Aliases for FLVCR2 Gene
External Ids for FLVCR2 Gene
Previous HGNC Symbols for FLVCR2 Gene
Previous GeneCards Identifiers for FLVCR2 Gene
This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]
GeneCards Summary for FLVCR2 Gene
FLVCR2 (FLVCR Heme Transporter 2) is a Protein Coding gene. Diseases associated with FLVCR2 include Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome and Hydranencephaly. Gene Ontology (GO) annotations related to this gene include heme binding and heme transporter activity. An important paralog of this gene is FLVCR1.
UniProtKB/Swiss-Prot Summary for FLVCR2 Gene
Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.