Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members ... See more...

Aliases for FMO3 Gene

Aliases for FMO3 Gene

  • Flavin Containing Dimethylaniline Monoxygenase 3 2 3 5
  • Dimethylaniline Monooxygenase [N-Oxide-Forming] 3 2 3 4
  • Flavin Containing Monooxygenase 3 2 3
  • Trimethylamine Monooxygenase 3 4
  • Dimethylaniline Oxidase 3 3 4
  • EC 1.14.13.8 4 51
  • FMO Form 2 3 4
  • FMOII 2 3
  • Hepatic Flavin-Containing Monooxygenase-3 3
  • Hepatic Flavin-Containing Monooxygenase 3 4
  • EC 1.14.13.148 4
  • EC 1.14.14.73 4
  • DJ127D3.1 3
  • FMO II 4
  • FMO 3 4
  • TMAU 3
  • FMO3 5

External Ids for FMO3 Gene

Previous GeneCards Identifiers for FMO3 Gene

  • GC01P168623
  • GC01P166689
  • GC0XP9N0049
  • GC01P168299
  • GC01P167791
  • GC01P169326
  • GC01P171060
  • GC01P142283

Summaries for FMO3 Gene

Entrez Gene Summary for FMO3 Gene

  • Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]

GeneCards Summary for FMO3 Gene

FMO3 (Flavin Containing Dimethylaniline Monoxygenase 3) is a Protein Coding gene. Diseases associated with FMO3 include Trimethylaminuria and Primary Trimethylaminuria. Among its related pathways are Imipramine/Desipramine Pathway, Pharmacokinetics and Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot Summary for FMO3 Gene

  • Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269).

Gene Wiki entry for FMO3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FMO3 Gene

Genomics for FMO3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FMO3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J171090 Promoter 0.7 EPDnew 600.7 +0.0 13 0.1 REST ATF3 YY1 RAD21 HNF4A HNF4G TAF1 SP1 FMO3 MIR1295B FMO2 ENSG00000231424
GH01J171138 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 22 +50.5 50452 5.4 CTCF PRDM10 REST TFE3 RXRB SP1 GABPA CEBPA ZNF561 ZBTB44 FMO3 MIR1295A FMO6P lnc-FMO2-1 FMO2 LOC105371611 ENSG00000231424
GH01J171157 Enhancer 0.9 Ensembl ENCODE 18 +69.3 69290 4.9 GATAD2A SP1 CEBPA MAFF ATF3 YY1 MAFK ZBTB33 TEAD1 KDM6A FMO3 MIR1295A FMO2 ENSG00000231424 lnc-FMO2-1 FMO6P LOC105371611
GH01J171126 Enhancer 0.7 Ensembl ENCODE dbSUPER 20.8 +36.5 36528 2.4 CEBPB ZFX FMO3 MIR1295A FMO2 FMO6P ENSG00000231424 LOC105371611
GH01J171185 Promoter/Enhancer 1 EPDnew FANTOM5 Ensembl 8.2 +96.0 96028 3.4 CTCF RFX5 FMO2 FMO3 MN309014 ENSG00000231424 FMO1 LOC105371611
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FMO3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FMO3

Top Transcription factor binding sites by QIAGEN in the FMO3 gene promoter:
  • c-Myc
  • C/EBPalpha
  • Gfi-1
  • HNF-1
  • HNF-1A
  • Max1
  • Pbx1a
  • RORalpha2
  • USF-1
  • USF1

Genomic Locations for FMO3 Gene

Genomic Locations for FMO3 Gene
chr1:171,090,873-171,117,819
(GRCh38/hg38)
Size:
26,947 bases
Orientation:
Plus strand
chr1:171,060,018-171,086,959
(GRCh37/hg19)
Size:
26,942 bases
Orientation:
Plus strand

Genomic View for FMO3 Gene

Genes around FMO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO3 Gene

Proteins for FMO3 Gene

  • Protein details for FMO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31513-FMO3_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 3
    Protein Accession:
    P31513
    Secondary Accessions:
    • B2R816
    • Q14854
    • Q8N5N5

    Protein attributes for FMO3 Gene

    Size:
    532 amino acids
    Molecular mass:
    60033 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for FMO3 Gene

Selected DME Specific Peptides for FMO3 Gene

P31513:
  • EEGRASIY
  • LRKEPVFND
  • GLGNSGCDIA
  • EVYFGPC
  • DIGGLWK
  • GARNAILTQW
  • VFDAVMVC
  • GKKESAVFD
  • SKEMMCF
  • ISSRSGSWVMSRVW
  • IGAKPNIP
  • FKGKCFHSRDYKEPG
  • FATGYSF
  • GGLWKFSDH
  • QMNARFKHENYGL
  • CLEEGLEPTCFE
  • AILTQWDR
  • PDDFPNFMH
  • LLKYIQF
  • EFTETSA
  • AVFDAVM
  • FGPCSPYQFRL
  • NIPWLFLTDP

Post-translational modifications for FMO3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMO3 Gene

Domains & Families for FMO3 Gene

Gene Families for FMO3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FMO3 Gene

InterPro:
Blocks:
  • Flavin-containing monooxygenase (FMO) signature
  • Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
  • Flavin-containing monooxygenase (FMO) 3 signature
ProtoNet:

Suggested Antigen Peptide Sequences for FMO3 Gene

GenScript: Design optimal peptide antigens:
  • Hepatic flavin-containing monooxygenase 3 (FMO3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31513

UniProtKB/Swiss-Prot:

FMO3_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO3: view

Function for FMO3 Gene

Molecular function for FMO3 Gene

UniProtKB/Swiss-Prot Function:
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+); Xref=Rhea:RHEA:24468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16269, ChEBI:CHEBI:17735, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.8; Evidence={ECO:0000269|PubMed:9536088};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NADPH + O2 + trimethylamine = H2O + NADP(+) + trimethylamine N-oxide; Xref=Rhea:RHEA:31979, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:15724, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58389; EC=1.14.13.148; Evidence={ECO:0000269|PubMed:9536088, ECO:0000269|PubMed:9776311};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:55928, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35812, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77092; EC=1.14.14.73; Evidence={ECO:0000269|PubMed:10759686};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:55924, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16664, ChEBI:CHEBI:16959, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.73; Evidence={ECO:0000269|PubMed:10759686};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(S)-nicotine + NADPH + O2 = H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide; Xref=Rhea:RHEA:58720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:59806, ChEBI:CHEBI:142660; Evidence={ECO:0000269|PubMed:30381441};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for trimethylamine (at pH 8.5) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=31 uM for trimethylamine (at pH 7.4 and 37 degrees Celsius) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=43 uM for benzydamine (at pH 7.4 and 37 degrees Celsius) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=55.7 uM for ethylenethiourea (at pH 8.5) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=71.8 uM for methimazole (at pH 8.5) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=150.1 uM for sulindac (at pH 8.5) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=248 uM for methyl p-tolyl sulfide (at pH 7.4 and 37 degrees Celsius) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949};
GENATLAS Biochemistry:
flavin containing monooxygenase 3,microsomal,major hepatic form

Enzyme Numbers (IUBMB) for FMO3 Gene

Phenotypes From GWAS Catalog for FMO3 Gene

Gene Ontology (GO) - Molecular Function for FMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA,IBA 21873635
GO:0004499 N,N-dimethylaniline monooxygenase activity IEA --
GO:0005515 protein binding IPI 25910212
GO:0016491 oxidoreductase activity IEA --
GO:0034899 trimethylamine monooxygenase activity IEA --
genes like me logo Genes that share ontologies with FMO3: view
genes like me logo Genes that share phenotypes with FMO3: view

Human Phenotype Ontology for FMO3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for FMO3 Gene

miRTarBase miRNAs that target FMO3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FMO3

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FMO3 Gene

Localization for FMO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO3 Gene

Microsome membrane. Single-pass membrane protein. Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMO3 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 4
plasma membrane 3
nucleus 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with FMO3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FMO3 Gene

Pathways & Interactions for FMO3 Gene

genes like me logo Genes that share pathways with FMO3: view

Gene Ontology (GO) - Biological Process for FMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FMO3: view

No data available for SIGNOR curated interactions for FMO3 Gene

Drugs & Compounds for FMO3 Gene

(40) Drugs for FMO3 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cimetidine Approved, Investigational Pharma Inhibitor, Inhibition, Enzyme, substrate H2 receptor antagonist 106
Olanzapine Approved, Investigational Pharma Antagonist, Agonist, Full agonist, Inverse agonist, Enzyme, substrate 442
Almotriptan Approved, Investigational Pharma Enzyme, substrate 14
Dasatinib Approved, Investigational Pharma Enzyme, substrate Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 324
Tamoxifen Approved Pharma Agonist, Antagonist, Enzyme, substrate TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 451

(17) Additional Compounds for FMO3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • NN-Dimethylaniline-N-oxide
  • Dimethylaniline N-oxide hydrochloride
874-52-2
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
N,N-Dimethylaniline
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-Dimethyl-N-phenylamine
  • N,N-Dimethylbenzenamine
121-69-7
Sulfide
  • S(2-)
  • Sulphide
  • Sulfanediide
  • Sulfur
18496-25-8
Tamoxifen N-oxide
genes like me logo Genes that share compounds with FMO3: view

Transcripts for FMO3 Gene

mRNA/cDNA for FMO3 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FMO3

Alternative Splicing Database (ASD) splice patterns (SP) for FMO3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for FMO3 Gene

GeneLoc Exon Structure for
FMO3

Expression for FMO3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FMO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO3 Gene

This gene is overexpressed in Liver (x33.9).

Protein differential expression in normal tissues from HIPED for FMO3 Gene

This gene is overexpressed in Gallbladder (31.6), Nasal epithelium (22.5), and Liver (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FMO3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FMO3

SOURCE GeneReport for Unigene cluster for FMO3 Gene:

Hs.445350

mRNA Expression by UniProt/SwissProt for FMO3 Gene:

P31513-FMO3_HUMAN
Tissue specificity: Liver.

Evidence on tissue expression from TISSUES for FMO3 Gene

  • Liver(4.9)
  • Nervous system(4.4)
  • Lung(4.3)
  • Kidney(2.3)
  • Urine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FMO3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • head
Thorax:
  • heart
  • heart valve
  • lung
Abdomen:
  • kidney
  • spleen
General:
  • blood
  • blood vessel
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with FMO3: view

No data available for Protein tissue co-expression partners for FMO3 Gene

Orthologs for FMO3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMO3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FMO3 30 31
  • 99.62 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FMO3 30 31
  • 86.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FMO3 30 31
  • 84.68 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fmo3 30 17 31
  • 83.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fmo3 30
  • 82.89 (n)
Oppossum
(Monodelphis domestica)
Mammalia FMO3 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 74 (a)
OneToMany
Chicken
(Gallus gallus)
Aves FMO3 31
  • 61 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 74 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fmo3 30
  • 63.26 (n)
Worm
(Caenorhabditis elegans)
Secernentea fmo-13 32
  • 42 (a)
fmo-15 32
  • 42 (a)
fmo-12 32
  • 40 (a)
fmo-11 32
  • 39 (a)
fmo-14 32
  • 36 (a)
C01H6.4 32
  • 34 (a)
Species where no ortholog for FMO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for FMO3 Gene

ENSEMBL:
Gene Tree for FMO3 (if available)
TreeFam:
Gene Tree for FMO3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FMO3: view image

Paralogs for FMO3 Gene

Paralogs for FMO3 Gene

(6) SIMAP similar genes for FMO3 Gene using alignment to 5 proteins:

  • FMO3_HUMAN
  • F5GZZ8_HUMAN
  • F5H261_HUMAN
  • V9GYP3_HUMAN
  • V9GZ60_HUMAN

Pseudogenes.org Pseudogenes for FMO3 Gene

genes like me logo Genes that share paralogs with FMO3: view

Variants for FMO3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FMO3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
713884 Conflicting Interpretations: Trimethylaminuria; not provided 171,117,373(+) C/T SYNONYMOUS_VARIANT
721720 Likely Benign: not provided 171,114,085(+) C/T SYNONYMOUS_VARIANT
725663 Benign: not provided 171,108,143(+) T/C SYNONYMOUS_VARIANT
748907 Likely Benign: not provided 171,108,179(+) G/A SYNONYMOUS_VARIANT
874042 Uncertain Significance: Trimethylaminuria 171,110,883(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for FMO3 Gene

Structural Variations from Database of Genomic Variants (DGV) for FMO3 Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV gain+loss 19812545
nsv1068705 CNV deletion 25765185

Variation tolerance for FMO3 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.99; 96.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FMO3 Gene

Human Gene Mutation Database (HGMD)
FMO3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FMO3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO3 Gene

Disorders for FMO3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for FMO3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
trimethylaminuria
  • tmau
primary trimethylaminuria
  • trimethylaminuria
familial adenomatous polyposis
  • fap
froelich syndrome
  • adiposogenital syndrome
choline deficiency disease
  • choline deficiency
- elite association - COSMIC cancer census association via MalaCards
Search FMO3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FMO3_HUMAN
  • Trimethylaminuria (TMAU) [MIM:602079]: Inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Affected individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine. {ECO:0000269 PubMed:10338091, ECO:0000269 PubMed:10479479, ECO:0000269 PubMed:11191884, ECO:0000269 PubMed:12893987, ECO:0000269 PubMed:17531949, ECO:0000269 PubMed:9536088}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for FMO3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
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No data available for Genatlas for FMO3 Gene

Publications for FMO3 Gene

  1. Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA. (PMID: 9417913) Dolphin CT … Phillips IR (Genomics 1997) 2 3 4 23
  2. Flavin-containing monooxygenase 3 polymorphisms in 13 ethnic populations from Europe, East Asia and sub-Saharan Africa: frequency and linkage analysis. (PMID: 19761368) Mao M … Dahl ML (Pharmacogenomics 2009) 3 23 41
  3. Analysis of flavin-containing monooxygenase 3 genotype data in populations administered the anti-schizophrenia agent olanzapine. (PMID: 19356079) Cashman JR … Braun A (Drug metabolism letters 2008) 3 23 41
  4. Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria. (PMID: 17531949) Yeung CK … Rettie AE (Archives of biochemistry and biophysics 2007) 3 4 23
  5. Genetic polymorphism of the flavin-containing monooxygenase 3 (FMO3) associated with trimethylaminuria (fish odor syndrome): observations from Japanese patients. (PMID: 17584019) Yamazaki H … Shimizu M (Current drug metabolism 2007) 3 23 41

Products for FMO3 Gene

Sources for FMO3 Gene