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Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) is a Protein Coding gene. Diseases associated with FLT3LG include Aplastic Anemia and Severe Combined Immunodeficiency. Among its related pathways are CNTF Signaling and Hematopoietic cell lineage. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cytokine activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | TAS | 8180375 |
GO:0005125 | cytokine activity | IEA | -- |
GO:0030971 | receptor tyrosine kinase binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005886 | plasma membrane | IEA | -- |
GO:0009986 | cell surface | IBA | 21873635 |
GO:0016020 | membrane | IEA,NAS | 8145851 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytokine Signaling in Immune system | ||
2 | Hematopoietic cell lineage | ||
3 | MAPK signaling pathway | ||
4 | Pathways in cancer | ||
5 | PI3K-Akt signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
GO:0007165 | signal transduction | IEA,TAS | 8180375 |
GO:0008284 | positive regulation of cell proliferation | IBA,IDA | 8180375 |
GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||
SP3: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FLT3LG 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FLT3LG 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FLT3LG 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC102547607 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Flt3l 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FLT3LG 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FLT3LG 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
780580 | Benign: not provided | 49,474,672(+) | A/G | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
aplastic anemia |
|
|
severe combined immunodeficiency |
|
|
myelodysplastic syndrome |
|
|
brain cancer |
|
|
glioblastoma multiforme |
|