Aliases for FLRT3 Gene
External Ids for FLRT3 Gene
Previous GeneCards Identifiers for FLRT3 Gene
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for FLRT3 Gene
FLRT3 (Fibronectin Leucine Rich Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with FLRT3 include Hypogonadotropic Hypogonadism 21 With Or Without Anosmia and Kallmann Syndrome. Among its related pathways are Signaling by GPCR and Downstream signaling of activated FGFR2. Gene Ontology (GO) annotations related to this gene include protein binding, bridging and chemorepellent activity. An important paralog of this gene is FLRT1.
UniProtKB/Swiss-Prot Summary for FLRT3 Gene
Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).