,345,721
(GRCh38/hg38)
Size:
4,124 bases
Orientation:
Minus strand
chr5:156,768,607-156,772,729
(GRCh37/hg19)
Size:
4,123 bases
Orientation:
Minus strand

Genomic View for FNDC9 Gene

Genes around FNDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC9 Gene

Proteins for FNDC9 Gene

  • Protein details for FNDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBE3-FNDC9_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 9
    Protein Accession:
    Q8TBE3
    Secondary Accessions:
    • A8K0Y6

    Protein attributes for FNDC9 Gene

    Size:
    224 amino acids
    Molecular mass:
    25275 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC9 Gene

Post-translational modifications for FNDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNDC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC9 Gene

Domains & Families for FNDC9 Gene

Gene Families for FNDC9 Gene

Protein Domains for FNDC9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNDC9 Gene

GenScript: Design optimal peptide antigens:
  • Fibronectin type III domain-containing protein 9 (FNDC9_HUMAN)
genes like me logo Genes that share domains with FNDC9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FNDC9 Gene

Function for FNDC9 Gene

Phenotypes From GWAS Catalog for FNDC9 Gene

genes like me logo Genes that share phenotypes with FNDC9: view

Animal Models for FNDC9 Gene

MGI Knock Outs for FNDC9:
  • Fndc9 Fndc9<tm1.1(KOMP)Vlcg>

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNDC9 Gene

Localization for FNDC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC9 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC9 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
golgi apparatus 1
extracellular 0
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for FNDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FNDC9 Gene

Pathways & Interactions for FNDC9 Gene

PathCards logo

SuperPathways for FNDC9 Gene

No Data Available

Interacting Proteins for FNDC9 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000310594 for FNDC9 Gene via STRING

;

Gene Ontology (GO) - Biological Process for FNDC9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC9 Gene

Drugs & Compounds for FNDC9 Gene

No Compound Related Data Available

Transcripts for FNDC9 Gene

mRNA/cDNA for FNDC9 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC9 Gene

No ASD Table

Relevant External Links for FNDC9 Gene

GeneLoc Exon Structure for
FNDC9

Expression for FNDC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FNDC9 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC9 Gene

This gene is overexpressed in Brain - Hypothalamus (x12.4), Brain - Nucleus accumbens (basal ganglia) (x6.4), Pituitary (x5.1), Brain - Frontal Cortex (BA9) (x4.3), and Brain - Cortex (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FNDC9

SOURCE GeneReport for Unigene cluster for FNDC9 Gene:

Hs.437066

Evidence on tissue expression from TISSUES for FNDC9 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with FNDC9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC9 Gene

Orthologs for FNDC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNDC9 31 30
  • 99.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FNDC9 31 30
  • 89.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FNDC9 31 30
  • 87.54 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fndc9 30
  • 86.46 (n)
mouse
(Mus musculus)
Mammalia Fndc9 17 31 30
  • 84.97 (n)
oppossum
(Monodelphis domestica)
Mammalia FNDC9 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNDC9 31 30
  • 56.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FNDC9 31
  • 27 (a)
OneToOne
Species where no ortholog for FNDC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FNDC9 Gene

ENSEMBL:
Gene Tree for FNDC9 (if available)
TreeFam:
Gene Tree for FNDC9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FNDC9: view image

Paralogs for FNDC9 Gene

Paralogs for FNDC9 Gene

genes like me logo Genes that share paralogs with FNDC9: view

Variants for FNDC9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FNDC9 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs10037485 - p.Val138Ile
rs17054522 - p.Pro166Ala
rs17852104 - p.His50Asn

Additional dbSNP identifiers (rs#s) for FNDC9 Gene

Structural Variations from Database of Genomic Variants (DGV) for FNDC9 Gene

Variant ID Type Subtype PubMed ID
nsv830526 CNV loss 17160897

Variation tolerance for FNDC9 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.83; 79.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FNDC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC9 Gene

Disorders for FNDC9 Gene

Additional Disease Information for FNDC9

No disorders were found for FNDC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC9 Gene

Publications for FNDC9 Gene

  1. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J … Elledge SJ (Cell 2009) 3 54
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 54
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 54
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for FNDC9 Gene

Sources for FNDC9 Gene