Aliases for FLII Gene
External Ids for FLII Gene
Previous GeneCards Identifiers for FLII Gene
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
GeneCards Summary for FLII Gene
FLII (FLII Actin Remodeling Protein) is a Protein Coding gene. Diseases associated with FLII include Smith-Magenis Syndrome and Ewing Sarcoma. Among its related pathways are Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is SVIL.
UniProtKB/Swiss-Prot Summary for FLII Gene
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.