Aliases for FNBP1L Gene
External Ids for FNBP1L Gene
Previous HGNC Symbols for FNBP1L Gene
Previous GeneCards Identifiers for FNBP1L Gene
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for FNBP1L Gene
FNBP1L (Formin Binding Protein 1 Like) is a Protein Coding gene. Diseases associated with FNBP1L include Malignant Breast Melanoma. Among its related pathways are Actin Nucleation by ARP-WASP Complex and Shigellosis. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is FNBP1.
UniProtKB/Swiss-Prot Summary for FNBP1L Gene
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.