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A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamin... See more...
Aliases for FN3KRP Gene
Aliases for FN3KRP Gene
External Ids for FN3KRP Gene
- HGNC: 25700
- Entrez Gene: 79672
- Ensembl: ENSG00000141560
- OMIM: 611683
- UniProtKB: Q9HA64
Previous GeneCards Identifiers for FN3KRP Gene
- GC17P081353
- GC17P078267
- GC17P080674
- GC17P076074
Summaries for FN3KRP Gene
-
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
GeneCards Summary for FN3KRP Gene
FN3KRP (Fructosamine 3 Kinase Related Protein) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is FN3K.
UniProtKB/Swiss-Prot Summary for FN3KRP Gene
-
Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.
Additional gene information for FN3KRP Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FN3KRP Gene
Genomics for FN3KRP Gene
GeneHancer (GH) Regulatory Elements for FN3KRP Gene
Promoters and enhancers for FN3KRP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FN3KRP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FN3KRP gene promoter:
-
- CBF(2)
- CBF-A
- CBF-B
- CBF-C
- CP1A
- CP1C
- Olf-1
- PPAR-gamma1
- PPAR-gamma2
- Sp1
Genomic Locations for FN3KRP Gene
Genomic Locations for FN3KRP Gene
- chr17:82,716,706-82,730,328
- (GRCh38/hg38)
- Size:
- 13,623 bases
- Orientation:
- Plus strand
- chr17:80,674,559-80,688,204
- (GRCh37/hg19)
- Size:
- 13,646 bases
- Orientation:
- Plus strand
Genomic View for FN3KRP Gene
Genes around FN3KRP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
FN3KRP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FN3KRP Gene
Proteins for FN3KRP Gene
-
Protein details for FN3KRP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HA64-KT3K_HUMAN
- Recommended name:
- Ketosamine-3-kinase
- Protein Accession:
- Q9HA64
- Q969F4
- Q9H0U7
Protein attributes for FN3KRP Gene
- Size:
- 309 amino acids
- Molecular mass:
- 34412 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAB66566.1; Type=Erroneous termination; Positions=198; Note=Translated as Leu.; Evidence={ECO:0000305};
Protein Expression for FN3KRP Gene
Post-translational modifications for FN3KRP Gene
Other Protein References for FN3KRP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-FN3KRP Antibody (HPA065831) and Anti-FN3KRP Antibody (HPA056172)
-
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-
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Protein Products
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-
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Assay Products
- antibodies-online: Show 4 available FN3KRP Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for FN3KRP Gene
Domains & Families for FN3KRP Gene
Gene Families for FN3KRP Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FN3KRP Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FN3KRP Gene
- GenScript: Design optimal peptide antigens:
-
- Fructosamine-3-kinase-related protein (KT3K_HUMAN)
- FN3KRP protein (Q6FIG5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9HA64- Family:
-
- Belongs to the fructosamine kinase family.
Function for FN3KRP Gene
Molecular function for FN3KRP Gene
- UniProtKB/Swiss-Prot Function:
- Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.
Enzyme Numbers (IUBMB) for FN3KRP Gene
Phenotypes From GWAS Catalog for FN3KRP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016301 | kinase activity | TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for FN3KRP Gene
- GenomeRNAi human phenotypes for FN3KRP:
-
- Decreased viability ratio
- Decreased Salmonella enterica Typhimurium invasion
- Decreased viability
- no effect
- Increased caspase activity
- Increased vaccinia virus (VACV) infection
- Increased cell number in S
- Transferrin accumulation in the perinuclear area
- Decreased vesicular stomatitis virus (VSV) infection
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
-
Taconic Biosciences Mouse Models for FN3KRP
CRISPR Products
-
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- Overview of 123 available FN3KRP gene related products
-
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miRNA for FN3KRP Gene
- miRTarBase miRNAs that target FN3KRP
-
- hsa-mir-342-3p (MIRT043690)
- hsa-mir-19a-3p (MIRT079465)
- hsa-mir-19b-3p (MIRT079466)
- hsa-mir-6883-5p (MIRT460709)
- hsa-mir-6785-5p (MIRT460710)
- hsa-mir-4728-5p (MIRT460711)
- hsa-mir-149-3p (MIRT460712)
- hsa-mir-4722-5p (MIRT460713)
- hsa-mir-1286 (MIRT460714)
- hsa-mir-873-5p (MIRT460715)
- hsa-mir-4734 (MIRT460716)
- hsa-mir-6764-5p (MIRT460717)
- hsa-mir-1915-3p (MIRT460718)
- hsa-mir-7113-5p (MIRT460719)
- hsa-mir-7160-3p (MIRT460720)
- hsa-mir-596 (MIRT460721)
- hsa-mir-191-5p (MIRT460722)
- hsa-mir-1273e (MIRT518818)
- hsa-mir-6807-5p (MIRT518819)
- hsa-mir-580-3p (MIRT518820)
- hsa-mir-25-5p (MIRT518821)
- hsa-mir-658 (MIRT518822)
- hsa-mir-3683 (MIRT518823)
- hsa-mir-1273c (MIRT518824)
- hsa-mir-1233-3p (MIRT518825)
- hsa-mir-1225-3p (MIRT518826)
- hsa-mir-219b-3p (MIRT518827)
- hsa-mir-302f (MIRT518828)
- hsa-mir-4662a-5p (MIRT540735)
- hsa-mir-4252 (MIRT540736)
- hsa-mir-449b-3p (MIRT540737)
- hsa-mir-4318 (MIRT540738)
- hsa-mir-3169 (MIRT765214)
- hsa-mir-5197-3p (MIRT773653)
- hsa-mir-7114-5p (MIRT781483)
- hsa-mir-7847-3p (MIRT782142)
miRNA Products
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Cell Line Products
-
Horizon Cell Lines for FN3KRP
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FN3KRP Gene
Localization for FN3KRP Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 3 |
| mitochondrion | 0 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FN3KRP Gene
Pathways & Interactions for FN3KRP Gene
Pathways by source for FN3KRP Gene
3 Reactome pathways for FN3KRP Gene
Interacting Proteins for FN3KRP Gene
GPS-Prot Interaction Network for FN3KRP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FN3KRP Gene
Drugs & Compounds for FN3KRP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
Transcripts for FN3KRP Gene
mRNA/cDNA for FN3KRP Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (236) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000269373 1822 bps (ENST00000269373.10)
- ENST00000574832 1422 bps (ENST00000574832.5)
- ENST00000574356 887 bps (ENST00000574356.5)
- ENST00000574206 683 bps (ENST00000574206.5)
- ENST00000577128 515 bps (ENST00000577128.1)
CRISPR Products
-
OriGene CRISPR knockouts for FN3KRP
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miRNA Products
Inhibitory RNA Products
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Recommended
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| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | - | - | - |
Expression for FN3KRP Gene
This gene is overexpressed in Uterus (8.6) and Lymph node (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FN3KRP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FN3KRP Gene:
FN3KRPSOURCE GeneReport for Unigene cluster for FN3KRP Gene:
Hs.31431mRNA Expression by UniProt/SwissProt for FN3KRP Gene:
Q9HA64-KT3K_HUMAN
Tissue specificity:
Expressed in erythrocytes.
Evidence on tissue expression from TISSUES for FN3KRP Gene
- Nervous system(4.8)
- Kidney(4.3)
- Eye(4.2)
Primer Products
-
OriGene qPCR primer pairs for FN3KRP
-
OriGene qPCR primer pairs and template standards for FN3KRP
- genomics-online: primer clones - Search for available FN3KRP Primer products
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Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FN3KRP Gene
Orthologs for FN3KRP Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FN3KRP 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FN3KRP 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FN3KRP 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fn3krp 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fn3krp 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FN3KRP 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FN3KRP 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FN3KRP 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FN3KRP 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fn3krp 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fn3krp 33 32 |
|
OneToMany | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11207 32 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_Y116A8C.25 32 |
|
||
| Y116A8C.25 33 |
|
OneToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G61080 32 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0117800 32 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for FN3KRP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for FN3KRP Gene
- ENSEMBL:
- Gene Tree for FN3KRP (if available)
- TreeFam:
- Gene Tree for FN3KRP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FN3KRP: view image
Paralogs for FN3KRP Gene
Variants for FN3KRP Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000646661 | -- | 82,724,850(+) | C/T | intron_variant | |
| rs1000857036 | -- | 82,716,366(+) | A/G | upstream_transcript_variant | |
| rs1000939777 | -- | 82,716,019(+) | G/A | upstream_transcript_variant | |
| rs1000964359 | -- | 82,725,498(+) | A/G | intron_variant | |
| rs1001006191 | -- | 82,720,539(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv21913 | CNV | gain+loss | 19812545 |
| esv2716524 | CNV | deletion | 23290073 |
| esv2762577 | CNV | gain+loss | 21179565 |
| nsv1061637 | CNV | loss | 25217958 |
| nsv1067553 | CNV | loss | 25217958 |
| nsv428351 | CNV | gain | 18775914 |
| nsv833575 | CNV | loss | 17160897 |
| nsv952395 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.68;
57.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FN3KRP Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FN3KRP Gene
Disorders for FN3KRP Gene
Additional Disease Information for FN3KRP
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for FN3KRP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FN3KRP Gene
Publications for FN3KRP Gene
- A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines. (PMID: 14633848) Collard F … Van Schaftingen E (Diabetes 2003) 2 3 4 23 56
- Fructosamine 3-kinase-related protein and deglycation in human erythrocytes. (PMID: 15137908) Collard F … Van Schaftingen E (The Biochemical journal 2004) 3 4 23 56
- Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. (PMID: 20858683) Soranzo N … Meigs JB (Diabetes 2010) 3 43 56
- Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine. (PMID: 18637789) Payne LS … Loomes KM (The Biochemical journal 2008) 3 23 56
- Fructosamine-3-kinase-related-protein phosphorylates glucitolamines on the C-4 hydroxyl: novel substrate specificity of an enigmatic enzyme. (PMID: 17686456) Szwergold B … Loomes K (Biochemical and biophysical research communications 2007) 3 23 56
ExternalLinks
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- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FN3KRP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FN3KRP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FN3KRP
Sources for FN3KRP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource