This locus represents naturally occurring readthrough transcription between the neighboring C7orf55 (chromosome 7 open reading frame 55) and LUC7L2 (LUC7-like 2) genes on chromosome 7. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2012] See more...

Aliases for FMC1-LUC7L2 Gene

Aliases for FMC1-LUC7L2 Gene

  • FMC1-LUC7L2 Readthrough 2 3 5
  • C7orf55-LUC7L2 Readthrough 2 3
  • Formation Of Mitochondrial Complex V Assembly Factor 1 Homolog 3
  • ATP Synthase Assembly Factor FMC1, Mitochondrial 3
  • Putative RNA-Binding Protein Luc7-Like 2 13
  • C7orf55-LUC7L2 Protein 3
  • Protein FMC1 Homolog 3
  • C7orf55-LUC7L2 3
  • C7orf55 3
  • FMC1 3

External Ids for FMC1-LUC7L2 Gene

Previous HGNC Symbols for FMC1-LUC7L2 Gene

  • C7orf55-LUC7L2

Previous GeneCards Identifiers for FMC1-LUC7L2 Gene

  • GC07P139361
  • GC07P139363
  • GC07P139365

Summaries for FMC1-LUC7L2 Gene

Entrez Gene Summary for FMC1-LUC7L2 Gene

  • This locus represents naturally occurring readthrough transcription between the neighboring C7orf55 (chromosome 7 open reading frame 55) and LUC7L2 (LUC7-like 2) genes on chromosome 7. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2012]

GeneCards Summary for FMC1-LUC7L2 Gene

FMC1-LUC7L2 (FMC1-LUC7L2 Readthrough) is a Protein Coding gene. An important paralog of this gene is LUC7L2.

Additional gene information for FMC1-LUC7L2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FMC1-LUC7L2 Gene

Genomics for FMC1-LUC7L2 Gene

GeneHancer (GH) Regulatory Elements for FMC1-LUC7L2 Gene

Promoters and enhancers for FMC1-LUC7L2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FMC1-LUC7L2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FMC1-LUC7L2

Genomic Locations for FMC1-LUC7L2 Gene

Genomic Locations for FMC1-LUC7L2 Gene
chr7:139,341,132-139,423,457
(GRCh38/hg38)
Size:
82,326 bases
Orientation:
Plus strand

Genomic View for FMC1-LUC7L2 Gene

Genes around FMC1-LUC7L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMC1-LUC7L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMC1-LUC7L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMC1-LUC7L2 Gene

Proteins for FMC1-LUC7L2 Gene

  • Protein details for FMC1-LUC7L2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYJ8-A0A0A6YYJ8_HUMAN
    Recommended name:
    Putative RNA-binding protein Luc7-like 2
    Protein Accession:
    A0A0A6YYJ8

    Protein attributes for FMC1-LUC7L2 Gene

    Size:
    458 amino acids
    Molecular mass:
    54224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FMC1-LUC7L2 Gene

Post-translational modifications for FMC1-LUC7L2 Gene

No Post-translational modifications

Other Protein References for FMC1-LUC7L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FMC1-LUC7L2 Gene

Domains & Families for FMC1-LUC7L2 Gene

Gene Families for FMC1-LUC7L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FMC1-LUC7L2 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with FMC1-LUC7L2: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FMC1-LUC7L2 Gene

Function for FMC1-LUC7L2 Gene

Phenotypes From GWAS Catalog for FMC1-LUC7L2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FMC1-LUC7L2 Gene

Localization for FMC1-LUC7L2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FMC1-LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005685 U1 snRNP IEA --
genes like me logo Genes that share ontologies with FMC1-LUC7L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FMC1-LUC7L2 Gene

Pathways & Interactions for FMC1-LUC7L2 Gene

PathCards logo

SuperPathways for FMC1-LUC7L2 Gene

No Data Available

Interacting Proteins for FMC1-LUC7L2 Gene

;

Gene Ontology (GO) - Biological Process for FMC1-LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IEA --
genes like me logo Genes that share ontologies with FMC1-LUC7L2: view

No data available for Pathways by source and SIGNOR curated interactions for FMC1-LUC7L2 Gene

Drugs & Compounds for FMC1-LUC7L2 Gene

No Compound Related Data Available

Transcripts for FMC1-LUC7L2 Gene

mRNA/cDNA for FMC1-LUC7L2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FMC1-LUC7L2 Gene

No ASD Table

Relevant External Links for FMC1-LUC7L2 Gene

GeneLoc Exon Structure for
FMC1-LUC7L2

Expression for FMC1-LUC7L2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FMC1-LUC7L2

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FMC1-LUC7L2 Gene

Orthologs for FMC1-LUC7L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FMC1-LUC7L2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LUC7L2 31
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Luc7l2 31
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves LUC7L2 31
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 86 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii C1H7orf55 31
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7564 31
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.8 31
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 31
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 58 (a)
OneToMany
Species where no ortholog for FMC1-LUC7L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FMC1-LUC7L2 Gene

ENSEMBL:
Gene Tree for FMC1-LUC7L2 (if available)
TreeFam:
Gene Tree for FMC1-LUC7L2 (if available)

Paralogs for FMC1-LUC7L2 Gene

Paralogs for FMC1-LUC7L2 Gene

genes like me logo Genes that share paralogs with FMC1-LUC7L2: view

Variants for FMC1-LUC7L2 Gene

Additional dbSNP identifiers (rs#s) for FMC1-LUC7L2 Gene

Structural Variations from Database of Genomic Variants (DGV) for FMC1-LUC7L2 Gene

Variant ID Type Subtype PubMed ID
esv2292861 CNV deletion 18987734
esv2371727 CNV deletion 18987734
esv2735212 CNV deletion 23290073
esv2735231 CNV deletion 23290073
esv3572165 CNV loss 25503493
esv3572166 CNV loss 25503493
nsv1110976 OTHER inversion 24896259
nsv1117762 CNV deletion 24896259
nsv1137296 CNV deletion 24896259
nsv478581 CNV novel sequence insertion 20440878

Variation tolerance for FMC1-LUC7L2 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FMC1-LUC7L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FMC1-LUC7L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FMC1-LUC7L2 Gene

Disorders for FMC1-LUC7L2 Gene

No disorders were found for FMC1-LUC7L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for FMC1-LUC7L2 Gene

Publications for FMC1-LUC7L2 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 13 54
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 54
  3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 54
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 54
  5. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3 54

Products for FMC1-LUC7L2 Gene

Sources for FMC1-LUC7L2 Gene