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Aliases for FLRT2 Gene

Aliases for FLRT2 Gene

  • Fibronectin Leucine Rich Transmembrane Protein 2 2 3 5
  • Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2 4
  • KIAA0405 4

External Ids for FLRT2 Gene

Previous GeneCards Identifiers for FLRT2 Gene

  • GC14P083593
  • GC14P079813
  • GC14P084077
  • GC14P085066
  • GC14P085996
  • GC14P066165

Summaries for FLRT2 Gene

Entrez Gene Summary for FLRT2 Gene

  • This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for FLRT2 Gene

FLRT2 (Fibronectin Leucine Rich Transmembrane Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein binding, bridging and chemorepellent activity. An important paralog of this gene is FLRT3.

UniProtKB/Swiss-Prot for FLRT2 Gene

  • Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.

Gene Wiki entry for FLRT2 Gene

Additional gene information for FLRT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLRT2 Gene

Genomics for FLRT2 Gene

GeneHancer (GH) Regulatory Elements for FLRT2 Gene

Promoters and enhancers for FLRT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I085526 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 561.1 +3.0 3011 13.2 SIN3A RAD21 ATF7 CEBPB REST SP1 MAFF STAT3 PRDM1 ZBTB26 FLRT2 ENSG00000258945 LOC100506731 GC14P085297 GC14P085198 LINC02328
GH14I085470 Enhancer 1 Ensembl ENCODE 17.7 -58.5 -58495 2.1 ELF3 FOXA2 ARID4B SIN3A ZSCAN9 RARA TCF12 FOS THAP11 MIXL1 FLRT2 LOC100506731 ENSG00000258902 LINC00911 GC14P085297 GC14P085198
GH14I085481 Enhancer 0.7 ENCODE 24.5 -47.6 -47600 2.6 DRAP1 ELF3 SOX13 FOXA2 SAP130 RAD21 THRB NR2F6 HOMEZ MAFK FLRT2 ENSG00000258902 LINC00911 GC14P085297 GC14P085198
GH14I085571 Enhancer 1 Ensembl ENCODE dbSUPER 16.7 +44.6 44640 6.4 JUN BACH1 ZNF384 MAFF JUND POLR2A CREB1 HNF4A FOS FOSL2 FLRT2 LOC100506731 GC14P085297 LINC02328
GH14I085474 Enhancer 0.9 Ensembl ENCODE 15.8 -54.4 -54415 1.8 SOX13 FOXA2 JUN CEBPG ZNF644 RARA HOMEZ GATAD2A NR2F1 HLF FLRT2 LOC100506731 ENSG00000258902 LINC00911 GC14P085297 GC14P085198
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FLRT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FLRT2 gene promoter:

Genomic Locations for FLRT2 Gene

Genomic Locations for FLRT2 Gene
chr14:85,530,105-85,654,426
(GRCh38/hg38)
Size:
124,322 bases
Orientation:
Plus strand
chr14:85,996,488-86,095,034
(GRCh37/hg19)

Genomic View for FLRT2 Gene

Genes around FLRT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLRT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLRT2 Gene

Proteins for FLRT2 Gene

  • Protein details for FLRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43155-FLRT2_HUMAN
    Recommended name:
    Leucine-rich repeat transmembrane protein FLRT2
    Protein Accession:
    O43155
    Secondary Accessions:
    • A0AV84
    • B7ZLP3

    Protein attributes for FLRT2 Gene

    Size:
    660 amino acids
    Molecular mass:
    74049 Da
    Quaternary structure:
    • Self-associates (via leucine-rich repeats), giving rise to homooligomers. Interacts with FGFR1. Interacts with FGFR2. Interacts (via extracellular domain) with ADGRL1/LPHN1. Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain). Interacts (via extracellular domain) with UNC5D (via the first Ig-like domain). Can also interact (via extracellular domain) with UNC5B, but with much lower affinity. Interacts (via extracellular domain) with FN1.
    SequenceCaution:
    • Sequence=BAA23701.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FLRT2 Gene

Post-translational modifications for FLRT2 Gene

  • N-glycosylated.
  • Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.
  • Glycosylation at Asn202, Asn298, posLast=433433, and posLast=521521

No data available for DME Specific Peptides for FLRT2 Gene

Domains & Families for FLRT2 Gene

Gene Families for FLRT2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FLRT2: view

No data available for UniProtKB/Swiss-Prot for FLRT2 Gene

Function for FLRT2 Gene

Molecular function for FLRT2 Gene

GENATLAS Biochemistry:
fibronectin,leucine rich transmembrane protein 2,extracellular matrix protein,expressed in pancreas,skeletal muscle,brain,heart
UniProtKB/Swiss-Prot Function:
Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.

Phenotypes From GWAS Catalog for FLRT2 Gene

Gene Ontology (GO) - Molecular Function for FLRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005057 signal transducer activity, downstream of receptor NAS 10644439
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0030674 protein binding, bridging NAS 10644439
GO:0045499 chemorepellent activity IEA --
genes like me logo Genes that share ontologies with FLRT2: view
genes like me logo Genes that share phenotypes with FLRT2: view

Animal Models for FLRT2 Gene

MGI Knock Outs for FLRT2:

Animal Model Products

miRNA for FLRT2 Gene

miRTarBase miRNAs that target FLRT2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLRT2 Gene

Localization for FLRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLRT2 Gene

Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cell junction, focal adhesion. Secreted, extracellular space, extracellular matrix. Microsome membrane. Secreted. Cell junction, synapse, synaptosome. Note=Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250 UniProtKB:Q8BLU0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLRT2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 3
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FLRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix NAS 10644439
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with FLRT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FLRT2 Gene

Pathways & Interactions for FLRT2 Gene

genes like me logo Genes that share pathways with FLRT2: view

Pathways by source for FLRT2 Gene

Gene Ontology (GO) - Biological Process for FLRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003007 heart morphogenesis ISS --
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0007155 cell adhesion IEA --
GO:0007275 multicellular organism development IEA --
GO:0007411 axon guidance IEA --
genes like me logo Genes that share ontologies with FLRT2: view

No data available for SIGNOR curated interactions for FLRT2 Gene

Drugs & Compounds for FLRT2 Gene

No Compound Related Data Available

Transcripts for FLRT2 Gene

Unigene Clusters for FLRT2 Gene

Fibronectin leucine rich transmembrane protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLRT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - -
SP7:

Relevant External Links for FLRT2 Gene

GeneLoc Exon Structure for
FLRT2
ECgene alternative splicing isoforms for
FLRT2

Expression for FLRT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLRT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLRT2 Gene

This gene is overexpressed in Pancreas (x4.8).

Protein differential expression in normal tissues from HIPED for FLRT2 Gene

This gene is overexpressed in Platelet (42.3) and Ovary (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FLRT2 Gene



NURSA nuclear receptor signaling pathways regulating expression of FLRT2 Gene:

FLRT2

SOURCE GeneReport for Unigene cluster for FLRT2 Gene:

Hs.533710

mRNA Expression by UniProt/SwissProt for FLRT2 Gene:

O43155-FLRT2_HUMAN
Tissue specificity: Expressed in pancreas, skeletal muscle, brain, and heart.

Evidence on tissue expression from TISSUES for FLRT2 Gene

  • Nervous system(4.9)
  • Liver(4)
genes like me logo Genes that share expression patterns with FLRT2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FLRT2 Gene

Orthologs for FLRT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLRT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLRT2 33 34
  • 99.49 (n)
oppossum
(Monodelphis domestica)
Mammalia FLRT2 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLRT2 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flrt2 33 16 34
  • 89.7 (n)
dog
(Canis familiaris)
Mammalia FLRT2 33 34
  • 89.19 (n)
rat
(Rattus norvegicus)
Mammalia Flrt2 33
  • 89.14 (n)
cow
(Bos Taurus)
Mammalia FLRT2 33 34
  • 88.43 (n)
chicken
(Gallus gallus)
Aves FLRT2 33 34
  • 81.62 (n)
lizard
(Anolis carolinensis)
Reptilia FLRT2 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia flrt2 33 33
  • 73.13 (n)
zebrafish
(Danio rerio)
Actinopterygii flrt2 33 34 34
  • 62.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
Species where no ortholog for FLRT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLRT2 Gene

ENSEMBL:
Gene Tree for FLRT2 (if available)
TreeFam:
Gene Tree for FLRT2 (if available)

Paralogs for FLRT2 Gene

Paralogs for FLRT2 Gene

(2) SIMAP similar genes for FLRT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FLRT2: view

Variants for FLRT2 Gene

Sequence variations from dbSNP and Humsavar for FLRT2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000065146 -- 85,548,327(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000109268 -- 85,562,876(+) AAAA/AAAAA genic_upstream_transcript_variant, intron_variant
rs1000130595 -- 85,626,967(+) T/A 3_prime_UTR_variant
rs1000164845 -- 85,593,463(+) G/T 5_prime_UTR_variant, intron_variant
rs1000231068 -- 85,610,339(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FLRT2 Gene

Variant ID Type Subtype PubMed ID
nsv952877 CNV deletion 24416366
nsv85122 CNV insertion 16902084
esv3635196 CNV gain 21293372
esv3635192 CNV gain 21293372
esv3327997 CNV insertion 20981092

Variation tolerance for FLRT2 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.63; 78.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FLRT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLRT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLRT2 Gene

Disorders for FLRT2 Gene

Additional Disease Information for FLRT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FLRT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FLRT2 Gene

Publications for FLRT2 Gene

  1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PMID: 10644439) Lacy SE … Kunkel LM (Genomics 1999) 2 3 4 58
  2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  3. Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. (PMID: 16872596) Haines BP … Rigby PW (Developmental biology 2006) 2 3 58
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FLRT2 Gene

Sources for FLRT2 Gene

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