Aliases for FNDC8 Gene

Aliases for FNDC8 Gene

  • Fibronectin Type III Domain Containing 8 2 3 5
  • Fibronectin Type III Domain-Containing Protein 8 3 4

External Ids for FNDC8 Gene

Previous GeneCards Identifiers for FNDC8 Gene

  • GC17P030473
  • GC17P033448
  • GC17P029633

Summaries for FNDC8 Gene

GeneCards Summary for FNDC8 Gene

FNDC8 (Fibronectin Type III Domain Containing 8) is a Protein Coding gene. Diseases associated with FNDC8 include Breast-Ovarian Cancer, Familial 4.

Additional gene information for FNDC8 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FNDC8 Gene

Genomics for FNDC8 Gene

GeneHancer (GH) Regulatory Elements for FNDC8 Gene

Promoters and enhancers for FNDC8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J035121 Promoter 0.3 EPDnew 750.6 0.0 0 0.1 ENSG00000267618 FNDC8 RAD51D RAD51L3-RFFL
GH17J035127 Enhancer 0.6 Ensembl ENCODE 0.4 +7.4 7425 4 POLR2A ZNF316 SUPT5H CBFA2T3 piR-47637 LIG3 RNU6-840P NLE1 FNDC8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FNDC8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FNDC8 gene promoter:
  • AML1a
  • c-Myc
  • GATA-1
  • Max
  • Max1
  • NCX
  • PPAR-gamma1
  • PPAR-gamma2
  • RREB-1
  • ZID

Genomic Locations for FNDC8 Gene

Genomic Locations for FNDC8 Gene
chr17:35,121,612-35,130,732
(GRCh38/hg38)
Size:
9,121 bases
Orientation:
Plus strand
chr17:33,448,598-33,457,751
(GRCh37/hg19)
Size:
9,154 bases
Orientation:
Plus strand

Genomic View for FNDC8 Gene

Genes around FNDC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC8 Gene

Proteins for FNDC8 Gene

  • Protein details for FNDC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC99-FNDC8_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 8
    Protein Accession:
    Q8TC99
    Secondary Accessions:
    • B2R9G6
    • Q9UFC2

    Protein attributes for FNDC8 Gene

    Size:
    324 amino acids
    Molecular mass:
    35921 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC8 Gene

Post-translational modifications for FNDC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNDC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC8 Gene

Domains & Families for FNDC8 Gene

Gene Families for FNDC8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FNDC8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNDC8 Gene

GenScript: Design optimal peptide antigens:
  • Fibronectin type III domain-containing protein 8 (FNDC8_HUMAN)
genes like me logo Genes that share domains with FNDC8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FNDC8 Gene

Function for FNDC8 Gene

genes like me logo Genes that share phenotypes with FNDC8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FNDC8

CRISPR Products

miRNA for FNDC8 Gene

miRTarBase miRNAs that target FNDC8

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC8 Gene

Localization for FNDC8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC8 gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for FNDC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with FNDC8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FNDC8 Gene

Pathways & Interactions for FNDC8 Gene

PathCards logo

SuperPathways for FNDC8 Gene

No Data Available

Interacting Proteins for FNDC8 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000158009 Q8TC99-FNDC8_HUMAN for FNDC8 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FNDC8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC8 Gene

Drugs & Compounds for FNDC8 Gene

No Compound Related Data Available

Transcripts for FNDC8 Gene

mRNA/cDNA for FNDC8 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC8 Gene

No ASD Table

Relevant External Links for FNDC8 Gene

GeneLoc Exon Structure for
FNDC8
ECgene alternative splicing isoforms for
FNDC8

Expression for FNDC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FNDC8 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC8 Gene

This gene is overexpressed in Testis (x49.6).

Protein differential expression in normal tissues from HIPED for FNDC8 Gene

This gene is overexpressed in Testis (37.0) and Ovary (31.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FNDC8 Gene



Protein tissue co-expression partners for FNDC8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FNDC8 Gene:

FNDC8

SOURCE GeneReport for Unigene cluster for FNDC8 Gene:

Hs.120369
genes like me logo Genes that share expression patterns with FNDC8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC8 Gene

Orthologs for FNDC8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FNDC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNDC8 33 32
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FNDC8 33 32
  • 85.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FNDC8 33 32
  • 83.28 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fndc8 17 33 32
  • 77.92 (n)
rat
(Rattus norvegicus)
Mammalia Fndc8 32
  • 77.81 (n)
oppossum
(Monodelphis domestica)
Mammalia FNDC8 33
  • 36 (a)
OneToOne
Species where no ortholog for FNDC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FNDC8 Gene

ENSEMBL:
Gene Tree for FNDC8 (if available)
TreeFam:
Gene Tree for FNDC8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FNDC8: view image

Paralogs for FNDC8 Gene

No data available for Paralogs for FNDC8 Gene

Variants for FNDC8 Gene

Sequence variations from dbSNP and Humsavar for FNDC8 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs114252524 likely-benign, Breast and Ovarian Cancer Susceptibility 35,119,651(+) C/A upstream_transcript_variant
rs1362923396 uncertain-significance, Hereditary cancer-predisposing syndrome 35,119,614(+) G/A
rs188262287 likely-benign, benign, Breast and Ovarian Cancer Susceptibility, Breast-ovarian cancer, familial 4 35,119,851(+) T/A upstream_transcript_variant
rs533209845 likely-benign, Breast-ovarian cancer, familial 4 35,119,712(+) A/G upstream_transcript_variant
rs549819451 uncertain-significance, Breast and Ovarian Cancer Susceptibility 35,119,777(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC8 Gene

Variant ID Type Subtype PubMed ID
esv3892998 CNV loss 25118596
nsv2036 CNV insertion 18451855

Variation tolerance for FNDC8 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FNDC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC8 Gene

Disorders for FNDC8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FNDC8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
breast-ovarian cancer, familial 4
  • breast-ovarian cancer, familial, susceptibility to, 4
- elite association - COSMIC cancer census association via MalaCards
Search FNDC8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FNDC8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FNDC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNDC8 Gene

Publications for FNDC8 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 56
  3. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A … DeKAF Investigators (Transplantation 2010) 43 56
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 56

Products for FNDC8 Gene

Sources for FNDC8 Gene