Aliases for FNDC1 Gene

Aliases for FNDC1 Gene

  • Fibronectin Type III Domain Containing 1 2 3 5
  • Fibronectin Type III Domain-Containing Protein 1 3 4
  • Fibronectin Type III Domain Containing 2 2 3
  • Expressed In Synovial Lining Protein 3 4
  • Activation-Associated CDNA Protein 3 4
  • MEL4B3 3 4
  • FNDC2 3 4
  • BA243O10.1 3
  • DJ322A24.1 3
  • EC 6.1.1.1 52
  • EC 2.7.2.3 52
  • KIAA1866 4
  • AGS8 3

External Ids for FNDC1 Gene

Previous HGNC Symbols for FNDC1 Gene

  • FNDC2

Previous GeneCards Identifiers for FNDC1 Gene

  • GC06P159484
  • GC06P159560
  • GC06P159609
  • GC06P159510
  • GC06P159590
  • GC06P157060
  • GC06P159193
  • GC06P159236
  • GC06P159245

Summaries for FNDC1 Gene

GeneCards Summary for FNDC1 Gene

FNDC1 (Fibronectin Type III Domain Containing 1) is a Protein Coding gene. Diseases associated with FNDC1 include Prostate Leiomyosarcoma and Prostate Sarcoma. An important paralog of this gene is ABI3BP.

UniProtKB/Swiss-Prot Summary for FNDC1 Gene

Additional gene information for FNDC1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FNDC1 Gene

Genomics for FNDC1 Gene

GeneHancer (GH) Regulatory Elements for FNDC1 Gene

Promoters and enhancers for FNDC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J159169 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 505.7 +1.2 1236 3.3 CTCF ZIC2 ZBTB26 EZH2 ZEB1 ZNF341 ZBTB17 ZNF263 ZFHX2 ZNF777 FNDC1 LOC101929122 FNDC1-IT1
GH06J159202 Enhancer 0.6 Ensembl ENCODE 36 +34.5 34504 2.6 BHLHE40 FOS ELF1 CEBPB FNDC1 LOC101929122 FNDC1-IT1
GH06J159211 Enhancer 0.4 Ensembl 27.5 +43.9 43904 1 ZIC2 PBX2 NR2F2 MEIS2 PKNOX1 FNDC1 FNDC1-IT1 LOC101929122
GH06J159125 Enhancer 1.4 VISTA Ensembl ENCODE dbSUPER 5.7 -42.6 -42619 4 CTCF SIN3A EP300 TRIM22 BCL11A TCF12 ZNF384 CEBPG SRF POLR2A FNDC1 lnc-FNDC1-2 LOC112267968
GH06J159217 Enhancer 0.8 Ensembl ENCODE 9.7 +48.4 48404 0.8 CTCF MYC SMC3 RAD21 TEAD3 ZNF614 MLX MNT MAX RBM39 FNDC1 FNDC1-IT1 LOC101929122
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FNDC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FNDC1

Top Transcription factor binding sites by QIAGEN in the FNDC1 gene promoter:
  • AREB6
  • E4BP4
  • GATA-6
  • Ik-1
  • IRF-2
  • ISGF-3
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for FNDC1 Gene

Genomic Locations for FNDC1 Gene
chr6:159,169,397-159,272,108
(GRCh38/hg38)
Size:
102,712 bases
Orientation:
Plus strand
chr6:159,590,429-159,693,141
(GRCh37/hg19)
Size:
102,713 bases
Orientation:
Plus strand

Genomic View for FNDC1 Gene

Genes around FNDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC1 Gene

Proteins for FNDC1 Gene

  • Protein details for FNDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4ZHG4-FNDC1_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 1
    Protein Accession:
    Q4ZHG4
    Secondary Accessions:
    • A6H8X2
    • B7ZBR4
    • B7ZBR5
    • B9EK49
    • Q5JPI0
    • Q5VU31
    • Q5VU32
    • Q5VXX4
    • Q70CQ6
    • Q96JG1

    Protein attributes for FNDC1 Gene

    Size:
    1894 amino acids
    Molecular mass:
    205558 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI46784.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI50608.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAY26234.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAE51894.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for FNDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNDC1 Gene

Selected DME Specific Peptides for FNDC1 Gene

Q4ZHG4:
  • PLRIKLG
  • EGKVLPG

Post-translational modifications for FNDC1 Gene

  • Glycosylation at Asn149, Ser713, Ser717, Thr732, Ser737, Ser738, Ser741, Ser759, Ser761, Thr762, Ser846, Ser847, Ser851, Thr852, Ser855, and Asn1661
  • Modification sites at PhosphoSitePlus

Other Protein References for FNDC1 Gene

Domains & Families for FNDC1 Gene

Gene Families for FNDC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FNDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNDC1 Gene

GenScript: Design optimal peptide antigens:
  • Expressed in synovial lining protein (FNDC1_HUMAN)
genes like me logo Genes that share domains with FNDC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FNDC1 Gene

Function for FNDC1 Gene

Molecular function for FNDC1 Gene

UniProtKB/Swiss-Prot Function:
May be an activator of G protein signaling.
UniProtKB/Swiss-Prot Induction:
By TGFB1 present in the melanoma cell conditioned medium (MCCM).

Enzyme Numbers (IUBMB) for FNDC1 Gene

Phenotypes From GWAS Catalog for FNDC1 Gene

genes like me logo Genes that share phenotypes with FNDC1: view

Animal Model Products

miRNA for FNDC1 Gene

miRTarBase miRNAs that target FNDC1

Clone Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC1 Gene

Localization for FNDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC1 gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with FNDC1: view

Pathways & Interactions for FNDC1 Gene

PathCards logo

SuperPathways for FNDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC1 Gene

Drugs & Compounds for FNDC1 Gene

No Compound Related Data Available

Transcripts for FNDC1 Gene

mRNA/cDNA for FNDC1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC1 Gene

No ASD Table

Relevant External Links for FNDC1 Gene

GeneLoc Exon Structure for
FNDC1

Expression for FNDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FNDC1 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC1 Gene

This gene is overexpressed in Thyroid (x9.6) and Colon - Sigmoid (x5.5).

Protein differential expression in normal tissues from HIPED for FNDC1 Gene

This gene is overexpressed in Amniocyte (14.8), Bone marrow mesenchymal stem cell (14.3), Breast (8.8), Fetal gut (7.7), Esophagus (7.3), and Fetal ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FNDC1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FNDC1

SOURCE GeneReport for Unigene cluster for FNDC1 Gene:

Hs.520525

mRNA Expression by UniProt/SwissProt for FNDC1 Gene:

Q4ZHG4-FNDC1_HUMAN
Tissue specificity: Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors, in the tumor cells themselves and in the epidermis of psoriasis.

Evidence on tissue expression from TISSUES for FNDC1 Gene

  • Nervous system(4.3)
  • Lymph node(4)
genes like me logo Genes that share expression patterns with FNDC1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC1 Gene

Orthologs for FNDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNDC1 31 30
  • 99.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FNDC1 31 30
  • 80.57 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fndc1 30
  • 76.51 (n)
cow
(Bos Taurus)
Mammalia FNDC1 31
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fndc1 31
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FNDC1 31
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNDC1 31
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNDC1 31
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 92 (a)
OneToMany
-- 31
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fndc1 31
  • 35 (a)
OneToOne
Species where no ortholog for FNDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC1 Gene

ENSEMBL:
Gene Tree for FNDC1 (if available)
TreeFam:
Gene Tree for FNDC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FNDC1: view image

Paralogs for FNDC1 Gene

Paralogs for FNDC1 Gene

genes like me logo Genes that share paralogs with FNDC1: view

Variants for FNDC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FNDC1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
708439 Benign: not provided 159,229,942(+) G/A SYNONYMOUS_VARIANT
709828 Likely Benign: not provided 159,233,507(+) G/A MISSENSE_VARIANT
712640 Benign: not provided 159,215,135(+) C/T SYNONYMOUS_VARIANT
715001 Likely Benign: not provided 159,233,665(+) C/A SYNONYMOUS_VARIANT
715606 Benign: not provided 159,249,043(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for FNDC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FNDC1 Gene

Variant ID Type Subtype PubMed ID
dgv3424n106 CNV deletion 24896259
dgv3425n106 CNV deletion 24896259
esv1197817 CNV deletion 17803354
esv1401887 CNV deletion 17803354
esv22549 CNV loss 19812545
esv2287378 CNV deletion 18987734
esv2307373 CNV deletion 18987734
esv2473194 CNV deletion 19546169
esv2595923 CNV deletion 19546169
esv2665874 CNV deletion 23128226
esv2733023 CNV deletion 23290073
esv2733024 CNV deletion 23290073
esv2733025 CNV deletion 23290073
esv2763604 CNV gain 21179565
esv3282607 CNV deletion 24192839
esv3540757 CNV deletion 23714750
esv3540758 CNV deletion 23714750
esv3611412 CNV loss 21293372
esv3611413 CNV loss 21293372
esv4520 CNV loss 18987735
esv992188 CNV deletion 20482838
esv995554 CNV deletion 20482838
nsv1019191 CNV gain 25217958
nsv1073603 CNV deletion 25765185
nsv1073604 CNV deletion 25765185
nsv1073605 CNV deletion 25765185
nsv1074440 CNV deletion 25765185
nsv1119090 CNV deletion 24896259
nsv1148320 CNV deletion 26484159
nsv1153310 CNV deletion 26484159
nsv349266 CNV deletion 16902084
nsv474187 CNV novel sequence insertion 20440878
nsv830850 CNV gain 17160897
nsv830851 CNV gain 17160897
nsv949877 CNV deletion 24416366
nsv956939 CNV deletion 24416366
nsv956943 CNV deletion 24416366

Variation tolerance for FNDC1 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.94; 97.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FNDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC1 Gene

Disorders for FNDC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FNDC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prostate leiomyosarcoma
  • leiomyosarcoma of the prostate
prostate sarcoma
  • sarcoma of the prostate
- elite association - COSMIC cancer census association via MalaCards
Search FNDC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FNDC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FNDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNDC1 Gene

Publications for FNDC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 54
  2. A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. (PMID: 21606135) Wild PS … Blankenberg S (Circulation. Cardiovascular genetics 2011) 3 41 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF-beta and pro-inflammatory cytokines. (PMID: 16098131) Anderegg U … Saalbach A (Experimental dermatology 2005) 3 4 54
  5. Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. (PMID: 9704633) Seki T … Winchester R (Arthritis and rheumatism 1998) 3 4 54

Products for FNDC1 Gene

Sources for FNDC1 Gene