Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawal... See more...

Aliases for FLT3LG Gene

Aliases for FLT3LG Gene

  • Fms Related Receptor Tyrosine Kinase 3 Ligand 2 3
  • Fms-Related Tyrosine Kinase 3 Ligand 2 3 4
  • Fms Related Tyrosine Kinase 3 Ligand 2 3 5
  • Flt3 Ligand 3 4
  • SL Cytokine 4
  • FLG3L 3
  • FLT3L 3
  • Flt3L 4
  • FL 3

External Ids for FLT3LG Gene

Previous GeneCards Identifiers for FLT3LG Gene

  • GC19P050635
  • GC19P050345
  • GC19P054653
  • GC19P054669
  • GC19P049977
  • GC19P046355

Summaries for FLT3LG Gene

Entrez Gene Summary for FLT3LG Gene

  • Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

GeneCards Summary for FLT3LG Gene

FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) is a Protein Coding gene. Diseases associated with FLT3LG include Aplastic Anemia and Severe Combined Immunodeficiency. Among its related pathways are Hematopoietic cell lineage and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cytokine activity.

UniProtKB/Swiss-Prot Summary for FLT3LG Gene

  • Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

Gene Wiki entry for FLT3LG Gene

Additional gene information for FLT3LG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FLT3LG Gene

Genomics for FLT3LG Gene

GeneHancer (GH) Regulatory Elements for FLT3LG Gene

Promoters and enhancers for FLT3LG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049472 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 500.7 +0.5 471 4.3 RXRA ZNF217 CTCF SIN3A MYC USF1 TEAD4 ZNF10 ZIC2 ZBTB10 ENSG00000273189 FLT3LG ALDH16A1 RPS11 PRR12 ENSG00000269469 RPL13A
GH19J049478 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 500.7 +4.7 4721 1 CTCF POLR2G JUND ZBTB11 GABPA ZBTB25 ZNF740 TOE1 MYC TGIF2 FLT3LG FCGRT RPS11 PRR12 ENSG00000273189 RPL13A ENSG00000269469
GH19J049480 Promoter 0.6 EPDnew 500.4 +6.2 6242 0.1 SCRT1 PCBP1 KDM1A FLT3LG RPS11 ENSG00000273189 RPL13A ENSG00000269469
GH19J048958 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 23.4 -510.1 -510143 10.2 EP300 FOXK2 ZNF217 SIN3A NRF1 TCF12 MYC POLR2G USF1 SP1 FTL ENSG00000267898 NONHSAG026207.2 NUP62 PRR12 PTOV1-AS2 IRF3 SNORD35A GRWD1 PIH1D1
GH19J048871 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 25.1 -598.5 -598535 8.5 RXRA FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A TCF12 ZNF300 POLR2G PPP1R15A lnc-TULP2-2 piR-37472-004 SNRNP70 PRR12 ENSG00000268047 PTOV1-AS2 GRWD1 IRF3 SNORD35A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FLT3LG on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FLT3LG

Top Transcription factor binding sites by QIAGEN in the FLT3LG gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • AP-4
  • c-Ets-1
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • TBP

Genomic Locations for FLT3LG Gene

Genomic Locations for FLT3LG Gene
chr19:49,474,172-49,486,234
(GRCh38/hg38)
Size:
12,063 bases
Orientation:
Plus strand
chr19:49,977,464-49,989,488
(GRCh37/hg19)
Size:
12,025 bases
Orientation:
Plus strand

Genomic View for FLT3LG Gene

Genes around FLT3LG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLT3LG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLT3LG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLT3LG Gene

Proteins for FLT3LG Gene

  • Protein details for FLT3LG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49771-FLT3L_HUMAN
    Recommended name:
    Fms-related tyrosine kinase 3 ligand
    Protein Accession:
    P49771
    Secondary Accessions:
    • A0AVC2
    • B9EGH2
    • Q05C96

    Protein attributes for FLT3LG Gene

    Size:
    235 amino acids
    Molecular mass:
    26416 Da
    Quaternary structure:
    • Homodimer (isoform 2).

    Three dimensional structures from OCA and Proteopedia for FLT3LG Gene

    Alternative splice isoforms for FLT3LG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLT3LG Gene

Post-translational modifications for FLT3LG Gene

  • Glycosylation at Asn126 and Asn149
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FLT3LG Gene

Domains & Families for FLT3LG Gene

Gene Families for FLT3LG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FLT3LG Gene

Suggested Antigen Peptide Sequences for FLT3LG Gene

GenScript: Design optimal peptide antigens:
  • FLT3LG protein (B7ZLY4_HUMAN)
  • SL cytokine (FLT3L_HUMAN)
  • cDNA FLJ61175, highly similar to SL cytokine (Q05C96_HUMAN)
genes like me logo Genes that share domains with FLT3LG: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FLT3LG Gene

Function for FLT3LG Gene

Molecular function for FLT3LG Gene

UniProtKB/Swiss-Prot Function:
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
GENATLAS Biochemistry:
FLT3 ligand,stimulating proliferation of hematopoietic cells

Phenotypes From GWAS Catalog for FLT3LG Gene

Gene Ontology (GO) - Molecular Function for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 8180375
GO:0005125 cytokine activity IEA --
GO:0030971 receptor tyrosine kinase binding IBA 21873635
genes like me logo Genes that share ontologies with FLT3LG: view
genes like me logo Genes that share phenotypes with FLT3LG: view

Animal Models for FLT3LG Gene

MGI Knock Outs for FLT3LG:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FLT3LG Gene

Localization for FLT3LG Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLT3LG Gene

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.
[Isoform 2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLT3LG gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
cytoskeleton 2
nucleus 2
endosome 2
lysosome 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IBA 21873635
GO:0016020 membrane NAS,IEA 8145851
genes like me logo Genes that share ontologies with FLT3LG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FLT3LG Gene

Pathways & Interactions for FLT3LG Gene

genes like me logo Genes that share pathways with FLT3LG: view

Interacting Proteins for FLT3LG Gene

;

SIGNOR curated interactions for FLT3LG Gene

Activates:

Gene Ontology (GO) - Biological Process for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction TAS,IEA 8180375
GO:0008284 positive regulation of cell proliferation IDA,IBA 8180375
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with FLT3LG: view

Drugs & Compounds for FLT3LG Gene

(5) Drugs for FLT3LG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FLT3LG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FLT3LG: view

Transcripts for FLT3LG Gene

mRNA/cDNA for FLT3LG Gene

5 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLT3LG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for FLT3LG Gene

GeneLoc Exon Structure for
FLT3LG

Expression for FLT3LG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FLT3LG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLT3LG Gene

This gene is overexpressed in Whole Blood (x5.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FLT3LG

SOURCE GeneReport for Unigene cluster for FLT3LG Gene:

Hs.428

Evidence on tissue expression from TISSUES for FLT3LG Gene

  • Spleen(4.7)
  • Nervous system(4.2)
  • Lymph node(3.3)
  • Bone marrow(2.8)
  • Blood(2.6)
  • Lung(2)
genes like me logo Genes that share expression patterns with FLT3LG: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FLT3LG Gene

Orthologs for FLT3LG Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLT3LG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLT3LG 31 30
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FLT3LG 31 30
  • 85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FLT3LG 31 30
  • 82.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102547607 30
  • 74.84 (n)
mouse
(Mus musculus)
Mammalia Flt3l 17 31 30
  • 73.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FLT3LG 31
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLT3LG 31
  • 28 (a)
OneToOne
Species where no ortholog for FLT3LG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FLT3LG Gene

ENSEMBL:
Gene Tree for FLT3LG (if available)
TreeFam:
Gene Tree for FLT3LG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FLT3LG: view image

Paralogs for FLT3LG Gene

(4) SIMAP similar genes for FLT3LG Gene using alignment to 7 proteins:

  • FLT3L_HUMAN
  • B7ZLY4_HUMAN
  • M0QXI0_HUMAN
  • M0QYM9_HUMAN
  • M0R2K0_HUMAN
  • M0R3A6_HUMAN
  • Q05C96_HUMAN
genes like me logo Genes that share paralogs with FLT3LG: view

No data available for Paralogs for FLT3LG Gene

Variants for FLT3LG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FLT3LG Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
780580 Benign: not provided 49,474,672(+) A/G SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for FLT3LG Gene

Structural Variations from Database of Genomic Variants (DGV) for FLT3LG Gene

Variant ID Type Subtype PubMed ID
esv3644624 CNV gain 21293372
nsv1109203 CNV deletion 24896259
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for FLT3LG Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FLT3LG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLT3LG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT3LG Gene

Disorders for FLT3LG Gene

MalaCards: The human disease database

(8) MalaCards diseases for FLT3LG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
aplastic anemia
  • aa
severe combined immunodeficiency
  • combined t and b cell inborn immunodeficiency
duodenum adenoma
myelodysplastic syndrome
  • mds
brain cancer
  • adult brain tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FLT3LG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FLT3LG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLT3LG Gene

Publications for FLT3LG Gene

  1. Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. (PMID: 10881197) Savvides SN … Andrew Karplus P (Nature structural biology 2000) 3 4 23 54
  2. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. (PMID: 8145851) Hannum C … Mattson J (Nature 1994) 2 3 4 54
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 41 54
  4. Human Flt-3-ligand-mobilized dendritic cells require additional activation to drive effective immune responses. (PMID: 17949888) Diener KR … Hayball JD (Experimental hematology 2008) 3 23 54
  5. Increased blood myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosis. (PMID: 15728521) Rolland A … Palucka AK (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 23 54

Products for FLT3LG Gene

Sources for FLT3LG Gene