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Aliases for FN3KRP Gene

Aliases for FN3KRP Gene

  • Fructosamine 3 Kinase Related Protein 2 3 5
  • FN3K-Related Protein 3 4
  • Testis Secretory Sperm-Binding Protein Li 211a 3
  • Fructosamine-3-Kinase-Related Protein 4
  • Ketosamine-3-Kinase 3
  • EC 2.7.1.- 4
  • FN3K-RP 4
  • FN3KL 3

External Ids for FN3KRP Gene

Previous GeneCards Identifiers for FN3KRP Gene

  • GC17P081353
  • GC17P078267
  • GC17P080674
  • GC17P076074

Summaries for FN3KRP Gene

Entrez Gene Summary for FN3KRP Gene

  • A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for FN3KRP Gene

FN3KRP (Fructosamine 3 Kinase Related Protein) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is FN3K.

UniProtKB/Swiss-Prot for FN3KRP Gene

  • Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.

Gene Wiki entry for FN3KRP Gene

Additional gene information for FN3KRP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FN3KRP Gene

Genomics for FN3KRP Gene

GeneHancer (GH) Regulatory Elements for FN3KRP Gene

Promoters and enhancers for FN3KRP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J082715 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 727.7 +0.4 365 2.7 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 FN3KRP LOC101929552 TBCD GPS1 FOXK2 ENSG00000263321 CCDC57 ENSG00000265678 OGFOD3 ENSG00000264548
GH17J082734 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 33.6 +22.0 22023 8.1 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FN3K FN3KRP DUS1L ENSG00000260563 OGFOD3 HEXDC ENSG00000262652 ARL2BPP9 ENSG00000262663 NARF-IT1
GH17J082880 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28.7 +171.2 171179 13.9 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 GC17M082887 FN3KRP ENSG00000260563 FN3K NARF-IT1 RAB40B ZNF750 WDR45B ENSG00000262652 ARL2BPP9
GH17J082862 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 25.1 +148.6 148550 5.2 HDGF PKNOX1 SMAD1 IRF4 GLIS2 ZNF143 FOS ATF7 RUNX3 JUNB FN3KRP TBCD RAB40B OGFOD3 ALYREF LOC101929552 CYBC1 NARF HEXDC GC17P082883
GH17J082751 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16 +35.5 35528 2.4 HDGF CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 E2F8 TBCD FN3KRP LOC101929552 FN3K ENSG00000263098
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FN3KRP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FN3KRP gene promoter:
  • Sp1
  • PPAR-gamma2
  • PPAR-gamma1
  • Olf-1
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C

Genomic Locations for FN3KRP Gene

Genomic Locations for FN3KRP Gene
chr17:82,716,683-82,730,328
(GRCh38/hg38)
Size:
13,646 bases
Orientation:
Plus strand
chr17:80,674,559-80,688,204
(GRCh37/hg19)
Size:
13,646 bases
Orientation:
Plus strand

Genomic View for FN3KRP Gene

Genes around FN3KRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FN3KRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FN3KRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FN3KRP Gene

Proteins for FN3KRP Gene

  • Protein details for FN3KRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA64-KT3K_HUMAN
    Recommended name:
    Ketosamine-3-kinase
    Protein Accession:
    Q9HA64
    Secondary Accessions:
    • Q969F4
    • Q9H0U7

    Protein attributes for FN3KRP Gene

    Size:
    309 amino acids
    Molecular mass:
    34412 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66566.1; Type=Erroneous termination; Positions=198; Note=Translated as Leu.; Evidence={ECO:0000305};

neXtProt entry for FN3KRP Gene

Post-translational modifications for FN3KRP Gene

  • Ubiquitination at isoforms=45
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FN3KRP Gene

Domains & Families for FN3KRP Gene

Gene Families for FN3KRP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FN3KRP Gene

Graphical View of Domain Structure for InterPro Entry

Q9HA64

UniProtKB/Swiss-Prot:

KT3K_HUMAN :
  • Belongs to the fructosamine kinase family.
Family:
  • Belongs to the fructosamine kinase family.
genes like me logo Genes that share domains with FN3KRP: view

Function for FN3KRP Gene

Molecular function for FN3KRP Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.

Enzyme Numbers (IUBMB) for FN3KRP Gene

Phenotypes From GWAS Catalog for FN3KRP Gene

Gene Ontology (GO) - Molecular Function for FN3KRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016301 kinase activity TAS,IBA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with FN3KRP: view
genes like me logo Genes that share phenotypes with FN3KRP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FN3KRP

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FN3KRP Gene

Localization for FN3KRP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FN3KRP gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FN3KRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FN3KRP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FN3KRP Gene

Pathways & Interactions for FN3KRP Gene

genes like me logo Genes that share pathways with FN3KRP: view

Gene Ontology (GO) - Biological Process for FN3KRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FN3KRP: view

No data available for SIGNOR curated interactions for FN3KRP Gene

Drugs & Compounds for FN3KRP Gene

(1) Drugs for FN3KRP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for FN3KRP Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fructosamine
  • 1-amino-1-Deoxy-D-fructose
  • D-Isoglucosamine
  • D Isoglucosamine
4429-04-3
genes like me logo Genes that share compounds with FN3KRP: view

Transcripts for FN3KRP Gene

mRNA/cDNA for FN3KRP Gene

Unigene Clusters for FN3KRP Gene

Fructosamine 3 kinase related protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FN3KRP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3: - - -

Relevant External Links for FN3KRP Gene

GeneLoc Exon Structure for
FN3KRP
ECgene alternative splicing isoforms for
FN3KRP

Expression for FN3KRP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FN3KRP Gene

Protein differential expression in normal tissues from HIPED for FN3KRP Gene

This gene is overexpressed in Uterus (8.6) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FN3KRP Gene



Protein tissue co-expression partners for FN3KRP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FN3KRP Gene:

FN3KRP

SOURCE GeneReport for Unigene cluster for FN3KRP Gene:

Hs.31431

mRNA Expression by UniProt/SwissProt for FN3KRP Gene:

Q9HA64-KT3K_HUMAN
Tissue specificity: Expressed in erythrocytes.

Evidence on tissue expression from TISSUES for FN3KRP Gene

  • Nervous system(4.8)
  • Kidney(4.3)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with FN3KRP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FN3KRP Gene

Orthologs for FN3KRP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FN3KRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FN3KRP 34 33
  • 99.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FN3KRP 34 33
  • 86.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FN3KRP 34 33
  • 85.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fn3krp 16 34 33
  • 85.33 (n)
rat
(Rattus norvegicus)
Mammalia Fn3krp 33
  • 84.47 (n)
oppossum
(Monodelphis domestica)
Mammalia FN3KRP 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FN3KRP 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves FN3KRP 34 33
  • 72.92 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FN3KRP 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fn3krp 33
  • 69.26 (n)
zebrafish
(Danio rerio)
Actinopterygii fn3krp 34 33
  • 66.56 (n)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11207 33
worm
(Caenorhabditis elegans)
Secernentea CELE_Y116A8C.25 33
  • 45.83 (n)
Y116A8C.25 34
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G61080 33
  • 48.36 (n)
rice
(Oryza sativa)
Liliopsida Os03g0117800 33
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToMany
Species where no ortholog for FN3KRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FN3KRP Gene

ENSEMBL:
Gene Tree for FN3KRP (if available)
TreeFam:
Gene Tree for FN3KRP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FN3KRP: view image

Paralogs for FN3KRP Gene

Paralogs for FN3KRP Gene

(1) SIMAP similar genes for FN3KRP Gene using alignment to 9 proteins:

  • KT3K_HUMAN
  • F5H4E4_HUMAN
  • I3L139_HUMAN
  • I3L2G3_HUMAN
  • I3L2K8_HUMAN
  • I3L378_HUMAN
  • I3L3W5_HUMAN
  • I3L407_HUMAN
  • Q6FIG5_HUMAN
genes like me logo Genes that share paralogs with FN3KRP: view

Variants for FN3KRP Gene

Sequence variations from dbSNP and Humsavar for FN3KRP Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000646661 -- 82,724,850(+) C/T intron_variant
rs1000857036 -- 82,716,366(+) A/G upstream_transcript_variant
rs1000939777 -- 82,716,019(+) G/A upstream_transcript_variant
rs1000964359 -- 82,725,498(+) A/G intron_variant
rs1001006191 -- 82,720,539(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FN3KRP Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2716524 CNV deletion 23290073
esv2762577 CNV gain+loss 21179565
nsv1061637 CNV loss 25217958
nsv1067553 CNV loss 25217958
nsv428351 CNV gain 18775914
nsv833575 CNV loss 17160897
nsv952395 CNV deletion 24416366

Variation tolerance for FN3KRP Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FN3KRP Gene

Human Gene Mutation Database (HGMD)
FN3KRP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FN3KRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FN3KRP Gene

Disorders for FN3KRP Gene

Additional Disease Information for FN3KRP

No disorders were found for FN3KRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FN3KRP Gene

Publications for FN3KRP Gene

  1. A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines. (PMID: 14633848) Collard F … Van Schaftingen E (Diabetes 2003) 2 3 4 22 58
  2. Fructosamine 3-kinase-related protein and deglycation in human erythrocytes. (PMID: 15137908) Collard F … Van Schaftingen E (The Biochemical journal 2004) 3 4 22 58
  3. Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. (PMID: 20858683) Soranzo N … Meigs JB (Diabetes 2010) 3 44 58
  4. Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine. (PMID: 18637789) Payne LS … Loomes KM (The Biochemical journal 2008) 3 22 58
  5. Fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP). (PMID: 16920277) Szwergold BS (Medical hypotheses 2007) 3 22 58

Products for FN3KRP Gene

Sources for FN3KRP Gene

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