Aliases for FNDC7 Gene

Aliases for FNDC7 Gene

  • Fibronectin Type III Domain Containing 7 2 3 5
  • Fibronectin Type III Domain-Containing Protein 7 3 4
  • FLJ35838 2
  • FNDC7 5

External Ids for FNDC7 Gene

Previous GeneCards Identifiers for FNDC7 Gene

  • GC01P108978
  • GC01P109066
  • GC01P109255
  • GC01P107149

Summaries for FNDC7 Gene

GeneCards Summary for FNDC7 Gene

FNDC7 (Fibronectin Type III Domain Containing 7) is a Protein Coding gene. An important paralog of this gene is FN1.

Additional gene information for FNDC7 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FNDC7 Gene

Genomics for FNDC7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FNDC7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J108681 Enhancer 0.7 Ensembl 11.7 -30.9 -30907 0.8 IKZF1 PKNOX1 MTA1 HDAC1 SOX6 HMBOX1 MTA3 CTBP1 HDAC2 MNT piR-51819-002 HENMT1 FNDC7 ENSG00000232971 piR-58313 PRPF38B
GH01J108741 Enhancer 0.3 Ensembl 10.9 +28.3 28293 0.4 PRDM10 SPI1 FNDC7 PRPF38B ENSG00000232971 lnc-STXBP3-2 STXBP3
GH01J108671 Enhancer 0.3 Ensembl 11.8 -41.5 -41507 0.4 SPI1 FNDC7 piR-33422-017 piR-52438-005 HENMT1 PRPF38B
GH01J108691 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -19.3 -19290 6 CREB1 GATAD2A PRDM10 ZNF629 LEF1 IKZF1 ZNF692 POLR2A NFRKB ZHX2 PRPF38B lnc-HENMT1-2 ENSG00000232971 NONHSAG002311.2 FNDC7
GH01J108718 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.4 +7.8 7793 4.2 PRDM10 ZNF629 LEF1 IKZF1 JUND FOXA1 PRDM1 MTA2 ZIC2 PKNOX1 PRPF38B STXBP3 FNDC7 ENSG00000232971
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FNDC7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FNDC7

Top Transcription factor binding sites by QIAGEN in the FNDC7 gene promoter:
  • AREB6
  • Bach2
  • CUTL1
  • FOXF2
  • GATA-6
  • HNF-1
  • HNF-1A
  • LCR-F1
  • Nkx2-5
  • Nkx3-1 v4

Genomic Locations for FNDC7 Gene

Genomic Locations for FNDC7 Gene
chr1:108,712,908-108,742,749
(GRCh38/hg38)
Size:
29,842 bases
Orientation:
Plus strand
chr1:109,255,279-109,285,371
(GRCh37/hg19)
Size:
30,093 bases
Orientation:
Plus strand

Genomic View for FNDC7 Gene

Genes around FNDC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC7 Gene

Proteins for FNDC7 Gene

  • Protein details for FNDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTL7-FNDC7_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 7
    Protein Accession:
    Q5VTL7
    Secondary Accessions:
    • A1L468
    • E9PAZ5
    • Q6PF16
    • Q8NA51

    Protein attributes for FNDC7 Gene

    Size:
    733 amino acids
    Molecular mass:
    78236 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH57762.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI30422.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC04077.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for FNDC7 Gene

Post-translational modifications for FNDC7 Gene

  • Glycosylation at Asn230 and Asn433
  • Modification sites at PhosphoSitePlus

Other Protein References for FNDC7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC7 Gene

Domains & Families for FNDC7 Gene

Gene Families for FNDC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FNDC7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNDC7 Gene

GenScript: Design optimal peptide antigens:
  • Fibronectin type III domain-containing protein 7 (FNDC7_HUMAN)
genes like me logo Genes that share domains with FNDC7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FNDC7 Gene

Function for FNDC7 Gene

Phenotypes From GWAS Catalog for FNDC7 Gene

Gene Ontology (GO) - Molecular Function for FNDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FNDC7: view
genes like me logo Genes that share phenotypes with FNDC7: view

Animal Models for FNDC7 Gene

MGI Knock Outs for FNDC7:
  • Fndc7 Fndc7<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNDC7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNDC7 Gene

Localization for FNDC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC7 gene
Compartment Confidence
extracellular 4
cytoskeleton 2
nucleus 2
plasma membrane 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FNDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FNDC7: view

Pathways & Interactions for FNDC7 Gene

PathCards logo

SuperPathways for FNDC7 Gene

No Data Available

Interacting Proteins for FNDC7 Gene

Gene Ontology (GO) - Biological Process for FNDC7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC7 Gene

Drugs & Compounds for FNDC7 Gene

No Compound Related Data Available

Transcripts for FNDC7 Gene

mRNA/cDNA for FNDC7 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNDC7

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC7 Gene

No ASD Table

Relevant External Links for FNDC7 Gene

GeneLoc Exon Structure for
FNDC7

Expression for FNDC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FNDC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FNDC7 Gene

This gene is overexpressed in Testis (x12.7) and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for FNDC7 Gene

This gene is overexpressed in Esophagus (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FNDC7 Gene



Protein tissue co-expression partners for FNDC7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FNDC7

SOURCE GeneReport for Unigene cluster for FNDC7 Gene:

Hs.258253

Evidence on tissue expression from TISSUES for FNDC7 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with FNDC7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC7 Gene

Orthologs for FNDC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FNDC7 30 31
  • 98.86 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FNDC7 30 31
  • 89.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FNDC7 30 31
  • 89.22 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fndc7 30 17 31
  • 84.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fndc7 30
  • 84.47 (n)
Oppossum
(Monodelphis domestica)
Mammalia FNDC7 31
  • 70 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FNDC7 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FNDC7 31
  • 60 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FNDC7 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100492589 30
  • 62.23 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100538169 30
  • 55.62 (n)
fndc7 31
  • 47 (a)
OneToMany
FNDC7 (3 of 7) 31
  • 44 (a)
OneToMany
FNDC7 (6 of 7) 31
  • 32 (a)
OneToMany
FNDC7 (5 of 7) 31
  • 27 (a)
OneToMany
FNDC7 (7 of 7) 31
  • 24 (a)
OneToMany
FNDC7 (4 of 7) 31
  • 21 (a)
OneToMany
FNDC7 (1 of 7) 31
  • 5 (a)
OneToMany
Species where no ortholog for FNDC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FNDC7 Gene

ENSEMBL:
Gene Tree for FNDC7 (if available)
TreeFam:
Gene Tree for FNDC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FNDC7: view image

Paralogs for FNDC7 Gene

genes like me logo Genes that share paralogs with FNDC7: view

Variants for FNDC7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FNDC7 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs11582005 - p.Ser309Asn
rs1277017 - p.Pro685Leu
rs3006870 - p.Asn367Ser
rs4494160 - p.Val353Ala

Additional dbSNP identifiers (rs#s) for FNDC7 Gene

Variation tolerance for FNDC7 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.55; 82.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FNDC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FNDC7 Gene

Disorders for FNDC7 Gene

Additional Disease Information for FNDC7

No disorders were found for FNDC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC7 Gene

Publications for FNDC7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 41
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for FNDC7 Gene

Sources for FNDC7 Gene