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Aliases for FLYWCH2 Gene

Aliases for FLYWCH2 Gene

  • FLYWCH Family Member 2 2 3 5

External Ids for FLYWCH2 Gene

Previous GeneCards Identifiers for FLYWCH2 Gene

  • GC16P002874
  • GC16P002934

Summaries for FLYWCH2 Gene

GeneCards Summary for FLYWCH2 Gene

FLYWCH2 (FLYWCH Family Member 2) is a Protein Coding gene. An important paralog of this gene is FLYWCH1.

Additional gene information for FLYWCH2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLYWCH2 Gene

Genomics for FLYWCH2 Gene

GeneHancer (GH) Regulatory Elements for FLYWCH2 Gene

Promoters and enhancers for FLYWCH2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I002881 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 573.8 +0.3 347 2.7 HDGF PKNOX1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B FLYWCH2 TBL3 FLYWCH1 ENSG00000261938 CREBBP ZNF598 TIGD7 SNHG19 ZNF597 CLUAP1
GH16I002893 Promoter 0.5 EPDnew 563.5 +11.0 10977 0.1 FLYWCH2 FLYWCH1
GH16I002266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.4 -614.6 -614592 3.2 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 RNPS1 LOC106660606 GC16M002266 GC16M002267 ZNF263 ENSG00000260051 ENSG00000261505 E4F1 AMDHD2 TSC2
GH16I002911 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.9 +29.5 29516 2.5 HDGF FOXA2 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 E2F8 FLYWCH1 FLYWCH2 PRSS27 LOC101929566 PRSS22 GC16M002924
GH16I002903 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.5 +22.8 22803 4 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF597 CREBBP TBL3 FLYWCH2 SRRM2 ENSG00000261938 TIGD7 ZNF598 FLYWCH1 ZNF263
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FLYWCH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FLYWCH2 gene promoter:

Genomic Locations for FLYWCH2 Gene

Genomic Locations for FLYWCH2 Gene
chr16:2,882,804-2,899,382
(GRCh38/hg38)
Size:
16,579 bases
Orientation:
Plus strand
chr16:2,933,187-2,949,383
(GRCh37/hg19)

Genomic View for FLYWCH2 Gene

Genes around FLYWCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLYWCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLYWCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLYWCH2 Gene

Proteins for FLYWCH2 Gene

  • Protein details for FLYWCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CP2-FWCH2_HUMAN
    Recommended name:
    FLYWCH family member 2
    Protein Accession:
    Q96CP2

    Protein attributes for FLYWCH2 Gene

    Size:
    140 amino acids
    Molecular mass:
    14564 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FLYWCH2 Gene

Post-translational modifications for FLYWCH2 Gene

No Post-translational modifications

Other Protein References for FLYWCH2 Gene

No data available for DME Specific Peptides for FLYWCH2 Gene

Domains & Families for FLYWCH2 Gene

Gene Families for FLYWCH2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FLYWCH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FLYWCH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FLYWCH2: view

No data available for UniProtKB/Swiss-Prot for FLYWCH2 Gene

Function for FLYWCH2 Gene

Phenotypes From GWAS Catalog for FLYWCH2 Gene

Gene Ontology (GO) - Molecular Function for FLYWCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with FLYWCH2: view

Animal Model Products

miRNA for FLYWCH2 Gene

miRTarBase miRNAs that target FLYWCH2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FLYWCH2 Gene

Localization for FLYWCH2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLYWCH2 gene
Compartment Confidence
nucleus 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FLYWCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with FLYWCH2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FLYWCH2 Gene

Pathways & Interactions for FLYWCH2 Gene

SuperPathways for FLYWCH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FLYWCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FLYWCH2: view

No data available for Pathways by source and SIGNOR curated interactions for FLYWCH2 Gene

Drugs & Compounds for FLYWCH2 Gene

No Compound Related Data Available

Transcripts for FLYWCH2 Gene

Unigene Clusters for FLYWCH2 Gene

FLYWCH family member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLYWCH2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for FLYWCH2 Gene

GeneLoc Exon Structure for
FLYWCH2
ECgene alternative splicing isoforms for
FLYWCH2

Expression for FLYWCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLYWCH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FLYWCH2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.3), CD8 Tcells (9.0), and Blymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FLYWCH2 Gene



Protein tissue co-expression partners for FLYWCH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FLYWCH2 Gene:

FLYWCH2

SOURCE GeneReport for Unigene cluster for FLYWCH2 Gene:

Hs.534525
genes like me logo Genes that share expression patterns with FLYWCH2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FLYWCH2 Gene

Orthologs for FLYWCH2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FLYWCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLYWCH2 34 33
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FLYWCH2 34 33
  • 84.59 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Flywch2 34 16 33
  • 83.91 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flywch2 33
  • 82.5 (n)
cow
(Bos Taurus)
Mammalia FLYWCH2 34 33
  • 82.18 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
OneToMany
Species where no ortholog for FLYWCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FLYWCH2 Gene

ENSEMBL:
Gene Tree for FLYWCH2 (if available)
TreeFam:
Gene Tree for FLYWCH2 (if available)

Paralogs for FLYWCH2 Gene

Paralogs for FLYWCH2 Gene

(1) SIMAP similar genes for FLYWCH2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FLYWCH2: view

Variants for FLYWCH2 Gene

Sequence variations from dbSNP and Humsavar for FLYWCH2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000044314 -- 2,891,551(+) C/A/G intron_variant
rs1000048971 -- 2,888,365(+) A/G intron_variant
rs1000115750 -- 2,890,788(+) A/T intron_variant
rs1000124235 -- 2,897,277(+) G/A intron_variant
rs1000344981 -- 2,882,769(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FLYWCH2 Gene

Variant ID Type Subtype PubMed ID
nsv952906 CNV deletion 24416366
nsv833124 CNV loss 17160897
nsv436210 CNV deletion 17901297
esv3637640 CNV loss 21293372
esv2673165 CNV deletion 23128226
esv2666650 CNV deletion 23128226

Variation tolerance for FLYWCH2 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FLYWCH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLYWCH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLYWCH2 Gene

Disorders for FLYWCH2 Gene

Additional Disease Information for FLYWCH2

No disorders were found for FLYWCH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FLYWCH2 Gene

Publications for FLYWCH2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. (PMID: 26752685) Scholz CC … Taylor CT (PLoS biology 2016) 3 58
  4. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for FLYWCH2 Gene

Sources for FLYWCH2 Gene

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