Aliases for FNDC4 Gene

Aliases for FNDC4 Gene

  • Fibronectin Type III Domain Containing 4 2 3 5
  • Fibronectin Type III Domain-Containing Protein 4 3 4
  • Fibronectin Type III Repeat-Containing Protein 1 3 4
  • FRCP1 3 4

External Ids for FNDC4 Gene

Previous GeneCards Identifiers for FNDC4 Gene

  • GC02M027689
  • GC02M027626
  • GC02M027568
  • GC02M027714
  • GC02M027456

Summaries for FNDC4 Gene

GeneCards Summary for FNDC4 Gene

FNDC4 (Fibronectin Type III Domain Containing 4) is a Protein Coding gene. Diseases associated with FNDC4 include Fuchs' Endothelial Dystrophy. An important paralog of this gene is FNDC5.

UniProtKB/Swiss-Prot Summary for FNDC4 Gene

  • Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.

Additional gene information for FNDC4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FNDC4 Gene

Genomics for FNDC4 Gene

GeneHancer (GH) Regulatory Elements for FNDC4 Gene

Promoters and enhancers for FNDC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J027493 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.4 448 3.1 ZBTB40 LCORL FOXA1 MLX RBPJ NR2F1 NR2F6 CREB1 HLF ZFX GCKR FNDC4 lnc-IFT172-1 SNX17 ENSG00000270210 IFT172
GH02J027496 Promoter/Enhancer 1.2 EPDnew ENCODE 750.6 -1.6 -1641 1 LCORL FOXA1 MLX RBPJ NR2F1 NR2F6 CREB1 ZNF652 ELF3 POLR2A GCKR FNDC4 lnc-IFT172-1 piR-57460-367
GH02J027427 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.6 +65.5 65496 4.8 GTF3C2 SIN3A ZBTB40 SP1 CTCF MLX RBPJ POLR2A TCF7L2 NR2F6 NRBP1 lnc-PPM1G-3 SNX17 GPN1 IFT172 SUPT7L ZNF512 CAD ENSG00000272056 ENSG00000234072
GH02J027770 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.3 -277.3 -277305 3.6 SIN3A SP1 ZBTB40 LCORL MLX RBPJ POLR2A NR2F6 ATF1 CREB1 HSALNG0013840 MRPL33 BABAM2 GTF3C2 GPN1 NRBP1 GTF3C2-AS1 AGBL5 CAD SNX17
GH02J027714 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.5 -220.9 -220877 3.3 POLR2A ZNF121 MNT SP7 EGR1 GLIS2 ZIC2 ZBTB8A SMARCC1 ZNF512 LINC01460 LOC105374378 SNX17 FNDC4 KRTCAP3 OST4 TRIM54 lnc-MRPL33-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FNDC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FNDC4 gene promoter:
  • CREB
  • deltaCREB
  • LCR-F1

Genomic Locations for FNDC4 Gene

Genomic Locations for FNDC4 Gene
3,414 bases
Minus strand
3,377 bases
Minus strand

Genomic View for FNDC4 Gene

Genes around FNDC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC4 Gene

Proteins for FNDC4 Gene

  • Protein details for FNDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibronectin type III domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • D6W560

    Protein attributes for FNDC4 Gene

    234 amino acids
    Molecular mass:
    25159 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC4 Gene

Post-translational modifications for FNDC4 Gene

  • Glycosylation at Asn52, Asn97, and Asn147
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FNDC4_HUMAN (2008)

Other Protein References for FNDC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC4 Gene

Domains & Families for FNDC4 Gene

Gene Families for FNDC4 Gene

Protein Domains for FNDC4 Gene


Suggested Antigen Peptide Sequences for FNDC4 Gene

GenScript: Design optimal peptide antigens:
  • Fibronectin type III repeat-containing protein 1 (FNDC4_HUMAN)
genes like me logo Genes that share domains with FNDC4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FNDC4 Gene

Function for FNDC4 Gene

Molecular function for FNDC4 Gene

UniProtKB/Swiss-Prot Function:
Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.
UniProtKB/Swiss-Prot Induction:
Induced by TGFB1.

Phenotypes From GWAS Catalog for FNDC4 Gene

genes like me logo Genes that share phenotypes with FNDC4: view

Animal Models for FNDC4 Gene

MGI Knock Outs for FNDC4:
  • Fndc4 Fndc4<tm1.1Mabo>
  • Fndc4 Fndc4<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for FNDC4 Gene

miRTarBase miRNAs that target FNDC4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNDC4 Gene

Localization for FNDC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC4 Gene

Membrane; Single-pass type I membrane protein. Secreted. Note=The N-terminus is probably cleaved to release a secreted extracellular portion of the protein. {ECO:0000250 UniProtKB:Q3TR08}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC4 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 4
cytosol 1
mitochondrion 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Aggresome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FNDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA 21873635
GO:0005615 extracellular space ISS,IEA --
GO:0005783 endoplasmic reticulum ISS,IEA --
GO:0005886 plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FNDC4: view

Pathways & Interactions for FNDC4 Gene

PathCards logo

SuperPathways for FNDC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050728 negative regulation of inflammatory response ISS,IEA --
GO:0071559 response to transforming growth factor beta IEP 27066907
genes like me logo Genes that share ontologies with FNDC4: view

No data available for Pathways by source and SIGNOR curated interactions for FNDC4 Gene

Drugs & Compounds for FNDC4 Gene

No Compound Related Data Available

Transcripts for FNDC4 Gene

mRNA/cDNA for FNDC4 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(136) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: -
SP4: - -

Relevant External Links for FNDC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNDC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FNDC4 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC4 Gene

This gene is overexpressed in Liver (x6.9) and Adrenal Gland (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of FNDC4 Gene:


SOURCE GeneReport for Unigene cluster for FNDC4 Gene:


mRNA Expression by UniProt/SwissProt for FNDC4 Gene:

Tissue specificity: Up-regulated in colon cells of patients with inflammatory bowel disease (IBD).

Evidence on tissue expression from TISSUES for FNDC4 Gene

  • Nervous system(4.6)
  • Liver(3.5)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with FNDC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC4 Gene

Orthologs for FNDC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FNDC4 33 32
  • 99.72 (n)
(Canis familiaris)
Mammalia FNDC4 33 32
  • 92.44 (n)
(Bos Taurus)
Mammalia FNDC4 33 32
  • 92 (n)
(Mus musculus)
Mammalia Fndc4 17 33 32
  • 89.28 (n)
(Monodelphis domestica)
Mammalia FNDC4 33
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia FNDC4 33
  • 51 (a)
(Gallus gallus)
Aves FNDC4 33 32
  • 69.77 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fndc4 32
  • 67.49 (n)
(Danio rerio)
Actinopterygii fndc4a 33 32
  • 66.67 (n)
FNDC4 (1 of 2) 33
  • 54 (a)
Species where no ortholog for FNDC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC4 Gene

Gene Tree for FNDC4 (if available)
Gene Tree for FNDC4 (if available)
Evolutionary constrained regions (ECRs) for FNDC4: view image

Paralogs for FNDC4 Gene

Paralogs for FNDC4 Gene

(1) SIMAP similar genes for FNDC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FNDC4: view

Variants for FNDC4 Gene

Sequence variations from dbSNP and Humsavar for FNDC4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs375836361 likely-pathogenic, not provided 27,497,334(-) C/G/T upstream_transcript_variant
rs1000571428 -- 27,492,517(-) G/C intron_variant
rs1001692053 -- 27,495,844(-) G/T upstream_transcript_variant
rs1001797559 -- 27,497,146(-) G/A upstream_transcript_variant
rs1002143901 -- 27,497,443(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC4 Gene

Variant ID Type Subtype PubMed ID
nsv817684 CNV gain 17921354

Variation tolerance for FNDC4 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FNDC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC4 Gene

Disorders for FNDC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FNDC4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards
Search FNDC4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FNDC4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FNDC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNDC4 Gene

Publications for FNDC4 Gene

  1. FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice. (PMID: 27066907) Bosma M … Boström PA (Nature communications 2016) 3 4 56
  2. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L … Lunetta KL (Nature genetics 2012) 3 43 56
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for FNDC4 Gene

Sources for FNDC4 Gene