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Aliases for FNDC5 Gene

Aliases for FNDC5 Gene

  • Fibronectin Type III Domain Containing 5 2 3 5
  • Fibronectin Type III Repeat-Containing Protein 2 3 4
  • Irisin 2 3
  • FRCP2 3 4
  • Fibronectin Type III Domain-Containing Protein 5 3

External Ids for FNDC5 Gene

Previous GeneCards Identifiers for FNDC5 Gene

  • GC01M032996
  • GC01M033100
  • GC01M033327
  • GC01M031443

Summaries for FNDC5 Gene

Entrez Gene Summary for FNDC5 Gene

  • This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for FNDC5 Gene

FNDC5 (Fibronectin Type III Domain Containing 5) is a Protein Coding gene. Diseases associated with FNDC5 include Gastric Adenosquamous Carcinoma. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is FNDC4.

UniProtKB/Swiss-Prot for FNDC5 Gene

  • Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.

Additional gene information for FNDC5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC5 Gene

Genomics for FNDC5 Gene

GeneHancer (GH) Regulatory Elements for FNDC5 Gene

Promoters and enhancers for FNDC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J032870 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 669.4 +0.6 614 2.6 PTBP1 RB1 ARNT KLF17 ZNF2 RAD21 ZNF335 GLIS2 EGR1 ZNF366 FNDC5 S100PBP YARS
GH01J032763 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 27.8 +106.4 106437 4.3 KLF1 USF1 KLF17 SIN3A PAX8 ZIC2 ZFHX2 POLR2A PATZ1 ZFP91 KIAA1522 FNDC5 S100PBP ENSG00000224409 SYNC YARS
GH01J032813 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.9 +55.3 55250 7.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 S100PBP YARS RBBP4 TXLNA KHDRBS1 TSSK3 ZBTB8A TMEM39B EIF3I FAM229A
GH01J032756 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.4 +112.3 112323 6.8 HDGF PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A YY1 FOS SP5 MXD4 FNDC5 S100PBP TXLNA ZBTB8B ENSG00000224409 RBBP4 ZBTB8A SYNC KPNA6 ADGRB2
GH01J032900 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 13.6 -28.8 -28763 1.6 RB1 KLF17 SIN3A ZBTB40 ZNF335 GLIS2 SMARCA5 GLIS1 IKZF1 KDM1A TMEM54 LOC105378632 FNDC5 S100PBP GC01P032892
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FNDC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FNDC5 gene promoter:
  • NRSF form 1
  • NRSF form 2
  • deltaCREB
  • CREB
  • GATA-2
  • Nkx3-1
  • Nkx3-1 v1

Genomic Locations for FNDC5 Gene

Genomic Locations for FNDC5 Gene
10,225 bases
Minus strand
10,215 bases
Minus strand

Genomic View for FNDC5 Gene

Genes around FNDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC5 Gene

Proteins for FNDC5 Gene

  • Protein details for FNDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibronectin type III domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • A6NMC9
    • D3DPQ6
    • Q6P6D9
    • Q7Z676

    Protein attributes for FNDC5 Gene

    212 amino acids
    Molecular mass:
    23659 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FNDC5 Gene

    Alternative splice isoforms for FNDC5 Gene


neXtProt entry for FNDC5 Gene

Post-translational modifications for FNDC5 Gene

Other Protein References for FNDC5 Gene

No data available for DME Specific Peptides for FNDC5 Gene

Domains & Families for FNDC5 Gene

Gene Families for FNDC5 Gene

Protein Domains for FNDC5 Gene


Suggested Antigen Peptide Sequences for FNDC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FNDC5: view

No data available for UniProtKB/Swiss-Prot for FNDC5 Gene

Function for FNDC5 Gene

Molecular function for FNDC5 Gene

UniProtKB/Swiss-Prot Function:
Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
UniProtKB/Swiss-Prot Induction:
Has been shown to be up-regulated some twofold by muscular exercise at the mRNA and protein level; this effect has been suggested to be mediated by PPARGC1A (PubMed:22237023). However, up-regulation upon exercise could not be reproduced, at least not at the mRNA level (PubMed:24040023).

Phenotypes From GWAS Catalog for FNDC5 Gene

Gene Ontology (GO) - Molecular Function for FNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FNDC5: view
genes like me logo Genes that share phenotypes with FNDC5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC5 Gene

Localization for FNDC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC5 Gene

Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway. {ECO:0000250}.
Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. {ECO:0000269 PubMed:22237023}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC5 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 4
endoplasmic reticulum 4
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for FNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005777 peroxisome IEA --
GO:0005778 peroxisomal membrane IEA --
GO:0005783 endoplasmic reticulum ISS,IBA --
GO:0005886 plasma membrane ISS,IBA --
genes like me logo Genes that share ontologies with FNDC5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FNDC5 Gene

Pathways & Interactions for FNDC5 Gene

SuperPathways for FNDC5 Gene

No Data Available

Interacting Proteins for FNDC5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000362570 Q8NAU1-FNDC5_HUMAN for FNDC5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0014850 response to muscle activity ISS --
GO:0090336 positive regulation of brown fat cell differentiation IBA,ISS --
genes like me logo Genes that share ontologies with FNDC5: view

No data available for Pathways by source and SIGNOR curated interactions for FNDC5 Gene

Drugs & Compounds for FNDC5 Gene

No Compound Related Data Available

Transcripts for FNDC5 Gene

mRNA/cDNA for FNDC5 Gene

Unigene Clusters for FNDC5 Gene

Fibronectin type III domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: -
SP2: - - - -
SP3: - -
SP4: - -

Relevant External Links for FNDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNDC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FNDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FNDC5 Gene

This gene is overexpressed in Muscle - Skeletal (x10.3), Brain - Cerebellum (x5.3), Heart - Left Ventricle (x4.3), and Brain - Cerebellar Hemisphere (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of FNDC5 Gene:


SOURCE GeneReport for Unigene cluster for FNDC5 Gene:


mRNA Expression by UniProt/SwissProt for FNDC5 Gene:

Tissue specificity: Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.

Evidence on tissue expression from TISSUES for FNDC5 Gene

  • Nervous system(4.7)
  • Muscle(3.8)
  • Liver(2.6)
  • Heart(2.4)
  • Lung(2)
genes like me logo Genes that share expression patterns with FNDC5: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC5 Gene

Orthologs for FNDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FNDC5 34
  • 100 (a)
(Canis familiaris)
Mammalia FNDC5 34 33
  • 92.52 (n)
(Rattus norvegicus)
Mammalia Fndc5 33
  • 92.19 (n)
(Mus musculus)
Mammalia Fndc5 16 34 33
  • 90.59 (n)
(Monodelphis domestica)
Mammalia FNDC5 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia FNDC5 34
  • 57 (a)
(Bos Taurus)
Mammalia FNDC5 34
  • 45 (a)
(Gallus gallus)
Aves FNDC5 34 33
  • 82.17 (n)
(Anolis carolinensis)
Reptilia FNDC5 34
  • 30 (a)
(Danio rerio)
Actinopterygii fndc5a 34 33
  • 71.82 (n)
fndc5b 34
  • 52 (a)
Species where no ortholog for FNDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC5 Gene

Gene Tree for FNDC5 (if available)
Gene Tree for FNDC5 (if available)
Evolutionary constrained regions (ECRs) for FNDC5: view image

Paralogs for FNDC5 Gene

Paralogs for FNDC5 Gene

(1) SIMAP similar genes for FNDC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FNDC5: view

Variants for FNDC5 Gene

Sequence variations from dbSNP and Humsavar for FNDC5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000007957 -- 32,866,994(-) G/A intron_variant
rs1000504178 -- 32,872,825(-) C/A/T upstream_transcript_variant
rs1001406244 -- 32,872,422(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001460771 -- 32,866,574(-) T/C intron_variant
rs1001782688 -- 32,861,788(-) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC5 Gene

Variant ID Type Subtype PubMed ID
nsv516302 CNV loss 19592680
nsv950584 CNV deletion 24416366

Variation tolerance for FNDC5 Gene

Gene Damage Index Score: 1.11; 22.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FNDC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC5 Gene

Disorders for FNDC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FNDC5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gastric adenosquamous carcinoma
  • adenosquamous carcinoma of stomach
- elite association - COSMIC cancer census association via MalaCards
Search FNDC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FNDC5

genes like me logo Genes that share disorders with FNDC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNDC5 Gene

Publications for FNDC5 Gene

  1. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. (PMID: 22237023) Boström P … Spiegelman BM (Nature 2012) 2 3 4 58
  2. Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. (PMID: 24120943) Wrann CD … Spiegelman BM (Cell metabolism 2013) 2 3 58
  3. Evidence against a beneficial effect of irisin in humans. (PMID: 24040023) Raschke S … Eckel J (PloS one 2013) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes. (PMID: 12384288) Teufel A … Westphal H (Gene 2002) 2 3 58

Products for FNDC5 Gene

Sources for FNDC5 Gene

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