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Aliases for FMO1 Gene

Aliases for FMO1 Gene

  • Flavin Containing Monooxygenase 1 2 3 5
  • Fetal Hepatic Flavin-Containing Monooxygenase 1 3 4
  • Dimethylaniline Oxidase 1 3 4
  • FMO 1 3 4
  • Dimethylaniline Monooxygenase [N-Oxide-Forming] 1 3
  • Flavin-Containing Monooxygenase 1 (Fetal Liver) 3
  • EC 4

External Ids for FMO1 Gene

Previous GeneCards Identifiers for FMO1 Gene

  • GC01P168781
  • GC01P166846
  • GC01P167798
  • GC01P168457
  • GC01P167949
  • GC01P169484
  • GC01P142440

Summaries for FMO1 Gene

Entrez Gene Summary for FMO1 Gene

  • Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for FMO1 Gene

FMO1 (Flavin Containing Monooxygenase 1) is a Protein Coding gene. Diseases associated with FMO1 include Trimethylaminuria. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and monooxygenase activity. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot for FMO1 Gene

  • This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

Gene Wiki entry for FMO1 Gene

Additional gene information for FMO1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO1 Gene

Genomics for FMO1 Gene

GeneHancer (GH) Regulatory Elements for FMO1 Gene

Promoters and enhancers for FMO1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J171247 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 660.5 +5.1 5065 11.9 FOXA2 NFIB ZSCAN4 BMI1 RAD21 ZNF335 GLIS2 SCRT2 ZNF143 FOS FMO1 ENSG00000231424 LOC105371611 GC01M171253 ENSG00000206692 FMO2 FMO4
GH01J171284 Enhancer 0.9 FANTOM5 ENCODE 8.8 +37.7 37725 2.4 JUNB BATF RFX5 GATA3 IKZF1 EED FOS FOSL2 PRDM1 RUNX3 FMO4 FMO1 PRRC2C HMGB1P11
GH01J171263 Enhancer 0.4 ENCODE 10.8 +15.6 15589 2 ZFP3 ZNF133 FMO4 FMO1 GC01P171270 ENSG00000206692 GC01M171253
GH01J171295 Enhancer 0.2 ENCODE 8.8 +47.6 47612 0.3 FMO4 FMO1 HMGB1P11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FMO1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FMO1 gene promoter:
  • HEN1
  • AP-4
  • Nkx5-1
  • AML1a
  • C/EBPalpha
  • AP-1
  • HFH-3
  • FOXI1
  • Evi-1
  • Arnt

Genomic Locations for FMO1 Gene

Genomic Locations for FMO1 Gene
37,508 bases
Plus strand
37,480 bases
Plus strand

Genomic View for FMO1 Gene

Genes around FMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO1 Gene

Proteins for FMO1 Gene

  • Protein details for FMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 1
    Protein Accession:
    Secondary Accessions:
    • A8K248
    • B7Z3P4
    • Q5QPT2
    • Q9UJC2

    Protein attributes for FMO1 Gene

    532 amino acids
    Molecular mass:
    60311 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FMO1 Gene


neXtProt entry for FMO1 Gene

Post-translational modifications for FMO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FMO1 Gene

Domains & Families for FMO1 Gene

Gene Families for FMO1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for FMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FMO family.
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO1: view

Function for FMO1 Gene

Molecular function for FMO1 Gene

UniProtKB/Swiss-Prot Function:
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
UniProtKB/Swiss-Prot CatalyticActivity:
N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
GENATLAS Biochemistry:
flavin containing monooxygenase 1,microsomal,expressed in fetal liver

Enzyme Numbers (IUBMB) for FMO1 Gene

Phenotypes From GWAS Catalog for FMO1 Gene

Gene Ontology (GO) - Molecular Function for FMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IDA 19262426
GO:0004499 N,N-dimethylaniline monooxygenase activity TAS,IDA --
GO:0005515 protein binding IPI 25910212
GO:0016491 oxidoreductase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with FMO1: view

Phenotypes for FMO1 Gene

genes like me logo Genes that share phenotypes with FMO1: view

Animal Model Products

miRNA for FMO1 Gene

miRTarBase miRNAs that target FMO1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FMO1 Gene

Localization for FMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO1 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMO1 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 3
cytosol 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FMO1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FMO1 Gene

Pathways & Interactions for FMO1 Gene

genes like me logo Genes that share pathways with FMO1: view

Gene Ontology (GO) - Biological Process for FMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IDA 15144220
GO:0006805 xenobiotic metabolic process TAS --
GO:0006970 response to osmotic stress IEA --
GO:0009404 toxin metabolic process IDA 15144220
GO:0017144 drug metabolic process IEA --
genes like me logo Genes that share ontologies with FMO1: view

No data available for SIGNOR curated interactions for FMO1 Gene

Drugs & Compounds for FMO1 Gene

(19) Drugs for FMO1 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Enzyme, substrate TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 408
Vandetanib Approved April 2011 Pharma Enzyme, substrate VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Cevimeline Approved Pharma Enzyme, substrate Muscarinic receptor agonist 5
Cimetidine Approved, Investigational Pharma Inhibition, Inhibitor, Enzyme, substrate H2 receptor antagonist 81
Voriconazole Approved, Investigational Pharma Enzyme, substrate CYP51 inhibitor 134

(18) Additional Compounds for FMO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • NN-Dimethylaniline-N-oxide
  • Dimethylaniline N-oxide hydrochloride
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-Dimethyl-N-phenylamine
  • N,N-Dimethylbenzenamine
  • beta-Nicotinamide adenine dinucleotide phosphate
  • NADP+
  • Nicotinamide adenine dinucleotide phosphate
  • Oxidized nicotinamide-adenine dinucleotide phosphate
  • TPN
genes like me logo Genes that share compounds with FMO1: view

Transcripts for FMO1 Gene

Unigene Clusters for FMO1 Gene

Flavin containing monooxygenase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMO1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8: - -

Relevant External Links for FMO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FMO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO1 Gene

This gene is overexpressed in Kidney - Cortex (x14.5) and Minor Salivary Gland (x4.8).

Protein differential expression in normal tissues from HIPED for FMO1 Gene

This gene is overexpressed in Kidney (37.7), Fetal Liver (11.6), and Fetal gut (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FMO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FMO1 Gene:


SOURCE GeneReport for Unigene cluster for FMO1 Gene:


mRNA Expression by UniProt/SwissProt for FMO1 Gene:

Tissue specificity: Expressed mainly in fetal and adult liver.

Evidence on tissue expression from TISSUES for FMO1 Gene

  • Liver(4.5)
  • Intestine(4.2)
  • Kidney(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FMO1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FMO1 Gene

Orthologs for FMO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FMO1 34 33
  • 99.5 (n)
(Canis familiaris)
Mammalia FMO1 34 33
  • 89.6 (n)
(Bos Taurus)
Mammalia FMO1 34 33
  • 88.1 (n)
(Mus musculus)
Mammalia Fmo1 16 34 33
  • 84.71 (n)
(Rattus norvegicus)
Mammalia Fmo1 33
  • 84.02 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fmo2 33
  • 59.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fmo-2 35
  • 36 (a)
(Caenorhabditis elegans)
Secernentea fmo-12 35
  • 41 (a)
fmo-15 35
  • 39 (a)
fmo-13 35
  • 38 (a)
Species where no ortholog for FMO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FMO1 Gene

Gene Tree for FMO1 (if available)
Gene Tree for FMO1 (if available)
Evolutionary constrained regions (ECRs) for FMO1: view image

Paralogs for FMO1 Gene

Paralogs for FMO1 Gene

(6) SIMAP similar genes for FMO1 Gene using alignment to 4 proteins:

  • B7Z3P4_HUMAN
  • L8E7C3_HUMAN
genes like me logo Genes that share paralogs with FMO1: view

Variants for FMO1 Gene

Sequence variations from dbSNP and Humsavar for FMO1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000024256 -- 171,263,734(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000268684 -- 171,247,516(+) G/A upstream_transcript_variant
rs1000421411 -- 171,277,849(+) A/T intron_variant
rs1000451140 -- 171,261,600(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000473138 -- 171,264,569(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FMO1 Gene

Variant ID Type Subtype PubMed ID
dgv117e212 CNV loss 25503493
esv28731 CNV gain+loss 19812545
esv3578269 CNV loss 25503493
nsv1144416 CNV deletion 24896259
nsv831882 CNV loss 17160897
nsv946500 CNV duplication 23825009

Variation tolerance for FMO1 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FMO1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO1 Gene

Disorders for FMO1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FMO1 Gene - From: HGMD, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • tmau
- elite association - COSMIC cancer census association via MalaCards
Search FMO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FMO1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FMO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FMO1 Gene

Publications for FMO1 Gene

  1. Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis. (PMID: 17127561) Cereda C … Ceroni M (Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2006) 3 22 44 58
  2. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PMID: 12527699) Furnes B … Schlenk D (Drug metabolism and disposition: the biological fate of chemicals 2003) 3 4 22 58
  3. Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1). (PMID: 1712018) Dolphin C … Phillips IR (The Journal of biological chemistry 1991) 3 4 22 58
  4. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 44 58
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58

Products for FMO1 Gene

Sources for FMO1 Gene

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