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Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008] See more...
Aliases for FLOT2 Gene
Aliases for FLOT2 Gene
External Ids for FLOT2 Gene
- HGNC: 3758
- Entrez Gene: 2319
- Ensembl: ENSG00000132589
- OMIM: 131560
- UniProtKB: Q14254
Previous HGNC Symbols for FLOT2 Gene
- M17S1
Previous GeneCards Identifiers for FLOT2 Gene
- GC17M027051
- GC17M029105
- GC17M027351
- GC17M024230
- GC17M027206
- GC17M023414
- GC17M028880
- GC17M029285
- GC17M029384
- GC17M029406
- GC17M029702
- GC17M028881
- GC17M028982
- GC17M029011
- GC17M029113
- GC17M029195
Summaries for FLOT2 Gene
-
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]
GeneCards Summary for FLOT2 Gene
FLOT2 (Flotillin 2) is a Protein Coding gene. Diseases associated with FLOT2 include Isolated Elevated Serum Creatine Phosphokinase Levels. Among its related pathways are SALM protein interactions at the synapses and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include protease binding and ionotropic glutamate receptor binding. An important paralog of this gene is FLOT1.
UniProtKB/Swiss-Prot Summary for FLOT2 Gene
-
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
Additional gene information for FLOT2 Gene
- HGNC(3758)
- Entrez Gene(2319)
- Ensembl(ENSG00000132589)
- OMIM(131560)
- UniProtKB(Q14254)
- Open Targets Platform(ENSG00000132589)
- Search for FLOT2 at DataMed
- Search for FLOT2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FLOT2 Gene
Genomics for FLOT2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FLOT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FLOT2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FLOT2
- Top Transcription factor binding sites by QIAGEN in the FLOT2 gene promoter:
-
- AhR
- AP-4
- Arnt
- CUTL1
- HSF1 (long)
- HSF1short
- PPAR-gamma1
- PPAR-gamma2
- Sox5
Genomic Locations for FLOT2 Gene
Genomic Locations for FLOT2 Gene
- chr17:28,879,335-28,897,733
- (GRCh38/hg38)
- Size:
- 18,399 bases
- Orientation:
- Minus strand
- chr17:27,206,353-27,224,715
- (GRCh37/hg19)
- Size:
- 18,363 bases
- Orientation:
- Minus strand
Genomic View for FLOT2 Gene
Genes around FLOT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q11.2 by HGNC
- 17q11.2 by Entrez Gene
- 17q11.2 by Ensembl
FLOT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FLOT2 Gene
Proteins for FLOT2 Gene
-
Protein details for FLOT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14254-FLOT2_HUMAN
- Recommended name:
- Flotillin-2
- Protein Accession:
- Q14254
Protein attributes for FLOT2 Gene
- Size:
- 428 amino acids
- Molecular mass:
- 47064 Da
- Quaternary structure:
-
- Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECPAS.
- SequenceCaution:
-
- Sequence=AAA65729.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for FLOT2 Gene
Post-translational modifications for FLOT2 Gene
- ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.
-
Ubiquitination at Lys81, Lys100, Lys160, Lys169, and Lys370
- NX_Q14254 (NX_Q14254-1)
- Modification sites at PhosphoSitePlus
Other Protein References for FLOT2 Gene
Antibody Products
- LifeSpan BioSciences FLOT2 / Flotillin 2 Antibody (LS-B4923) and FLOT2 / Flotillin 2 Antibody (LS-B11418)
- G Biosciences Immunotag™ ESA Antibody
- NSJ Bioreagents Flotillin 2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for FLOT2
- Novus Biologicals Antibodies for FLOT2
- Invitrogen Antibodies for FLOT2 (AFLGC-FLOT2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for FLOT2
- Sino Biological Antibodies for FLOT2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FLOT2
- Origene Custom Protein Services for FLOT2
-
Abcam proteins for FLOT2
Assay Products
- G Biosciences Immunotag™ Human FLOT2 (Flotillin 2) ELISA and Immunotag™ Flotillin-2 ELISA Kit
No data available for DME Specific Peptides for FLOT2 Gene
Domains & Families for FLOT2 Gene
Gene Families for FLOT2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FLOT2 Gene
- InterPro:
- Blocks:
-
- Flotillin
- ProtoNet:
Suggested Antigen Peptide Sequences for FLOT2 Gene
- GenScript: Design optimal peptide antigens:
-
- Membrane component chromosome 17 surface marker 1 (FLOT2_HUMAN)
- HCG1998851, isoform CRA_e (Q6FG43_HUMAN)
- FLOT2 protein (Q9BTI6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14254- Family:
-
- Belongs to the band 7/mec-2 family. Flotillin subfamily.
Function for FLOT2 Gene
Molecular function for FLOT2 Gene
- UniProtKB/Swiss-Prot Function:
- May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
- GENATLAS Biochemistry:
- flotillin 2,35kDa,resident integral membrane protein of caveolae from epithelial surface, involved in cell adhesion
Phenotypes From GWAS Catalog for FLOT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 17113085 |
| GO:0035255 | ionotropic glutamate receptor binding | IEA | -- |
Phenotypes for FLOT2 Gene
- MGI mutant phenotypes for FLOT2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FLOT2:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Increased gamma-H2AX phosphorylation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased viability
- Increased shRNA abundance
- FOXO1 nuclear localization
- Decreased Sindbis virus (SINV) infection
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for FLOT2 Gene
- MGI Knock Outs for FLOT2:
-
- Flot2 Flot2<tm1Mak>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FLOT2 - Select products 50% OFF >
- * FLOT2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FLOT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLOT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLOT2
miRNA for FLOT2 Gene
- miRTarBase miRNAs that target FLOT2
-
- mmu-miR-15a-5p (MIRT011733)
- mmu-miR-124-3p (MIRT015835)
- hsa-miR-148b-3p (MIRT019295)
- hsa-miR-124-3p (MIRT022325)
- hsa-miR-1-3p (MIRT023557)
- hsa-miR-423-3p (MIRT042495)
- hsa-miR-4433a-5p (MIRT691681)
- hsa-miR-6858-5p (MIRT691682)
- hsa-miR-4689 (MIRT691683)
- hsa-miR-4303 (MIRT691684)
- hsa-miR-4320 (MIRT691685)
- hsa-miR-6081 (MIRT691686)
- hsa-miR-6836-5p (MIRT691687)
- hsa-miR-6132 (MIRT691688)
- hsa-miR-4445-5p (MIRT691689)
- hsa-miR-6766-3p (MIRT691690)
- hsa-miR-4782-3p (MIRT691691)
- hsa-miR-219a-5p (MIRT691692)
- hsa-miR-508-3p (MIRT691693)
- hsa-miR-4765 (MIRT691694)
- hsa-miR-4784 (MIRT691695)
- hsa-miR-3150b-3p (MIRT691696)
- hsa-miR-4693-3p (MIRT691697)
- hsa-miR-7162-3p (MIRT691698)
- hsa-miR-4649-3p (MIRT691699)
- hsa-miR-3918 (MIRT691700)
- hsa-miR-761 (MIRT691701)
- hsa-miR-3619-5p (MIRT691702)
- hsa-miR-214-3p (MIRT691703)
- hsa-miR-8062 (MIRT691704)
- hsa-miR-6895-5p (MIRT691705)
- hsa-miR-6510-5p (MIRT691706)
- hsa-miR-6838-5p (MIRT691707)
- hsa-miR-497-5p (MIRT691708)
- hsa-miR-424-5p (MIRT691709)
- hsa-miR-195-5p (MIRT691710)
- hsa-miR-16-5p (MIRT691711)
- hsa-miR-15b-5p (MIRT691712)
- hsa-miR-15a-5p (MIRT691713)
- hsa-miR-5586-3p (MIRT691714)
- hsa-miR-449a (MIRT732072)
- hsa-miR-34a-5p (MIRT733318)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLOT2
- Browse OriGene Inhibitory RNA Products For FLOT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLOT2
Clone Products
- Applied Biological Materials (abm): Clones for FLOT2 - Select products 50% OFF >
- * FLOT2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205924
- MG222238
- MR205924
- MR205924L3
- MR205924L4
- MR222238
- MR222238L3
- MR222238L4
- MR229590
- MR229999
- RC220884
- RC220884L1
- RC220884L2
- RC220884L3
- RC220884L4
- RG220884
- RR201193
- RR201193L3
- RR201193L4
- RR216524
- RR216649
- MR205924L3V
- MR205924L4V
- MR222238L3V
- MR222238L4V
- RC220884L1V
- RC220884L2V
- RC220884L3V
- RC220884L4V
- RR201193L3V
- RR201193L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FLOT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLOT2
Cell Line Products
-
Horizon Cell Lines for FLOT2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLOT2 Gene
Localization for FLOT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FLOT2 Gene
- Cell membrane. Peripheral membrane protein. Membrane, caveola. Peripheral membrane protein. Endosome. Membrane. Lipid-anchor. Note=Membrane-associated protein of caveolae.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| extracellular | 4 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Plasma membrane (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001931 | uropod | IDA | 21696602 |
| GO:0002080 | acrosomal membrane | IEA | -- |
| GO:0005768 | endosome | IEA,IDA | 20682791 |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0005901 | caveola | IDA | 24013648 |
Pathways & Interactions for FLOT2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
| 2 | Cytoskeletal Signaling | ||
| 3 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
| 4 | Beta-Adrenergic Signaling |
Insulin Receptor Pathway
.37
|
|
| 5 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for FLOT2 Gene
2 BioSystems pathways for FLOT2 Gene
3 Reactome pathways for FLOT2 Gene
1 KEGG pathway for FLOT2 Gene
1 Qiagen pathway for FLOT2 Gene
- Insulin Receptor Pathway
1 Cell Signaling Technology pathway for FLOT2 Gene
Interacting Proteins for FLOT2 Gene
Selected Interacting proteins:
Q14254-FLOT2_HUMAN
ENSP00000378368
for FLOT2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FLOT2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001765 | membrane raft assembly | IMP | 25204797 |
| GO:0007155 | cell adhesion | NAS,IEA | -- |
| GO:0008544 | epidermis development | TAS | 8051082 |
| GO:0010629 | negative regulation of gene expression | IMP | 24612608 |
| GO:0034114 | NOT regulation of heterotypic cell-cell adhesion | IMP | 25204797 |
No data available for SIGNOR curated interactions for FLOT2 Gene
Transcripts for FLOT2 Gene
mRNA/cDNA for FLOT2 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000394906 2756 nts (view in UCSC)
- ENST00000394908 2668 nts (view in UCSC)
- ENST00000465427 746 nts (view in UCSC)
- ENST00000577789 2503 nts (view in UCSC)
- ENST00000580313 429 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FLOT2 - Select products 50% OFF >
- * FLOT2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FLOT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLOT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLOT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLOT2
- Browse OriGene Inhibitory RNA Products For FLOT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLOT2
Clone Products
- Applied Biological Materials (abm): Clones for FLOT2 - Select products 50% OFF >
- * FLOT2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205924
- MG222238
- MR205924
- MR205924L3
- MR205924L4
- MR222238
- MR222238L3
- MR222238L4
- MR229590
- MR229999
- RC220884
- RC220884L1
- RC220884L2
- RC220884L3
- RC220884L4
- RG220884
- RR201193
- RR201193L3
- RR201193L4
- RR216524
- RR216649
- MR205924L3V
- MR205924L4V
- MR222238L3V
- MR222238L4V
- RC220884L1V
- RC220884L2V
- RC220884L3V
- RC220884L4V
- RR201193L3V
- RR201193L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FLOT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLOT2
Relevant External Links for FLOT2 Gene
- GeneLoc Exon Structure for
- FLOT2
Expression for FLOT2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Hematopoietic Bone Marrow
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Pancreas (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for FLOT2 Gene
This gene is overexpressed in Whole Blood (x16.9).
This gene is overexpressed in Peripheral blood mononuclear cells (14.5) and Nasal epithelium (9.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FLOT2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FLOT2
SOURCE GeneReport for Unigene cluster for FLOT2 Gene:
Hs.514038mRNA Expression by UniProt/SwissProt for FLOT2 Gene:
Q14254-FLOT2_HUMAN
Tissue specificity:
In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes.
Evidence on tissue expression from TISSUES for FLOT2 Gene
- Skin(4.5)
- Liver(4.5)
- Pancreas(4.4)
- Nervous system(4)
- Lung(3.3)
- Blood(3.1)
- Kidney(2.9)
- Heart(2.8)
- Intestine(2.7)
- Muscle(2.7)
- Spleen(2.7)
- Lymph node(2.7)
- Eye(2.5)
- Bone marrow(2.4)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs for FLOT2
-
OriGene qPCR primer pairs and template standards for FLOT2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FLOT2 Gene
Orthologs for FLOT2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FLOT2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FLOT2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FLOT2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Flot2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FLOT2 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Flot2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FLOT2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FLOT2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FLOT2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | flot2 30 |
|
||
| Str.3461 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | flot2-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | flot2a 31 |
|
OneToMany | |
| flot2b 30 31 |
|
OneToMany | |||
| zgc64103 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9615 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Flo-2 30 31 32 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003789 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8302 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2729 30 |
|
- Species where no ortholog for FLOT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FLOT2 Gene
- ENSEMBL:
- Gene Tree for FLOT2 (if available)
- TreeFam:
- Gene Tree for FLOT2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FLOT2: view image
Paralogs for FLOT2 Gene
Variants for FLOT2 Gene
Residual Variation Intolerance Score:
43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.51;
43.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FLOT2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FLOT2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLOT2 Gene
Disorders for FLOT2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| isolated elevated serum creatine phosphokinase levels |
|
|
Search FLOT2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FLOT2
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FLOT2 Gene
Publications for FLOT2 Gene
- Cloning and characterization of a novel epidermal cell surface antigen (ESA). (PMID: 8051082) Schroeder WT … Duvic M (The Journal of biological chemistry 1994) 3 4 23
- The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12. (PMID: 1769667) Schroeder WT … Duvic M (Genomics 1991) 2 3 23
- DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. (PMID: 22081607) Li Y … Hofmann SL (The Journal of biological chemistry 2012) 3 4
- A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C … Rechsteiner M (The Journal of biological chemistry 2010) 3 4
- Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease. (PMID: 19542222) Hung YH … Bush AI (The Journal of biological chemistry 2009) 3 23
ExternalLinks
Products for FLOT2 Gene
- Custom Antibody ServicesOriGene Antibodies for FLOT2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for FLOT2
- Origene Custom Protein Services for FLOT2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLOT2
- Browse OriGene Inhibitory RNA Products For FLOT2
- OriGene qPCR primer pairs for FLOT2
- OriGene qPCR primer pairs and template standards for FLOT2
- OriGene CRISPR knockouts for FLOT2
- MG205924
- MG222238
- MR205924
- MR205924L3
- MR205924L4
- MR222238
- MR222238L3
- MR222238L4
- MR229590
- MR229999
- RC220884
- RC220884L1
- RC220884L2
- RC220884L3
- RC220884L4
- RG220884
- RR201193
- RR201193L3
- RR201193L4
- RR216524
- RR216649
- MR205924L3V
- MR205924L4V
- MR222238L3V
- MR222238L4V
- RC220884L1V
- RC220884L2V
- RC220884L3V
- RC220884L4V
- RR201193L3V
- RR201193L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FLOT2
- Sino Biological Human cDNA Clone for FLOT2
- Browse Sino Biological Recombinant Proteins
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- Sino Biological Antibodies for FLOT2
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FLOT2
- Novus Biologicals proteins and lysates for FLOT2
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- Abcam proteins for FLOT2
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- Invitrogen Antibodies for FLOT2 (AFLGC-FLOT2)
- VectorBuilder Custom and pre-made DNA vectors for FLOT2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FLOT2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FLOT2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FLOT2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FLOT2
- antibodies-online: Show 21 available Flotillin 2 Antibodies ranked by validation data
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- antibodies-online: Show 23 available Flotillin 2 Elisa Kits ranked by validation data
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- antibodies-online: Show 9 available Flotillin 2 Proteins ranked by validation data
- Compare Top Flotillin 2 Proteins
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- Santa Cruz Biotechnology (SCBT) Antibodies for FLOT2
- Search Santa Cruz Biotechnology (SCBT) for FLOT2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FLOT2
- Horizon Cell Lines for FLOT2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLOT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLOT2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FLOT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLOT2
Sources for FLOT2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB