This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagul... See more...

Aliases for FN1 Gene

Aliases for FN1 Gene

  • Fibronectin 1 2 3 5
  • Cold-Insoluble Globulin 2 3 4
  • Migration-Stimulating Factor 2 3
  • Fibronectin 3 4
  • CIG 3 4
  • FN 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • GFND2 3
  • SMDCF 3
  • ED-B 3
  • FINC 3
  • GFND 3
  • LETS 3
  • FNZ 3
  • MSF 3

External Ids for FN1 Gene

Previous GeneCards Identifiers for FN1 Gene

  • GC02M214388
  • GC02M214950
  • GC02M216189
  • GC02M216428
  • GC02M216050
  • GC02M215933
  • GC02M216225
  • GC02M208082

Summaries for FN1 Gene

Entrez Gene Summary for FN1 Gene

  • This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]

GeneCards Summary for FN1 Gene

FN1 (Fibronectin 1) is a Protein Coding gene. Diseases associated with FN1 include Glomerulopathy With Fibronectin Deposits 2 and Spondylometaphyseal Dysplasia, Corner Fracture Type. Among its related pathways are RET signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and protease binding. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot Summary for FN1 Gene

  • Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.
  • Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Gene Wiki entry for FN1 Gene

Additional gene information for FN1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FN1 Gene

Genomics for FN1 Gene

GeneHancer (GH) Regulatory Elements for FN1 Gene

Promoters and enhancers for FN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J215429 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.9 1943 9.4 EP300 ZBTB40 ZSCAN5C TCF12 NRF1 POLR2G JUND PHF8 FOS ZIC2 FN1 JA662170 XRCC5 SMARCAL1 ATIC ENSG00000230695 LOC105373868 lnc-ATIC-10 lnc-FN1-4
GH02J215826 Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10 -394.8 -394834 10.8 EP300 FOXK2 ZNF217 CTCF TCF12 MYC POLR2G NCOR1 KDM6A TCF7 LINC01963 FN1 ATIC LINC00607 piR-61945-291
GH02J215617 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas 10 -182.0 -181970 6.3 EP300 FOXK2 TCF12 NCOR1 GTF2E2 JUND ZIC2 REST KDM6A TCF7 LINC01963 FN1 LINC00607 LOC102724861 piR-61861-015 ENSG00000237525
GH02J215868 Enhancer 1.2 Ensembl ENCODE dbSUPER 10 -433.6 -433579 3.3 CTCF GTF2E2 REST TGIF2 CTBP1 EP300 MYC HINFP NFRKB NEUROD1 ENSG00000227824 FN1 LINC00607
GH02J215747 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 4.8 -313.9 -313899 4.6 POLR2G NCOR1 JUND FOS KDM6A TCF7 RFX1 ZBTB25 SKI TEAD1 ATIC FN1 lnc-TMEM169-9 piR-31937-113 LINC00607
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FN1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FN1

Top Transcription factor binding sites by QIAGEN in the FN1 gene promoter:
  • AP-1
  • STAT3

Genomic Locations for FN1 Gene

Genomic Locations for FN1 Gene
chr2:215,360,440-215,436,167
(GRCh38/hg38)
Size:
75,728 bases
Orientation:
Minus strand
chr2:216,225,163-216,300,895
(GRCh37/hg19)
Size:
75,733 bases
Orientation:
Minus strand

Genomic View for FN1 Gene

Genes around FN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FN1 Gene

Proteins for FN1 Gene

  • Protein details for FN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02751-FINC_HUMAN
    Recommended name:
    Fibronectin
    Protein Accession:
    P02751
    Secondary Accessions:
    • B7ZLF0
    • E9PE77
    • E9PG29
    • O95609
    • O95610
    • Q14312
    • Q14325
    • Q14326
    • Q17RV7
    • Q53S27
    • Q564H7
    • Q585T2
    • Q59EH1
    • Q60FE4
    • Q68DP8
    • Q68DP9
    • Q68DT4
    • Q6LDP6
    • Q6MZS0
    • Q6MZU5
    • Q6N025
    • Q6N0A6
    • Q7Z391
    • Q86T27
    • Q8IVI8
    • Q96KP7
    • Q96KP8
    • Q96KP9
    • Q9H1B8
    • Q9HAP3
    • Q9UMK2

    Protein attributes for FN1 Gene

    Size:
    2477 amino acids
    Molecular mass:
    272320 Da
    Quaternary structure:
    • Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity). Interacts with COMP (PubMed:12225811). Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth (By similarity). Interacts with FST3 and MYOC.
    • (Microbial infection) Interacts with S.aureus FnbA.
    • (Microbial infection) Interacts with M.bovis FbpB via the collagen-binding region.
    • (Microbial infection) Interacts with recombinant S.pneumoniae PavA (rqcH).
    • (Microbial infection) Interacts with recombinant S.suis FbpS (rqcH) via fibronectin's N-terminal 30 kDa region.
    • (Microbial infection) Interacts with fibronectin-binding proteins from other Mycobacteria.
    Miscellaneous:
    • [Isoform 16]: Expressed by fetal and tumor-associated cells.
    SequenceCaution:
    • Sequence=AAA52463.1; Type=Erroneous translation; Evidence={ECO:0000305}; Sequence=AAX76513.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD93077.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAD91166.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAD97964.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAD97965.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAD97984.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAE45847.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAH18136.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FN1 Gene

neXtProt entry for FN1 Gene

Post-translational modifications for FN1 Gene

  • Sulfated.
  • It is not known whether both or only one of Thr-2155 and Thr-2156 are/is glycosylated.
  • Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
  • Phosphorylated by FAM20C in the extracellular medium.
  • Proteolytic processing produces the C-terminal NC1 peptide, anastellin.
  • Some lysine residues are oxidized to allysine by LOXL3, promoting fibronectin activation and matrix formation.
  • Glycosylation at Thr278, Thr279, Ser280, Ser281, Ser283, Thr287, Asn430, Asn528, Asn542, Asn877, Asn1007, Asn1236, Asn1244, Thr1276, Ser1565, Ser1566, Ser1567, Thr1570, Thr1641, Thr2060, Thr2061, Thr2064, Thr2065, Thr2067, Thr1999, Ser2341, Thr2345, Thr2346, Ser2349, and Asn2108
  • Ubiquitination at Lys1050
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FINC_HUMAN (161)

Antibody Products

No data available for DME Specific Peptides for FN1 Gene

Domains & Families for FN1 Gene

Gene Families for FN1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FN1 Gene

Blocks:
  • Type II fibronectin collagen-binding domain
  • Fibronectin type III repeat signature
  • Fibronectin, type I
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FN1 Gene

GenScript: Design optimal peptide antigens:
  • Fibronectin splice variant A (A6YID2_HUMAN)
  • Fibronectin splice variant B (A6YID3_HUMAN)
  • Fibronectin splice variant C (A6YID4_HUMAN)
  • Fibronectin splice variant D (A6YID5_HUMAN)
  • Fibronectin splice variant E (A6YID6_HUMAN)
genes like me logo Genes that share domains with FN1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FN1 Gene

Function for FN1 Gene

Molecular function for FN1 Gene

UniProtKB/Swiss-Prot Function:
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.
UniProtKB/Swiss-Prot Function:
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
GENATLAS Biochemistry:
fibronectin 1,plasma,cell adhesion factor,playing a role in the susceptibility to lung fibrosing alveolitis in systemic sclerosis,overexpressed in prostate cancer cells

LifeMap Function Summary for FN1 Gene

FN1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for FN1 Gene

Gene Ontology (GO) - Molecular Function for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 22952693
GO:0005102 signaling receptor binding IPI 17849409
GO:0005178 integrin binding IPI 11792823
GO:0005201 extracellular matrix structural constituent RCA 20551380
GO:0005515 protein binding IPI,IEA 1400330
genes like me logo Genes that share ontologies with FN1: view
genes like me logo Genes that share phenotypes with FN1: view

Human Phenotype Ontology for FN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FN1 Gene

MGI Knock Outs for FN1:
  • Fn1 Fn1<tm2.1Ref>
  • Fn1 Fn1<tm1Bwg>
  • Fn1 Fn1<tm3Hyn>
  • Fn1 Fn1<tm1Hyn>
  • Fn1 Fn1<tm2Hyn>
  • Fn1 Fn1<tm4Hyn>
  • Fn1 Fn1<tm1Ksek>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for FN1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FN1 Gene

Localization for FN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FN1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FN1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 4
cytoskeleton 4
mitochondrion 3
nucleus 3
cytosol 3
lysosome 3
peroxisome 2
endosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005577 fibrinogen complex IDA 3997886
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IDA 15292204
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with FN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FN1 Gene

Pathways & Interactions for FN1 Gene

PathCards logo

SuperPathways for FN1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Integrin Pathway
.67
.67
.56
.56
.50
.38
3 ERK Signaling
.61
.61
.58
.51
.49
4 Paradoxical activation of RAF signaling by kinase inactive BRAF
5 Integrin alphaIIb beta3 signaling
genes like me logo Genes that share pathways with FN1: view

Pathways by source for FN1 Gene

11 GeneGo (Thomson Reuters) pathways for FN1 Gene
  • Cell adhesion Integrin inside-out signaling
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion_ECM remodeling
  • Cell adhesion_Endothelial cell contacts by non-junctional mechanisms
  • Cell adhesion_Plasmin signaling
14 Qiagen pathways for FN1 Gene
  • ERK Signaling
  • FAK1 Signaling
  • GnRH Signaling
  • ILK Signaling
  • Inhibition of Angiogenesis by TSP1

SIGNOR curated interactions for FN1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001932 regulation of protein phosphorylation IDA 11792823
GO:0002576 platelet degranulation TAS --
GO:0006953 acute-phase response IEA --
GO:0007044 cell-substrate junction assembly IEA --
genes like me logo Genes that share ontologies with FN1: view

Drugs & Compounds for FN1 Gene

(63) Drugs for FN1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 1028
Ocriplasmin Approved Pharma Target, cleavage 0
Zinc Approved, Investigational Pharma Target 2822
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0

(64) Additional Compounds for FN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FN1: view

Transcripts for FN1 Gene

mRNA/cDNA for FN1 Gene

19 REFSEQ mRNAs :
75 NCBI additional mRNA sequence :
27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for FN1

Alternative Splicing Database (ASD) splice patterns (SP) for FN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b · 34c ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39 ^ 40 ^ 41a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:

ExUns: 41b · 41c ^ 42a · 42b ^ 43a · 43b · 43c · 43d ^ 44a · 44b ^ 45a · 45b · 45c ^ 46a · 46b ^ 47a · 47b ^ 48a · 48b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - -
SP8:
SP9:
SP10: -
SP11: - -
SP12: - -
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:

Relevant External Links for FN1 Gene

GeneLoc Exon Structure for
FN1

Expression for FN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery