Aliases for FMNL3 Gene
External Ids for FMNL3 Gene
Previous GeneCards Identifiers for FMNL3 Gene
The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for FMNL3 Gene
FMNL3 (Formin Like 3) is a Protein Coding gene. Diseases associated with FMNL3 include Malignant Breast Melanoma and Cerebral Amyloid Angiopathy, Itm2b-Related, 2. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include binding and Rho GTPase binding. An important paralog of this gene is FMNL2.
UniProtKB/Swiss-Prot Summary for FMNL3 Gene
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.