Aliases for FLYWCH1 Gene

Aliases for FLYWCH1 Gene

  • FLYWCH-Type Zinc Finger 1 2 3 5
  • FLYWCH-Type Zinc Finger-Containing Protein 1 3 4
  • KIAA1552 4

External Ids for FLYWCH1 Gene

Previous GeneCards Identifiers for FLYWCH1 Gene

  • GC16P002902
  • GC16P002961
  • GC16P002935

Summaries for FLYWCH1 Gene

GeneCards Summary for FLYWCH1 Gene

FLYWCH1 (FLYWCH-Type Zinc Finger 1) is a Protein Coding gene. Diseases associated with FLYWCH1 include Parenchymatous Neurosyphilis and Tertiary Neurosyphilis. An important paralog of this gene is FLYWCH2.

Additional gene information for FLYWCH1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FLYWCH1 Gene

Genomics for FLYWCH1 Gene

GeneHancer (GH) Regulatory Elements for FLYWCH1 Gene

Promoters and enhancers for FLYWCH1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FLYWCH1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FLYWCH1 gene promoter:
  • CREB
  • deltaCREB
  • Elk-1
  • HSF1 (long)
  • HSF1short
  • LUN-1
  • Spz1

Genomic Locations for FLYWCH1 Gene

Genomic Locations for FLYWCH1 Gene
chr16:2,911,921-2,951,208
(GRCh38/hg38)
Size:
39,288 bases
Orientation:
Plus strand
chr16:2,961,938-3,001,209
(GRCh37/hg19)
Size:
39,272 bases
Orientation:
Plus strand

Genomic View for FLYWCH1 Gene

Genes around FLYWCH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLYWCH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLYWCH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLYWCH1 Gene

Proteins for FLYWCH1 Gene

  • Protein details for FLYWCH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VC44-FWCH1_HUMAN
    Recommended name:
    FLYWCH-type zinc finger-containing protein 1
    Protein Accession:
    Q4VC44
    Secondary Accessions:
    • D3DUA1
    • Q6ZSQ1
    • Q8WV62
    • Q9BQG6
    • Q9BUS5
    • Q9HCM0

    Protein attributes for FLYWCH1 Gene

    Size:
    716 amino acids
    Molecular mass:
    80108 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13378.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FLYWCH1 Gene

    Alternative splice isoforms for FLYWCH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLYWCH1 Gene

Post-translational modifications for FLYWCH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FLYWCH1 Gene

Domains & Families for FLYWCH1 Gene

Gene Families for FLYWCH1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FLYWCH1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FLYWCH1 Gene

GenScript: Design optimal peptide antigens:
  • FLYWCH-type zinc finger-containing protein 1 (FWCH1_HUMAN)
genes like me logo Genes that share domains with FLYWCH1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FLYWCH1 Gene

Function for FLYWCH1 Gene

Phenotypes From GWAS Catalog for FLYWCH1 Gene

Gene Ontology (GO) - Molecular Function for FLYWCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FLYWCH1: view
genes like me logo Genes that share phenotypes with FLYWCH1: view

Animal Models for FLYWCH1 Gene

MGI Knock Outs for FLYWCH1:
  • Flywch1 Flywch1<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLYWCH1 Gene

Localization for FLYWCH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLYWCH1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLYWCH1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FLYWCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with FLYWCH1: view

Pathways & Interactions for FLYWCH1 Gene

PathCards logo

SuperPathways for FLYWCH1 Gene

No Data Available

Interacting Proteins for FLYWCH1 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q4VC44-FWCH1_HUMAN ENSP00000399938 for FLYWCH1 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for FLYWCH1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FLYWCH1 Gene

Drugs & Compounds for FLYWCH1 Gene

No Compound Related Data Available

Transcripts for FLYWCH1 Gene

mRNA/cDNA for FLYWCH1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLYWCH1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6: -

Relevant External Links for FLYWCH1 Gene

GeneLoc Exon Structure for
FLYWCH1
ECgene alternative splicing isoforms for
FLYWCH1

Expression for FLYWCH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLYWCH1 Gene

Protein differential expression in normal tissues from HIPED for FLYWCH1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FLYWCH1 Gene



Protein tissue co-expression partners for FLYWCH1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FLYWCH1 Gene:

FLYWCH1

SOURCE GeneReport for Unigene cluster for FLYWCH1 Gene:

Hs.655321

Evidence on tissue expression from TISSUES for FLYWCH1 Gene

  • Eye(4.5)
  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with FLYWCH1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FLYWCH1 Gene

Orthologs for FLYWCH1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FLYWCH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLYWCH1 33 32
  • 98.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FLYWCH1 33 32
  • 83.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FLYWCH1 33 32
  • 83.68 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flywch1 32
  • 79.06 (n)
mouse
(Mus musculus)
Mammalia Flywch1 17 33 32
  • 76.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 24 (a)
OneToMany
Species where no ortholog for FLYWCH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FLYWCH1 Gene

ENSEMBL:
Gene Tree for FLYWCH1 (if available)
TreeFam:
Gene Tree for FLYWCH1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FLYWCH1: view image

Paralogs for FLYWCH1 Gene

Paralogs for FLYWCH1 Gene

(1) SIMAP similar genes for FLYWCH1 Gene using alignment to 8 proteins:

  • FWCH1_HUMAN
  • I3L0R3_HUMAN
  • I3L188_HUMAN
  • I3L1A7_HUMAN
  • I3L231_HUMAN
  • I3L287_HUMAN
  • I3L4V9_HUMAN
  • J3KNW1_HUMAN

Pseudogenes.org Pseudogenes for FLYWCH1 Gene

genes like me logo Genes that share paralogs with FLYWCH1: view

Variants for FLYWCH1 Gene

Sequence variations from dbSNP and Humsavar for FLYWCH1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000041829 -- 2,917,957(+) C/A intron_variant
rs1000186042 -- 2,951,333(+) CCTCCT/CCT downstream_transcript_variant
rs1000240596 -- 2,917,836(+) G/C/T intron_variant
rs1000280817 -- 2,932,327(+) G/T intron_variant
rs1000297428 -- 2,917,529(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FLYWCH1 Gene

Variant ID Type Subtype PubMed ID
esv2667921 CNV deletion 23128226
esv2671794 CNV deletion 23128226
esv2750387 CNV deletion 23290073
esv29676 CNV loss 19812545
esv29718 CNV gain 19812545
esv3637641 CNV loss 21293372
esv3637642 CNV loss 21293372
esv3637643 CNV loss 21293372
esv3637644 CNV loss 21293372
nsv1070314 CNV deletion 25765185
nsv509588 CNV insertion 20534489
nsv510673 CNV deletion 20534489
nsv571245 CNV loss 21841781
nsv571246 CNV loss 21841781
nsv571247 CNV loss 21841781
nsv819421 CNV loss 19587683
nsv827524 CNV loss 20364138
nsv833124 CNV loss 17160897
nsv952906 CNV deletion 24416366
nsv977105 CNV duplication 23825009

Variation tolerance for FLYWCH1 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FLYWCH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLYWCH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLYWCH1 Gene

Disorders for FLYWCH1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FLYWCH1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parenchymatous neurosyphilis
tertiary neurosyphilis
  • late neurosyphilis
orthostatic intolerance
  • floppy mitral valve
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FLYWCH1

genes like me logo Genes that share disorders with FLYWCH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLYWCH1 Gene

Publications for FLYWCH1 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 56
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. (PMID: 29656893) Gupta R … Choudhary C (Cell 2018) 3 56
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 56

Products for FLYWCH1 Gene

Sources for FLYWCH1 Gene