Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and... See more...

Aliases for FMO5 Gene

Aliases for FMO5 Gene

  • Flavin Containing Dimethylaniline Monoxygenase 5 2 3 5
  • Dimethylaniline Monooxygenase [N-Oxide-Forming] 5 3 4
  • Hepatic Flavin-Containing Monooxygenase 5 3 4
  • Flavin Containing Monooxygenase 5 2 3
  • Dimethylaniline Oxidase 5 3 4
  • EC 1.14.13.8 4 52
  • FMO 5 3 4

External Ids for FMO5 Gene

Previous GeneCards Identifiers for FMO5 Gene

  • GC01M144872
  • GC01M143383
  • GC01M144001
  • GC01M144164
  • GC01M143882
  • GC01M145124
  • GC01M146655
  • GC01M120068

Summaries for FMO5 Gene

Entrez Gene Summary for FMO5 Gene

  • Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for FMO5 Gene

FMO5 (Flavin Containing Dimethylaniline Monoxygenase 5) is a Protein Coding gene. Diseases associated with FMO5 include Trimethylaminuria and Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot Summary for FMO5 Gene

  • In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

Gene Wiki entry for FMO5 Gene

Additional gene information for FMO5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FMO5 Gene

Genomics for FMO5 Gene

GeneHancer (GH) Regulatory Elements for FMO5 Gene

Promoters and enhancers for FMO5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FMO5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FMO5

Top Transcription factor binding sites by QIAGEN in the FMO5 gene promoter:
  • AML1a
  • AREB6
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Nkx6-1
  • Pax-4a
  • POU2F1
  • POU2F1a

Genomic Locations for FMO5 Gene

Genomic Locations for FMO5 Gene
chr1:147,175,351-147,243,050
(GRCh38/hg38)
Size:
67,700 bases
Orientation:
Minus strand
chr1:146,646,930-146,714,700
(GRCh37/hg19)
Size:
67,771 bases
Orientation:
Minus strand

Genomic View for FMO5 Gene

Genes around FMO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO5 Gene

Proteins for FMO5 Gene

  • Protein details for FMO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49326-FMO5_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 5
    Protein Accession:
    P49326
    Secondary Accessions:
    • B2RBG1
    • C9JJD1
    • Q8IV22

    Protein attributes for FMO5 Gene

    Size:
    533 amino acids
    Molecular mass:
    60221 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FMO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMO5 Gene

Selected DME Specific Peptides for FMO5 Gene

P49326:
  • EEGRASIY
  • FPFLEDSVKVV
  • SFPGIEKFKG
  • LPLESFPGI
  • EEGLEPVCFER
  • SKEMMCF
  • IGIGNSGGDLAVEIS
  • FDLLKYI
  • FATGYSF
  • SQRHTIQGDYI
  • SLYKKVFPPNLE
  • GKWDGAR
  • GLIQPLG

Post-translational modifications for FMO5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for FMO5 Gene

Gene Families for FMO5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FMO5 Gene

Blocks:
  • Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
  • Flavin-containing monooxygenase (FMO) signature
  • Flavin-containing monooxygenase (FMO) 5 signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FMO5 Gene

GenScript: Design optimal peptide antigens:
  • Hepatic flavin-containing monooxygenase 5 (FMO5_HUMAN)
  • cDNA FLJ12110 fis, clone MAMMA1000020, highly similar to H.sapiens flavin-containing monooxygenase 5 (FMO5) (Q9HA79_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49326

UniProtKB/Swiss-Prot:

FMO5_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO5: view

Function for FMO5 Gene

Molecular function for FMO5 Gene

UniProtKB/Swiss-Prot Function:
In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+); Xref=Rhea:RHEA:24468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16269, ChEBI:CHEBI:17735, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.8;.
GENATLAS Biochemistry:
flavin containing monooxygenase 5,microsomal

Enzyme Numbers (IUBMB) for FMO5 Gene

Phenotypes From GWAS Catalog for FMO5 Gene

Gene Ontology (GO) - Molecular Function for FMO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IBA 21873635
GO:0004499 N,N-dimethylaniline monooxygenase activity IBA 21873635
GO:0016491 oxidoreductase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with FMO5: view
genes like me logo Genes that share phenotypes with FMO5: view

Animal Models for FMO5 Gene

MGI Knock Outs for FMO5:
  • Fmo5 Fmo5<tm1Eshe>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FMO5

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FMO5 Gene

Localization for FMO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO5 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMO5 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FMO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FMO5: view

Pathways & Interactions for FMO5 Gene

genes like me logo Genes that share pathways with FMO5: view

Gene Ontology (GO) - Biological Process for FMO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FMO5: view

No data available for SIGNOR curated interactions for FMO5 Gene

Drugs & Compounds for FMO5 Gene

(8) Drugs for FMO5 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 2154
FAD Approved Pharma 0
Oxygen Approved, Vet_approved Pharma 0
Tamoxifen Approved Pharma Antagonist TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 455
Water Approved Pharma 0

(9) Additional Compounds for FMO5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • NN-Dimethylaniline-N-oxide
  • Dimethylaniline N-oxide hydrochloride
874-52-2
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
N,N-Dimethylaniline
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-Dimethyl-N-phenylamine
  • N,N-Dimethylbenzenamine
121-69-7
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Tamoxifen N-oxide
genes like me logo Genes that share compounds with FMO5: view

Transcripts for FMO5 Gene

mRNA/cDNA for FMO5 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FMO5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMO5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3:

Relevant External Links for FMO5 Gene

GeneLoc Exon Structure for
FMO5

Expression for FMO5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FMO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO5 Gene

This gene is overexpressed in Liver (x12.5) and Stomach (x11.3).

Protein differential expression in normal tissues from HIPED for FMO5 Gene

This gene is overexpressed in Liver (30.9) and Gallbladder (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FMO5 Gene



Protein tissue co-expression partners for FMO5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FMO5

SOURCE GeneReport for Unigene cluster for FMO5 Gene:

Hs.642706

mRNA Expression by UniProt/SwissProt for FMO5 Gene:

P49326-FMO5_HUMAN
Tissue specificity: Expressed in fetal and adult liver.

Evidence on tissue expression from TISSUES for FMO5 Gene

  • Liver(4.6)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FMO5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FMO5 Gene

Orthologs for FMO5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FMO5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMO5 31 30
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FMO5 31 30
  • 89.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FMO5 31 30
  • 87.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo5 17 31 30
  • 84.24 (n)
rat
(Rattus norvegicus)
Mammalia Fmo5 30
  • 83.99 (n)
oppossum
(Monodelphis domestica)
Mammalia FMO5 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FMO5 31
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 67 (a)
OneToMany
LOC100857724 30
  • 65.91 (n)
-- 31
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 69 (a)
OneToMany
-- 31
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fmo5 31 30 30
  • 63.65 (n)
ManyToMany
si:dkey-239i20.2 31
  • 56 (a)
ManyToMany
si:dkey-239i20.4 31
  • 50 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fmo-2 31 32
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fmo-5 31 30
  • 51.68 (n)
ManyToMany
fmo-3 31
  • 44 (a)
ManyToMany
fmo-15 32
  • 44 (a)
fmo-13 32
  • 44 (a)
fmo-12 32
  • 43 (a)
fmo-11 32
  • 43 (a)
fmo-2 31
  • 42 (a)
ManyToMany
fmo-14 32
  • 42 (a)
fmo-1 31
  • 41 (a)
ManyToMany
fmo-4 31
  • 37 (a)
ManyToMany
C01H6.4 32
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMO1 31
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
Species where no ortholog for FMO5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FMO5 Gene

ENSEMBL:
Gene Tree for FMO5 (if available)
TreeFam:
Gene Tree for FMO5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FMO5: view image

Paralogs for FMO5 Gene

Paralogs for FMO5 Gene

(6) SIMAP similar genes for FMO5 Gene using alignment to 5 proteins:

  • FMO5_HUMAN
  • E9PJF3_HUMAN
  • E9PP51_HUMAN
  • E9PQ84_HUMAN
  • Q9HA79_HUMAN

Pseudogenes.org Pseudogenes for FMO5 Gene

genes like me logo Genes that share paralogs with FMO5: view

Variants for FMO5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FMO5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
758686 Likely Benign: not provided 147,201,145(-) C/T INTRON_VARIANT
781779 Benign: not provided 147,201,163(-) T/C MISSENSE_VARIANT,INTRON_VARIANT
783294 Benign: not provided 147,201,336(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
785842 Benign: not provided 147,212,527(-) T/C MISSENSE_VARIANT,INTRON_VARIANT
rs28381218 - p.Pro400Ala

Additional dbSNP identifiers (rs#s) for FMO5 Gene

Structural Variations from Database of Genomic Variants (DGV) for FMO5 Gene

Variant ID Type Subtype PubMed ID
dgv327n100 CNV gain 25217958
dgv66e199 CNV deletion 23128226
dgv67e199 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
esv3587435 CNV loss 21293372
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1077657 CNV deletion 25765185
nsv1121713 CNV deletion 24896259
nsv1132304 CNV duplication 24896259
nsv159869 CNV insertion 16902084
nsv437047 CNV loss 16327808
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv547676 CNV gain 21841781
nsv946304 CNV duplication 23825009

Variation tolerance for FMO5 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FMO5 Gene

Human Gene Mutation Database (HGMD)
FMO5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FMO5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO5 Gene

Disorders for FMO5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for FMO5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
trimethylaminuria
  • tmau
chromosome 1q21.1 deletion syndrome, 1.35-mb
  • chromosome 1q21.1 deletion syndrome
duodenal atresia
  • duodenal stenosis
chromosome 1p36 deletion syndrome
  • monosomy 1p36 syndrome
tetralogy of fallot
  • tof
- elite association - COSMIC cancer census association via MalaCards
Search FMO5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FMO5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FMO5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FMO5 Gene

Publications for FMO5 Gene

  1. Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21. (PMID: 9119381) Gelb BD … Desnick RJ (Genomics 1997) 2 3 23 54
  2. Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. (PMID: 8786146) McCombie RR … Shephard EA (Genomics 1996) 2 3 23 54
  3. Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. (PMID: 7872795) Overby LH … Philpot RM (Archives of biochemistry and biophysics 1995) 3 4 23 54
  4. Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism. (PMID: 28783300) Fiorentini F … Mattevi A (ACS chemical biology 2017) 2 3 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for FMO5 Gene

Sources for FMO5 Gene