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Aliases for FLOT2 Gene

Aliases for FLOT2 Gene

  • Flotillin 2 2 3 5
  • Membrane Component, Chromosome 17, Surface Marker 1 (35kD Protein Identified By Monoclonal Antibody ECS-1) 2 3
  • Membrane Component Chromosome 17 Surface Marker 1 3 4
  • Flotillin 2 (Epidermal Surface Antigen 1) 2 3
  • Epidermal Surface Antigen 3 4
  • M17S1 3 4
  • ESA1 3 4
  • ESA 3 4
  • Flotillin-2 3
  • ECS-1 3
  • ECS1 3

External Ids for FLOT2 Gene

Previous HGNC Symbols for FLOT2 Gene

  • M17S1

Previous GeneCards Identifiers for FLOT2 Gene

  • GC17M027051
  • GC17M029105
  • GC17M027351
  • GC17M024230
  • GC17M027206
  • GC17M023414
  • GC17M028880
  • GC17M028881
  • GC17M028982
  • GC17M029011

Summaries for FLOT2 Gene

Entrez Gene Summary for FLOT2 Gene

  • Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLOT2 Gene

FLOT2 (Flotillin 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include protease binding and ionotropic glutamate receptor binding. An important paralog of this gene is FLOT1.

UniProtKB/Swiss-Prot for FLOT2 Gene

  • May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.

Gene Wiki entry for FLOT2 Gene

Additional gene information for FLOT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLOT2 Gene

Genomics for FLOT2 Gene

GeneHancer (GH) Regulatory Elements for FLOT2 Gene

Promoters and enhancers for FLOT2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J028891 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.4 2373 7.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF207 ZNF143 FLOT2 NUFIP2 SUPT6H PHF12 ENSG00000264577 ENSG00000265908 ENSG00000265205 RPL23A SDF2 PROCA1
GH17J028936 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 27.2 -39.6 -39608 1.6 ELF3 FOXA2 ARID4B YY1 EGR1 ATF7 CREM THAP11 MIXL1 RXRA FLOT2 PHF12 DHRS13 TIAF1 NUFIP2 UNC119 SDF2 TAOK1 ENSG00000265908 LOC101927018
GH17J028854 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.9 +42.6 42639 1.7 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ERAL1 FAM222B FLOT2 DHRS13 SNORD42A SNORD4A SNORD4B PROCA1
GH17J028807 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +87.3 87258 6.8 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 SUPT6H TRAF4 LOC101927018 ENSG00000264577 ENSG00000265205 NUFIP2 ENSG00000265908 ERAL1 FAM222B PIGS
GH17J028923 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -28.4 -28366 4.8 PKNOX1 ATF1 FEZF1 IRF4 ZNF766 FOS ATF7 RUNX3 JUNB NCOA1 LOC101927018 PHF12 FLOT2 DHRS13 ERAL1 FAM222B SEZ6 SUPT6H NUFIP2 SNORD42A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FLOT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FLOT2 gene promoter:
  • CUTL1
  • AP-4
  • Sox5
  • AhR
  • HSF1 (long)
  • HSF1short
  • Arnt
  • PPAR-gamma2
  • PPAR-gamma1

Genomic Locations for FLOT2 Gene

Genomic Locations for FLOT2 Gene
18,363 bases
Minus strand
18,363 bases
Minus strand

Genomic View for FLOT2 Gene

Genes around FLOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLOT2 Gene

Proteins for FLOT2 Gene

  • Protein details for FLOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for FLOT2 Gene

    428 amino acids
    Molecular mass:
    47064 Da
    Quaternary structure:
    • Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECPAS.
    • Sequence=AAA65729.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FLOT2 Gene

Post-translational modifications for FLOT2 Gene

  • ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.
  • Ubiquitination at isoforms=370, Lys169, isoforms=160, isoforms=100, and Lys81
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FLOT2 Gene

Domains & Families for FLOT2 Gene

Gene Families for FLOT2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FLOT2 Gene

Suggested Antigen Peptide Sequences for FLOT2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
genes like me logo Genes that share domains with FLOT2: view

Function for FLOT2 Gene

Molecular function for FLOT2 Gene

UniProtKB/Swiss-Prot Function:
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
GENATLAS Biochemistry:
flotillin 2,35kDa,resident integral membrane protein of caveolae from epithelial surface, involved in cell adhesion

Phenotypes From GWAS Catalog for FLOT2 Gene

Gene Ontology (GO) - Molecular Function for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0005515 protein binding IPI 17113085
GO:0035255 ionotropic glutamate receptor binding IEA --
GO:0046982 protein heterodimerization activity IMP 21696602
genes like me logo Genes that share ontologies with FLOT2: view
genes like me logo Genes that share phenotypes with FLOT2: view

Animal Models for FLOT2 Gene

MGI Knock Outs for FLOT2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLOT2 Gene

Localization for FLOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLOT2 Gene

Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Endosome. Membrane; Lipid-anchor. Note=Membrane-associated protein of caveolae.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLOT2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
mitochondrion 3
nucleus 3
cytosol 3
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 21696602
GO:0002080 acrosomal membrane IEA --
GO:0005768 endosome IDA,IEA 20682791
GO:0005886 plasma membrane NAS,TAS --
GO:0005901 caveola IDA 24013648
genes like me logo Genes that share ontologies with FLOT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FLOT2 Gene

Pathways & Interactions for FLOT2 Gene

genes like me logo Genes that share pathways with FLOT2: view

Pathways by source for FLOT2 Gene

1 Qiagen pathway for FLOT2 Gene
1 Cell Signaling Technology pathway for FLOT2 Gene

Gene Ontology (GO) - Biological Process for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001765 membrane raft assembly IMP 25204797
GO:0007155 cell adhesion IEA,NAS --
GO:0008544 epidermis development TAS 8051082
GO:0010629 negative regulation of gene expression IMP 24612608
GO:0034114 NOT regulation of heterotypic cell-cell adhesion IMP 25204797
genes like me logo Genes that share ontologies with FLOT2: view

No data available for SIGNOR curated interactions for FLOT2 Gene

Drugs & Compounds for FLOT2 Gene

(3) Drugs for FLOT2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FLOT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FLOT2: view

Transcripts for FLOT2 Gene

Unigene Clusters for FLOT2 Gene

Flotillin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLOT2 Gene

No ASD Table

Relevant External Links for FLOT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FLOT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLOT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLOT2 Gene

This gene is overexpressed in Whole Blood (x16.9).

Protein differential expression in normal tissues from HIPED for FLOT2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5) and Nasal epithelium (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FLOT2 Gene

Protein tissue co-expression partners for FLOT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FLOT2 Gene:


SOURCE GeneReport for Unigene cluster for FLOT2 Gene:


mRNA Expression by UniProt/SwissProt for FLOT2 Gene:

Tissue specificity: In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes.

Evidence on tissue expression from TISSUES for FLOT2 Gene

  • Liver(4.4)
  • Pancreas(4.3)
  • Skin(4.3)
  • Nervous system(3.7)
  • Lung(2.9)
  • Blood(2.7)
  • Muscle(2.4)
  • Heart(2.2)
  • Intestine(2.2)
  • Kidney(2.2)
  • Lymph node(2.2)
  • Eye(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with FLOT2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FLOT2 Gene

Orthologs for FLOT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLOT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FLOT2 34 33
  • 99.61 (n)
(Bos Taurus)
Mammalia FLOT2 34 33
  • 92.52 (n)
(Canis familiaris)
Mammalia FLOT2 34 33
  • 92.33 (n)
(Mus musculus)
Mammalia Flot2 16 34 33
  • 90.65 (n)
(Monodelphis domestica)
Mammalia FLOT2 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Flot2 33
  • 88.79 (n)
(Ornithorhynchus anatinus)
Mammalia FLOT2 34
  • 85 (a)
(Gallus gallus)
Aves FLOT2 34
  • 84 (a)
(Anolis carolinensis)
Reptilia FLOT2 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia flot2 33
  • 76.13 (n)
Str.3461 33
African clawed frog
(Xenopus laevis)
Amphibia flot2-prov 33
(Danio rerio)
Actinopterygii flot2a 34
  • 81 (a)
flot2b 34 33
  • 73.15 (n)
zgc64103 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9615 33
fruit fly
(Drosophila melanogaster)
Insecta Flo-2 34 35 33
  • 65.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003789 33
  • 64.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8302 34
  • 65 (a)
Cin.2729 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2729 33
Species where no ortholog for FLOT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLOT2 Gene

Gene Tree for FLOT2 (if available)
Gene Tree for FLOT2 (if available)
Evolutionary constrained regions (ECRs) for FLOT2: view image

Paralogs for FLOT2 Gene

Paralogs for FLOT2 Gene

(1) SIMAP similar genes for FLOT2 Gene using alignment to 8 proteins:

  • K7EJ47_HUMAN
  • Q6FG43_HUMAN
genes like me logo Genes that share paralogs with FLOT2: view

Variants for FLOT2 Gene

Sequence variations from dbSNP and Humsavar for FLOT2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000087723 -- 28,893,859(-) T/C/G intron_variant
rs1000197598 -- 28,897,409(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000237236 -- 28,887,297(-) G/A intron_variant
rs1000336539 -- 28,893,504(-) C/T intron_variant
rs1000708204 -- 28,893,744(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FLOT2 Gene

Variant ID Type Subtype PubMed ID
nsv457719 CNV loss 19166990
nsv574662 CNV loss 21841781

Variation tolerance for FLOT2 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FLOT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLOT2 Gene

Disorders for FLOT2 Gene

Additional Disease Information for FLOT2

No disorders were found for FLOT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FLOT2 Gene

Publications for FLOT2 Gene

  1. Cloning and characterization of a novel epidermal cell surface antigen (ESA). (PMID: 8051082) Schroeder WT … Duvic M (The Journal of biological chemistry 1994) 3 4 22 58
  2. The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12. (PMID: 1769667) Schroeder WT … Duvic M (Genomics 1991) 2 3 22 58
  3. DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. (PMID: 22081607) Li Y … Hofmann SL (The Journal of biological chemistry 2012) 3 4 58
  4. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C … Rechsteiner M (The Journal of biological chemistry 2010) 3 4 58
  5. Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. (PMID: 19318123) Babuke T … Tikkanen R (Cellular signalling 2009) 3 22 58

Products for FLOT2 Gene

Sources for FLOT2 Gene

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