Aliases for FMOD Gene
External Ids for FMOD Gene
Previous GeneCards Identifiers for FMOD Gene
Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
GeneCards Summary for FMOD Gene
FMOD (Fibromodulin) is a Protein Coding gene. Diseases associated with FMOD include Hypochondrogenesis and Pseudoachondroplasia. Among its related pathways are Keratan sulfate/keratin metabolism and Defective B4GALT1 causes B4GALT1-CDG (CDG-2d). An important paralog of this gene is LUM.
UniProtKB/Swiss-Prot Summary for FMOD Gene
Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).