Aliases for FMO5 Gene
External Ids for FMO5 Gene
Previous GeneCards Identifiers for FMO5 Gene
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
GeneCards Summary for FMO5 Gene
FMO5 (Flavin Containing Dimethylaniline Monoxygenase 5) is a Protein Coding gene. Diseases associated with FMO5 include Trimethylaminuria and Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO2.
UniProtKB/Swiss-Prot Summary for FMO5 Gene
In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.