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Aliases for FLOT1 Gene

Aliases for FLOT1 Gene

  • Flotillin 1 2 3 5
  • Integral Membrane Component Of Caveolae 3
  • Flotillin-1 3

External Ids for FLOT1 Gene

Previous GeneCards Identifiers for FLOT1 Gene

  • GC06M030751
  • GC06M030466
  • GC06M030801
  • GC06M030803
  • GC06M030695

Summaries for FLOT1 Gene

Entrez Gene Summary for FLOT1 Gene

  • This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for FLOT1 Gene

FLOT1 (Flotillin 1) is a Protein Coding gene. Diseases associated with FLOT1 include Mycobacterium Marinum. Among its related pathways are Cytoskeletal Signaling and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include protease binding and ionotropic glutamate receptor binding. An important paralog of this gene is FLOT2.

UniProtKB/Swiss-Prot for FLOT1 Gene

  • May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

Gene Wiki entry for FLOT1 Gene

Additional gene information for FLOT1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLOT1 Gene

Genomics for FLOT1 Gene

GeneHancer (GH) Regulatory Elements for FLOT1 Gene

Promoters and enhancers for FLOT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J030739 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 656.1 -0.2 -173 6.5 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 FLOT1 IER3 IER3-AS1 HCG20 LY6G5B DDX39B MDC1 TRIM39 DHX16 RPL3P2
GH06J030798 Enhancer 1.3 Ensembl ENCODE dbSUPER 22.8 -57.5 -57458 3.9 PKNOX1 ATF1 FOXA2 RARA ZNF766 ZSCAN5C FOS ATF7 CREM CAVIN1 DDR1 IER3 FLOT1 VARS2 LINC00243 DDR1-DT GTF2H4 MUCL3 HCG21 HCG18
GH06J030757 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14 -21.6 -21586 14 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF263 IER3 PPP1R10 MDC1 TRIM39 DDX39B LY6G5B ZNRD1 VARS2 GTF2H4 NRM
GH06J030777 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.4 -39.6 -39632 10.1 MLX ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC PPARGC1A MEF2D SSRP1 IER3 VARS2 PPP1R10 MDC1 DHX16 DDX39B GTF2H4 PAIP1P1 LY6G5B ETF1P1
GH06J030879 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.2 -141.7 -141650 9.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 FOS DDR1 VARS2 PSORS1C1 HLA-C GNL1 PSORS1C3 SFTA2 HCG18 IER3 FLOT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FLOT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FLOT1 gene promoter:
  • AML1a

Genomic Locations for FLOT1 Gene

Genomic Locations for FLOT1 Gene
15,025 bases
Minus strand
15,025 bases
Minus strand

Genomic View for FLOT1 Gene

Genes around FLOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for FLOT1 Gene

  • Protein details for FLOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DVY7
    • Q969J8
    • Q9UHW1
    • Q9UNV8

    Protein attributes for FLOT1 Gene

    427 amino acids
    Molecular mass:
    47355 Da
    Quaternary structure:
    • Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECPAS.

    Alternative splice isoforms for FLOT1 Gene


neXtProt entry for FLOT1 Gene

Post-translational modifications for FLOT1 Gene

  • Ubiquitination at isoforms=2422, Lys211, and isoforms=78
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FLOT1 Gene

Domains & Families for FLOT1 Gene

Gene Families for FLOT1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FLOT1 Gene

Suggested Antigen Peptide Sequences for FLOT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
genes like me logo Genes that share domains with FLOT1: view

Function for FLOT1 Gene

Molecular function for FLOT1 Gene

UniProtKB/Swiss-Prot Function:
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

Phenotypes From GWAS Catalog for FLOT1 Gene

Gene Ontology (GO) - Molecular Function for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA,IPI 24612608
GO:0005515 protein binding IPI 15469992
GO:0035255 ionotropic glutamate receptor binding IEA --
GO:0046982 protein heterodimerization activity IMP 21696602
genes like me logo Genes that share ontologies with FLOT1: view
genes like me logo Genes that share phenotypes with FLOT1: view

Animal Models for FLOT1 Gene

MGI Knock Outs for FLOT1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLOT1 Gene

Localization for FLOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLOT1 Gene

Cell membrane; Peripheral membrane protein. Endosome. Membrane, caveola; Peripheral membrane protein. Melanosome. Membrane raft. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Membrane-associated protein of caveola (By similarity). {ECO:0000250 UniProtKB:O08917, ECO:0000269 PubMed:17081065}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLOT1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
lysosome 5
endosome 5
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 21696602
GO:0005765 lysosomal membrane HDA 17897319
GO:0005768 endosome IDA,IEA 20682791
GO:0005769 early endosome IDA 21399631
GO:0005815 microtubule organizing center IDA 18000879
genes like me logo Genes that share ontologies with FLOT1: view

Pathways & Interactions for FLOT1 Gene

genes like me logo Genes that share pathways with FLOT1: view

Pathways by source for FLOT1 Gene

1 Qiagen pathway for FLOT1 Gene
1 Cell Signaling Technology pathway for FLOT1 Gene

Gene Ontology (GO) - Biological Process for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001765 membrane raft assembly IMP 25204797
GO:0001819 positive regulation of cytokine production IMP 25204797
GO:0001934 positive regulation of protein phosphorylation IMP 25204797
GO:0002090 regulation of receptor internalization IMP 21399631
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with FLOT1: view

No data available for SIGNOR curated interactions for FLOT1 Gene

Drugs & Compounds for FLOT1 Gene

(4) Drugs for FLOT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for FLOT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FLOT1: view

Transcripts for FLOT1 Gene

Unigene Clusters for FLOT1 Gene

Flotillin 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLOT1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - - -
SP2: - - - - - - - - -
SP4: - -
SP5: - -
SP7: - - - - - - - -

Relevant External Links for FLOT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FLOT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLOT1 Gene

mRNA differential expression in normal tissues according to GTEx for FLOT1 Gene

This gene is overexpressed in Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for FLOT1 Gene

This gene is overexpressed in Nasal epithelium (12.6) and Peripheral blood mononuclear cells (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FLOT1 Gene

Protein tissue co-expression partners for FLOT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FLOT1 Gene:


SOURCE GeneReport for Unigene cluster for FLOT1 Gene:


Evidence on tissue expression from TISSUES for FLOT1 Gene

  • Lung(4.7)
  • Nervous system(4.6)
  • Blood(4.5)
  • Adrenal gland(4.3)
  • Liver(4.3)
  • Stomach(4.3)
  • Intestine(3.7)
  • Skin(2.8)
  • Muscle(2.7)
  • Eye(2.6)
  • Kidney(2.4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with FLOT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FLOT1 Gene

Orthologs for FLOT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLOT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FLOT1 34 33
  • 99.84 (n)
(Bos Taurus)
Mammalia FLOT1 34 33
  • 93.05 (n)
(Monodelphis domestica)
Mammalia FLOT1 34
  • 93 (a)
(Canis familiaris)
Mammalia FLOT1 34 33
  • 92.74 (n)
(Rattus norvegicus)
Mammalia Flot1 33
  • 90.16 (n)
(Mus musculus)
Mammalia Flot1 16 34 33
  • 89.93 (n)
(Anolis carolinensis)
Reptilia FLOT1 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia flot1 33
  • 72.2 (n)
Str.7164 33
(Danio rerio)
Actinopterygii flot1b 34
  • 79 (a)
flot1a 34 33
  • 74.8 (n)
wufb53d05 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007494 33
  • 66.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta Flo-1 34 33
  • 66.35 (n)
Flo 35
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 62 (a)
Cin.4127 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4127 33
Species where no ortholog for FLOT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLOT1 Gene

Gene Tree for FLOT1 (if available)
Gene Tree for FLOT1 (if available)
Evolutionary constrained regions (ECRs) for FLOT1: view image

Paralogs for FLOT1 Gene

Paralogs for FLOT1 Gene

(1) SIMAP similar genes for FLOT1 Gene using alignment to 11 proteins:

  • A2AB09_HUMAN
  • A2AB10_HUMAN
  • A2AB11_HUMAN
  • A2AB12_HUMAN
  • A2AB13_HUMAN
  • Q5ST80_HUMAN
  • Q6IB58_HUMAN
genes like me logo Genes that share paralogs with FLOT1: view

Variants for FLOT1 Gene

Sequence variations from dbSNP and Humsavar for FLOT1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000011447 -- 30,733,354(-) T/C intron_variant
rs1000214172 -- 30,743,854(-) G/A upstream_transcript_variant
rs1001100498 -- 30,743,309(-) A/G upstream_transcript_variant
rs1001525518 -- 30,727,909(-) C/G/T 3_prime_UTR_variant
rs1001533409 -- 30,743,107(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FLOT1 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv2759413 CNV loss 17122850
esv3411275 CNV duplication 20981092
esv3576135 CNV gain 25503493
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv830626 CNV loss 17160897

Variation tolerance for FLOT1 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FLOT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLOT1 Gene

Disorders for FLOT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FLOT1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mycobacterium marinum
  • fish tank granuloma
- elite association - COSMIC cancer census association via MalaCards
Search FLOT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FLOT1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FLOT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLOT1 Gene

Publications for FLOT1 Gene

  1. Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. (PMID: 11167132) Edgar AJ … Polak JM (The international journal of biochemistry & cell biology 2001) 3 4 22 58
  2. Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. (PMID: 25893292) Hwangbo C … Lee JH (Oncogene 2016) 3 4 58
  3. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C … Rechsteiner M (The Journal of biological chemistry 2010) 3 4 58
  4. The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. (PMID: 19815536) Lee BY … Horwitz MA (Molecular & cellular proteomics : MCP 2010) 3 22 58
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58

Products for FLOT1 Gene

Sources for FLOT1 Gene