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Aliases for FMNL3 Gene

Aliases for FMNL3 Gene

  • Formin Like 3 2 3 5
  • Formin Homology 2 Domain-Containing Protein 3 3 4
  • FHOD3 3 4
  • WBP-3 3 4
  • FRL2 3 4
  • WBP3 3 4
  • WW Domain Binding Protein 3 3
  • WW Domain-Binding Protein 3 4
  • Formin-Like Protein 3 3
  • Formin-Like 3 2
  • KIAA2014 4

External Ids for FMNL3 Gene

Previous GeneCards Identifiers for FMNL3 Gene

  • GC12M048317
  • GC12M050031
  • GC12M047063

Summaries for FMNL3 Gene

Entrez Gene Summary for FMNL3 Gene

  • The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for FMNL3 Gene

FMNL3 (Formin Like 3) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include binding and Rho GTPase binding. An important paralog of this gene is FMNL2.

UniProtKB/Swiss-Prot for FMNL3 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.

Gene Wiki entry for FMNL3 Gene

Additional gene information for FMNL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMNL3 Gene

Genomics for FMNL3 Gene

GeneHancer (GH) Regulatory Elements for FMNL3 Gene

Promoters and enhancers for FMNL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I049702 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 564.9 +3.0 2984 6.1 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF213 FMNL3 FAM186B DDX23 CCNT1 LOC390314 LMBR1L KMT2D LIMA1 ENSG00000257964 CERS5
GH12I049621 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.5 +84.5 84463 3.6 PKNOX1 CLOCK MLX ARID4B SIN3A IRF4 YY1 POLR2B ZNF143 FOS PRPF40B FMNL3 RNU6-834P TMBIM6 MCRS1 C1QL4 HIGD1AP9 PIR31660
GH12I049669 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +35.2 35195 7 HDGF PKNOX1 SMAD1 ATF1 FOXA2 ARNT TCF12 ZNF766 ZNF143 ATF7 FMNL3 TMBIM6 NCKAP5L FAM186B RNU6-834P TUBA1C ENSG00000257464 SPATS2 MCRS1 TUBA1A
GH12I049661 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.7 +44.4 44397 4.9 HDGF ATF1 PKNOX1 ZNF133 IRF4 ETS1 ZNF121 ZNF766 ATF7 RUNX3 FMNL3 MCRS1 TMBIM6 LOC390314 SMARCD1 LMBR1L KANSL2 DDX23 KMT2D TUBA1C
GH12I049740 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.5 -34.8 -34753 4.3 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 TMBIM6 PIR62478 LMBR1L DDX23 KMT2D SMARCD1 LOC390314 ENSG00000257298 BCDIN3D FAM186B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FMNL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FMNL3 gene promoter:

Genomic Locations for FMNL3 Gene

Genomic Locations for FMNL3 Gene
chr12:49,636,499-49,708,165
(GRCh38/hg38)
Size:
71,667 bases
Orientation:
Minus strand
chr12:50,031,724-50,101,948
(GRCh37/hg19)

Genomic View for FMNL3 Gene

Genes around FMNL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMNL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMNL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMNL3 Gene

Proteins for FMNL3 Gene

  • Protein details for FMNL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVF7-FMNL3_HUMAN
    Recommended name:
    Formin-like protein 3
    Protein Accession:
    Q8IVF7
    Secondary Accessions:
    • B0JZA7
    • Q6ZRJ1

    Protein attributes for FMNL3 Gene

    Size:
    1028 amino acids
    Molecular mass:
    117213 Da
    Quaternary structure:
    • Interacts with SRGAP2 (via SH3 domain).
    SequenceCaution:
    • Sequence=BAC23110.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FMNL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMNL3 Gene

Post-translational modifications for FMNL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FMNL3 Gene

Domains & Families for FMNL3 Gene

Gene Families for FMNL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FMNL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVF7

UniProtKB/Swiss-Prot:

FMNL3_HUMAN :
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Belongs to the formin homology family.
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with FMNL3: view

Function for FMNL3 Gene

Molecular function for FMNL3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.

Phenotypes From GWAS Catalog for FMNL3 Gene

Gene Ontology (GO) - Molecular Function for FMNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0017048 Rho GTPase binding IEA --
GO:0032794 GTPase activating protein binding ISS --
genes like me logo Genes that share ontologies with FMNL3: view
genes like me logo Genes that share phenotypes with FMNL3: view

Animal Models for FMNL3 Gene

MGI Knock Outs for FMNL3:

Animal Model Products

miRNA for FMNL3 Gene

miRTarBase miRNAs that target FMNL3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FMNL3 Gene

Localization for FMNL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMNL3 Gene

Cytoplasm. Cell membrane; Lipid-anchor. Note=Enriched in lamellipodia.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMNL3 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
mitochondrion 3
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FMNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 21834987
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA,IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FMNL3: view

Pathways & Interactions for FMNL3 Gene

genes like me logo Genes that share pathways with FMNL3: view

Pathways by source for FMNL3 Gene

Gene Ontology (GO) - Biological Process for FMNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007010 cytoskeleton organization IMP,IEA 21834987
GO:0007275 multicellular organism development IEA --
GO:0008360 regulation of cell shape IMP,IEA 21834987
GO:0016043 cellular component organization IEA --
genes like me logo Genes that share ontologies with FMNL3: view

No data available for SIGNOR curated interactions for FMNL3 Gene

Drugs & Compounds for FMNL3 Gene

No Compound Related Data Available

Transcripts for FMNL3 Gene

Unigene Clusters for FMNL3 Gene

Formin-like 3:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMNL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2:
SP3:
SP4: -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for FMNL3 Gene

GeneLoc Exon Structure for
FMNL3
ECgene alternative splicing isoforms for
FMNL3

Expression for FMNL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FMNL3 Gene

Protein differential expression in normal tissues from HIPED for FMNL3 Gene

This gene is overexpressed in Bone (13.1), Fetal gut (12.1), Pancreas (10.5), Placenta (6.4), and Fetal heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FMNL3 Gene



Protein tissue co-expression partners for FMNL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of FMNL3 Gene:

FMNL3

SOURCE GeneReport for Unigene cluster for FMNL3 Gene:

Hs.179838

mRNA Expression by UniProt/SwissProt for FMNL3 Gene:

Q8IVF7-FMNL3_HUMAN
Tissue specificity: Expressed in endothelial cells.

Evidence on tissue expression from TISSUES for FMNL3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with FMNL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FMNL3 Gene

Orthologs for FMNL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FMNL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMNL3 33 34
  • 98.52 (n)
dog
(Canis familiaris)
Mammalia FMNL3 33 34
  • 92.17 (n)
cow
(Bos Taurus)
Mammalia FMNL3 33 34
  • 91.89 (n)
rat
(Rattus norvegicus)
Mammalia Fmnl3 33
  • 89.93 (n)
mouse
(Mus musculus)
Mammalia Fmnl3 33 16 34
  • 89.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FMNL3 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FMNL3 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fmnl3 33
  • 74.15 (n)
Str.12987 33
zebrafish
(Danio rerio)
Actinopterygii fmnl3 34
  • 75 (a)
OneToOne
wufa31c06 33
fruit fly
(Drosophila melanogaster)
Insecta CG32138 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea frl-1 34
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNR1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2508 33
Species where no ortholog for FMNL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FMNL3 Gene

ENSEMBL:
Gene Tree for FMNL3 (if available)
TreeFam:
Gene Tree for FMNL3 (if available)

Paralogs for FMNL3 Gene

Paralogs for FMNL3 Gene

(4) SIMAP similar genes for FMNL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FMNL3: view

Variants for FMNL3 Gene

Sequence variations from dbSNP and Humsavar for FMNL3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000008830 -- 49,693,460(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000016086 -- 49,637,274(-) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000055983 -- 49,641,230(-) G/A 3_prime_UTR_variant
rs1000086690 -- 49,641,547(-) C/T 3_prime_UTR_variant
rs1000140851 -- 49,668,894(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FMNL3 Gene

Variant ID Type Subtype PubMed ID
esv25495 CNV loss 19812545
esv2674876 CNV deletion 23128226
esv2745865 CNV deletion 23290073
esv3549187 CNV deletion 23714750
esv3629465 CNV loss 21293372
nsv832406 CNV loss 17160897
nsv952177 CNV deletion 24416366

Variation tolerance for FMNL3 Gene

Residual Variation Intolerance Score: 7.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FMNL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FMNL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMNL3 Gene

Disorders for FMNL3 Gene

Additional Disease Information for FMNL3

No disorders were found for FMNL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FMNL3 Gene

Publications for FMNL3 Gene

  1. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PMID: 12684686) Katoh M … Katoh M (International journal of oncology 2003) 2 3 4 22 58
  2. The formin FMNL3 is a cytoskeletal regulator of angiogenesis. (PMID: 22275430) Hetheridge C … Mellor H (Journal of cell science 2012) 3 4 58
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. MicroRNA-127 is a tumor suppressor in human esophageal squamous cell carcinoma through the regulation of oncogene FMNL3. (PMID: 27645894) Gao X … Wu H (European journal of pharmacology 2016) 3 58

Products for FMNL3 Gene

Sources for FMNL3 Gene

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