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Aliases for FN1 Gene

Aliases for FN1 Gene

  • Fibronectin 1 2 3 5
  • Cold-Insoluble Globulin 2 3 4
  • Migration-Stimulating Factor 2 3
  • CIG 3 4
  • FN 3 4
  • Fibronectin 3
  • GFND2 3
  • SMDCF 3
  • ED-B 3
  • FINC 3
  • GFND 3
  • LETS 3
  • FNZ 3
  • MSF 3

External Ids for FN1 Gene

Previous GeneCards Identifiers for FN1 Gene

  • GC02M214388
  • GC02M214950
  • GC02M216189
  • GC02M216428
  • GC02M216050
  • GC02M215933
  • GC02M216225
  • GC02M208082

Summaries for FN1 Gene

Entrez Gene Summary for FN1 Gene

  • This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]

GeneCards Summary for FN1 Gene

FN1 (Fibronectin 1) is a Protein Coding gene. Diseases associated with FN1 include Glomerulopathy With Fibronectin Deposits 2 and Spondylometaphyseal Dysplasia, Corner Fracture Type. Among its related pathways are RET signaling and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and protease binding. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot for FN1 Gene

  • Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.

  • Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Gene Wiki entry for FN1 Gene

Additional gene information for FN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FN1 Gene

Genomics for FN1 Gene

GeneHancer (GH) Regulatory Elements for FN1 Gene

Promoters and enhancers for FN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I215429 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.9 1948 9.4 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 FN1 XRCC5 ATIC LOC105373868 GC02P215427
GH02I215747 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.8 -313.9 -313894 4.6 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 ATF7 ATIC FN1 LINC01614 ENSG00000216721 LINC00607
GH02I215623 Enhancer 1.3 FANTOM5 Ensembl ENCODE 3.1 -188.5 -188540 1.8 ELF3 FOXA2 ZFP64 ARID4B DMAP1 RAD21 RARA SMARCC2 CREM THAP11 ATIC FN1 GC02M215662 ENSG00000227981 LOC102724861 LINC00607
GH02I215736 Enhancer 0.8 Ensembl dbSUPER 4.4 -300.9 -300928 0.6 CTCF ESRRA ZNF644 RAD21 SP1 IKZF1 FOSL2 WT1 HOMEZ FN1 LINC01614 ENSG00000216721 LINC00607
GH02I215535 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -100.8 -100827 2.6 ELF3 FOXA2 SAP130 MLX CEBPG RARA SLC30A9 GATA3 POLR2A HOMEZ FN1 LOC102724861 ENSG00000234938
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FN1 gene promoter:

Genomic Locations for FN1 Gene

Genomic Locations for FN1 Gene
chr2:215,360,440-215,436,172
(GRCh38/hg38)
Size:
75,733 bases
Orientation:
Minus strand
chr2:216,225,163-216,300,895
(GRCh37/hg19)

Genomic View for FN1 Gene

Genes around FN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FN1 Gene

Proteins for FN1 Gene

  • Protein details for FN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02751-FINC_HUMAN
    Recommended name:
    Fibronectin
    Protein Accession:
    P02751
    Secondary Accessions:
    • B7ZLF0
    • E9PE77
    • E9PG29
    • O95609
    • O95610
    • Q14312
    • Q14325
    • Q14326
    • Q17RV7
    • Q564H7
    • Q585T2
    • Q59EH1
    • Q60FE4
    • Q68DP8
    • Q68DP9
    • Q68DT4
    • Q6LDP6
    • Q6MZS0
    • Q6MZU5
    • Q6N025
    • Q6N0A6
    • Q7Z391
    • Q86T27
    • Q8IVI8
    • Q96KP7
    • Q96KP8
    • Q96KP9
    • Q9H1B8
    • Q9HAP3
    • Q9UMK2

    Protein attributes for FN1 Gene

    Size:
    2386 amino acids
    Molecular mass:
    262625 Da
    Quaternary structure:
    • Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity). Interacts with COMP (PubMed:12225811). Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth (By similarity). Interacts with FST3 and MYOC.
    • (Microbial infection) Interacts with S.aureus fnbA (PubMed:12736686). Interacts with M.bovis fbpB via the collagen-binding region; also interacts with fibronectin-binding proteins from other Mycobacteria (PubMed:8406884).
    SequenceCaution:
    • Sequence=AAX76513.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD93077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD91166.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97964.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97984.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FN1 Gene

neXtProt entry for FN1 Gene

Post-translational modifications for FN1 Gene

  • Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
  • It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated.
  • Phosphorylated by FAM20C in the extracellular medium.
  • Proteolytic processing produces the C-terminal NC1 peptide, anastellin.
  • Some lysine residues are oxidized to allysine by LOXL3, promoting fibronectin activation and matrix formation.
  • Sulfated.
  • Ubiquitination at posLast=10501050
  • Glycosylation at Thr278, posLast=279279, posLast=280280, Ser281, posLast=283283, posLast=287287, posLast=430430, Asn528, posLast=542542, Asn877, posLast=10071007, posLast=12441244, posLast=12761276, posLast=15661566, posLast=16411641, posLast=19991999, Thr2061, posLast=20642064, Thr2065, posLast=20672067, Asn2108, posLast=23412341, posLast=23452345, posLast=23462346, and posLast=23492349

Antibody Products

No data available for DME Specific Peptides for FN1 Gene

Domains & Families for FN1 Gene

Gene Families for FN1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FN1: view

No data available for UniProtKB/Swiss-Prot for FN1 Gene

Function for FN1 Gene

Molecular function for FN1 Gene

GENATLAS Biochemistry:
fibronectin 1,plasma,cell adhesion factor,playing a role in the susceptibility to lung fibrosing alveolitis in systemic sclerosis,overexpressed in prostate cancer cells
UniProtKB/Swiss-Prot Function:
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.
UniProtKB/Swiss-Prot Function:
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

LifeMap Function Summary for FN1 Gene

FN1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for FN1 Gene

Gene Ontology (GO) - Molecular Function for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 22952693
GO:0005102 receptor binding IPI 17849409
GO:0005178 integrin binding IPI 11792823
GO:0005515 protein binding IPI 1400330
GO:0005518 collagen binding NAS 3024962
genes like me logo Genes that share ontologies with FN1: view
genes like me logo Genes that share phenotypes with FN1: view

Human Phenotype Ontology for FN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FN1 Gene

MGI Knock Outs for FN1:

Clone Products

  • Addgene plasmids for FN1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FN1 Gene

Localization for FN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FN1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FN1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 3
cytoskeleton 2
nucleus 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA --
GO:0005577 fibrinogen complex IDA 3997886
GO:0005578 proteinaceous extracellular matrix IDA 26571399
GO:0005604 basement membrane IEA --
GO:0005605 basal lamina IEA --
genes like me logo Genes that share ontologies with FN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FN1 Gene

Pathways & Interactions for FN1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Integrin Pathway
3 ERK Signaling
4 Signaling by moderate kinase activity BRAF mutants
5 Integrin alphaIIb beta3 signaling
genes like me logo Genes that share pathways with FN1: view

SIGNOR curated interactions for FN1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001932 regulation of protein phosphorylation IDA 11792823
GO:0002576 platelet degranulation TAS --
GO:0006953 acute-phase response IEA --
GO:0007044 cell-substrate junction assembly IEA --
genes like me logo Genes that share ontologies with FN1: view

Drugs & Compounds for FN1 Gene

(59) Drugs for FN1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 905,282
Ocriplasmin Approved Pharma Target, cleavage 0
Zinc Approved, Investigational Pharma Target 2430
Aldosterone Experimental, Investigational Pharma Agonist 0
AS1409 Investigational Pharma binder 0

(65) Additional Compounds for FN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FN1: view

Transcripts for FN1 Gene

Unigene Clusters for FN1 Gene

Fibronectin 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for FN1

Alternative Splicing Database (ASD) splice patterns (SP) for FN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b · 34c ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39 ^ 40 ^ 41a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:

ExUns: 41b · 41c ^ 42a · 42b ^ 43a · 43b · 43c · 43d ^ 44a · 44b ^ 45a · 45b · 45c ^ 46a · 46b ^ 47a · 47b ^ 48a · 48b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - -
SP8:
SP9:
SP10: -
SP11: - -
SP12: - -
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:

Relevant External Links for FN1 Gene

GeneLoc Exon Structure for
FN1
ECgene alternative splicing isoforms for
FN1

Expression for FN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FN1 Gene

This gene is overexpressed in Artery - Coronary (x5.5) and Artery - Aorta (x5.4).

Protein differential expression in normal tissues from HIPED for FN1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (40.8) and Amniocyte (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FN1 Gene



Protein tissue co-expression partners for FN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FN1 Gene:

FN1

SOURCE GeneReport for Unigene cluster for FN1 Gene:

Hs.203717

mRNA Expression by UniProt/SwissProt for FN1 Gene:

P02751-FINC_HUMAN
Tissue specificity: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.

Evidence on tissue expression from TISSUES for FN1 Gene

  • Nervous system(5)
  • Bone(4.9)
  • Liver(4.9)
  • Lung(4.9)
  • Muscle(4.9)
  • Skin(4.9)
  • Eye(4.8)
  • Heart(4.8)
  • Kidney(4.8)
  • Blood(4.6)
  • Intestine(4.6)
  • Bone marrow(4.5)
  • Pancreas(4.3)
  • Urine(4.2)
  • Thyroid gland(3.8)
  • Stomach(3.7)
  • Lymph node(2.5)
  • Gall bladder(2.2)
  • Spleen(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FN1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • respiratory
  • skeletal muscle
  • urinary
Regions:
Head and neck:
  • ear
Thorax:
  • heart
  • lung
Abdomen:
  • kidney
Pelvis:
  • ureter
  • urinary bladder
Limb:
  • lower limb
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with FN1: view

Orthologs for FN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FN1 33 34
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia FN1 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FN1 33 34
  • 90.91 (n)
oppossum
(Monodelphis domestica)
Mammalia FN1 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fn1 33 16 34
  • 87.33 (n)
rat
(Rattus norvegicus)
Mammalia Fn1 33
  • 87.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FN1 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves FN1 33 34
  • 77.72 (n)
lizard
(Anolis carolinensis)
Reptilia FN1 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fn1 33
  • 69.77 (n)
Str.6682 33
African clawed frog
(Xenopus laevis)
Amphibia fibronectin 33
zebrafish
(Danio rerio)
Actinopterygii fn1a 33 34
  • 61.76 (n)
fn1b 34
  • 55 (a)
OneToMany
FN1 (4 of 4) 34
  • 20 (a)
OneToMany
col12a1b 34
  • 15 (a)
OneToMany
fn1 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3745 33
worm
(Caenorhabditis elegans)
Secernentea D1009.3 34
  • 11 (a)
OneToOne
Species where no ortholog for FN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FN1 Gene

ENSEMBL:
Gene Tree for FN1 (if available)
TreeFam:
Gene Tree for FN1 (if available)

Paralogs for FN1 Gene

Variants for FN1 Gene

Sequence variations from dbSNP and Humsavar for FN1 Gene