Aliases for FMO6P Gene

Aliases for FMO6P Gene

  • Flavin Containing Dimethylaniline Monoxygenase 6, Pseudogene 2 3
  • Flavin Containing Monooxygenase 6, Pseudogene 2 3 5
  • EC 1.14.13.8 4 54
  • FMO6 3 4
  • Putative Dimethylaniline Monooxygenase [N-Oxide-Forming] 6 4
  • Novel Flavin Containing Monooxygenase 3
  • Flavin-Containing Monooxygenase 6 4
  • Flavin Containing Monooxygenase 6 2
  • Dimethylaniline Oxidase 6 4
  • FMO 6 4

External Ids for FMO6P Gene

Previous HGNC Symbols for FMO6P Gene

  • FMO6

Previous GeneCards Identifiers for FMO6P Gene

  • GC01P169375
  • GC01P142330

Summaries for FMO6P Gene

GeneCards Summary for FMO6P Gene

FMO6P (Flavin Containing Dimethylaniline Monoxygenase 6, Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADP binding.

UniProtKB/Swiss-Prot Summary for FMO6P Gene

  • It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full-length transcripts.

Additional gene information for FMO6P Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FMO6P Gene

Genomics for FMO6P Gene

GeneHancer (GH) Regulatory Elements for FMO6P Gene

Promoters and enhancers for FMO6P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J171137 Enhancer 0.5 Ensembl CraniofacialAtlas 750.6 0.0 -39 1.4 OVOL3 ZNF843 FMO6P FMO2 MIR1295A LOC105371611 ENSG00000231424
GH01J171110 Enhancer 0.5 Ensembl ENCODE dbSUPER 10.9 -26.6 -26592 1.5 FMO6P FMO3 MIR1295A ENSG00000231424
GH01J172117 Enhancer 0.6 Ensembl ENCODE 4.6 +980.4 980360 1.8 RELA ZNF687 IKZF1 PKNOX1 RUNX3 FMO6P lnc-C1orf105-6 piR-50968-011 DNM3
GH01J171138 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.6 +3.6 3585 5.4 FOXA1 CREB1 ZNF362 HLF RAD21 NFIB SP1 TFE3 CEBPG SP7 FMO3 MIR1295A FMO6P lnc-FMO2-1 LOC105371611 ENSG00000231424
GH01J171157 Enhancer 0.9 Ensembl ENCODE 0.3 +22.4 22423 4.9 MIXL1 HLF SP1 CEBPG ZNF644 CEBPA RXRA GATAD2A MAFK JUND FMO3 MIR1295A FMO2 ENSG00000231424 lnc-FMO2-1 FMO6P LOC105371611
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FMO6P on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FMO6P gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • HSF2
  • NF-Y
  • NF-YA
  • p53

Genomic Locations for FMO6P Gene

Genomic Locations for FMO6P Gene
chr1:171,137,740-171,161,568
(GRCh38/hg38)
Size:
23,829 bases
Orientation:
Plus strand
chr1:171,106,879-171,130,707
(GRCh37/hg19)
Size:
23,829 bases
Orientation:
Plus strand

Genomic View for FMO6P Gene

Genes around FMO6P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO6P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO6P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO6P Gene

Proteins for FMO6P Gene

  • Protein details for FMO6P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60774-FMO6_HUMAN
    Recommended name:
    Putative dimethylaniline monooxygenase [N-oxide-forming] 6
    Protein Accession:
    O60774

    Protein attributes for FMO6P Gene

    Size:
    539 amino acids
    Molecular mass:
    61291 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for FMO6P Gene

Selected DME Specific Peptides for FMO6P Gene

O60774:
  • EEGRASIY
  • IGAKPNIP
  • CFERSDD
  • LRKEPVFND
  • GGLWKFSDH
  • EVYFGPC
  • CLEEGLEPTCFE
  • QSQTLQT
  • GARNAILTQW
  • GRASIYQSV
  • TLFKGIFPP
  • EFTETSA
  • GNSGSDIAVELS
  • FGPCSPYQFRL
  • SKEMMCF
  • NIPWLFLTDP
  • GKWDGAR

Post-translational modifications for FMO6P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for FMO6P Gene

Gene Families for FMO6P Gene

Suggested Antigen Peptide Sequences for FMO6P Gene

GenScript: Design optimal peptide antigens:
  • Flavin-containing monooxygenase 6 (FMO6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60774

UniProtKB/Swiss-Prot:

FMO6_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO6P: view

Function for FMO6P Gene

Molecular function for FMO6P Gene

UniProtKB/Swiss-Prot Function:
It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full-length transcripts.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+); Xref=Rhea:RHEA:24468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16269, ChEBI:CHEBI:17735, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.8;.

Enzyme Numbers (IUBMB) for FMO6P Gene

Phenotypes From GWAS Catalog for FMO6P Gene

genes like me logo Genes that share phenotypes with FMO6P: view

Animal Model Products

CRISPR Products

miRNA for FMO6P Gene

miRTarBase miRNAs that target FMO6P

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FMO6P Gene

Localization for FMO6P Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO6P Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMO6P gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 1
peroxisome 1
mitochondrion 0
lysosome 0

No data available for Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FMO6P Gene

Pathways & Interactions for FMO6P Gene

PathCards logo

SuperPathways for FMO6P Gene

No Data Available

Gene Ontology (GO) - Biological Process for FMO6P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FMO6P Gene

Drugs & Compounds for FMO6P Gene

(3) Drugs for FMO6P Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(4) Additional Compounds for FMO6P Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • NN-Dimethylaniline-N-oxide
  • Dimethylaniline N-oxide hydrochloride
874-52-2
N,N-Dimethylaniline
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-Dimethyl-N-phenylamine
  • N,N-Dimethylbenzenamine
121-69-7
NADP
  • beta-Nicotinamide adenine dinucleotide phosphate
  • NADP+
  • Nicotinamide adenine dinucleotide phosphate
  • Oxidized nicotinamide-adenine dinucleotide phosphate
  • TPN
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with FMO6P: view

Transcripts for FMO6P Gene

mRNA/cDNA for FMO6P Gene

(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMO6P Gene

No ASD Table

Relevant External Links for FMO6P Gene

GeneLoc Exon Structure for
FMO6P
ECgene alternative splicing isoforms for
FMO6P

Expression for FMO6P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FMO6P Gene

mRNA differential expression in normal tissues according to GTEx for FMO6P Gene

This gene is overexpressed in Minor Salivary Gland (x16.7), Stomach (x12.4), and Cervix - Endocervix (x7.4).

NURSA nuclear receptor signaling pathways regulating expression of FMO6P Gene:

FMO6P

SOURCE GeneReport for Unigene cluster for FMO6P Gene:

Hs.448988
genes like me logo Genes that share expression patterns with FMO6P: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FMO6P Gene

Orthologs for FMO6P Gene

This gene was present in the common ancestor of chordates.

Orthologs for FMO6P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMO6P 33
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo6 33
  • 67 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FMO6P 33
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO6P 33
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FMO6P 33
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves FMO3 33
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 72 (a)
ManyToMany
-- 33
  • 56 (a)
ManyToMany
Species where no ortholog for FMO6P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FMO6P Gene

ENSEMBL:
Gene Tree for FMO6P (if available)
TreeFam:
Gene Tree for FMO6P (if available)

Paralogs for FMO6P Gene

(6) SIMAP similar genes for FMO6P Gene using alignment to 2 proteins:

  • FMO6_HUMAN
  • B5MDN4_HUMAN
genes like me logo Genes that share paralogs with FMO6P: view

No data available for Paralogs for FMO6P Gene

Variants for FMO6P Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FMO6P Gene

FMO6_HUMAN-O60774
There are two alleles; one major, FMO6X105 (truncated form) and one minor, FMO6Q105, (shown here) (full-length form similar to the protein found in other mammals) (PubMed:12527699). A nonsense mutation transforms the Gln-105 into a premature stop codon (PubMed:12527699). The truncated protein is catalytically inactive (PubMed:12527699).

Sequence variations from dbSNP and Humsavar for FMO6P Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000049031 -- 171,136,579(+) C/T upstream_transcript_variant
rs1000160082 -- 171,146,905(+) T/C intron_variant
rs1000247885 -- 171,138,649(+) G/A intron_variant
rs1000284805 -- 171,159,704(+) A/G intron_variant
rs1000332021 -- 171,161,789(+) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FMO6P Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV gain+loss 19812545
nsv1144415 CNV deletion 24896259

Variation tolerance for FMO6P Gene

Gene Damage Index Score: 4.88; 67.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FMO6P Gene

Human Gene Mutation Database (HGMD)
FMO6P
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FMO6P

SNP Genotyping and Copy Number Assay Products

Disorders for FMO6P Gene

Additional Disease Information for FMO6P

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FMO6P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FMO6P Gene

Publications for FMO6P Gene

  1. Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. (PMID: 15077013) Hernandez D … Shephard EA (Pharmacogenetics 2004) 2 3 23 56
  2. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross CJ … CPNDS Consortium (Nature genetics 2009) 3 43 56
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  4. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PMID: 12527699) Furnes B … Schlenk D (Drug metabolism and disposition: the biological fate of chemicals 2003) 3 4 56
  5. Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase. (PMID: 12130684) Hines RN … Begun FP (Molecular pharmacology 2002) 3 4 56

Products for FMO6P Gene

Sources for FMO6P Gene