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This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle for... See more...
Aliases for FNBP4 Gene
Aliases for FNBP4 Gene
External Ids for FNBP4 Gene
- HGNC: 19752
- Entrez Gene: 23360
- Ensembl: ENSG00000109920
- OMIM: 615265
- UniProtKB: Q8N3X1
Previous GeneCards Identifiers for FNBP4 Gene
- GC11M048615
- GC11M047769
- GC11M047702
- GC11M047694
- GC11M047443
- GC11M047805
- GC11M048082
- GC11M048805
- GC11M049910
- GC11M047913
- GC11M047961
- GC11M055824
- GC11M056049
- GC11M056195
- GC11M059716
- GC11M050808
- GC11M051603
- GC11M052265
- GC11M052925
- GC11M053593
- GC11M054259
- GC11M054925
- GC11M055627
Summaries for FNBP4 Gene
-
This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017]
GeneCards Summary for FNBP4 Gene
FNBP4 (Formin Binding Protein 4) is a Protein Coding gene. Diseases associated with FNBP4 include Microphthalmia With Limb Anomalies and Cerebral Amyloid Angiopathy, Itm2b-Related, 2. An important paralog of this gene is DIAPH1.
Additional gene information for FNBP4 Gene
- HGNC(19752)
- Entrez Gene(23360)
- Ensembl(ENSG00000109920)
- OMIM(615265)
- UniProtKB(Q8N3X1)
- Open Targets Platform(ENSG00000109920)
- Search for FNBP4 at DataMed
- Search for FNBP4 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FNBP4 Gene
Genomics for FNBP4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FNBP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FNBP4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FNBP4
- Top Transcription factor binding sites by QIAGEN in the FNBP4 gene promoter:
-
- CUTL1
- Evi-1
- FOXF2
- HNF-1
- HNF-1A
- HNF-4alpha1
- HNF-4alpha2
- MZF-1
- POU2F1
- POU2F1a
Genomic Locations for FNBP4 Gene
Genomic Locations for FNBP4 Gene
- chr11:47,716,494-47,767,460
- (GRCh38/hg38)
- Size:
- 50,967 bases
- Orientation:
- Minus strand
- chr11:47,738,069-47,788,995
- (GRCh37/hg19)
- Size:
- 50,927 bases
- Orientation:
- Minus strand
Genomic View for FNBP4 Gene
Genes around FNBP4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by HGNC
- 11p11.2 by Entrez Gene
- 11p11.2 by Ensembl
FNBP4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FNBP4 Gene
Proteins for FNBP4 Gene
-
Protein details for FNBP4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N3X1-FNBP4_HUMAN
- Recommended name:
- Formin-binding protein 4
- Protein Accession:
- Q8N3X1
- Q9H985
- Q9NT81
- Q9Y2L7
Protein attributes for FNBP4 Gene
- Size:
- 1017 amino acids
- Molecular mass:
- 110266 Da
- Quaternary structure:
-
- Binds FMN1. Interacts with the Arg/Gly-rich-flanked Pro-rich of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding.
- SequenceCaution:
-
- Sequence=BAA76858.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for FNBP4 Gene
Post-translational modifications for FNBP4 Gene
Other Protein References for FNBP4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FNBP4 Antibody
- Novus Biologicals Antibodies for FNBP4
-
Abcam antibodies for FNBP4
- Invitrogen Antibodies for FNBP4 (AFLGC-FNBP4)
- antibodies-online: Show 3 available FNBP4 Antibodies ranked by validation data
-
Boster Bio Antibodies for FNBP4
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FNBP4
- Origene Custom Protein Services for FNBP4
No data available for DME Specific Peptides for FNBP4 Gene
Domains & Families for FNBP4 Gene
Gene Families for FNBP4 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for FNBP4 Gene
- GenScript: Design optimal peptide antigens:
-
- Formin binding protein 4, isoform CRA_d (D3DQS4_HUMAN)
- Formin-binding protein 30 (FNBP4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8N3X1UniProtKB/Swiss-Prot:
FNBP4_HUMAN :- These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity).
- Domain:
-
- These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity).
Function for FNBP4 Gene
Phenotypes From GWAS Catalog for FNBP4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17500595 |
Phenotypes for FNBP4 Gene
Animal Model Products
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CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FNBP4 - Select products 50% OFF >
- * FNBP4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
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-
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miRNA for FNBP4 Gene
- miRTarBase miRNAs that target FNBP4
miRNA Products
Inhibitory RNA Products
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Clone Products
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- Sino Biological Human cDNA Clone for FNBP4
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNBP4 Gene
Localization for FNBP4 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 0 |
- Nuclear speckles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016607 | nuclear speck | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FNBP4 Gene
Pathways & Interactions for FNBP4 Gene
Interacting Proteins for FNBP4 Gene
Selected Interacting proteins:
Q8N3X1-FNBP4_HUMAN
ENSP00000263773
for FNBP4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FNBP4
No data available for Pathways by source and SIGNOR curated interactions for FNBP4 Gene
Transcripts for FNBP4 Gene
mRNA/cDNA for FNBP4 Gene
- 2 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263773 4035 nts (view in UCSC)
- ENST00000524696 481 nts (view in UCSC)
- ENST00000525316 412 nts (view in UCSC)
- ENST00000525792 840 nts (view in UCSC)
- ENST00000526109 673 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FNBP4 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for FNBP4
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-
Santa Cruz Biotechnology (SCBT) CRISPR for FNBP4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FNBP4
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FNBP4
Clone Products
- Applied Biological Materials (abm): Clones for FNBP4 - Select products 50% OFF >
- * FNBP4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FNBP4
- Addgene plasmids for FNBP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FNBP4
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: |
| ExUns: | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||
| SP13: | - | - | - | ||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||
| SP15: | - | - | |||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||
| SP18: | - |
Relevant External Links for FNBP4 Gene
- GeneLoc Exon Structure for
- FNBP4
Expression for FNBP4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in CD8 Tcells (12.9), Monocytes (11.9), and Testis (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FNBP4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FNBP4
SOURCE GeneReport for Unigene cluster for FNBP4 Gene:
Hs.6834mRNA Expression by UniProt/SwissProt for FNBP4 Gene:
Q8N3X1-FNBP4_HUMAN
Tissue specificity:
Highly expressed in the eye.
Evidence on tissue expression from TISSUES for FNBP4 Gene
- Nervous system(4.8)
- Skin(2.3)
- Heart(2.2)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for FNBP4
-
OriGene qPCR primer pairs and template standards for FNBP4
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNBP4 Gene
Orthologs for FNBP4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FNBP4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FNBP4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FNBP4 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fnbp4 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Fnbp4 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FNBP4 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FNBP4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FNBP4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FNBP4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC734003 30 |
|
||
| Str.10228 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | fnbp4-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fnbp4 30 31 |
|
OneToOne | |
| Dr.15154 30 |
|
- Species where no ortholog for FNBP4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FNBP4 Gene
- ENSEMBL:
- Gene Tree for FNBP4 (if available)
- TreeFam:
- Gene Tree for FNBP4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FNBP4: view image
Paralogs for FNBP4 Gene
Paralogs for FNBP4 Gene
(1) SIMAP similar genes for FNBP4 Gene using alignment to 3 proteins:
- FNBP4_HUMAN
- D3DQS4_HUMAN
- F5GXL1_HUMAN
Variants for FNBP4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FNBP4 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709285 | Likely Benign: not provided | 47,751,244(-) | C/A | SYNONYMOUS_VARIANT | |
| 710941 | Likely Benign: not provided | 47,753,111(-) | T/C | INTRON_VARIANT | |
| 712079 | Benign: not provided | 47,767,256(-) | A/G | SYNONYMOUS_VARIANT | |
| 729687 | Benign: not provided | 47,767,211(-) | C/A | SYNONYMOUS_VARIANT | |
| 736960 | Likely Benign: not provided | 47,724,774(-) | AGAACCT/A | SPLICE_ACCEPTOR_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1111n100 | CNV | gain | 25217958 |
| esv2676370 | CNV | deletion | 23128226 |
| esv3547713 | CNV | deletion | 23714750 |
| esv3626207 | CNV | loss | 21293372 |
| nsv1110683 | CNV | insertion | 24896259 |
| nsv469858 | CNV | gain | 16826518 |
| nsv832143 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.59;
91.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FNBP4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNBP4 Gene
Disorders for FNBP4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| microphthalmia with limb anomalies |
|
|
| cerebral amyloid angiopathy, itm2b-related, 2 |
|
|
| microphthalmia |
|
|
Search FNBP4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FNBP4
No data available for UniProtKB/Swiss-Prot and Genatlas for FNBP4 Gene
Publications for FNBP4 Gene
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
- Whole-exome sequencing identified a homozygous FNBP4 mutation in a family with a condition similar to microphthalmia with limb anomalies. (PMID: 23703728) Kondo Y … Matsumoto N (American journal of medical genetics. Part A 2013) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. (PMID: 10748127) Bedford MT … Richard S (The Journal of biological chemistry 2000) 3 4
- H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
ExternalLinks
Products for FNBP4 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
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- OriGene qPCR primer pairs for FNBP4
- OriGene qPCR primer pairs and template standards for FNBP4
- OriGene CRISPR knockouts for FNBP4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for FNBP4
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for FNBP4
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- Abcam antibodies for FNBP4
- Find your target
- Browse Primary Antibodies
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- Browse Recombinant Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for FNBP4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FNBP4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FNBP4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FNBP4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FNBP4
- Addgene plasmids for FNBP4
- antibodies-online: Show 3 available FNBP4 Antibodies ranked by validation data
- antibodies-online: Search results for available FNBP4 related products ranked by validation data
- antibodies-online: Search results for available FNBP4 related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FNBP4
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- Boster Bio Antibodies for FNBP4
- Browse Boster Bio ELISA Kits
Sources for FNBP4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
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