Aliases for FLT3LG Gene
External Ids for FLT3LG Gene
Previous GeneCards Identifiers for FLT3LG Gene
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
GeneCards Summary for FLT3LG Gene
FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) is a Protein Coding gene. Diseases associated with FLT3LG include Aplastic Anemia and Severe Combined Immunodeficiency. Among its related pathways are CNTF Signaling and Hematopoietic cell lineage. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cytokine activity.
UniProtKB/Swiss-Prot Summary for FLT3LG Gene
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.