Aliases for FLOT2 Gene
Aliases for FLOT2 Gene
External Ids for FLOT2 Gene
- HGNC: 3758
- Entrez Gene: 2319
- Ensembl: ENSG00000132589
- OMIM: 131560
- UniProtKB: Q14254
Previous HGNC Symbols for FLOT2 Gene
- M17S1
Previous GeneCards Identifiers for FLOT2 Gene
- GC17M027051
- GC17M029105
- GC17M027351
- GC17M024230
- GC17M027206
- GC17M023414
- GC17M028880
- GC17M028881
- GC17M028982
- GC17M029011
Summaries for FLOT2 Gene
-
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]
GeneCards Summary for FLOT2 Gene
FLOT2 (Flotillin 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include protease binding and ionotropic glutamate receptor binding. An important paralog of this gene is FLOT1.
UniProtKB/Swiss-Prot for FLOT2 Gene
-
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLOT2 Gene
Genomics for FLOT2 Gene
GeneHancer (GH) Regulatory Elements for FLOT2 Gene
Promoters and enhancers for FLOT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FLOT2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FLOT2 gene promoter:
-
- CUTL1
- AP-4
- Sox5
- AhR
- HSF1 (long)
- HSF1short
- Arnt
- PPAR-gamma2
- PPAR-gamma1
Regulatory Element Products
Genomic Locations for FLOT2 Gene
Genomic Locations for FLOT2 Gene
- chr17:28,879,335-28,897,697
- (GRCh38/hg38)
- Size:
- 18,363 bases
- Orientation:
- Minus strand
- chr17:27,206,353-27,224,715
- (GRCh37/hg19)
- Size:
- 18,363 bases
- Orientation:
- Minus strand
Genomic View for FLOT2 Gene
Genes around FLOT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q11.2 by Entrez Gene
- 17q11.2 by HGNC
- 17q11.2 by Ensembl
FLOT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FLOT2 Gene
Proteins for FLOT2 Gene
-
Protein details for FLOT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14254-FLOT2_HUMAN
- Recommended name:
- Flotillin-2
- Protein Accession:
- Q14254
Protein attributes for FLOT2 Gene
- Size:
- 428 amino acids
- Molecular mass:
- 47064 Da
- Quaternary structure:
-
- Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECPAS.
- SequenceCaution:
-
- Sequence=AAA65729.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for FLOT2 Gene
Post-translational modifications for FLOT2 Gene
- ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.
- Ubiquitination at isoforms=370, Lys169, isoforms=160, isoforms=100, and Lys81
- Modification sites at PhosphoSitePlus
Other Protein References for FLOT2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FLOT2
- Novus Biologicals Antibodies for FLOT2
-
Abcam antibodies for FLOT2
- Invitrogen Antibodies for FLOT2
- GeneTex FLOT2 Antibody for FLOT2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FLOT2
- Sino Biological Antibodies for FLOT2
Protein Products
-
OriGene Purified Proteins for FLOT2
- Search Origene for MassSpec and Protein Over-expression Lysates for FLOT2
- Origene Custom Protein Services for FLOT2
- Search GeneTex for Proteins for FLOT2
-
Abcam proteins for FLOT2
Assay Products
No data available for DME Specific Peptides for FLOT2 Gene
Domains & Families for FLOT2 Gene
Gene Families for FLOT2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FLOT2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FLOT2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14254- Family:
-
- Belongs to the band 7/mec-2 family. Flotillin subfamily.
Function for FLOT2 Gene
Molecular function for FLOT2 Gene
- UniProtKB/Swiss-Prot Function:
- May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
- GENATLAS Biochemistry:
- flotillin 2,35kDa,resident integral membrane protein of caveolae from epithelial surface, involved in cell adhesion
Phenotypes From GWAS Catalog for FLOT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 17113085 |
| GO:0035255 | ionotropic glutamate receptor binding | IEA | -- |
| GO:0046982 | protein heterodimerization activity | IMP | 21696602 |
Phenotypes for FLOT2 Gene
- MGI mutant phenotypes for FLOT2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FLOT2:
Animal Models for FLOT2 Gene
- MGI Knock Outs for FLOT2:
-
- Flot2 Flot2<tm1Mak>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FLOT2
-
CRISPR Products
-
OriGene CRISPR knockouts for FLOT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLOT2
- genomics-online: gRNA clones - Search results for 144 available Flotillin 2 gene related products
- Overview of 144 available Flotillin 2 gene related products
- Applied Biological Materials CRISPR for FLOT2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLOT2
- GenScript: Design CRISPR guide RNA sequences for FLOT2
miRNA for FLOT2 Gene
- miRTarBase miRNAs that target FLOT2
-
- hsa-mir-148b-3p (MIRT019295)
- hsa-mir-124-3p (MIRT022325)
- hsa-mir-1-3p (MIRT023557)
- hsa-mir-423-3p (MIRT042495)
- hsa-mir-4433a-5p (MIRT691681)
- hsa-mir-6858-5p (MIRT691682)
- hsa-mir-4689 (MIRT691683)
- hsa-mir-4303 (MIRT691684)
- hsa-mir-4320 (MIRT691685)
- hsa-mir-6081 (MIRT691686)
- hsa-mir-6836-5p (MIRT691687)
- hsa-mir-6132 (MIRT691688)
- hsa-mir-4445-5p (MIRT691689)
- hsa-mir-6766-3p (MIRT691690)
- hsa-mir-4782-3p (MIRT691691)
- hsa-mir-219a-5p (MIRT691692)
- hsa-mir-508-3p (MIRT691693)
- hsa-mir-4765 (MIRT691694)
- hsa-mir-4784 (MIRT691695)
- hsa-mir-3150b-3p (MIRT691696)
- hsa-mir-4693-3p (MIRT691697)
- hsa-mir-7162-3p (MIRT691698)
- hsa-mir-4649-3p (MIRT691699)
- hsa-mir-3918 (MIRT691700)
- hsa-mir-761 (MIRT691701)
- hsa-mir-3619-5p (MIRT691702)
- hsa-mir-214-3p (MIRT691703)
- hsa-mir-8062 (MIRT691704)
- hsa-mir-6895-5p (MIRT691705)
- hsa-mir-6510-5p (MIRT691706)
- hsa-mir-6838-5p (MIRT691707)
- hsa-mir-497-5p (MIRT691708)
- hsa-mir-424-5p (MIRT691709)
- hsa-mir-195-5p (MIRT691710)
- hsa-mir-16-5p (MIRT691711)
- hsa-mir-15b-5p (MIRT691712)
- hsa-mir-15a-5p (MIRT691713)
- hsa-mir-5586-3p (MIRT691714)
- hsa-mir-449a (MIRT732072)
- hsa-mir-34a-5p (MIRT733318)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLOT2
- Browse OriGene Inhibitory RNA Products For FLOT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLOT2
- genomics-online: shRNA clones - Search results for 144 available Flotillin 2 gene related products
- Overview of 144 available Flotillin 2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FLOT2
- VectorBuilder custom plasmid, inducible vectors for FLOT2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FLOT2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLOT2
- Applied Biological Materials Clones for FLOT2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FLOT2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLOT2 Gene
Localization for FLOT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FLOT2 Gene
- Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Endosome. Membrane; Lipid-anchor. Note=Membrane-associated protein of caveolae.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endosome | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001931 | uropod | IDA | 21696602 |
| GO:0002080 | acrosomal membrane | IEA | -- |
| GO:0005768 | endosome | IDA,IEA | 20682791 |
| GO:0005886 | plasma membrane | NAS,TAS | -- |
| GO:0005901 | caveola | IDA | 24013648 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FLOT2 Gene
Pathways & Interactions for FLOT2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
| 2 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
| 3 | Cytoskeletal Signaling | ||
| 4 | Beta-Adrenergic Signaling | ||
| 5 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for FLOT2 Gene
2 BioSystems pathways for FLOT2 Gene
3 Reactome pathways for FLOT2 Gene
1 KEGG pathway for FLOT2 Gene
1 Qiagen pathway for FLOT2 Gene
1 Cell Signaling Technology pathway for FLOT2 Gene
Interacting Proteins for FLOT2 Gene
Selected Interacting proteins:
ENSP00000378368
Q14254-FLOT2_HUMAN
for FLOT2 Gene via
STRING
IID
MINT
UniProtKB
GPS-Prot Interaction Network for FLOT2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001765 | membrane raft assembly | IMP | 25204797 |
| GO:0007155 | cell adhesion | IEA,NAS | -- |
| GO:0008544 | epidermis development | TAS | 8051082 |
| GO:0010629 | negative regulation of gene expression | IMP | 24612608 |
| GO:0034114 | NOT regulation of heterotypic cell-cell adhesion | IMP | 25204797 |
No data available for SIGNOR curated interactions for FLOT2 Gene
Transcripts for FLOT2 Gene
mRNA/cDNA for FLOT2 Gene
- (8) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (565) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000394906 2756 bps (uc060dft.1)
- ENST00000394908 2618 bps (uc002hdc.4)
- ENST00000580805 2679 bps (uc060dfu.1)
- ENST00000584569 266 bps (uc060dfv.1)
- ENST00000577789 2503 bps (uc060dfw.1)
CRISPR Products
-
OriGene CRISPR knockouts for FLOT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLOT2
- genomics-online: gRNA clones - Search results for 144 available Flotillin 2 gene related products
- Overview of 144 available Flotillin 2 gene related products
- Applied Biological Materials CRISPR for FLOT2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLOT2
- GenScript: Design CRISPR guide RNA sequences for FLOT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLOT2
- Browse OriGene Inhibitory RNA Products For FLOT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLOT2
- genomics-online: shRNA clones - Search results for 144 available Flotillin 2 gene related products
- Overview of 144 available Flotillin 2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FLOT2
- VectorBuilder custom plasmid, inducible vectors for FLOT2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FLOT2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLOT2
- Applied Biological Materials Clones for FLOT2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FLOT2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Hematopoietic Bone Marrow
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Pancreas (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for FLOT2 Gene
This gene is overexpressed in Whole Blood (x16.9).
This gene is overexpressed in Peripheral blood mononuclear cells (14.5) and Nasal epithelium (9.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FLOT2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FLOT2 Gene:
FLOT2SOURCE GeneReport for Unigene cluster for FLOT2 Gene:
Hs.514038mRNA Expression by UniProt/SwissProt for FLOT2 Gene:
Q14254-FLOT2_HUMAN
Tissue specificity:
In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes.
Evidence on tissue expression from TISSUES for FLOT2 Gene
- Liver(4.4)
- Pancreas(4.3)
- Skin(4.3)
- Nervous system(3.7)
- Lung(2.9)
- Blood(2.7)
- Muscle(2.4)
- Heart(2.2)
- Intestine(2.2)
- Kidney(2.2)
- Lymph node(2.2)
- Eye(2.1)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for FLOT2
-
OriGene qPCR primer pairs for FLOT2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FLOT2 Gene
Orthologs for FLOT2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FLOT2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FLOT2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FLOT2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Flot2 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FLOT2 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Flot2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FLOT2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FLOT2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FLOT2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | flot2 33 |
|
||
| Str.3461 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | flot2-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | flot2a 34 |
|
OneToMany | |
| flot2b 34 33 |
|
OneToMany | |||
| zgc64103 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9615 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Flo-2 34 35 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003789 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8302 34 |
|
OneToOne | |
| Cin.2729 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2729 33 |
|
- Species where no ortholog for FLOT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for FLOT2 Gene
- ENSEMBL:
- Gene Tree for FLOT2 (if available)
- TreeFam:
- Gene Tree for FLOT2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FLOT2: view image
Paralogs for FLOT2 Gene
Variants for FLOT2 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000087723 | -- | 28,893,859(-) | T/C/G | intron_variant | |
| rs1000197598 | -- | 28,897,409(-) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000237236 | -- | 28,887,297(-) | G/A | intron_variant | |
| rs1000336539 | -- | 28,893,504(-) | C/T | intron_variant | |
| rs1000708204 | -- | 28,893,744(-) | C/A | intron_variant |
Residual Variation Intolerance Score:
43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.51;
43.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FLOT2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FLOT2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLOT2 Gene
Disorders for FLOT2 Gene
Additional Disease Information for FLOT2
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for FLOT2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FLOT2 Gene
Publications for FLOT2 Gene
- Cloning and characterization of a novel epidermal cell surface antigen (ESA). (PMID: 8051082) Schroeder WT … Duvic M (The Journal of biological chemistry 1994) 3 4 22 58
- The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12. (PMID: 1769667) Schroeder WT … Duvic M (Genomics 1991) 2 3 22 58
- DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. (PMID: 22081607) Li Y … Hofmann SL (The Journal of biological chemistry 2012) 3 4 58
- A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C … Rechsteiner M (The Journal of biological chemistry 2010) 3 4 58
- Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. (PMID: 19318123) Babuke T … Tikkanen R (Cellular signalling 2009) 3 22 58
Products for FLOT2 Gene
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cyagen custom Knockout/knockin (KOKI) mouse models for FLOT2
- VectorBuilder custom plasmid, inducible vectors for FLOT2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FLOT2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 101 available Flotillin 2 Antibodies ranked by validation data
- Compare Top Flotillin 2 Antibodies
- antibodies-online: Search results for 19 available Flotillin 2 Elisa Kits ranked by validation data
- Compare Top Flotillin 2 Elisa Kits
- antibodies-online: Search results for 7 available Flotillin 2 Proteins ranked by validation data
- Compare Top Flotillin 2 Proteins
- Quality Products:
- GeneTex FLOT2 Antibody for FLOT2
- Search GeneTex for Proteins for FLOT2
- Santa Cruz Biotechnology (SCBT) Antibodies for FLOT2
- Search Santa Cruz Biotechnology (SCBT) for FLOT2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FLOT2
- Horizon Cell Lines for FLOT2
- genomics-online: cdna clones - Search results for 144 available Flotillin 2 gene related products
- Overview of 144 available Flotillin 2 gene related products
- orf clones - Search results for 144 available Flotillin 2 gene related products
- Overview of 144 available Flotillin 2 gene related products
- genomics-online: gRNA clones - Search results for 144 available Flotillin 2 gene related products
- Overview of 144 available Flotillin 2 gene related products
- genomics-online: primer clones - Search results for 144 available Flotillin 2 gene related products
- Overview of 144 available Flotillin 2 gene related products
- genomics-online: shRNA clones - Search results for 144 available Flotillin 2 gene related products
- Overview of 144 available Flotillin 2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLOT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLOT2
- GeneCopoeia miRNA 3'UTR Target clone products for FLOT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLOT2
Sources for FLOT2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt