Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B a... See more...
Aliases for FLT1 Gene
Aliases for FLT1 Gene
- Fms Related Receptor Tyrosine Kinase 1 2 3 5
- Vascular Endothelial Growth Factor Receptor 1 2 3 4
- Vascular Permeability Factor Receptor 2 3 4
- VEGFR1 2 3 4
- Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor) 2 3
- Tyrosine-Protein Kinase Receptor FLT 3 4
- Fms Related Tyrosine Kinase 1 2 3
- Tyrosine-Protein Kinase FRT 3 4
External Ids for FLT1 Gene
- HGNC: 3763
- Entrez Gene: 2321
- Ensembl: ENSG00000102755
- OMIM: 165070
- UniProtKB: P17948
Previous HGNC Symbols for FLT1 Gene
- FLT
Previous GeneCards Identifiers for FLT1 Gene
- GC13M026854
- GC13M022854
- GC13M027805
- GC13M026673
- GC13M027773
- GC13M028874
- GC13M009695
Summaries for FLT1 Gene
-
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
GeneCards Summary for FLT1 Gene
FLT1 (Fms Related Receptor Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with FLT1 include Pre-Eclampsia and Corneal Neovascularization. Among its related pathways are Transcriptional misregulation in cancer and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is KDR.
UniProtKB/Swiss-Prot Summary for FLT1 Gene
-
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.
-
Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and vasculogenesis. VEGF binds to and activates a receptor tyrosine kinase, VEGFR, through transphosphorylation. Three VEGFR isoforms have been identified in humans.
Additional gene information for FLT1 Gene
- HGNC(3763)
- Entrez Gene(2321)
- Ensembl(ENSG00000102755)
- OMIM(165070)
- UniProtKB(P17948)
- Open Targets Platform(ENSG00000102755)
- Monarch Initiative
- Search for FLT1 at DataMed
- Search for FLT1 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FLT1 Gene
Genomics for FLT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FLT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FLT1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FLT1
- Top Transcription factor binding sites by QIAGEN in the FLT1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- STAT1
- STAT1alpha
- STAT1beta
Genomic Locations for FLT1 Gene
Genomic Locations for FLT1 Gene
- chr13:28,300,346-28,495,145
- (GRCh38/hg38)
- Size:
- 194,800 bases
- Orientation:
- Minus strand
- chr13:28,874,483-29,069,265
- (GRCh37/hg19)
- Size:
- 194,783 bases
- Orientation:
- Minus strand
Genomic View for FLT1 Gene
Genes around FLT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q12.3 by HGNC
- 13q12.3 by Entrez Gene
- 13q12.3 by Ensembl
FLT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FLT1 Gene
Proteins for FLT1 Gene
-
Protein details for FLT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17948-VGFR1_HUMAN
- Recommended name:
- Vascular endothelial growth factor receptor 1
- Protein Accession:
- P17948
- A3E342
- A3E344
- A8KA71
- B0LPF1
- B2BF46
- B2BF47
- B2BF48
- B3FR89
- B5A923
- F5H5L6
- O60722
- P16057
- Q12954
Protein attributes for FLT1 Gene
- Size:
- 1338 amino acids
- Molecular mass:
- 150769 Da
- Quaternary structure:
-
- Interacts with VEGFA, VEGFB and PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in the presence of bound VEGFA, VEGFB and PGF. Can also form a heterodimer with KDR. Interacts (when tyrosine phosphorylated) with CBL, CRK, GRB2, NCK1, PIK3R1, PLCG, PSEN1 and PTPN11. Probably interacts also with PTPRB. Interacts with RACK1. Identified in a complex with CBL and CD2AP.
Three dimensional structures from OCA and Proteopedia for FLT1 Gene
Protein Expression for FLT1 Gene
Selected DME Specific Peptides for FLT1 Gene
- P17948:
-
- KMLKEGAT
- QVARGME
- RLPLKWMAPE
- RDLAARN
- YLSIIMDP
- VAVKMLK
- RIKTFEE
- HLNVVNLLGACTK
- WEIFSLG
- KICDFGLARD
- KWMAPESIF
- SRKCIHRDLAARNILLSE
- GPLMVIVE
- YSLIIKDV
- SLSDVEEE
- VNVKPQIYE
- YQIMLDCW
- CKYGNLSN
- ARERLKLGKSLG
- GAFGKVVQASAFGIKKSPTCR
- PDYVRKG
- DFGLARDI
Post-translational modifications for FLT1 Gene
- N-glycosylated.
- Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation.
- Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-1169 is important for interaction with PLCG. Phosphorylation at Tyr-1213 is important for interaction with PIK3R1, PTPN11, GRB2, and PLCG. Phosphorylation at Tyr-1333 is important for endocytosis and for interaction with CBL, NCK1 and CRK. Is probably dephosphorylated by PTPRB.
-
Glycosylation at Asn100, Asn164, Asn196, Asn251, Asn323, Asn402, Asn417, Asn474, Asn547, Asn597, Asn620, Asn625, and Asn666
- NX_P17948 (NX_P17948-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- VGFR1_HUMAN (771)
Other Protein References for FLT1 Gene
Antibody Products
- LifeSpan BioSciences FLT1 / VEGFR1 Antibody (LS-A9405) and FLT1 / VEGFR1 Antibody (LS-A9440)
- G Biosciences Immunotag™ Phospho-VEGFR1 (Tyr1213) Antibody and Immunotag™ VEGFR1 Antibody
- NSJ Bioreagents VEGFR1 Antibody (Mouse Monoclonal)
- Creative Diagnostics Anti-FLT1 monoclonal antibody, clone Gmu-2/FXD
-
Creative Biolabs
- Recombinant Human Anti-Human FLT1 Antibody scFv Fragment, clone 867.23A
- Anti-Human VEGFR-1 Therapeutic Antibody (Icrucumab)
- Anti-Human FLT1 Therapeutic Antibody
- Anti-Human FLT1 Therapeutic Antibody scFv Fragment (01A04)
- Anti-Human FLT1 Therapeutic Antibody Fab Fragment (AG10B)
- Mouse Anti-FLT1 Recombinant Antibody (CBYY-1043)
- Mouse Anti-FLT1 (AA 781-1338) Recombinant Antibody (8G6)
- Mouse Anti-FLT1 Recombinant Antibody (FLT1/659)
- Mouse Anti-FLT1 Recombinant Antibody (3D10)
- Mouse Anti-FLT1 Recombinant Antibody (CBXF-3469)
- Mouse Anti-FLT1 Recombinant Antibody (FLT12)
- Recombinant Human Anti-FLT1 Antibody scFv Fragment (Antibody II)
- Humanized Anti-FLT1 Antibody Fab Fragment (25G9)
- Afuco™ Anti-FLT1 ADCC Theraputic Antibody (Icrucumab), ADCC Enhanced
- Recombinant Mouse Anti-FLT1 Antibody (CA0071-Z2ZA-01171)
- Humanized Anti-FLT1 Antibody scFv Fragment (27H4)
- Recombinant Rabbit Anti-FLT1 Polyclonal Antibody (CBPCN-654)
- Recombinant Human Anti-FLT1 Antibody Fab Fragment (15F11)
- Recombinant Mouse Anti-FLT1 Antibody Fab Fragment (1-833-527)
- Recombinant Mouse Anti-FLT1 Antibody (D16F7)
- Recombinant Humanized Anti-FLT1 Antibody (27G9)
- BioLegend VEGFR1 Antibody (394903) and VEGFR1 Antibody (394904)
-
Custom Antibody ServicesOriGene Antibodies for FLT1
- AM06366SU-N
- AM20682PU-N
- AM50321PU-S
- AM50321PU-T
- AM50322PU-S
- AM50322PU-T
- AP01883PU-N
- AP06592PU-N
- AP54509PU-N
- AP55288SU-N
- AP55778PU-N
- AP55778PU-S
- AP55933PU-N
- AP55933PU-S
- CF806766
- CF806786
- DM3504
- DM3504B
- DM3505
- DM3506
- DM3506B
- DM3507
- DM3507B
- DP3510
- DP3510S
- DP3522
- DP3522S
- TA313883
- TA313886
- TA320332
- TA323071
- TA324003
- TA325465
- TA327855
- TA332785
- TA336313
- TA341129
- TA341135
- TA354699
- TA806766
- TA806766S
- TA806786
- TA806786S
- Novus Biologicals Antibodies for FLT1
-
Abcam antibodies for FLT1
- Invitrogen Antibodies for FLT1 (AFLGC-FLT1)
- antibodies-online: Show 121 available FLT1 Antibodies ranked by validation data
- Compare Top FLT1 Antibodies
-
Recommended
- 240 WB Antibodies (anti-human)
- 59 IF Antibodies (anti-human)
- 29 IHC (p) Antibodies (anti-human)
- 13 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 IHC Antibodies (anti-human)
- 7 IP Antibodies (anti-human)
- 71 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 8 IHC (p) Antibodies (anti-rat)
- 5 FACS Antibodies (anti-rat)
- 5 IHC Antibodies (anti-rat)
- 98 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 11 FACS Antibodies (anti-mouse)
- 9 IHC (p) Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
-
Boster Bio Antibodies for FLT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FLT1
- Sino Biological Antibodies for FLT1
Protein Products
- G Biosciences Human VEGF R1/Flt-1/FLT1, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for FLT1
- Origene Custom Protein Services for FLT1
- Novus Biologicals proteins for FLT1
- Sino Biological Recombinant Proteins for FLT1
- Sino Biological Cell Lysates for FLT1
- ProSpec Recombinant Proteins for FLT1
-
ProSci Proteins for FLT1
-
Abcam proteins for FLT1
Assay Products
- RayBiotech Human VEGFR1 ELISA
- Novus Biologicals ELISA Kits for FLT1
- antibodies-online: Show 88 available FLT1 Elisa Kits ranked by validation data
- Compare Top FLT1 Elisa Kits
-
Quality Products:
- ABIN414833
- ABIN411372
- ABIN2703569
- ABIN456775
- ABIN5676256
- ABIN492312
- ABIN1030143
- ABIN3198627
- ABIN1379996
- ABIN5525044
- ABIN424117
- ABIN366339
- ABIN492313
- ABIN625188
- ABIN1030144
- ABIN3032850
- ABIN5525045
- ABIN2684287
- ABIN5510576
- ABIN5594904
- ABIN416520
- ABIN5563540
- ABIN1573056
- ABIN5525047
- ABIN5594905
- ABIN772619
- ABIN2748745
- ABIN6386142
- ABIN5691973
- ABIN5659884
- ABIN775894
- ABIN6231020
-
Abcam assays for FLT1
Domains & Families for FLT1 Gene
Gene Families for FLT1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for FLT1 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-2 type
- Immunoglobulin I-set
- Receptor tyrosine kinase, class III
- Tyrosine protein kinase, active site
- Vascular endothelial growth factor receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for FLT1 Gene
- GenScript: Design optimal peptide antigens:
-
- N2idVEGFR-1 (A3E342_HUMAN)
- TVEGFR-1 (A3E344_HUMAN)
- Fms-related tyrosine kinase 1 (Vascular endothelial growth factor/vascular permeability factor receptor), isoform CRA_b (B0LPF1_HUMAN)
- Soluble FLT1 variant e15a (B1AC84_HUMAN)
- cDNA FLJ60350, highly similar to Vascular endothelial growth factor receptor 1precursor (EC 2.7.10.1) (B3FR89_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P17948UniProtKB/Swiss-Prot:
VGFR1_HUMAN :- The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding.
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
- Domain:
-
- The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Function for FLT1 Gene
Molecular function for FLT1 Gene
- UniProtKB/Swiss-Prot Function:
- Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:9299537, ECO:0000269|PubMed:9722576};.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in coculture of VSMC/endothelial cell (EC) or by direct exposure to VEGF of VSMC monoculture. Up-regulated from the second trimester of pregnancy to the term and in the placenta of women with preeclampsia (PE). Up-regulated in monocytes exposed to bacterial lipopolysaccharide (LPS).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFB or PGF leads to dimerization and activation by autophosphorylation on tyrosine residues.
- GENATLAS Biochemistry:
- fms-related receptor tyrosine kinase 1,expressed on the surface on endothelial cells
Enzyme Numbers (IUBMB) for FLT1 Gene
Phenotypes From GWAS Catalog for FLT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | IEA | -- |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | TAS,IBA | 21873635 |
| GO:0005021 | vascular endothelial growth factor-activated receptor activity | IBA,IMP | 11312102 |
Phenotypes for FLT1 Gene
- MGI mutant phenotypes for FLT1:
-
inferred from 8 alleles
- nervous system phenotype
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- reproductive system phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for FLT1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased cell migration
- Increased transferrin (TF) endocytosis
- Increased viability
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Increased cell death in HCC-1954 cells
- Synthetic lethal with gemcitabine
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Decreased senescence-associated beta-galactosidase protein expression after pRB stimulation
Animal Models for FLT1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FLT1 - Select products 50% OFF >
- * FLT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FLT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLT1
miRNA for FLT1 Gene
- miRTarBase miRNAs that target FLT1
-
- mmu-miR-200b-3p (MIRT005945)
- mmu-miR-200c-3p (MIRT005946)
- mmu-miR-200a-3p (MIRT005947)
- mmu-miR-429-3p (MIRT005948)
- hsa-miR-200b-3p (MIRT006441)
- hsa-miR-100-5p (MIRT006850)
- hsa-miR-200c-3p (MIRT006885)
- mmu-miR-181a-5p (MIRT014392)
- mmu-miR-9-5p (MIRT015585)
- hsa-miR-155-5p (MIRT020776)
- hsa-miR-6844 (MIRT443663)
- hsa-miR-4671-3p (MIRT443664)
- hsa-miR-4473 (MIRT443665)
- hsa-miR-5189-3p (MIRT443666)
- hsa-miR-519e-3p (MIRT443667)
- hsa-miR-515-3p (MIRT443668)
- hsa-miR-33b-3p (MIRT443669)
- hsa-miR-371a-3p (MIRT443670)
- hsa-miR-371b-3p (MIRT443671)
- hsa-miR-582-5p (MIRT608055)
- hsa-miR-935 (MIRT608056)
- hsa-miR-4789-3p (MIRT608057)
- hsa-miR-8485 (MIRT608058)
- hsa-miR-199a-3p (MIRT735200)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLT1
- Browse OriGene Inhibitory RNA Products For FLT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLT1
Clone Products
- Applied Biological Materials (abm): Clones for FLT1 - Select products 50% OFF >
- * FLT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210050
- MG225716
- MR210050
- MR210050L3
- MR210050L4
- MR225716
- MR225716L3
- MR225716L4
- RC224406
- RC224406L1
- RC224406L2
- RC224406L3
- RC224406L4
- RC228438
- RC228438L3
- RC228438L4
- RC228562
- RC228562L3
- RC228562L4
- RC228996
- RC228996L1
- RC228996L2
- RC228996L3
- RC228996L4
- RC600026
- RG224406
- RG228438
- RG228562
- RG228996
- RR201567
- MR210050L3V
- MR210050L4V
- MR225716L3V
- MR225716L4V
- RC224406L1V
- RC224406L2V
- RC224406L3V
- RC224406L4V
- RC228438L3V
- RC228438L4V
- RC228562L3V
- RC228562L4V
- RC228996L1V
- RC228996L2V
- RC228996L3V
- RC228996L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FLT1
- Addgene plasmids for FLT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLT1
Cell Line Products
-
Horizon Cell Lines for FLT1
No data available for Transcription Factor Targets and HOMER Transcription for FLT1 Gene
Localization for FLT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FLT1 Gene
- [Isoform 1]: Cell membrane. Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes ubiquitination and endocytosis.
- [Isoform 2]: Secreted.
- [Isoform 3]: Secreted.
- [Isoform 4]: Secreted.
- [Isoform 5]: Cytoplasm.
- [Isoform 6]: Cytoplasm.
- [Isoform 7]: Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| endosome | 5 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| mitochondrion | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
- Actin filaments (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | TAS | 8248162 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for FLT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
|
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
| 5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
Pathways by source for FLT1 Gene
7 BioSystems pathways for FLT1 Gene
5 Reactome pathways for FLT1 Gene
5 PharmGKB pathways for FLT1 Gene
8 KEGG pathways for FLT1 Gene
2 GeneGo (Thomson Reuters) pathways for FLT1 Gene
- Development VEGF-family signaling
- Transcription_P53 signaling pathway
3 R&D Systems pathways for FLT1 Gene
4 Tocris pathways for FLT1 Gene
56 Qiagen pathways for FLT1 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
2 Cell Signaling Technology pathways for FLT1 Gene
Interacting Proteins for FLT1 Gene
Selected Interacting proteins:
P17948-VGFR1_HUMAN
ENSP00000282397
for FLT1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FLT1
SIGNOR curated interactions for FLT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0002040 | sprouting angiogenesis | IBA | -- |
| GO:0002244 | hematopoietic progenitor cell differentiation | IBA | 21873635 |
| GO:0002548 | monocyte chemotaxis | IDA | 8605350 |
| GO:0006468 | protein phosphorylation | IEA | -- |
Drugs & Compounds for FLT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sunitinib | Approved, Investigational | Pharma | Target, inhibitor | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 552 | |
| Axitinib | Approved, Investigational | Pharma | Target, inhibitor, Inhibition | Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 144 | |
| Lenvatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 155 | |
| Nintedanib | Approved | Pharma | Target, inhibitor | VEGFR, FGFR, PDGFR, and FLT3 inhibitor, Kinase Inhibitors | 145 | |
| Pazopanib | Approved | Pharma | Target, inhibitor | VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
| XL 184 |
|
849217-68-1 |
|
|
(4) Tocris Compounds for FLT1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| SU 4312 | Potent inhibitor of VEGFR tyrosine kinase | 5812-07-7 |
| SU 5416 | VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 | 204005-46-9 |
| Sunitinib malate | Potent VEGFR, PDGFRbeta and KIT inhibitor | 341031-54-7 |
| XL 184 | Potent VEGFR inhibitor; also inhibits other RTKs | 849217-68-1 |
(29) ApexBio Compounds for FLT1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (E)-FeCP-oxindole | 884338-18-5 | |
| (Z)-FeCP-oxindole | 1137967-28-2 | |
| Axitinib (AG 013736) | VEGFR1/ c-Kit inhibitor | 319460-85-0 |
| Cabozantinib (XL184, BMS-907351) | VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor | 849217-68-1 |
| Cediranib (AZD217) | VEGFR inhibitor receptor,highly potent | 288383-20-0 |
| DMH4 | 515880-75-8 | |
| Dovitinib (TKI258) Lactate | Oral tyrosine kinase inhibitor (TKI) against FGFR1–3, VEGFR1–3, and platelet-derived growth factor receptor (PDGFR) | 915769-50-5 |
| Dovitinib (TKI-258, CHIR-258) | Multitargeted RTK inhibitor | 405169-16-6 |
| Dovitinib Dilactic acid | 852433-84-2 | |
| Foretinib (GSK1363089) | VEGF and HGF receptor inhibitor | 849217-64-7 |
| Fruquintinib(HMPL-013) | Potent and selective inhibitor of VEGFR 1, 2, 3 | 1194506-26-7 |
| Ki8751 | VEGFR-2 inhibitor,potent and selective | 228559-41-9 |
| KRN 633 | VEGFR inhibitor,ATP-competitive | 286370-15-8 |
| Lenvatinib (E7080) | VEGFR inhibitor | 417716-92-8 |
| Linifanib (ABT-869) | VEGFR/PDGFR inhibitor | 796967-16-3 |
| MGCD-265 | Met/Flt/Flk/Ron/Tie-2 inhibitor | 875337-44-3 |
| Motesanib Diphosphate (AMG-706) | VEGFR/ PDGFR/c-Kit/Ret inhibitor | 857876-30-3 |
| OSI-930 | Inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck | 728033-96-3 |
| Pazopanib (GW-786034) | VEGFR/PDGFR/FGFR inhibitor | 635702-64-6 |
| Pazopanib Hydrochloride | VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor | 635702-64-6 |
| PD 173074 | FGFR inhibitor | 219580-11-7 |
| SKLB610 | Potent VEGFR inhibitor | 1125780-41-7 |
| SU 4312 | 5812-07-7 | |
| Sunitinib | RTK inhibitor | 557795-19-4 |
| Sunitinib malate | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor | 341031-54-7 |
| Tivozanib (AV-951) | VEGFR inhibitor,potent and selective | 475108-18-0 |
| Vatalanib | VEGFR-1/-2 inhibitor,cell-permeable | 212141-54-3 |
| Vatalanib (PTK787) 2HCl | Tyrosine kinase receptor inhibitor | 212141-51-0 |
| ZM 306416 | VEGFR (Flt and KDR) inhibitor | 690206-97-4 |
Transcripts for FLT1 Gene
mRNA/cDNA for FLT1 Gene
- 4 REFSEQ mRNAs :
- 31 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000282397 7123 nts (view in UCSC)
- ENST00000539099 1911 nts (view in UCSC)
- ENST00000540678 1927 nts (view in UCSC)
- ENST00000541932 2969 nts (view in UCSC)
- ENST00000543394 1275 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FLT1 - Select products 50% OFF >
- * FLT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FLT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLT1
- Browse OriGene Inhibitory RNA Products For FLT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLT1
Clone Products
- Applied Biological Materials (abm): Clones for FLT1 - Select products 50% OFF >
- * FLT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210050
- MG225716
- MR210050
- MR210050L3
- MR210050L4
- MR225716
- MR225716L3
- MR225716L4
- RC224406
- RC224406L1
- RC224406L2
- RC224406L3
- RC224406L4
- RC228438
- RC228438L3
- RC228438L4
- RC228562
- RC228562L3
- RC228562L4
- RC228996
- RC228996L1
- RC228996L2
- RC228996L3
- RC228996L4
- RC600026
- RG224406
- RG228438
- RG228562
- RG228996
- RR201567
- MR210050L3V
- MR210050L4V
- MR225716L3V
- MR225716L4V
- RC224406L1V
- RC224406L2V
- RC224406L3V
- RC224406L4V
- RC228438L3V
- RC228438L4V
- RC228562L3V
- RC228562L4V
- RC228996L1V
- RC228996L2V
- RC228996L3V
- RC228996L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FLT1
- Addgene plasmids for FLT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLT1
Relevant External Links for FLT1 Gene
- GeneLoc Exon Structure for
- FLT1
Expression for FLT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Endothelium (Cardiovascular System)
- Endothelial Cells Chorionic Villus
- Arterial Endothelial Cells Paired Dorsal Aorta
- Angioblasts Perineural Capillary Plexus
- Angioblasts Embryonic Capillary Plexus
- Arterial Endothelial Cells Dorsal Aorta
-
Eye (Sensory Organs)
- Adult Corneal Superficial Epithelial Cells Corneal Epithelium
- Keratocytes Corneal Stroma
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
- Adult Corneal Basal Epithelial Cells Corneal Epithelium
-
Bone (Muscoskeletal System)
- Endochondral Preosteoblasts Stylopod Perichondrium
- Endochondral Preosteoblasts Zeugopod Perichondrium
- Endochondral Preosteoblasts Autopod Perichondrium
- Bone marrow-derived adherent progenitor cells (MultiStem)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Arterial Endothelial Cells Paired Dorsal Aorta
- Angioblasts Embryonic Capillary Plexus
- Angioblasts Embryonic Blood Islands
- Angioblasts Proepicardium
- Umbilical Cord (Extraembryonic Tissues)
-
Epithelial Cells
- Adult Corneal Superficial Epithelial Cells Corneal Epithelium
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
- Adult Corneal Basal Epithelial Cells Corneal Epithelium
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Arterial Endothelial Cells Dorsal Aorta
- Heart Tube
- Mesenchymal Stem Cells (Uncategorized)
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Conventional Dendritic Cells I Spleen
-
Placenta (Extraembryonic Tissues)
- Endothelial Cells Chorionic Villus
- Primitive Cytotrophoblast Cells Chorion Frondosum
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Epiblast (Early Embryonic Tissues)
- Inner Cell Mass (Early Embryonic Tissues)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
-
Fibroblasts
- Keratocytes Corneal Stroma
-
Neural Tube (Nervous System)
- Angioblasts Perineural Capillary Plexus
-
Brain (Nervous System)
- Angioblasts Perineural Capillary Plexus
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
- Spleen (Hematopoietic System)
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Kidney (Urinary System)
- Adipose (Muscoskeletal System)
- NULL (Uncategorized)
This gene is overexpressed in Heart (19.3), Placenta (18.5), Pancreatic juice (11.0), and Plasma (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FLT1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FLT1
SOURCE GeneReport for Unigene cluster for FLT1 Gene:
Hs.594454mRNA Expression by UniProt/SwissProt for FLT1 Gene:
P17948-VGFR1_HUMAN
Tissue specificity:
Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).
Evidence on tissue expression from TISSUES for FLT1 Gene
- Heart(3.9)
- Nervous system(3.9)
- Blood(3.4)
- Liver(3.3)
- Muscle(3.3)
- Kidney(3.2)
- Spleen(3.2)
- Eye(3.2)
- Lung(3.1)
- Intestine(2.9)
- Thyroid gland(2.9)
- Bone marrow(2.8)
- Lymph node(2.7)
- Skin(2.7)
- Pancreas(2.5)
- Bone(2.4)
- Stomach(2.3)
- Adrenal gland(2.2)
- Urine(2.2)
Primer Products
-
OriGene qPCR primer pairs for FLT1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FLT1 Gene
Orthologs for FLT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FLT1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FLT1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FLT1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FLT1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Flt1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FLT1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FLT1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FLT1 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | flt1 30 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | tor 32 |
|
|
|
| CG3277 32 |
|
|
|||
| Cad96Ca 31 |
|
ManyToMany | |||
| Pvr 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | Y50D4B.6 32 |
|
|
|
| kin-16 32 |
|
|
|||
| R09D1.12 32 |
|
|
|||
| ver-2 32 |
|
|
|||
| ver-3 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3210 30 |
|
- Species where no ortholog for FLT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for FLT1 Gene
- ENSEMBL:
- Gene Tree for FLT1 (if available)
- TreeFam:
- Gene Tree for FLT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FLT1: view image
Paralogs for FLT1 Gene
Paralogs for FLT1 Gene
- KDR 5
- FLT4 5
- PDGFRA 5
- KIT 5
- PDGFRB 5
- FLT3 5
- CSF1R 5
- RET 5
- ENSG00000282278 5
- FGFR2 5
- FGFR1 5
- FGFR3 5
- ERBB3 5
- FGFR4 5
- TEK 5
- EGFR 5
- ROS1 5
- ERBB2 5
- ERBB4 5
- MERTK 5
- EPHA3 5
- INSR 5
- EPHA2 5
- EPHA5 5
- EPHA6 5
- TIE1 5
- EPHA8 5
- EPHB2 5
- EPHB4 5
- EPHA7 5
- EPHA4 5
- EPHB3 5
- AXL 5
- EPHB1 5
- IGF1R 5
- NTRK2 5
- MST1R 5
- EPHB6 5
- INSRR 5
- NTRK1 5
- ALK 5
- MET 5
- ROR2 5
- EPHA1 5
- NTRK3 5
- MUSK 5
- ROR1 5
- TYRO3 5
- DDR2 5
- EPHA10 5
- LTK 5
- DDR1 5
- RYK 5
- LMTK2 5
(43) SIMAP similar genes for FLT1 Gene using alignment to 7 proteins:
- VGFR1_HUMAN
- B1AC84_HUMAN
- H9N1E7_HUMAN
- H9N1E8_HUMAN
- L7RSL3_HUMAN
- V9Q458_HUMAN
- V9Q5H8_HUMAN
- KIT
- RET
- FGFR2
- FGFR1
- ABL1
- FGFR3
- RYK
- MST1R
- FLT4
- TYK2
- FES
- BTK kinase deficient isoform 6
- KDR
- MET
- EPHA2
- tec
- urf-ret
- MERTK
- KIF5B-RET(NM_020975)_K23;R12
- KIF5B-RET(NM_020975)_K22;R12
- KIF5B-RET(NM_020975)_K16;R12
- KIF5B-RET(NM_020975)_K15;R12
- KIF5B-RET(NM_020630)_K24;R11
- KIF5B-RET(NM_020630)_K23;R12
- KIF5B-RET(NM_020630)_K22;R12
- KIF5B-RET(NM_020630)_K16;R12
- KIF5B-RET(NM_020630)_K15;R12
- CCDC6-RETc
- CCDC6-RETa
- TXK
- TYRO3
- MAP3K10
- CDK7
- MAP3K11
- RPS6KA2
- MAPK3
- STK25
- FGR
- BRAF
- STK11
- ULK1
- NEK9
- CDK4
Pseudogenes.org Pseudogenes for FLT1 Gene
Variants for FLT1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FLT1 Gene
| SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709270 | Benign: not provided | 28,339,274(-) | G/A | SYNONYMOUS_VARIANT | |
| 710183 | Benign: not provided | 28,405,857(-) | G/A | SYNONYMOUS_VARIANT | |
| 713356 | Likely Benign: not provided | 28,303,215(-) | C/T | SYNONYMOUS_VARIANT | |
| 713357 | Likely Benign: not provided | 28,396,976(-) | T/C | MISSENSE_VARIANT | |
| 713553 | Likely Benign: not provided | 28,311,623(-) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3388394 | CNV | duplication | 20981092 |
| esv34052 | CNV | loss | 18971310 |
| esv3412790 | CNV | duplication | 20981092 |
| esv3550237 | CNV | deletion | 23714750 |
| nsv455850 | CNV | loss | 19166990 |
| nsv561389 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
3.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.40;
42.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FLT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT1 Gene
Disorders for FLT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pre-eclampsia |
|
|
| corneal neovascularization |
|
|
| eclampsia |
|
|
| placental insufficiency |
|
|
| anal canal squamous cell carcinoma |
|
|
Search FLT1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
VGFR1_HUMAN- Note=Can contribute to cancer cell survival, proliferation, migration, and invasion, and tumor angiogenesis and metastasis. May contribute to cancer pathogenesis by promoting inflammatory responses and recruitment of tumor-infiltrating macrophages.
- Note=Abnormally high expression of soluble isoforms (isoform 2, isoform 3 or isoform 4) may be a cause of preeclampsia.
Additional Disease Information for FLT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for FLT1 Gene
Publications for FLT1 Gene
- Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. (PMID: 2158038) Shibuya M … Sato M (Oncogene 1990) 2 3 4 23
- Allelic variations in angiogenic pathway genes are associated with preeclampsia. (PMID: 20223440) Srinivas SK … Elovitz MA (American journal of obstetrics and gynecology 2010) 3 23 41
- Mutation analysis of the growth factor genes PlGF, Flt1, IGF-I, and IGF-IR in intrauterine growth restriction with abnormal placental blood flow. (PMID: 19658040) Muetze S … Rudnik-Schoeneborn S (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2010) 3 23 41
- Dinucleotide repeat polymorphism in Fms-like tyrosine kinase-1 (Flt-1) gene is not associated with preeclampsia. (PMID: 18631405) Kim SY … Ryu HM (BMC medical genetics 2008) 3 23 41
- Natural selection of FLT1 alleles and their association with malaria resistance in utero. (PMID: 18779584) Muehlenbachs A … Duffy PE (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 23 41
ExternalLinks
Products for FLT1 Gene
- View all 39 R&D Systems FLT1 (VEGFR1/Flt-1) Products
- View all 2 R&D Systems FLT1 (VEGFR1/Flt-1) Proteins and Enzymes
- View all 28 R&D Systems FLT1 (VEGFR1/Flt-1) Primary Antibodies
- View all 4 R&D Systems FLT1 (VEGFR1/Flt-1) ELISAs
- View all R&D Systems FLT1 (VEGFR1/Flt-1) Simple Plex Assays
- View all R&D Systems FLT1 (VEGFR1/Flt-1) Luminex Assays
- View all 2 R&D Systems FLT1 (VEGFR1/Flt-1) Proteome Profiler Antibody Arrays
- View all R&D Systems FLT1 (VEGFR1/Flt-1) cDNA Clones
- Learn more about R&D Systems custom FLT1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for FLT1
- AM06366SU-N
- AM20682PU-N
- AM50321PU-S
- AM50321PU-T
- AM50322PU-S
- AM50322PU-T
- AP01883PU-N
- AP06592PU-N
- AP54509PU-N
- AP55288SU-N
- AP55778PU-N
- AP55778PU-S
- AP55933PU-N
- AP55933PU-S
- CF806766
- CF806786
- DM3504
- DM3504B
- DM3505
- DM3506
- DM3506B
- DM3507
- DM3507B
- DP3510
- DP3510S
- DP3522
- DP3522S
- TA313883
- TA313886
- TA320332
- TA323071
- TA324003
- TA325465
- TA327855
- TA332785
- TA336313
- TA341129
- TA341135
- TA354699
- TA806766
- TA806766S
- TA806786
- TA806786S
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for FLT1
- Origene Custom Protein Services for FLT1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLT1
- Browse OriGene Inhibitory RNA Products For FLT1
- OriGene qPCR primer pairs for FLT1
- OriGene CRISPR knockouts for FLT1
- MG210050
- MG225716
- MR210050
- MR210050L3
- MR210050L4
- MR225716
- MR225716L3
- MR225716L4
- RC224406
- RC224406L1
- RC224406L2
- RC224406L3
- RC224406L4
- RC228438
- RC228438L3
- RC228438L4
- RC228562
- RC228562L3
- RC228562L4
- RC228996
- RC228996L1
- RC228996L2
- RC228996L3
- RC228996L4
- RC600026
- RG224406
- RG228438
- RG228562
- RG228996
- RR201567
- MR210050L3V
- MR210050L4V
- MR225716L3V
- MR225716L4V
- RC224406L1V
- RC224406L2V
- RC224406L3V
- RC224406L4V
- RC228438L3V
- RC228438L4V
- RC228562L3V
- RC228562L4V
- RC228996L1V
- RC228996L2V
- RC228996L3V
- RC228996L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FLT1
- Sino Biological Human cDNA Clone for FLT1
- Sino Biological Recombinant Proteins for FLT1
- Sino Biological Cell Lysates for FLT1
- Sino Biological Antibodies for FLT1
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FLT1
- Novus Biologicals proteins for FLT1
- Novus Biologicals ELISA Kits for FLT1
- Browse Antibodies
- Browse Peptides and Proteins