Aliases for FMO2 Gene
External Ids for FMO2 Gene
Previous GeneCards Identifiers for FMO2 Gene
This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
GeneCards Summary for FMO2 Gene
FMO2 (Flavin Containing Dimethylaniline Monoxygenase 2) is a Protein Coding gene. Diseases associated with FMO2 include Trimethylaminuria and Prader-Willi Syndrome. Among its related pathways are Busulfan Pathway, Pharmacodynamics and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and monooxygenase activity. An important paralog of this gene is FMO3.
UniProtKB/Swiss-Prot for FMO2 Gene
Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.