FLT3 Gene (Protein Coding)

Fms Related Tyrosine Kinase 3

GC13M028003
GIFtS:
54
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multipl... See more...

Aliases for FLT3 Gene

Aliases for FLT3 Gene

  • Fms Related Tyrosine Kinase 3 2 3 5
  • Receptor-Type Tyrosine-Protein Kinase FLT3 3 4
  • Stem Cell Tyrosine Kinase 1 3 4
  • Fms-Like Tyrosine Kinase 3 3 4
  • FL Cytokine Receptor 3 4
  • CD135 Antigen 3 4
  • EC 2.7.10.1 4 54
  • CD135 3 4
  • FLK-2 3 4
  • FLK2 3 4
  • STK1 3 4
  • Growth Factor Receptor Tyrosine Kinase Type III 3
  • Fms-Related Tyrosine Kinase 3 2
  • Fetal Liver Kinase 2 3
  • Fetal Liver Kinase-2 4
  • EC 2.7.10 54
  • FLT-3 4
  • STK-1 4

External Ids for FLT3 Gene

Previous GeneCards Identifiers for FLT3 Gene

  • GC13M026557
  • GC13M022557
  • GC13M027507
  • GC13M026375
  • GC13M027475
  • GC13M028577
  • GC13M009398

Summaries for FLT3 Gene

Entrez Gene Summary for FLT3 Gene

  • This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

CIViC Summary for FLT3 Gene

  • FLT3 is an important cytokine receptor involved in normal hematopoiesis. Mutations in this gene are common in acute myeloid leukemia (AML) and screening for mutations in this gene has been recommended by the World Health Organization in patients with AML, particularly in cases of cytogenetically normal AML (CN-AML). FLT3 mutations commonly co-occur with mutations such as NPM1 that are associated with CN-AML and likely modulate prognostic impact. While FLT3-ITD mutations have been associated with poorer prognosis in AML, the prognostic impact of FLT3-TKD mutations are still up for debate.

GeneCards Summary for FLT3 Gene

FLT3 (Fms Related Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with FLT3 include Leukemia, Acute Myeloid and Acute Myeloblastic Leukemia Without Maturation. Among its related pathways are Cytokine Signaling in Immune system and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CSF1R.

UniProtKB/Swiss-Prot Summary for FLT3 Gene

  • Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Tocris Summary for FLT3 Gene

  • FMS-like receptor tyrosine kinase-3 (FLT3) is a member of the class III RTK (receptor tyrosine kinase) family and is expressed primarily in hematopoietic progenitor cells. Its expression in these cells means that FLT3 has an important role in the pathogenesis of AML.

Gene Wiki entry for FLT3 Gene

Additional gene information for FLT3 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FLT3 Gene

Genomics for FLT3 Gene

GeneHancer (GH) Regulatory Elements for FLT3 Gene

Promoters and enhancers for FLT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH13J028099 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.2 191 2 ZNF785 MYC MAX MNT SP7 EZH2 ZNF547 ZIC2 RNF2 ZBTB8A FLT3 HSALNG0095991 PAN3-AS1
GH13J028102 Promoter 0.4 Ensembl 750.6 -1.4 -1409 0.4 HLF FLT3 HSALNG0095991 CHCHD2P8 lnc-PAN3-2
GH13J028098 Enhancer 0.4 FANTOM5 767.3 +1.7 1675 0.2 ZNF133 RNF2 FLT3 HSALNG0095991 KATNBL1P1 lnc-PAN3-3
GH13J028031 Enhancer 0.7 ENCODE 30.4 +68.9 68882 0.9 MYC ETV6 MAX MLLT1 ZNF687 CREM ZBTB33 IKZF1 CEBPA BACH1 FLT3 PAN3 piR-43107-080 piR-43105-135
GH13J028022 Enhancer 0.7 Ensembl ENCODE 30.4 +77.4 77392 1.6 NR2F6 SOX13 HNF4A SMAD4 BCL6 XRCC5 lnc-URAD-2-002 FLT3 lnc-URAD-2-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FLT3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FLT3 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • GATA-2
  • Hlf
  • NF-kappaB1
  • Pax-5
  • STAT3
  • STAT5B

Genomic Locations for FLT3 Gene

Genomic Locations for FLT3 Gene
chr13:28,003,274-28,100,592
(GRCh38/hg38)
Size:
97,319 bases
Orientation:
Minus strand
chr13:28,577,411-28,674,729
(GRCh37/hg19)
Size:
97,319 bases
Orientation:
Minus strand

Genomic View for FLT3 Gene

Genes around FLT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLT3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FLT3 Gene

Proteins for FLT3 Gene

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  • Protein details for FLT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36888-FLT3_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein kinase FLT3
    Protein Accession:
    P36888
    Secondary Accessions:
    • A0AVG9
    • B7ZLT7
    • B7ZLT8
    • F5H0A0
    • Q13414

    Protein attributes for FLT3 Gene

    Size:
    993 amino acids
    Molecular mass:
    112903 Da
    Quaternary structure:
    • Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. Interacts with FIZ1 following ligand activation (By similarity). Interacts with FES, FER, LYN, FGR, HCK, SRC and GRB2. Interacts with PTPRJ/DEP-1 and PTPN11/SHP2. Interacts with RNF115 and RNF126 (By similarity).
    • (Microbial infection) Interacts with human cytomegalovirus protein UL7.
    Miscellaneous:
    • Can be used as diagnostic tool to establish the exact cause of acute myeloid leukemia, and to determine the optimal therapy.

    Three dimensional structures from OCA and Proteopedia for FLT3 Gene

    Alternative splice isoforms for FLT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLT3 Gene

Protein Expression for FLT3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for FLT3 Gene

P36888:
  • RDLAARN
  • VAVKMLK
  • LPVKWMA
  • NIVNLLGACT
  • SDVWSYGI
  • ALMSELK
  • WEIFSLG
  • KICDFGLARD
  • AARNVLV
  • EYCCYGDLLN
  • GILLWEIF
  • PVKWMAPE
  • DFGLARDI

Post-translational modifications for FLT3 Gene

  • N-glycosylated, contains complex N-glycans with sialic acid.
  • Autophosphorylated on several tyrosine residues in response to FLT3LG binding. FLT3LG binding also increases phosphorylation of mutant kinases that are constitutively activated. Dephosphorylated by PTPRJ/DEP-1, PTPN1, PTPN6/SHP-1, and to a lesser degree by PTPN12. Dephosphorylation is important for export from the endoplasmic reticulum and location at the cell membrane.
  • Rapidly ubiquitinated by UBE2L6 and the E3 ubiquitin-protein ligase SIAH1 after autophosphorylation, leading to its proteasomal degradation.
  • Glycosylation at Asn43, Asn100, Asn151, Asn306, Asn323, Asn351, Asn354, Asn473, Asn502, and Asn541
  • Ubiquitination at Lys614 and Lys623
  • Modification sites at PhosphoSitePlus

Other Protein References for FLT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

Domains & Families for FLT3 Gene

Gene Families for FLT3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for FLT3 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FLT3 Gene

GenScript: Design optimal peptide antigens:
  • Tyrosine-protein kinase receptor FLT3 (FLT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P36888

UniProtKB/Swiss-Prot:

FLT3_HUMAN :
  • The juxtamembrane autoregulatory region is important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand. Upon tyrosine phosphorylation, it mediates interaction with the SH2 domains of numerous signaling partners. In-frame internal tandem duplications (ITDs) result in constitutive activation of the kinase. The activity of the mutant kinase can be stimulated further by FLT3LG binding.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Domain:
  • The juxtamembrane autoregulatory region is important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand. Upon tyrosine phosphorylation, it mediates interaction with the SH2 domains of numerous signaling partners. In-frame internal tandem duplications (ITDs) result in constitutive activation of the kinase. The activity of the mutant kinase can be stimulated further by FLT3LG binding.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with FLT3: view

Function for FLT3 Gene

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Molecular function for FLT3 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255 PROSITE-ProRule:PRU10028, ECO:0000269 PubMed:15831474};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. FLT3LG binding leads to dimerization and activation by autophosphorylation.
GENATLAS Biochemistry:
fms-related receptor tyrosine kinase 3,expressed on endothelial cell,duplicated in childhood acute myeloid leukemia with poor prognosis and acute lymphoblastic leukemia but not in myelodysplastic syndrome

Enzyme Numbers (IUBMB) for FLT3 Gene

Phenotypes From GWAS Catalog for FLT3 Gene

Gene Ontology (GO) - Molecular Function for FLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA,TAS 19549778
GO:0004896 cytokine receptor activity ISS --
genes like me logo Genes that share ontologies with FLT3: view
genes like me logo Genes that share phenotypes with FLT3: view

Human Phenotype Ontology for FLT3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FLT3 Gene

MGI Knock Outs for FLT3:

Animal Model Products

CRISPR Products

miRNA for FLT3 Gene

miRTarBase miRNAs that target FLT3

Clone Products

  • Addgene plasmids for FLT3

No data available for Transcription Factor Targets and HOMER Transcription for FLT3 Gene

Localization for FLT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLT3 Gene

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLT3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
extracellular 3
nucleus 3
cytosol 3
cytoskeleton 1
mitochondrion 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA,IEA --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with FLT3: view

Pathways & Interactions for FLT3 Gene

PathCards logo

SuperPathways for FLT3 Gene

SuperPathway Contained pathways
1 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
2 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
3 Nanog in Mammalian ESC Pluripotency
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
4 Actin Nucleation by ARP-WASP Complex
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
CDC42 Pathway
.41
5 Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA
.77
Activation of PKA through GPCR
.71
genes like me logo Genes that share pathways with FLT3: view

Pathways by source for FLT3 Gene

1 GeneGo (Thomson Reuters) pathway for FLT3 Gene
29 Qiagen pathways for FLT3 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
1 Cell Signaling Technology pathway for FLT3 Gene

SIGNOR curated interactions for FLT3 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001776 leukocyte homeostasis ISS --
GO:0002244 hematopoietic progenitor cell differentiation IBA 21873635
GO:0002318 myeloid progenitor cell differentiation ISS --
GO:0002328 pro-B cell differentiation ISS --
genes like me logo Genes that share ontologies with FLT3: view

Drugs & Compounds for FLT3 Gene

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  1. Drug

(105) Drugs for FLT3 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sunitinib Approved, Investigational Pharma Target, inhibitor VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 540
Sorafenib Approved, Investigational Pharma Target, antagonist, inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 762
midostaurin Approved, Investigational Pharma Target, antagonist, inhibitor Kinase Inhibitors 43
Idarubicin Approved Pharma inhibitor 247
gilteritinib Approved, Investigational Pharma Target, inhibitor 0

(22) Additional Compounds for FLT3 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
CHMFL-FLT3-122
1839150-56-9

(3) Tocris Compounds for FLT3 Gene

Compound Action Cas Number
5'-Fluoroindirubinoxime FLT3 inhibitor; displays antiproliferative activity 861214-33-7
CHMFL-FLT3-122 Potent and selective FLT3 inhibitor 1839150-56-9
TCS 359 Potent FLT3 inhibitor 301305-73-7

(30) ApexBio Compounds for FLT3 Gene

Compound Action Cas Number
5'-Fluoroindirubinoxime 861214-33-7
AMG 925 FLT3/CDK4 inhibitor,potent and selective 1401033-86-0
Amuvatinib (MP-470, HPK 56) Tyrosine kinase inhibitor 850879-09-3
AZD2932 inhibitor of VEGFR-2, PDGFRβ, Flt-3, and c-Kit 883986-34-3
BIBF 1120 VEGFR/PDGF/FGFR inhibitor 656247-17-5
CHIR-124 Chk1 inhibitor,novel and potent 405168-58-3
Dovitinib (TKI-258, CHIR-258) Multitargeted RTK inhibitor 405169-16-6
Dovitinib Dilactic acid 852433-84-2
ENMD-2076 Selective Aurora A/Flt3 inhibitor 934353-76-1
G-749 FLT3 inhibitor 1457983-28-6
KW 2449 Multikinase inhibitor 1000669-72-6
Lestaurtinib JAK2/FLT3/TrkA inhibitor 111358-88-4
Linifanib (ABT-869) VEGFR/PDGFR inhibitor 796967-16-3
Pacritinib Selective JAK2/FLT3 inhibitor 937272-79-2
Pacritinib (SB1518) JAK2/FLT3 inhibitor 937272-79-2
Quizartinib (AC220) FLT3 inhibitor,potent and selective 950769-58-1
SB1317 CDK,JAK and FLT inhibitor 937270-47-8
Silvestrol Antineoplastic 697235-38-4
Sorafenib Raf kinases and tyrosine kinases inhibitor 284461-73-0
SU14813 double bond Z Tyrosine kinase inhibitor 452105-23-6
SU14813 maleate VEGFR/PDGFR/Kit/FLT-3 inhibitor 849643-15-8
SU5416 VEGF receptor inhibitor and AHR agonist 204005-46-9
Sunitinib malate VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor 341031-54-7
Tandutinib (MLN518) FLT3 inhibitor,potent and selective 387867-13-2
TCS 359 Potent FLT3 inhibitor 301305-73-7
TG 100801 Multi-kinase inhibitor 867331-82-6
TG 100801 Hydrochloride VEGFr2 inhibitor 1018069-81-2
TG101209 JAK2/3 inhibitor 936091-14-4
UNC2025 1429881-91-3
VX-680 (MK-0457,Tozasertib) Aurora kinase inhibitor 639089-54-6
genes like me logo Genes that share compounds with FLT3: view

Transcripts for FLT3 Gene

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  1. CRISPR
  2. miRNA
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  4. Clone

mRNA/cDNA for FLT3 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for FLT3

Alternative Splicing Database (ASD) splice patterns (SP) for FLT3 Gene

No ASD Table

Relevant External Links for FLT3 Gene

GeneLoc Exon Structure for
FLT3
ECgene alternative splicing isoforms for
FLT3

Expression for FLT3 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLT3 Gene

mRNA expression in normal human tissues for FLT3 Gene
mRNA expression by BioGPS for FLT3 GenemRNA expression by GTEx for FLT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLT3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.9), Brain - Cerebellum (x10.0), and Whole Blood (x8.3).

Protein differential expression in normal tissues from HIPED for FLT3 Gene

This gene is overexpressed in Brain (49.3) and Fetal gut (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FLT3 Gene



Protein tissue co-expression partners for FLT3 Gene

NURSA nuclear receptor signaling pathways regulating expression of FLT3 Gene:

FLT3

SOURCE GeneReport for Unigene cluster for FLT3 Gene:

Hs.507590

mRNA Expression by UniProt/SwissProt for FLT3 Gene:

P36888-FLT3_HUMAN
Tissue specificity: Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.

Evidence on tissue expression from TISSUES for FLT3 Gene

  • Blood(4.7)
  • Bone marrow(4.7)
  • Spleen(3.4)
  • Lymph node(3.3)
  • Liver(2.1)
  • Heart(2)
  • Lung(2)
  • Nervous system(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FLT3 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Regions:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with FLT3: view

Orthologs for FLT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FLT3 33 32
  • 99.6 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia FLT3 33 32
  • 90.74 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia FLT3 33 32
  • 88.27 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Flt3 17 33 32
  • 83.15 (n)
rat
(Rattus norvegicus)
 Mammalia Flt3 32
  • 82.31 (n)
oppossum
(Monodelphis domestica)
 Mammalia FLT3 33
  • 74 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia FLT3 33
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FLT3 33 32
  • 65.12 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia FLT3 33
  • 52 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia flt3 32
  • 59.73 (n)
zebrafish
(Danio rerio)
 Actinopterygii flt3 33 32
  • 53.5 (n)
 OneToOne
Species where no ortholog for FLT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLT3 Gene

ENSEMBL:
Gene Tree for FLT3 (if available)
TreeFam:
Gene Tree for FLT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FLT3: view image

Paralogs for FLT3 Gene

Paralogs for FLT3 Gene

(16) SIMAP similar genes for FLT3 Gene using alignment to 3 proteins:

  • FLT3_HUMAN
  • E7ER61_HUMAN
  • Q5VTU6_HUMAN
genes like me logo Genes that share paralogs with FLT3: view

Variants for FLT3 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for FLT3 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1057519726 likely-pathogenic, pathogenic, Acute myeloid leukemia 28,018,502(-) T/A/C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1057519762 likely-pathogenic, Acute myeloid leukemia 28,018,484(-) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1057519763 likely-pathogenic, Acute myeloid leukemia 28,018,504(-) TC/AA coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1057519764 likely-pathogenic, Acute myeloid leukemia 28,027,222(-) A/C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1057519765 likely-pathogenic, Acute myeloid leukemia 28,027,236(-) T/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FLT3 Gene

Variant ID Type Subtype PubMed ID
esv1336289 CNV insertion 17803354
esv2674990 CNV deletion 23128226
esv2677792 CNV deletion 23128226
esv275421 CNV loss 21479260
esv3349981 CNV insertion 20981092
esv34052 CNV loss 18971310
esv3550234 CNV deletion 23714750
esv3550235 CNV deletion 23714750
esv3580585 CNV loss 25503493
esv3631627 CNV loss 21293372
esv3631628 CNV loss 21293372
esv3631630 CNV loss 21293372
esv3631631 CNV loss 21293372
esv3631632 CNV loss 21293372
nsv1070579 CNV deletion 25765185
nsv826599 CNV loss 20364138
nsv973 CNV insertion 18451855

Variation tolerance for FLT3 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.22; 92.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FLT3 Gene

Human Gene Mutation Database (HGMD)
FLT3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT3 Gene

Disorders for FLT3 Gene

MalaCards: The human disease database

(38) MalaCards diseases for FLT3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FLT3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FLT3_HUMAN
  • Leukemia, acute myelogenous (AML) [MIM:601626]: A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes. {ECO:0000269 PubMed:11090077, ECO:0000269 PubMed:11290608, ECO:0000269 PubMed:11442493, ECO:0000269 PubMed:14504097, ECO:0000269 PubMed:16266983, ECO:0000269 PubMed:18305215, ECO:0000269 PubMed:8946930, ECO:0000269 PubMed:9737679}. Note=The gene represented in this entry may be involved in disease pathogenesis. Somatic mutations that lead to constitutive activation of FLT3 are frequent in AML patients. These mutations fall into two classes, the most common being in-frame internal tandem duplications of variable length in the juxtamembrane region that disrupt the normal regulation of the kinase activity. Likewise, point mutations in the activation loop of the kinase domain can result in a constitutively activated kinase.

Additional Disease Information for FLT3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FLT3: view

No data available for Genatlas for FLT3 Gene

Publications for FLT3 Gene

  1. The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and CEBPA. (PMID: 19965647) Burnett AK … Gale RE (Blood 2010) 3 23 43 56
  2. High transcript level of FLT3 associated with high risk of relapse in pediatric acute myeloid leukemia. (PMID: 20514303) Kang HJ … Ahn HS (Journal of Korean medical science 2010) 3 23 43 56
  3. Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations in acute promyelocytic leukemia: a systematic review. (PMID: 20096459) Beitinjaneh A … Majhail NS (Leukemia research 2010) 3 23 43 56
  4. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. (PMID: 20212254) Ravandi F … Kantarjian HM (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010) 3 23 43 56
  5. [Correlation of Fms-like tyrosine kinase 3 (FLT3) gene expression to FLT3/internal tandem duplication mutation in peripheral blood of acute myeloid leukemia.]. (PMID: 19635202) Xu B … Zhou SY (Ai zheng = Aizheng = Chinese journal of cancer 2009) 3 23 43 56

ExternalLinks

View latest publications for FLT3 gene in Mastermind

Products for FLT3 Gene

  • Addgene plasmids for FLT3

Sources for FLT3 Gene