Aliases for FNDC5 Gene
External Ids for FNDC5 Gene
Previous GeneCards Identifiers for FNDC5 Gene
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
GeneCards Summary for FNDC5 Gene
FNDC5 (Fibronectin Type III Domain Containing 5) is a Protein Coding gene. Diseases associated with FNDC5 include Gastric Adenosquamous Carcinoma and Acanthosis Nigricans. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is FNDC4.
UniProtKB/Swiss-Prot Summary for FNDC5 Gene
[Irisin]: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.