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Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]
FLOT2 (Flotillin 2) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include protease binding and ionotropic glutamate receptor binding. An important paralog of this gene is FLOT1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002020 | protease binding | IEA | -- |
GO:0005515 | protein binding | IPI | 17113085 |
GO:0035255 | ionotropic glutamate receptor binding | IEA | -- |
GO:0046982 | protein heterodimerization activity | IMP | 21696602 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001931 | uropod | IDA | 21696602 |
GO:0002080 | acrosomal membrane | IEA | -- |
GO:0005768 | endosome | IEA,IDA | 20682791 |
GO:0005886 | plasma membrane | TAS,NAS | -- |
GO:0005901 | caveola | IDA | 24013648 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
2 | Cytoskeletal Signaling | ||
3 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
4 | Beta-Adrenergic Signaling |
Insulin Receptor Pathway
.37
|
|
5 | Transmission across Chemical Synapses |
.62
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001765 | membrane raft assembly | IMP | 25204797 |
GO:0007155 | cell adhesion | NAS,IEA | -- |
GO:0008544 | epidermis development | TAS | 8051082 |
GO:0010629 | negative regulation of gene expression | IMP | 24612608 |
GO:0034114 | NOT regulation of heterotypic cell-cell adhesion | IMP | 25204797 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | FLOT2 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | FLOT2 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | FLOT2 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Flot2 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | FLOT2 33 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Flot2 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | FLOT2 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | FLOT2 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | FLOT2 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | flot2 32 |
|
||
Str.3461 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | flot2-prov 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | flot2a 33 |
|
OneToMany | |
flot2b 33 32 |
|
OneToMany | |||
zgc64103 32 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9615 32 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Flo-2 33 34 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003789 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8302 33 |
|
OneToOne | |
Cin.2729 32 |
|
||||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2729 32 |
|
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000087723 | -- | 28,893,859(-) | T/C/G | intron_variant | |
rs1000197598 | -- | 28,897,409(-) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000237236 | -- | 28,887,297(-) | G/A | intron_variant | |
rs1000336539 | -- | 28,893,504(-) | C/T | intron_variant | |
rs1000708204 | -- | 28,893,744(-) | C/A | intron_variant |
No disorders were found for FLOT2 Gene.