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Aliases for FMO4 Gene

Aliases for FMO4 Gene

  • Flavin Containing Monooxygenase 4 2 3 5
  • Hepatic Flavin-Containing Monooxygenase 4 3 4
  • Dimethylaniline Oxidase 4 3 4
  • FMO 4 3 4
  • FMO2 3 4
  • Dimethylaniline Monooxygenase [N-Oxide-Forming] 4 3
  • EC 4

External Ids for FMO4 Gene

Previous HGNC Symbols for FMO4 Gene

  • FMO2

Previous GeneCards Identifiers for FMO4 Gene

  • GC01P168847
  • GC01P166912
  • GC01P167864
  • GC01P168522
  • GC01P168015
  • GC01P169549
  • GC01P142506

Summaries for FMO4 Gene

Entrez Gene Summary for FMO4 Gene

  • Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]

GeneCards Summary for FMO4 Gene

FMO4 (Flavin Containing Monooxygenase 4) is a Protein Coding gene. Diseases associated with FMO4 include Trimethylaminuria. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot for FMO4 Gene

  • This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

Gene Wiki entry for FMO4 Gene

Additional gene information for FMO4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO4 Gene

Genomics for FMO4 Gene

GeneHancer (GH) Regulatory Elements for FMO4 Gene

Promoters and enhancers for FMO4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J171313 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 665 +0.0 45 1.8 FOXA2 PKNOX1 CLOCK ATF1 ARID4B SIN3A YY1 ZNF143 ATF7 RUNX3 FMO4 TOP1P1
GH01J171738 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 +427.3 427292 6.2 ZFP64 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 ZNF610 GLIS1 NBN VAMP4 PRRC2C METTL13 PIGC FMO4 SUCO MYOC PIR43253
GH01J171247 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.3 -60.6 -60601 11.9 FOXA2 NFIB ZSCAN4 BMI1 RAD21 ZNF335 GLIS2 SCRT2 ZNF143 FOS FMO1 ENSG00000231424 ENSG00000206692 GC01M171253 LOC105371611 FMO2 FMO4
GH01J171343 Enhancer 0.8 ENCODE 24.8 +30.2 30193 2.2 SOX13 FOXA2 TAF1 MAX CEBPG ZNF644 RAD21 YY1 HNF4G NR2F6 GC01M171347 SRP14P4 ENSG00000225704 FMO4 TOP1P1
GH01J171284 Enhancer 0.9 FANTOM5 ENCODE 20.4 -27.9 -27941 2.4 JUNB BATF RFX5 GATA3 IKZF1 EED FOS FOSL2 PRDM1 RUNX3 FMO4 FMO1 PRRC2C HMGB1P11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FMO4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FMO4 gene promoter:
  • POU3F1
  • Evi-1
  • COMP1
  • HTF
  • GATA-1
  • STAT5A
  • Pbx1a
  • POU2F1a
  • POU2F1
  • HNF-4alpha2

Genomic Locations for FMO4 Gene

Genomic Locations for FMO4 Gene
27,948 bases
Plus strand
27,877 bases
Plus strand

Genomic View for FMO4 Gene

Genes around FMO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO4 Gene

Proteins for FMO4 Gene

  • Protein details for FMO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 4
    Protein Accession:
    Secondary Accessions:
    • Q53XR0

    Protein attributes for FMO4 Gene

    558 amino acids
    Molecular mass:
    63343 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for FMO4 Gene

Post-translational modifications for FMO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMO4 Gene

No data available for DME Specific Peptides for FMO4 Gene

Domains & Families for FMO4 Gene

Gene Families for FMO4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for FMO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FMO family.
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO4: view

Function for FMO4 Gene

Molecular function for FMO4 Gene

UniProtKB/Swiss-Prot Function:
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
UniProtKB/Swiss-Prot CatalyticActivity:
N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
GENATLAS Biochemistry:
flavin containing monooxygenase 4,microsomal

Enzyme Numbers (IUBMB) for FMO4 Gene

Phenotypes From GWAS Catalog for FMO4 Gene

Gene Ontology (GO) - Molecular Function for FMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IBA --
GO:0004499 N,N-dimethylaniline monooxygenase activity NAS 1417778
GO:0016491 oxidoreductase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with FMO4: view
genes like me logo Genes that share phenotypes with FMO4: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FMO4 Gene

Localization for FMO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO4 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMO4 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 2
cytosol 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with FMO4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FMO4 Gene

Pathways & Interactions for FMO4 Gene

genes like me logo Genes that share pathways with FMO4: view

Pathways by source for FMO4 Gene

Gene Ontology (GO) - Biological Process for FMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042737 drug catabolic process IEA --
GO:0055114 oxidation-reduction process IBA --
genes like me logo Genes that share ontologies with FMO4: view

No data available for SIGNOR curated interactions for FMO4 Gene

Drugs & Compounds for FMO4 Gene

(4) Drugs for FMO4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Oxygen Approved, Vet_approved Pharma 0
Tamoxifen Approved Pharma Antagonist TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 408
Water Approved Pharma 0

(8) Additional Compounds for FMO4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • NN-Dimethylaniline-N-oxide
  • Dimethylaniline N-oxide hydrochloride
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-Dimethyl-N-phenylamine
  • N,N-Dimethylbenzenamine
  • beta-Nicotinamide adenine dinucleotide phosphate
  • NADP+
  • Nicotinamide adenine dinucleotide phosphate
  • Oxidized nicotinamide-adenine dinucleotide phosphate
  • TPN
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
genes like me logo Genes that share compounds with FMO4: view

Transcripts for FMO4 Gene

mRNA/cDNA for FMO4 Gene

Unigene Clusters for FMO4 Gene

Flavin containing monooxygenase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMO4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - - - -
SP2: -

Relevant External Links for FMO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FMO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FMO4 Gene

mRNA differential expression in normal tissues according to GTEx for FMO4 Gene

This gene is overexpressed in Liver (x6.7).

Protein differential expression in normal tissues from HIPED for FMO4 Gene

This gene is overexpressed in Gallbladder (42.3), Liver (19.2), and Kidney (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FMO4 Gene

Protein tissue co-expression partners for FMO4 Gene

NURSA nuclear receptor signaling pathways regulating expression of FMO4 Gene:


SOURCE GeneReport for Unigene cluster for FMO4 Gene:


mRNA Expression by UniProt/SwissProt for FMO4 Gene:

Tissue specificity: Liver.

Evidence on tissue expression from TISSUES for FMO4 Gene

  • Liver(4.5)
  • Skin(4.1)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with FMO4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FMO4 Gene

Orthologs for FMO4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FMO4 34 33
  • 99.52 (n)
(Canis familiaris)
Mammalia FMO4 34 33
  • 88.05 (n)
(Bos Taurus)
Mammalia FMO4 34 33
  • 87.76 (n)
(Mus musculus)
Mammalia Fmo4 16 34 33
  • 83.21 (n)
(Rattus norvegicus)
Mammalia Fmo4 33
  • 82.61 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
-- 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia FMO4 34
  • 64 (a)
(Gallus gallus)
Aves FMO4 34 33
  • 59.31 (n)
(Anolis carolinensis)
Reptilia FMO4 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fmo1 33
  • 59.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fmo-1 35
  • 35 (a)
(Caenorhabditis elegans)
Secernentea fmo-15 35
  • 42 (a)
fmo-13 35
  • 40 (a)
fmo-11 35
  • 39 (a)
C01H6.4 35
  • 35 (a)
Species where no ortholog for FMO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FMO4 Gene

Gene Tree for FMO4 (if available)
Gene Tree for FMO4 (if available)
Evolutionary constrained regions (ECRs) for FMO4: view image

Paralogs for FMO4 Gene

Paralogs for FMO4 Gene

(6) SIMAP similar genes for FMO4 Gene using alignment to 1 proteins:

  • FMO4_HUMAN Pseudogenes for FMO4 Gene

genes like me logo Genes that share paralogs with FMO4: view

Variants for FMO4 Gene

Sequence variations from dbSNP and Humsavar for FMO4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000319188 -- 171,338,499(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000427504 -- 171,317,792(+) T/A intron_variant
rs1000600894 -- 171,327,271(+) A/G intron_variant
rs1000653502 -- 171,326,902(+) A/T intron_variant
rs1000733598 -- 171,329,860(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FMO4 Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV gain+loss 19812545
nsv1002423 CNV loss 25217958
nsv527149 CNV gain 19592680
nsv548188 CNV loss 21841781
nsv831882 CNV loss 17160897
nsv946501 CNV duplication 23825009

Variation tolerance for FMO4 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FMO4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO4 Gene

Disorders for FMO4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FMO4 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
  • tmau
- elite association - COSMIC cancer census association via MalaCards
Search FMO4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FMO4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FMO4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FMO4 Gene

Publications for FMO4 Gene

  1. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PMID: 12527699) Furnes B … Schlenk D (Drug metabolism and disposition: the biological fate of chemicals 2003) 3 4 22 58
  2. A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. (PMID: 8311461) Lawton MP … Phillips IR (Archives of biochemistry and biophysics 1994) 2 3 22 58
  3. Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. (PMID: 1417778) Dolphin CT … Phillips IR (The Biochemical journal 1992) 3 4 22 58
  4. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. (PMID: 19307449) Novick RM … Elfarra AA (The Journal of pharmacology and experimental therapeutics 2009) 3 22 58
  5. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross CJ … CPNDS Consortium (Nature genetics 2009) 3 44 58

Products for FMO4 Gene

Sources for FMO4 Gene

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