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Aliases for FNDC3B Gene

Aliases for FNDC3B Gene

  • Fibronectin Type III Domain Containing 3B 2 3 5
  • Factor For Adipocyte Differentiation 104 3 4
  • HCV NS5A-Binding Protein 37 3 4
  • FAD104 3 4
  • Fibronectin Type III Domain-Containing Protein 3B 3
  • YVTM2421 3
  • NS5ABP37 4
  • PRO4979 3

External Ids for FNDC3B Gene

Previous GeneCards Identifiers for FNDC3B Gene

  • GC03P173241
  • GC03P171757
  • GC03P169127

Summaries for FNDC3B Gene

GeneCards Summary for FNDC3B Gene

FNDC3B (Fibronectin Type III Domain Containing 3B) is a Protein Coding gene. Diseases associated with FNDC3B include Urethra Adenocarcinoma and Urethra Clear Cell Adenocarcinoma. An important paralog of this gene is FNDC3A.

UniProtKB/Swiss-Prot for FNDC3B Gene

  • May be a positive regulator of adipogenesis.

Additional gene information for FNDC3B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC3B Gene

Genomics for FNDC3B Gene

GeneHancer (GH) Regulatory Elements for FNDC3B Gene

Promoters and enhancers for FNDC3B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J172038 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.5 1478 5.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FNDC3B TMEM212-IT1 TMEM212-AS1 BZW1P1 RPS27AP8
GH03J172094 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 661.6 +60.2 60172 11.2 PKNOX1 FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 IRF4 YY1 ZNF766 FNDC3B RPS27AP8
GH03J172124 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 30.7 +101.6 101641 33.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 FNDC3B PLD1 RPS27AP8
GH03J171804 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.3 -230.9 -230941 9.3 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 SP3 MEF2D SSRP1 ZNF610 PLD1 RPL22L1 FNDC3B TMEM212 ECT2 TNIK ENSG00000234594
GH03J171828 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 23.7 -210.1 -210110 2.6 PKNOX1 SMAD1 MLX ARID4B YBX1 ZNF2 ZNF48 TCF12 ZNF766 ZNF143 FNDC3B PLD1 TMEM212
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FNDC3B on UCSC Golden Path with GeneCards custom track

Genomic Locations for FNDC3B Gene

Genomic Locations for FNDC3B Gene
chr3:172,039,628-172,401,665
(GRCh38/hg38)
Size:
362,038 bases
Orientation:
Plus strand
chr3:171,757,418-172,119,455
(GRCh37/hg19)
Size:
362,038 bases
Orientation:
Plus strand

Genomic View for FNDC3B Gene

Genes around FNDC3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC3B Gene

Proteins for FNDC3B Gene

  • Protein details for FNDC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53EP0-FND3B_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 3B
    Protein Accession:
    Q53EP0
    Secondary Accessions:
    • B2RB36
    • B3KXR8
    • D3DNQ7
    • Q5U5T8
    • Q6PIJ3
    • Q6UXG1
    • Q6UXZ5
    • Q8IXB2
    • Q8NBU7
    • Q96D78
    • Q9H5I7
    • Q9NSQ8

    Protein attributes for FNDC3B Gene

    Size:
    1204 amino acids
    Molecular mass:
    132888 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH12204.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH33635.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88513.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88733.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15639.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11480.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FNDC3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNDC3B Gene

Post-translational modifications for FNDC3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FNDC3B Gene

Domains & Families for FNDC3B Gene

Gene Families for FNDC3B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for FNDC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53EP0

UniProtKB/Swiss-Prot:

FND3B_HUMAN :
  • Belongs to the FNDC3 family.
Family:
  • Belongs to the FNDC3 family.
genes like me logo Genes that share domains with FNDC3B: view

Function for FNDC3B Gene

Molecular function for FNDC3B Gene

UniProtKB/Swiss-Prot Function:
May be a positive regulator of adipogenesis.

Phenotypes From GWAS Catalog for FNDC3B Gene

Gene Ontology (GO) - Molecular Function for FNDC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FNDC3B: view
genes like me logo Genes that share phenotypes with FNDC3B: view

Animal Models for FNDC3B Gene

MGI Knock Outs for FNDC3B:

Animal Model Products

  • Taconic Biosciences Mouse Models for FNDC3B

miRNA for FNDC3B Gene

miRTarBase miRNAs that target FNDC3B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNDC3B Gene

Localization for FNDC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC3B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC3B gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FNDC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC3B: view

Pathways & Interactions for FNDC3B Gene

SuperPathways for FNDC3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNDC3B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC3B Gene

Drugs & Compounds for FNDC3B Gene

No Compound Related Data Available

Transcripts for FNDC3B Gene

Unigene Clusters for FNDC3B Gene

Fibronectin type III domain containing 3B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC3B Gene

No ASD Table

Relevant External Links for FNDC3B Gene

GeneLoc Exon Structure for
FNDC3B
ECgene alternative splicing isoforms for
FNDC3B

Expression for FNDC3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FNDC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FNDC3B Gene

This gene is overexpressed in Placenta (23.9) and Islet of Langerhans (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FNDC3B Gene



Protein tissue co-expression partners for FNDC3B Gene

NURSA nuclear receptor signaling pathways regulating expression of FNDC3B Gene:

FNDC3B

SOURCE GeneReport for Unigene cluster for FNDC3B Gene:

Hs.744888

mRNA Expression by UniProt/SwissProt for FNDC3B Gene:

Q53EP0-FND3B_HUMAN
Tissue specificity: Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expression increased in the early stage of adipogenesis.

Evidence on tissue expression from TISSUES for FNDC3B Gene

  • Kidney(4.3)
  • Lung(4.3)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with FNDC3B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC3B Gene

Orthologs for FNDC3B Gene

This gene was present in the common ancestor of animals.

Orthologs for FNDC3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNDC3B 34 33
  • 99.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FNDC3B 34 33
  • 92.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FNDC3B 34 33
  • 91.69 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fndc3b 16 34 33
  • 86.71 (n)
rat
(Rattus norvegicus)
Mammalia Fndc3b 33
  • 86.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FNDC3B 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FNDC3B 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNDC3B 34 33
  • 79.55 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FNDC3B 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fndc3b 33
  • 72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18133 33
zebrafish
(Danio rerio)
Actinopterygii fndc3ba 34 33
  • 68.59 (n)
OneToMany
fndc3bb 34
  • 58 (a)
OneToMany
wufa13e05 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4438 33
fruit fly
(Drosophila melanogaster)
Insecta CG42389 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-805 34
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
Species where no ortholog for FNDC3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNDC3B Gene

ENSEMBL:
Gene Tree for FNDC3B (if available)
TreeFam:
Gene Tree for FNDC3B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FNDC3B: view image

Paralogs for FNDC3B Gene

Paralogs for FNDC3B Gene

(3) SIMAP similar genes for FNDC3B Gene using alignment to 3 proteins:

  • FND3B_HUMAN
  • A8MYM6_HUMAN
  • C9JKH7_HUMAN
genes like me logo Genes that share paralogs with FNDC3B: view

Variants for FNDC3B Gene

Sequence variations from dbSNP and Humsavar for FNDC3B Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_035921 A breast cancer sample p.Pro927Ser
rs1000003302 -- 172,157,201(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000003703 -- 172,377,309(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000003966 -- 172,115,553(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000017992 -- 172,290,427(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC3B Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER inversion 18451855
nsv592517 CNV loss 21841781
nsv592516 CNV loss 21841781
nsv592515 CNV loss 21841781
nsv592514 CNV loss 21841781
nsv592513 CNV loss 21841781
nsv592512 CNV loss 21841781
nsv522798 CNV loss 19592680
nsv514998 CNV gain 21397061
nsv4116 CNV insertion 18451855
nsv1145006 CNV deletion 24896259
nsv1125785 CNV tandem duplication 24896259
nsv1118983 CNV deletion 24896259
esv3598664 CNV loss 21293372
esv3598663 CNV loss 21293372
esv3598658 CNV gain 21293372
esv3569117 CNV loss 25503493
esv3569116 CNV loss 25503493
esv3444992 CNV duplication 20981092
esv3410350 CNV insertion 20981092
esv3303105 CNV mobile element insertion 20981092
esv2726212 CNV deletion 23290073
esv2464172 CNV deletion 19546169
esv24577 CNV gain 19812545
esv23444 CNV gain 19812545
esv1000089 CNV insertion 20482838
dgv8729n54 CNV loss 21841781

Variation tolerance for FNDC3B Gene

Residual Variation Intolerance Score: 7.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FNDC3B Gene

Human Gene Mutation Database (HGMD)
FNDC3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC3B Gene

Disorders for FNDC3B Gene

MalaCards: The human disease database

(5) MalaCards diseases for FNDC3B Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
urethra adenocarcinoma
  • adenocarcinoma of the urethra
urethra clear cell adenocarcinoma
  • clear cell adenocarcinoma of the urethra
urethral benign neoplasm
  • neoplasm of urethra
keratoconus
  • conical cornea
glaucoma, primary open angle
  • poag
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FNDC3B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FNDC3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNDC3B Gene

Publications for FNDC3B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis. (PMID: 15527760) Tominaga K … Imagawa M (FEBS letters 2004) 2 3 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for FNDC3B Gene

Sources for FNDC3B Gene

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